Enhanced morphine analgesia in mice lacking β-arrestin 2

Science

Volumn 286, Issue 5449, 1999, Pages 2495-2498

  Bohn, Laura M ^a   Lefkowitz, Robert J ^a   Gainetdinov, Raul R ^a   Peppel, Karsten ^a   Caron, Marc G ^a   Lin, Fang Tsyr ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; GENE DELETION; GENE EXPRESSION; HYPOTHERMIA; MOUSE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANALGESIA; ANALGESICS, OPIOID; ANIMALS; ARRESTINS; BINDING SITES; BODY TEMPERATURE; BRAIN; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; PAIN THRESHOLD; PHOSPHORYLATION; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033601341     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5449.2495     Document Type: Article

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44. We thank B. H. Koller for homologous recombinant mouse embryonic stem cells and chimeric mice, M. R. Capecchi for plasmid plC19R/MCl-TK, and R. Hen for plasmid pD383. R.R.G. is a visiting scientist from the Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. Supported in part by NIH grants NS 19576 (M.G.C.) and HL16037, and by a cardiovascular unrestricted grant from Bristol-Myers Squibb (R.J.L). R.J.L. and M.G.C. are Investigators of the Howard Hughes Medical Institute.