Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

Molecular and Cellular Biology

Volumn 21, Issue 13, 2001, Pages 4177-4187

  Melillo, R M ^a   Santoro, M ^a   Ong, S H ^a   Billaud, M ^a   Fusco, A ^a   Hadari, Y R ^a   Schlessinger, J ^a   Lax, I ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; FRS2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HIRSCHSPRUNG DISEASE; MOUSE; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA SPLICING; THYROID CARCINOMA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; CELL CYCLE; CELL LINE; DROSOPHILA PROTEINS; GENES, REPORTER; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HIRSCHSPRUNG DISEASE; HUMANS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS;

ANIMALIA;

EID: 0034967978     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.13.4177-4187.2001     Document Type: Article

References (50)

1. GDNF family neurotrophic factor signaling: Four masters, one servant?
2. Grb2 binding to the different isoforms of Ret tyrosine kinase
3. Identification of Shc docking site on Ret tyrosine kinase
4. A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins
5. The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
6. Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase
7. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase C gamma
8. Molecular heterogeneity of RET loss of function in Hirschsprung's disease
9. Overexpression of the HIP gene coding for a heparin/heparan sulfate-binding protein in human thyroid carcinomas
10. Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival
11. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2
12. Mitogenic signaling by Ret/ptc2 requires association with Enigma via a LIM domain
13. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
14. Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signaling effectors to a multifunctional docking site
15. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
16. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
17. cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line
18. Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation
19. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas
20. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins
21. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
22. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
23. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities
24. RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
25. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
26. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
27. Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: A novel C-terminus for RET
28. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
29. Stimulation of PI-3 kinase by FGF receptors is mediated by coordinated recruitment of multiple docking proteins
30. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10
31. Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
32. Loss of function effect of RET mutations causing Hirschsprung disease
33. Signaling through scaffold, anchoring, and adaptor proteins
34. Constitutive phosphorylation of Shc proteins in human tumors
35. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
36. Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts
37. The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome
38. The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
39. The GDNF protein family: Gene ablation studies reveal what they really do and how
40. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
41. Molecular characterization of RET/PTC3; a novel rearranged version of the RET protooncogene in a human thyroid papillary carcinoma
42. An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: Evidence for a retspecific signaling pathway
43. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice
44. The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line
45. Cell signaling by receptor tyrosine kinases
46. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
47. GFR alpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival
48. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity
49. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
50. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins