Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5674-5682

  Corbalan Garcia, S ^a   Yang, S S ^a   Degenhardt, K R ^a   Bar Sagi, D ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; PRIORITY JOURNAL;

EID: 0029791452     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5674     Document Type: Article

References (39)

1. Aronheim, A., D. Engelberg, N. Li, N. al-Alawi, J. Schlessinger, and M. Karin. 1994. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78:949-961.
2. Baltensperger, K., L. M. Kozma, A. D. Cherniack, J. K. Klarlund, A. Chawla, U. Barnerjee, and M. P. Czech. 1993. Binding of the ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science 260: 1950-1952.
3. Blattler, D. P., F. Garner, K. Van Slyke, and A. Bradley. 1972. Quantitative electrophoresis in polyacrylamide of 2-40%. J. Chromatogr. 64:147-155.
4. Boyle, N. J., P. Van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer plates. Methods Enzymol. 201:110-149.
5. ras through the formation of a complex receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor. Cell 48:611-620.
6. Buday, L., P. H. Warne, and J. Downward. 1995. Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. Oncogene 11: 1327-1331.
7. Burgering, B. M. T., G. J. Pronk, P. C. van Weeren, P. Chardin, and J. L. Bos. 1993. cAMP antagonizes p21 ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12:4211-4220.
8. Chardin, P., J. H. Camonis, N. W. Gale, L. Van Aelst, J. Schlessinger, M. H. Wigler, and D. Bar-Sagi. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to Grb2. Science 260:1338-1343.
9. Chen, D., S. B. Waters, K. H. Holt, and J. E. Pessin. 1996. Sos phosphorylation and disassociation of the Grb2-Sos complex by ERK and JNK signaling pathways. J. Biol. Chem. 271:6328-6332.
10. ras desensitization by insulin. J. Biol. Chem. 270:1485-1488.
11. Cherniack, A. D., J. K. Klarlund, and M. P. Czech. 1994. Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase. J. Biol. Chem. 269:4717-4720.
12. mpk, the meiosis-activated myelin basic protein kinase. J. Biol. Chem. 266:15180-15184.
13. Corbalan-Garcia, S., K. R. Degenhardt, and D. Bar-Sagi. 1996. Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation. Oncogene 12:1063-1068.
14. Corbalan-Garcia, S., A. Whitmarsh, R. J. Davis, and D. Bar-Sagi. Unpublished observations.
15. Egan, S. E., B. W. Giddings, M. W. Brooks, L. Buday, A. M. Sizeland, and R. Weinberg. 1993. Association of Sos ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (London) 363:45-51.
16. Gonzalez, F. A., D. L. Raden, and R. J. Davis. 1991. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 266:22159-22163.
17. Haycock, J. W., N. G. Ahn, M. H. Cobb, and E. G. Krebs. 1992. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc. Natl. Acad. Sci. USA 89:2365-2369.
18. Holt, K. H., B. G. Kasson, and J. E. Pessin. 1996. Insulin stimulation of a MEK-dependent but ERK-independent Sos protein kinase. Mol. Cell. Biol. 16:577-583.
19. Karlovich, C. A., L. Bonfini, L. McCollam, R. D. Rogge, A. Daga, M. P. Czech, and U. Banerjee. 1995. In vivo functional analysis of the Ras exchange factor Son of Sevenless. Science 268:570-579.
20. Li, N., A. Batzer, R. Daly, V. Yajnik, E. Skolnik, P. Chardin, D. Bar-Sagi, B. Margolis, and J. Schlessinger. 1993. Guanine-nucleotide-releasing factor hSos1 hinds to Grb2 and links receptor tyrosine kinases to ras signaling. Nature (London) 363:85-88.
21. Li, N., J. Schlessinger, and B. Margolis. 1994. Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins. Oncogene 9:3457-3465.
22. Lowenstein, E. R., R. J. Daly, A. G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein Grb2 links receptor tyrosine kinases to ras signaling. Cell 70:431-442.
23. Mayer, B. J., and D. Baltimore. 1993. Signaling through SH2 and SH3 domains. Trends Cell Biol. 3:8-13.
24. McCollam, L., L. Bonfini, C. A. Karlovich, B. R. Conway, L. M. Kozma, U. Banerjee, and M. P. Czech. 1995. Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son of sevenless. J. Biol. Chem. 270:15954-15957.
25. Porfiri, E., and F. McCormick. 1996. Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSos1. J. Biol. Chem. 271:5871-5877.
26. Rozakis-Adcock, M., R. Fernley, J. Wade, T. Pawson, and D. Bowtell. 1993. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 . Nature (London) 363:83-85.
27. Rozakis-Adcock, M., J. McGlade, G. Mbamalu, G. Pelicci, R. Daly, W. Li, A. Batzer, S. Thomas, J. Brugge, P. G. Pelicci, J. Schlessinger, and T. Pawson. 1992. Association of the Shc and Grb2/Scm5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (London) 360:689-692.
28. Rozakis-Adcock, M., P. van der Geer, G. Mbamalu, and T. Pawson. 1995. MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes. Oncogene 11:1417-1426.
29. Russo, G. L., M. T. Vandernberg, I. J. Yu, Y.-S. Bae, B. R. Franza, and D. R. Marshak. 1992. Caseine kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle. J. Biol. Chem. 267:20317-20325.
30. Schlessinger, J., and D. Bar-Sagi. 1994. Activation of Ras and other signaling pathways by receptor tyrosine kinases. Cold Spring Harbor Symp. Quant. Biol. 59:173-179.
31. Shibuya, E. K., A. J. Polverino, E. Chang, M. Wigler, and J. V. Ruderman. 1992. Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc. Natl. Acad. Sci. USA 89:9831-9835.
32. Skolnik, E. Y., C. H. Lee, A. Batzer, L. M. Vicentini, M. Zhou, R. Daly, M. J. Myers, J. M. Backer, A. Ullrich, M. F. White, and J. Schlessinger. 1993. The SH2/SH3 domain containing protein Grb2 interacts with tyrosine phosphorylated IRS-1 and Shc: implications for insulin control of Ras signaling. EMBO J. 12:1929-1936.
33. Songyang, Z., S. Blechner, N. Hoagland, M. F. Hoekstra, H. Piwnica-Worms, and L. C. Cantley. 1994. Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr. Biol. 4:973-982.
34. Wang, W., E. M. C. Fisher, Q. Jia, J. M. Dum, E. Porfiri, J. Downward, and S. E. Egan. 1995. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nat. Genet. 10:294-300.
35. Waters, S. B., K. H. Holt, S. E. Ross, L.-J. Syu, K.-L. Guan, A. R. Saltiel, G. A. Koretzky, and J. E. Pessin. 1995. Desensitization of Ras activation by a feedback dissociation of the Sos-Grb2 complex. J. Biol. Chem. 270:20883-20886.
36. Waters, S. B., K. Yamauchi, and J. E. Pessin. 1995. Insulin-stimulated disassociation of the Sos-Grb2 complex. Mol. Cell. Biol. 15:2791-2799.
37. Wigler, M., S. Silverstein, L. S. Lee, A. Pellicer, Y. C. Cheng, and R. Axel. 1977. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11:223-227.
38. Yang, S. S., L. Van Aelst, and D. Bar-Sagi, 1995. Differential interactions of human Sos1 and Sos2 with Grb2. J. Biol. Chem. 270:18212-18215.
39. Zhao, L.-J., Q. X. Zhang, and R. Padmanabhan. 1993. Polymerase chain reaction-based point mutagenesis protocol. Methods Enzymol. 217:218-227.