KSR: A MAPK scaffold of the Ras pathway?

Journal of Cell Science

Volumn 114, Issue 9, 2001, Pages 1609-1612

  Morrison, Deborah K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

KSR MAPK cascade; Scaffolding protein; Signal transduction

Indexed keywords

KINASE SUPPRESSOR OF RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; RAS PROTEIN; UNCLASSIFIED DRUG;

CAENORHABDITIS ELEGANS; CELL MEMBRANE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; ENZYME INACTIVATION; GENE MUTATION; GENETICS; NONHUMAN; NOTE; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; PROTEIN KINASES; RAS PROTEINS; SIGNAL TRANSDUCTION;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0035018017     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (23)

1. Bell, B., Xing, H., Van, H., Gautam, N. and Muslin, A. J. (1999). KSR1 binds to G-protein βγ subunits and inhibits βγ-induced mitogen-activated protein kinase activation. J. Biol. Chem. 274, 7982-7986.
2. Cacace, A. M., Michaud, N. R., Therrien, M., Mathes, K., Copeland, T., Rubin, G. M. and Morrison, D. K. (1999). Identification of constitutive and Ras-inducible phosphorylation sites of KSR: implication for 14-3-3 bindings, mitogen-activated protein kinase binding, and KSR overexpression. Mol. Cell. Biol. 19, 229-240.
3. Denouel-Galy, A., Douville, E. M., Warne, P. H., Papin, C., Laugier, D., Calothy, G., Downward, J. and Eychene, A. (1997). Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr. Biol. 8, 46-55.
4. Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L. and Davis, R. J. (1997). A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696.
5. Jacobs, D., Glossip, D., Xing, H., Muslin, A. J. and Kornfeld, K. (1999). Multiple docking sites on substrate proteins forms a modular system that mediates the recognition by ERK MAP kinase. Genes Dev. 13, 163-175.
6. Joneson, T., Fulton, J. A., Volle, D. J., Chaika, O. V., Bar-Sagi, D. and Lewis, R. E. (1998). Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J. Biol. Chem. 273, 7743-7748.
7. Karandikar, M., Xu, S. and Cobb, M. H. (2000). MEKK1 binds Raf-1 and the ERK2 cascade components. J. Biol. Chem. 275, 40120-40127.
8. Kornfeld, K., Hom, D. B. and Horvitz, H. R. (1995). The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83, 903-913.
9. Michaud, N. R., Therrien, M., Cacace, A., Edsall, L. C., Spiegel, S., Rubin, G. M. and Morrison, D. K. (1997). KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Nat. Acad. Sci. USA 94, 12792-12796.
10. Morrison, D. K. and Cutler, R. E., Jr (1997). The Complexity of Raf-1 Regulation. Curr. Opin. Cell Biol. 9, 174-179.
11. Muller, J., Cacace, A. M., Lyons, W. E., McGill, C. B. and Morrison, D. K. (2000). Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol. Cell. Biol. 20, 5529-5539.
12. Schaeffer, H. J., Catling, A. D., Eblen, S. T., Collier, L. S., Krauss, A. and Weber, M. J. (1998). MP1: a MEK binding partner that enhances enzymatic activity of the MAP kinase cascade. Science 281, 1668-1671.
13. Stewart, S., Sundaram, M., Zhang, V., Lee, J., Han, M. and Guan, K.-L. (1999). Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19, 5523-5534.
14. Sugimoto, T., Stewart, S., Han, M. and Guan, K.-L. (1997). The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling elk-1 phopshorylation from MAP kinase activation. EMBO J. 17, 1717-1727.
15. Sundaram, M. and Han, M. (1995). The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83, 889-901.
16. Therrien, M., Chang, H. C., Solomon, N. M., Karim, F. D., Wassarman, D. A. and Rubin, G. M. (1995). KSR, a novel protein kinase required for RAS signal transduction. Cell 83, 879-888.
17. Therrien, M., Michaud, N. R., Rubin, G. M. and Morrison, D. K. (1996). KSR modulates signal propagation within the MAPK cascade. Genes Dev. 10, 2684-2695.
18. Volle, D. J., Fulton, J. A., Chaika, O. V., McDermott, K., Huang, H., Steinke, L. A. and Lewis, R. E. (1999). Phosphorylation of kinase suppressor of Ras by associated kinases. Biochemistry 38, 5130-5137.
19. Xing, H. R. and Kolesnick, R. (2001). Kinase suppressor of Ras signals through Thr269 of c-Raf-1. J. Biol. Chem. (in press).
20. Xing, H., Kornfeld, K. and Muslin, A. J. (1997) The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr. Biol. 7, 294-300.
21. Xu, B., English, J. M., Wilsbacher, J. L., Stippec, S., Goldsmith, E. J. and Cobb, M. H. (2000). WNK, a novel mammalian serine/threonine kinase lacking the catalytic lysine in subdomain II. J. Biol. Chem. 275, 16795-16801.
22. Yu, W., Fantl, W. J., Harrowe, G. and Williams, L. T. (1997) Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr. Biol. 8, 56-64.
23. Zhang, Y., Yao, B., Delikat, S., Bayoumy, S., Lin, X.-H., Basu, S., McGinley, M., Chan-Hui, P.-Y., Lichenstein, H. and Kolesnick, R. (1997). Kinase suppressor of Ras is ceramide-activated protein kinase. Cell 89, 63-72.