Kinase suppressor of Ras is necessary for tumor necrosis factor α activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells

Cancer Research

Volumn 61, Issue 3, 2001, Pages 963-969

  Yan, Fang ^a   Polk, D Brent ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KSR; PROTEIN RAF1; RAF PROTEIN; RAS PROTEIN; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOREGULATION; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ANIMALS; CELL LINE; CERAMIDES; COLON; ENZYME ACTIVATION; EPITHELIAL CELLS; INTESTINAL MUCOSA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 1; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035116903     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
2. Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells
3. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
4. Conversion of TNFα from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase
5. Kip1, and p53 in IEC-6 cells
6. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
7. Identification of the major phosphorylation sites of the Raf-1 kinase
8. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity
9. Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A
10. Phosphorylation of Raf by ceramide-activated protein kinase
11. How M.A.P. kinases are regulated
12. Mitogen-activated protein kinase pathways
13. Regulation of transcription by MAP kinase cascades
14. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor a for Crohn's disease
15. Predominant pathogenic role of tumor necrosis factor in experimental colitis
16. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
17. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase
18. Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells
19. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor κB activation in mouse colonocytes
20. Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor α
21. Renaturation and tumor necrosis factor-α stimulation of a 97 kDa ceramide-activated protein kinase
22. The protein kinase KSR interacts with 14-3-3 protein and Raf
23. Kinase suppressor of Ras is ceramide-activated protein kinase
24. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
25. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
26. KSR, a novel protein kinase required for RAS signal transduction
27. KSR. A novel player in the Ras pathway
28. Tumor necrosis factor a regulates proliferation in a mouse intestinal cell line
29. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
30. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
31. Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras
32. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of N1H 3T3 cells
33. Raf-1 interacts with Fyn and Src in a nonphosphotyrosine-dependent manner
34. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
35. Fas/CD95/Apo-1 activates the acidic sphinomyelinase via caspases
36. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase
37. Phosphorylation of the kinase suppressor of Ras by associated kinases
38. KSR modulates signal propagation within the MAPK cascade
39. A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway
40. Identification of constitutive and Ras-inducible phosphorylation sites of KSR: Implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression
41. Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors
42. Kinase suppressor of Ras forms multiprotein signaling complex and modulates MEK localization
43. KSR stimulates Raf-1 activity in a kinase-independent manner
44. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
45. Osmotic activation of the HOG MAPK pathway via Stellp MAPKKK: Scaffold role of Pbs2p MAPKK
46. A mammalian scaffold complex that selectively mediates MAP kinase activation
47. The JIP group of mitogen-activated protein kinase scaffold proteins
48. CNK, a RAF-binding mutidomain protein required for RAS signaling