A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment

Journal of Cell Biology

Volumn 152, Issue 4, 2001, Pages 765-776

  Wunderlich, Winfried ^a   Fialka, Irene ^a   Teis, David ^a   Alpi, Arno ^a   Pfeifer, Andrea ^a   Parton, Robert G ^b   Lottspeich, Friedrich ^c   Huber, Lukas A ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Endocytosis; ERK; MEK; Signal transduction scaffold; Subcellular localization

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P14;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CYTOPLASM; ENDOCYTOSIS; ENDOSOME; ENZYME ANALYSIS; IMMUNOPRECIPITATION; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SEDIMENTATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL COMPARTMENTATION; CONSERVED SEQUENCE; ENDOSOMES; INTRACELLULAR MEMBRANES; LYSOSOMES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 0035911147     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.4.765     Document Type: Article

References (52)

1. Regulated secretion of conventional lysosomes
2. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
3. Rab7: A key to lysosome biogenesis
4. Signal transduction: Hanging on a scaffold
5. Regulation of signal transduction by endocytosis
6. Endomembrane trafficking of ras: The CAAX motif targets proteins to the ER and Golgi
7. Vacuolar ATPase activity is required for endosomal carrier vesicle formation
8. Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERKI/2
9. Endocytosis and mitogenic signaling
10. A-kinase anchoring proteins: Protein kinase A and beyond
11. Routing MAP kinase cascades
12. Molecular glue: Kinase anchoring and scaffold proteins
13. The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions
14. Subcellular fractionation of polarized epithelial cells and identification of organelle-specific proteins by two-dimensional gel electrophoresis
15. Loss of epithelial polarity is accompanied by differential association of proteins with intracellular membranes
16. Isolation of intracellular membranes by means of sodium carbonate treatment: Application to endoplasmic reticulum
17. Organization and regulation of mitogen-activated protein kinase signaling pathways
18. In vitro reconstitution of endocytic vesicle fusion
19. Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts
20. Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gammal signaling pathway
21. Regulation of EGF signaling by cell polarity in MDCK kidney epithelial cells
22. Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: Application of a differential interaction trap assay for examining protein-protein interactions
23. Extracellular signal-related kinase 1/2 and p38 mitogen-activated protein kinase pathways serve opposite roles in neutrophil cytotoxicity
24. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells
25. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
26. Initiation of translation in prokaryotes and eukaryotes
27. Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase
28. Calreticulin
29. Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cells
30. The I.M.A.G.E Consortium: An integrated molecular analysis of genomes and their expression
31. Yeast mating pheromone alpha factor inhibits adenylate cyclase
32. The autophagic and endocytic pathways converge at the nascent autophagic vacuoles
33. Caveolin-3 associates with developing T-tubules during muscle differentiation
34. Preparative two-dimensional gel electrophoresis of membrane proteins
35. Subcellular fractionation, electromigration analysis and mapping of organelles
36. Signaling through scaffold, anchoring, and adaptor proteins
37. Uncoupling Rat1 from MEK1/2 impairs only a subset of cellular responses to Raf activation
38. Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment
39. Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes
40. MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
41. Rab GTPases coordinate endocytosis
42. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11
43. The endocytosis of epidermal growth factor in A431 cells: A pH of microenvironment and the dynamics of receptor complex dissociation
44. Epidermal growth factor receptor expression in primary cultured human colorectal carcinoma cells
45. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases
46. Rab11 regulates recycling through the pericentriolar recycling endosome
47. Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10
48. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
49. Epithelial cell polarity and disease
50. Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via ras and rap1
51. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
52. The path to specificity