The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)

Journal of Biological Chemistry

Volumn 281, Issue 13, 2006, Pages 8645-8655

  Hopfer, Ulrike ^a,c   Hopfer, Helmut ^a   Jablonski, Katarina ^a   Stahl, Rolf A K ^a   Wolf, Gunter ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c Center for Innovative Medicine   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; DNA; HYDROXYLATION; MOLECULAR BIOLOGY; OXYGEN;

CYTOPLASM; HYDROXYLATE; HYPOXIA; PROLYL HYDROXYLASES (PHD);

ENZYMES;

COMPLEMENTARY DNA; HYPOXIA INDUCIBLE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 3; PROTEIN MORG 1; RNA; UNCLASSIFIED DRUG; CARRIER PROTEIN; LUCIFERASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRYPSIN;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SCREENING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BASE PAIRING; BINDING SITE; BIOSYNTHESIS; CELL HYPOXIA; CELL NUCLEUS; CELL STRAIN; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SERODIAGNOSIS; TWO HYBRID SYSTEM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BASE PAIRING; BASE SEQUENCE; BINDING SITES; BLOTTING, NORTHERN; CARRIER PROTEINS; CELL HYPOXIA; CELL NUCLEUS; CYTOPLASM; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, REPORTER; HYPOXIA-INDUCIBLE FACTOR 1; LUCIFERASES; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PC12 CELLS; PRECIPITIN TESTS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; TRANSCRIPTION, GENETIC; TRYPSIN; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33646852807     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513751200     Document Type: Article

References (77)

1. Bruick, R. K. (2003) Genes Dev. 17, 2614-2623
2. Wenger, R. H. (2002) FASEB J. 16, 1151-1162
3. Wang, G. L., and Semenza, G. L. (1995) J. Biol. Chem. 270, 1230-1237
4. Wang, G. L., Jiang, B. H., Rue, E. A., and Semenza, G. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5510-5514
5. Tian, H., McKnight, S. L., and Russell, D. W. (1997) Genes Dev. 11, 72-82
6. Gu, Y. Z., Moran, S. M., Hogenesch, J. B., Wartman, L., and Bradfield, C. A. (1998) Gene Expr. 7, 205-213
7. Jiang, B. H., Rue, E., Wang, G. L., Roe, R., and Semenza, G. L. (1996) J. Biol. Chem. 271, 17771-17778
8. Huang, J., Zhao, Q., Mooney, S. M., and Lee, F. S. (2002) J. Biol. Chem. 277, 39792-39800
9. Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (2000) J. Biol. Chem. 275, 25733-25741
10. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G., Jr. (2001) Science 292, 464-468
11. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Science 292, 468-472
12. Yu, F., White, S. B., Zhao, Q., and Lee, F. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9630-9635
13. Bruick, R. K., and McKnight, S. L. (2001) Science 294, 1337-1340
14. Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Gunzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W., and Kaelin, W. G., Jr. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13459-13464
15. Erez, N., Milyavsky, M., Goldfinger, N., Peles, E., Gudkov, A. V., and Rotter, V. (2002) Oncogene 21, 6713-6721
16. Epstein, A. C., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., Tian, Y. M., Masson, N., Hamilton, D. L., Jaakkola, P., Barstead, R., Hodgkin, J., Maxwell, P. H., Pugh, C. W., Schofield, C. J., and Ratcliffe, P. J. (2001) Cell 107, 43-54
17. Hirsila, M., Koivunen, P., Gunzler, V., Kivirikko, K. I., and Myllyharju, J. (2003) J. Biol. Chem. 278, 30772-30780
18. Taylor, M. S. (2001) Gene (Amst.) 275, 125-132
19. Lavista-Llanos, S., Centanin, L., Irisarri, M., Russo, D. M., Gleadle, J. M., Bocca, S. N., Muzzopappa, M., Ratcliffe, P. J., and Wappner, P. (2002) Mol. Cell. Biol. 22, 6842-6853
20. Appelhoff, R. J., Tian, Y. M., Raval, R. R., Turley, H., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., and Gleadle, J. M. (2004) J. Biol. Chem. 279, 38458-38465
21. Cioffi, C. L., Liu, X. Q., Kosinski, P. A., Garay, M., and Bowen, B. R. (2003) Biochem. Biophys. Res. Commun. 303, 947-953
22. Lieb, M. E., Menzies, K., Moschella, M. C., Ni, R., and Taubman, M. B. (2002) Biochem. Cell Biol. 80, 421-426
23. Wax, S. D., Rosenfield, C. L., and Taubman, M. B. (1994) J. Biol. Chem. 269, 13041-13047
24. Dupuy, D., Aubert, I., Duperat, V. G., Petit, J., Taine, L., Stef, M., Bloch, B., and Arveiler, B. (2000) Genomics 69, 348-354
25. Oehme, F., Ellinghaus, P., Kolkhof, P., Smith, T. J., Ramakrishnan, S., Hutter, J., Schramm, M., and Flamme, I. (2002) Biochem. Biophys. Res. Commun. 296, 343-349
26. Marxsen, J. H., Stengel, P., Doege, K., Heikkinen, P., Jokilehto, T., Wagner, T., Jelkmann, W., Jaakkola, P., and Metzen, E. (2004) Biochem. J. 381, 761-767
27. Berra, E., Benizri, E., Ginouves, A., Volmat, V., Roux, D., and Pouyssegur, J. (2003) EMBO J. 22, 4082-4090
28. Metzen, E., Stiehl, D. P., Doege, K., Marxsen, J. H., Hellwig-Burgel, T., and Jelkmann, W. (2005) Biochem. J. 387, 711-717
29. del Peso, L., Castellanos, M. C., Temes, E., Martin-Puig, S., Cuevas, Y., Olmos, G., and Landazuri, M. O. (2003) J. Biol. Chem. 278, 48690-48695
30. Hewitson, K. S., McNeill, L. A., Elkins, J. M., and Schofield, C. J. (2003) Biochem. Soc. Trans. 31, 510-515
31. Straub, J. A., Lipscomb, E. A., Yoshida, E. S., and Freeman, R. S. (2003) J. Neurochem. 85, 318-328
32. Lipscomb, E. A., Sarmiere, P. D., Crowder, R. J., and Freeman, R. S. (1999) J. Neurochem. 73, 429-432
33. Lipscomb, E. A., Sarmiere, P. D., and Freeman, R. S. (2001) J. Biol. Chem. 276, 5085-5092
34. Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H., and Beaudry, G. A. (1996) Cancer Res. 56, 5384-5390
35. Menzies, K., Liu, B., Kim, W. J., Moschella, M. C., and Taubman, M. B. (2004) Biochem. Biophys. Res. Commun. 317, 801-810
36. Wolf, G., Harendza, S., Schroeder, R., Wenzel, U., Zahner, G., Butzmann, U., Freeman, R. S., and Stahl, R. A. (2002) Lab. Investig. 82, 1305-1317
37. Wax, S. D., Tsao, L., Lieb, M. E., Fallon, J. T., and Taubman, M. B. (1996) Lab. Investig. 74, 797-808
38. Zahner, G., Wolf, G., Ayoub, M., Reinking, R., Panzer, U., Shankland, S. J., and Stahl, R. A. (2002) J. Biol. Chem. 277, 9763-9771
39. Hopfer, U., Fukai, N., Hopfer, H., Wolf, G., Joyce, N., Li, N., and Olsen, B. (2005) FASEB J. 19, 1232-1244
40. Garcia-Higuera, I., Fenoglio, J., Li, Y., Lewis, C., Panchenko, M. P., Reiner, O., Smith, T. F., and Neer, E. J. (1996) Biochemistry 35, 13985-13994
41. Wolf, G., Hannken, T., Schroeder, R., Zahner, G., Ziyadeh, F. N., and Stahl, R. A. (2001) FEBS Lett. 488, 154-159
42. Harendza, S., Lovett, D. H., and Stahl, R. A. (2000) J. Biol. Chem. 275, 19552-19559
43. Hopfer, H., Maron, R., Butzmann, U., Helmchen, U., Weiner, H. L., and Kalluri, R. (2003) FASEB J. 17, 860-868
44. Wolf, G., Schroeder, R., and Stahl, R. A. (2004) Am. J. Nephrol. 24, 415-421
45. Vomastek, T., Schaeffer, H. J., Tarcsafalvi, A., Smolkin, M. E., Bissonette, E. A., and Weber, M. J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 6981-6986
46. Kozak, M. (1996) Mamm. Genome 7, 563-574
47. Tuckerman, J. R., Zhao, Y., Hewitson, K. S., Tian, Y. M., Pugh, C. W., Ratcliffe, P. J., and Mole, D. R. (2004) FEBS Lett. 576, 145-150
48. Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Burgel, T., Jelkmann, W., Acker, H., and Fandrey, J. (2003) J. Cell Sci. 116, 1319-1326
49. Warnecke, C., Griethe, W., Weidemann, A., Jurgensen, J. S., Willam, C., Bachmann, S., Ivashchenko, Y., Wagner, I., Frei, U., Wiesener, M., and Eckardt, K. U. (2003) FASEB J. 17, 1186-1188
50. Duan, D. R., Humphrey, J. S., Chen, D. Y., Weng, Y., Sukegawa, J., Lee, S., Gnarra, J. R., Linehan, W. M., and Klausner, R. D. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6459-6463
51. Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., and Pause, A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12436-12441
52. Lisztwan, J., Imbert, G., Wirbelauer, C., Gstaiger, M., and Krek, W. (1999) Genes Dev. 13, 1822-1833
53. Lonergan, K. M., Iliopoulos, O., Ohh, M., Kamura, T., Conaway, R. C., Conaway, J. W., and Kaelin, W. G., Jr. (1998) Mol. Cell Biol. 18, 732-741
54. Kibel, A., Iliopoulos, O., DeCaprio, J. A., and Kaelin, W. G., Jr. (1995) Science 269, 1444-1446
55. Kamura, T., Koepp, D. M., Conrad, M. N., Skowyra, D., Moreland, R. J., Iliopoulos, O., Lane, W. S., Kaelin, W. G., Jr., Elledge, S. J., Conaway, R. C., Harper, J. W., and Conaway, J. W. (1999) Science 284, 657-661
56. Freeman, R. S., Hasbani, D. M., Lipscomb, E. A., Straub, J. A., and Xie, L. (2003) Mol. Cells 16, 1-12
57. Yu, L., Gaitatzes, C., Neer, E., and Smith, T. F. (2000) Protein Sci. 9, 2470-2476
58. Li, D., and Roberts, R. (2001) Cell Mol. Life Sci. 58, 2085-2097
59. Smith, T. F., Gaitatzes, C., Saxena, K., and Neer, E. J. (1999) Trends Biochem. Sci. 24, 181-185
60. Sondek, J., Bohm, A., Lambright, D. G., Hamm, H. E., and Sigler, P. B. (1996) Nature 379, 369-374
61. Wall, M. A., Coleman, D. E., Lee, E., Iniguez-Lluhi, J. A., Posner, B. A., Gilman, A. G., and Sprang, S. R. (1995) Cell 83, 1047-1058
62. van der Voorn, L., and Ploegh, H. L. (1992) FEBS Lett. 307, 131-134
63. Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E., and Sigler, P. B. (1996) Nature 379, 311-319
64. Wilson, D. K., Cerna, D., and Chew, E. (2005) J. Biol. Chem. 280, 13944-13951
65. Janda, L., Tichy, P., Spizek, J., and Petricek, M. (1996) J. Bacteriol. 178, 1487-1489
66. Futey, L. M., Medley, Q. G., Cote, G. P., and Egelhoff, T. T. (1995) J. Biol. Chem. 270, 523-529
67. Groulx, I., and Lee, S. (2002) Mol. Cell. Biol. 22, 5319-5336
68. Nakayama, K., Frew, I. J., Hagensen, M., Skals, M., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument-Bromage, H., Tempst, P., Frappell, P. B., Bowtell, D. D., and Ronai, Z. (2004) Cell 117, 941-952
69. Borden, K. L. (2000) J. Mol. Biol. 295, 1103-1112
70. Willems, A. R., Schwab, M., and Tyers, M. (2004) Biochim. Biophys. Acta 1695, 133-170
71. Vodermaier, H. C. (2001) Curr. Biol. 11, R834-R837
72. Vodermaier, H. C. (2004) Curr. Biol. 14, R787-R796
73. Hur, E., Chang, K. Y., Lee, E., Lee, S. K., and Park, H. (2001) Mol. Pharmacol. 59, 1216-1224
74. Richard, D. E., Berra, E., Gothie, E., Roux, D., and Pouyssegur, J. (1999) J. Biol. Chem. 274, 32631-32637
75. Cheng, H., He, X., and Moore, C. (2004) Mol. Cell Biol. 24, 2932-2943
76. Deleted in proof
77. Butzmann, U., Jablonski, K., Schröder, R., Stahl, R. A. K., and Wolf, G. (2002) J. Am. Soc. Nephrol. 13, Suppl. S, 495A-495A