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Volumn 70, Issue 4, 2013, Pages 661-687

Aurora A kinase (AURKA) in normal and pathological cell division

Author keywords

AURKA; Aurora A; Cancer; Cell cycle; Centrosome; Cilia; Kinase; Mitosis

Indexed keywords

1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL]UREA; 4 [[9 CHLORO 7 (2,6 DIFLUOROPHENYL) 5H PYRIMIDO[5,4 D][2]BENZAZEPIN 2 YL]AMINO]BENZOIC ACID; ALISERTIB; AURORA A KINASE; AURORA A KINASE INHIBITOR; BARASERTIB; CELL CYCLE PROTEIN; CENISERTIB; CYTARABINE; DANUSERTIB; MK 5108; PACLITAXEL; PF 3814735; PROTEIN SERINE THREONINE KINASE INHIBITOR; TOZASERTIB; UNCLASSIFIED DRUG;

EID: 84873721726     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1073-7     Document Type: Review
Times cited : (358)

References (252)
  • 1
    • 0027515186 scopus 로고
    • Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast
    • 8293973 1:CAS:528:DyaK2cXjtFOjtbc%3D
    • Chan CS, Botstein D (1993) Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135:677-691
    • (1993) Genetics , vol.135 , pp. 677-691
    • Chan, C.S.1    Botstein, D.2
  • 2
    • 0025295139 scopus 로고
    • Poly(A) metabolism and polysomal recruitment of maternal mRNAs during early Xenopus development
    • 2358121 1:CAS:528:DyaK3cXkslGhsL8%3D
    • Paris J, Philippe M (1990) Poly(A) metabolism and polysomal recruitment of maternal mRNAs during early Xenopus development. Dev Biol 140:221-224
    • (1990) Dev Biol , vol.140 , pp. 221-224
    • Paris, J.1    Philippe, M.2
  • 3
    • 0343917044 scopus 로고    scopus 로고
    • The kinase Eg2 is a component of the Xenopus oocyte progesterone- activated signaling pathway
    • 9755163 1:CAS:528:DyaK1cXmvVyjs7g%3D
    • Andresson T, Ruderman JV (1998) The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway. EMBO J 17:5627-5637
    • (1998) EMBO J , vol.17 , pp. 5627-5637
    • Andresson, T.1    Ruderman, J.V.2
  • 4
    • 0031938231 scopus 로고    scopus 로고
    • The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
    • 9454730 1:CAS:528:DyaK1cXit1egtLY%3D
    • Roghi C, Giet R, Uzbekov R, Morin N, Chartrain I, Le Guellec R, Couturier A, Doree M, Philippe M, Prigent C (1998) The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J Cell Sci 111(Pt 5):557-572
    • (1998) J Cell Sci , vol.111 , Issue.PART 5 , pp. 557-572
    • Roghi, C.1    Giet, R.2    Uzbekov, R.3    Morin, N.4    Chartrain, I.5    Le Guellec, R.6    Couturier, A.7    Doree, M.8    Philippe, M.9    Prigent, C.10
  • 5
    • 0028938482 scopus 로고
    • Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
    • 7720077 1:CAS:528:DyaK2MXkvFOisrc%3D
    • Glover DM, Leibowitz MH, McLean DA, Parry H (1995) Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81:95-105
    • (1995) Cell , vol.81 , pp. 95-105
    • Glover, D.M.1    Leibowitz, M.H.2    McLean, D.A.3    Parry, H.4
  • 6
    • 52949115363 scopus 로고    scopus 로고
    • Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    • 18854163 1:CAS:528:DC%2BD1cXht1Gkt7bN
    • Wirtz-Peitz F, Nishimura T, Knoblich JA (2008) Linking cell cycle to asymmetric division: aurora-A phosphorylates the Par complex to regulate Numb localization. Cell 135:161-173
    • (2008) Cell , vol.135 , pp. 161-173
    • Wirtz-Peitz, F.1    Nishimura, T.2    Knoblich, J.A.3
  • 7
    • 0037017398 scopus 로고    scopus 로고
    • Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
    • 11827981 1:CAS:528:DC%2BD38XhtVOqt7g%3D
    • Giet R, McLean D, Descamps S, Lee MJ, Raff JW, Prigent C, Glover DM (2002) Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J Cell Biol 156:437-451
    • (2002) J Cell Biol , vol.156 , pp. 437-451
    • Giet, R.1    McLean, D.2    Descamps, S.3    Lee, M.J.4    Raff, J.W.5    Prigent, C.6    Glover, D.M.7
  • 8
    • 33845702193 scopus 로고    scopus 로고
    • Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    • 17182871 1:CAS:528:DC%2BD2sXhs1ejtw%3D%3D
    • Lee CY, Andersen RO, Cabernard C, Manning L, Tran KD, Lanskey MJ, Bashirullah A, Doe CQ (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Gene Dev 20:3464-3474
    • (2006) Gene Dev , vol.20 , pp. 3464-3474
    • Lee, C.Y.1    Andersen, R.O.2    Cabernard, C.3    Manning, L.4    Tran, K.D.5    Lanskey, M.J.6    Bashirullah, A.7    Doe, C.Q.8
  • 9
    • 33845704687 scopus 로고    scopus 로고
    • Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    • 17182870 1:CAS:528:DC%2BD2sXhs1ejtg%3D%3D
    • Wang H, Somers GW, Bashirullah A, Heberlein U, Yu F, Chia W (2006) Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Gene Dev 20:3453-3463
    • (2006) Gene Dev , vol.20 , pp. 3453-3463
    • Wang, H.1    Somers, G.W.2    Bashirullah, A.3    Heberlein, U.4    Yu, F.5    Chia, W.6
  • 10
    • 51649095569 scopus 로고    scopus 로고
    • The Aurora kinase family in cell division and cancer
    • 18662747 1:CAS:528:DC%2BD1cXhtFCktrfE
    • Vader G, Lens SM (2008) The Aurora kinase family in cell division and cancer. Biochim Biophys Acta 1786:60-72
    • (2008) Biochim Biophys Acta , vol.1786 , pp. 60-72
    • Vader, G.1    Lens, S.M.2
  • 11
    • 0037084163 scopus 로고    scopus 로고
    • Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
    • 11847097 1:CAS:528:DC%2BD38XhvFGrtbs%3D
    • Meraldi P, Honda R, Nigg EA (2002) Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J 21:483-492
    • (2002) EMBO J , vol.21 , pp. 483-492
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 12
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • 12559175 1:CAS:528:DC%2BD3sXhtFamt7Y%3D
    • Anand S, Penrhyn-Lowe S, Venkitaraman AR (2003) AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3:51-62
    • (2003) Cancer Cell , vol.3 , pp. 51-62
    • Anand, S.1    Penrhyn-Lowe, S.2    Venkitaraman, A.R.3
  • 13
    • 9944220985 scopus 로고    scopus 로고
    • Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models
    • 15480417 1:CAS:528:DC%2BD2cXpvV2rtbY%3D
    • Zhang D, Hirota T, Marumoto T, Shimizu M, Kunitoku N, Sasayama T, Arima Y, Feng L, Suzuki M, Takeya M, Saya H (2004) Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 23:8720-8730
    • (2004) Oncogene , vol.23 , pp. 8720-8730
    • Zhang, D.1    Hirota, T.2    Marumoto, T.3    Shimizu, M.4    Kunitoku, N.5    Sasayama, T.6    Arima, Y.7    Feng, L.8    Suzuki, M.9    Takeya, M.10    Saya, H.11
  • 14
    • 0032213515 scopus 로고    scopus 로고
    • Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells
    • 9809983 1:CAS:528:DyaK1cXnt1yisrs%3D
    • Tatsuka M, Katayama H, Ota T, Tanaka T, Odashima S, Suzuki F, Terada Y (1998) Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res 58:4811-4816
    • (1998) Cancer Res , vol.58 , pp. 4811-4816
    • Tatsuka, M.1    Katayama, H.2    Ota, T.3    Tanaka, T.4    Odashima, S.5    Suzuki, F.6    Terada, Y.7
  • 16
    • 79952107079 scopus 로고    scopus 로고
    • Sensing centromere tension: Aurora B and the regulation of kinetochore function
    • 21106376 1:CAS:528:DC%2BC3MXjs1Wksb0%3D
    • Lampson MA, Cheeseman IM (2011) Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol 21:133-140
    • (2011) Trends Cell Biol , vol.21 , pp. 133-140
    • Lampson, M.A.1    Cheeseman, I.M.2
  • 18
    • 84857687584 scopus 로고    scopus 로고
    • Pattern formation in centrosome assembly
    • 22245706 1:CAS:528:DC%2BC38XjtlOlt78%3D
    • Mahen R, Venkitaraman AR (2012) Pattern formation in centrosome assembly. Curr Opin Cell Biol 24:14-23
    • (2012) Curr Opin Cell Biol , vol.24 , pp. 14-23
    • Mahen, R.1    Venkitaraman, A.R.2
  • 19
    • 78650484299 scopus 로고    scopus 로고
    • Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation
    • 21097701 1:CAS:528:DC%2BC3cXhsFyrsbbK
    • Joukov V, De Nicolo A, Rodriguez A, Walter JC, Livingston DM (2010) Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation. Proc Natl Acad Sci U S A 107:21022-21027
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21022-21027
    • Joukov, V.1    De Nicolo, A.2    Rodriguez, A.3    Walter, J.C.4    Livingston, D.M.5
  • 20
    • 33746544622 scopus 로고    scopus 로고
    • Mitotic activation of the kinase Aurora-A requires its binding partner Bora
    • 16890155 1:CAS:528:DC%2BD28XosVeksL4%3D
    • Hutterer A, Berdnik D, Wirtz-Peitz F, Zigman M, Schleiffer A, Knoblich JA (2006) Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell 11:147-157
    • (2006) Dev Cell , vol.11 , pp. 147-157
    • Hutterer, A.1    Berdnik, D.2    Wirtz-Peitz, F.3    Zigman, M.4    Schleiffer, A.5    Knoblich, J.A.6
  • 21
    • 27144495462 scopus 로고    scopus 로고
    • The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome
    • 16184168 1:CAS:528:DC%2BD2MXhtVGjs7bI
    • Pugacheva EN, Golemis EA (2005) The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol 7:937-946
    • (2005) Nat Cell Biol , vol.7 , pp. 937-946
    • Pugacheva, E.N.1    Golemis, E.A.2
  • 22
    • 0035945342 scopus 로고    scopus 로고
    • Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans
    • 11748251 1:CAS:528:DC%2BD38Xhslyiuw%3D%3D
    • Hannak E, Kirkham M, Hyman AA, Oegema K (2001) Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol 155:1109-1116
    • (2001) J Cell Biol , vol.155 , pp. 1109-1116
    • Hannak, E.1    Kirkham, M.2    Hyman, A.A.3    Oegema, K.4
  • 24
    • 31444456040 scopus 로고    scopus 로고
    • LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis
    • 16413547 1:CAS:528:DC%2BD28XhtFejsLk%3D
    • Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T (2006) LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett 580:782-788
    • (2006) FEBS Lett , vol.580 , pp. 782-788
    • Abe, Y.1    Ohsugi, M.2    Haraguchi, K.3    Fujimoto, J.4    Yamamoto, T.5
  • 27
    • 0037117408 scopus 로고    scopus 로고
    • Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis
    • 11967150 1:CAS:528:DC%2BD38XjtVeiu7s%3D
    • Berdnik D, Knoblich JA (2002) Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr Biol 12:640-647
    • (2002) Curr Biol , vol.12 , pp. 640-647
    • Berdnik, D.1    Knoblich, J.A.2
  • 28
    • 0034713226 scopus 로고    scopus 로고
    • Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events
    • 10854050
    • De Souza CP, Ellem KA, Gabrielli BG (2000) Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. Exp Cell Res 257:11-21
    • (2000) Exp Cell Res , vol.257 , pp. 11-21
    • De Souza, C.P.1    Ellem, K.A.2    Gabrielli, B.G.3
  • 29
    • 0037322744 scopus 로고    scopus 로고
    • Active cyclin B1-Cdk1 first appears on centrosomes in prophase
    • 12524548 1:CAS:528:DC%2BD3sXot12qtg%3D%3D
    • Jackman M, Lindon C, Nigg EA, Pines J (2003) Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 5:143-148
    • (2003) Nat Cell Biol , vol.5 , pp. 143-148
    • Jackman, M.1    Lindon, C.2    Nigg, E.A.3    Pines, J.4
  • 30
    • 46249084662 scopus 로고    scopus 로고
    • Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
    • 18566290 1:CAS:528:DC%2BD1cXnt1Oju7g%3D
    • Seki A, Coppinger JA, Jang CY, Yates JR, Fang G (2008) Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 320:1655-1658
    • (2008) Science , vol.320 , pp. 1655-1658
    • Seki, A.1    Coppinger, J.A.2    Jang, C.Y.3    Yates, J.R.4    Fang, G.5
  • 32
    • 51549085203 scopus 로고    scopus 로고
    • Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora
    • 18521620 1:CAS:528:DC%2BD1cXhtV2jsbvM
    • Chan EH, Santamaria A, Sillje HH, Nigg EA (2008) Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma 117:457-469
    • (2008) Chromosoma , vol.117 , pp. 457-469
    • Chan, E.H.1    Santamaria, A.2    Sillje, H.H.3    Nigg, E.A.4
  • 34
    • 4444321565 scopus 로고    scopus 로고
    • Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells
    • 15350223
    • van Vugt MA, Bras A, Medema RH (2004) Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell 15:799-811
    • (2004) Mol Cell , vol.15 , pp. 799-811
    • Van Vugt, M.A.1    Bras, A.2    Medema, R.H.3
  • 35
    • 0242515843 scopus 로고    scopus 로고
    • Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates
    • 12595692 1:CAS:528:DC%2BD3sXht12jtbs%3D
    • Elia AE, Cantley LC, Yaffe MB (2003) Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299:1228-1231
    • (2003) Science , vol.299 , pp. 1228-1231
    • Elia, A.E.1    Cantley, L.C.2    Yaffe, M.B.3
  • 36
    • 0033634850 scopus 로고    scopus 로고
    • Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex
    • 11106762 1:CAS:528:DC%2BD3cXosV2mt7Y%3D
    • Mendez R, Murthy KG, Ryan K, Manley JL, Richter JD (2000) Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol Cell 6:1253-1259
    • (2000) Mol Cell , vol.6 , pp. 1253-1259
    • Mendez, R.1    Murthy, K.G.2    Ryan, K.3    Manley, J.L.4    Richter, J.D.5
  • 37
    • 0037123787 scopus 로고    scopus 로고
    • Translational control of the embryonic cell cycle
    • 12086604 1:CAS:528:DC%2BD38XjvFKgtLg%3D
    • Groisman I, Jung MY, Sarkissian M, Cao Q, Richter JD (2002) Translational control of the embryonic cell cycle. Cell 109:473-483
    • (2002) Cell , vol.109 , pp. 473-483
    • Groisman, I.1    Jung, M.Y.2    Sarkissian, M.3    Cao, Q.4    Richter, J.D.5
  • 38
    • 0037099704 scopus 로고    scopus 로고
    • Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation
    • 12110596 1:CAS:528:DC%2BD38XlslOkur0%3D
    • Cao Q, Richter JD (2002) Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation. EMBO J 21:3852-3862
    • (2002) EMBO J , vol.21 , pp. 3852-3862
    • Cao, Q.1    Richter, J.D.2
  • 39
    • 34249908103 scopus 로고    scopus 로고
    • CPEB: A life in translation
    • 17481902 1:CAS:528:DC%2BD2sXmtlahsbw%3D
    • Richter JD (2007) CPEB: a life in translation. Trends Biochem Sci 32:279-285
    • (2007) Trends Biochem Sci , vol.32 , pp. 279-285
    • Richter, J.D.1
  • 40
    • 0034721667 scopus 로고    scopus 로고
    • CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: Implications for local translational control of cell division
    • 11081630 1:CAS:528:DC%2BD3cXnvF2ks7Y%3D
    • Groisman I, Huang YS, Mendez R, Cao Q, Theurkauf W, Richter JD (2000) CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. Cell 103:435-447
    • (2000) Cell , vol.103 , pp. 435-447
    • Groisman, I.1    Huang, Y.S.2    Mendez, R.3    Cao, Q.4    Theurkauf, W.5    Richter, J.D.6
  • 42
    • 84857735639 scopus 로고    scopus 로고
    • Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: A role for the nuclear export signal, CRM1, and Aurora A kinase
    • 22262852 1:CAS:528:DC%2BC38XjtFyksLk%3D
    • Brodie KM, Henderson BR (2012) Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase. J Biol Chem 287:7701-7716
    • (2012) J Biol Chem , vol.287 , pp. 7701-7716
    • Brodie, K.M.1    Henderson, B.R.2
  • 44
    • 33645823588 scopus 로고    scopus 로고
    • Aurora A, mitotic entry, and spindle bipolarity
    • 16581905 1:CAS:528:DC%2BD28XktFaitrs%3D
    • Liu Q, Ruderman JV (2006) Aurora A, mitotic entry, and spindle bipolarity. Proc Natl Acad Sci U S A 103:5811-5816
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5811-5816
    • Liu, Q.1    Ruderman, J.V.2
  • 45
    • 0347324949 scopus 로고    scopus 로고
    • Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells
    • 14523000 1:CAS:528:DC%2BD3sXpslOgt7o%3D
    • Marumoto T, Honda S, Hara T, Nitta M, Hirota T, Kohmura E, Saya H (2003) Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 278:51786-51795
    • (2003) J Biol Chem , vol.278 , pp. 51786-51795
    • Marumoto, T.1    Honda, S.2    Hara, T.3    Nitta, M.4    Hirota, T.5    Kohmura, E.6    Saya, H.7
  • 46
    • 50849139592 scopus 로고    scopus 로고
    • Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells
    • 18773538 1:CAS:528:DC%2BD1cXht1ymsLjF
    • Katayama H, Sasai K, Kloc M, Brinkley BR, Sen S (2008) Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle 7:2691-2704
    • (2008) Cell Cycle , vol.7 , pp. 2691-2704
    • Katayama, H.1    Sasai, K.2    Kloc, M.3    Brinkley, B.R.4    Sen, S.5
  • 47
    • 48249109896 scopus 로고    scopus 로고
    • Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A
    • 18663142 1:CAS:528:DC%2BD1cXpt12gsrc%3D
    • Bird AW, Hyman AA (2008) Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol 182:289-300
    • (2008) J Cell Biol , vol.182 , pp. 289-300
    • Bird, A.W.1    Hyman, A.A.2
  • 48
    • 34948901399 scopus 로고    scopus 로고
    • Aurora-A: The maker and breaker of spindle poles
    • 17715155 1:CAS:528:DC%2BD2sXhtFKrtbnJ
    • Barr AR, Gergely F (2007) Aurora-A: the maker and breaker of spindle poles. J Cell Sci 120:2987-2996
    • (2007) J Cell Sci , vol.120 , pp. 2987-2996
    • Barr, A.R.1    Gergely, F.2
  • 50
    • 34347218996 scopus 로고    scopus 로고
    • Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: A novel pharmacodynamic method for measuring Aurora A activity
    • 17545617 1:CAS:528:DC%2BD2sXmtVait7o%3D
    • LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA (2007) Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. Cancer Res 67:5362-5370
    • (2007) Cancer Res , vol.67 , pp. 5362-5370
    • Leroy, P.J.1    Hunter, J.J.2    Hoar, K.M.3    Burke, K.E.4    Shinde, V.5    Ruan, J.6    Bowman, D.7    Galvin, K.8    Ecsedy, J.A.9
  • 52
    • 25444485717 scopus 로고    scopus 로고
    • Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules
    • 16186253 1:CAS:528:DC%2BD2MXhtVKnsbrL
    • Barros TP, Kinoshita K, Hyman AA, Raff JW (2005) Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J Cell Biol 170:1039-1046
    • (2005) J Cell Biol , vol.170 , pp. 1039-1046
    • Barros, T.P.1    Kinoshita, K.2    Hyman, A.A.3    Raff, J.W.4
  • 53
    • 50849131840 scopus 로고    scopus 로고
    • Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity
    • 18434591 1:CAS:528:DC%2BD1cXoslWitrc%3D
    • Zhang X, Ems-McClung SC, Walczak CE (2008) Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. Mol Biol Cell 19:2752-2765
    • (2008) Mol Biol Cell , vol.19 , pp. 2752-2765
    • Zhang, X.1    Ems-Mcclung, S.C.2    Walczak, C.E.3
  • 54
    • 37049023673 scopus 로고    scopus 로고
    • Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation
    • 18056443 1:CAS:528:DC%2BD2sXhtlyiurnE
    • Sankaran S, Crone DE, Palazzo RE, Parvin JD (2007) Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res 67:11186-11194
    • (2007) Cancer Res , vol.67 , pp. 11186-11194
    • Sankaran, S.1    Crone, D.E.2    Palazzo, R.E.3    Parvin, J.D.4
  • 55
    • 37549018498 scopus 로고    scopus 로고
    • Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis
    • 18000399 1:CAS:528:DC%2BD1cXhsFOltbg%3D
    • Chakrabarti R, Jones JL, Oelschlager DK, Tapia T, Tousson A, Grizzle WE (2007) Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis. Cell Cycle 6:2944-2952
    • (2007) Cell Cycle , vol.6 , pp. 2944-2952
    • Chakrabarti, R.1    Jones, J.L.2    Oelschlager, D.K.3    Tapia, T.4    Tousson, A.5    Grizzle, W.E.6
  • 56
    • 84856112589 scopus 로고    scopus 로고
    • A functional cooperativity between Aurora A kinase and LIM kinase1: Implication in the mitotic process
    • 22214762 1:CAS:528:DC%2BC38XjtVSqs74%3D
    • Ritchey L, Ottman R, Roumanos M, Chakrabarti R (2012) A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process. Cell Cycle 11:296-309
    • (2012) Cell Cycle , vol.11 , pp. 296-309
    • Ritchey, L.1    Ottman, R.2    Roumanos, M.3    Chakrabarti, R.4
  • 57
    • 0033591432 scopus 로고    scopus 로고
    • The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5
    • 10329703 1:CAS:528:DyaK1MXks1Kqtro%3D
    • Giet R, Uzbekov R, Cubizolles F, Le Guellec K, Prigent C (1999) The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. J Biol Chem 274:15005-15013
    • (1999) J Biol Chem , vol.274 , pp. 15005-15013
    • Giet, R.1    Uzbekov, R.2    Cubizolles, F.3    Le Guellec, K.4    Prigent, C.5
  • 58
    • 62849098748 scopus 로고    scopus 로고
    • Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly
    • 19204145 1:CAS:528:DC%2BD1MXitV2rtrc%3D
    • Toso A, Winter JR, Garrod AJ, Amaro AC, Meraldi P, McAinsh AD (2009) Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly. J Cell Biol 184:365-372
    • (2009) J Cell Biol , vol.184 , pp. 365-372
    • Toso, A.1    Winter, J.R.2    Garrod, A.J.3    Amaro, A.C.4    Meraldi, P.5    McAinsh, A.D.6
  • 59
    • 34250640194 scopus 로고    scopus 로고
    • Cooperative mechanisms of mitotic spindle formation
    • 17502482
    • O'Connell CB, Khodjakov AL (2007) Cooperative mechanisms of mitotic spindle formation. J Cell Sci 120:1717-1722
    • (2007) J Cell Sci , vol.120 , pp. 1717-1722
    • O'Connell, C.B.1    Khodjakov, A.L.2
  • 60
    • 28444447726 scopus 로고    scopus 로고
    • Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly
    • 16332542 1:CAS:528:DC%2BD2MXhtlSiu77I
    • Tsai MY, Zheng Y (2005) Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly. Curr Biol 15:2156-2163
    • (2005) Curr Biol , vol.15 , pp. 2156-2163
    • Tsai, M.Y.1    Zheng, Y.2
  • 61
    • 48249105448 scopus 로고    scopus 로고
    • Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain
    • 18321990 1:CAS:528:DC%2BD1cXlslelsLw%3D
    • Wong J, Lerrigo R, Jang CY, Fang G (2008) Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol Biol Cell 19:2083-2091
    • (2008) Mol Biol Cell , vol.19 , pp. 2083-2091
    • Wong, J.1    Lerrigo, R.2    Jang, C.Y.3    Fang, G.4
  • 62
    • 33646024346 scopus 로고    scopus 로고
    • HURP is part of a Ran-dependent complex involved in spindle formation
    • 16631581 1:CAS:528:DC%2BD28XjvFWmt7k%3D
    • Koffa MD, Casanova CM, Santarella R, Kocher T, Wilm M, Mattaj IW (2006) HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol 16:743-754
    • (2006) Curr Biol , vol.16 , pp. 743-754
    • Koffa, M.D.1    Casanova, C.M.2    Santarella, R.3    Kocher, T.4    Wilm, M.5    Mattaj, I.W.6
  • 63
    • 4644233153 scopus 로고    scopus 로고
    • The mechanism of spindle assembly: Functions of Ran and its target TPX2
    • 15452138 1:CAS:528:DC%2BD2cXotVeht7k%3D
    • Gruss OJ, Vernos I (2004) The mechanism of spindle assembly: functions of Ran and its target TPX2. J Cell Biol 166:949-955
    • (2004) J Cell Biol , vol.166 , pp. 949-955
    • Gruss, O.J.1    Vernos, I.2
  • 64
    • 77954740977 scopus 로고    scopus 로고
    • Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E
    • 20691903 1:CAS:528:DC%2BC3cXpvFKrt70%3D
    • Kim Y, Holland AJ, Lan W, Cleveland DW (2010) Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142:444-455
    • (2010) Cell , vol.142 , pp. 444-455
    • Kim, Y.1    Holland, A.J.2    Lan, W.3    Cleveland, D.W.4
  • 65
    • 10744225982 scopus 로고    scopus 로고
    • CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
    • 14667408 1:CAS:528:DC%2BD3sXhtVWgtLvE
    • Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, Hatakeyama K, Ushio Y, Saya H, Hirota T (2003) CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell 5:853-864
    • (2003) Dev Cell , vol.5 , pp. 853-864
    • Kunitoku, N.1    Sasayama, T.2    Marumoto, T.3    Zhang, D.4    Honda, S.5    Kobayashi, O.6    Hatakeyama, K.7    Ushio, Y.8    Saya, H.9    Hirota, T.10
  • 66
    • 84856768059 scopus 로고    scopus 로고
    • Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics
    • 22184196 1:CAS:528:DC%2BC38XktlGktA%3D%3D
    • Hegarat N, Smith E, Nayak G, Takeda S, Eyers PA, Hochegger H (2011) Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics. J Cell Biol 195:1103-1113
    • (2011) J Cell Biol , vol.195 , pp. 1103-1113
    • Hegarat, N.1    Smith, E.2    Nayak, G.3    Takeda, S.4    Eyers, P.A.5    Hochegger, H.6
  • 67
    • 36849052501 scopus 로고    scopus 로고
    • Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation
    • 17563743 1:CAS:528:DC%2BD2sXhtl2gur7K
    • Rong R, Jiang LY, Sheikh MS, Huang Y (2007) Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation. Oncogene 26:7700-7708
    • (2007) Oncogene , vol.26 , pp. 7700-7708
    • Rong, R.1    Jiang, L.Y.2    Sheikh, M.S.3    Huang, Y.4
  • 68
    • 65549154498 scopus 로고    scopus 로고
    • Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity
    • 19276349 1:CAS:528:DC%2BD1MXjtFyqtLs%3D
    • Song SJ, Song MS, Kim SJ, Kim SY, Kwon SH, Kim JG, Calvisi DF, Kang D, Lim DS (2009) Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res 69:2314-2323
    • (2009) Cancer Res , vol.69 , pp. 2314-2323
    • Song, S.J.1    Song, M.S.2    Kim, S.J.3    Kim, S.Y.4    Kwon, S.H.5    Kim, J.G.6    Calvisi, D.F.7    Kang, D.8    Lim, D.S.9
  • 69
    • 55249088712 scopus 로고    scopus 로고
    • APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase
    • 18976910 1:CAS:528:DC%2BD1cXhtlGmtrjL
    • Floyd S, Pines J, Lindon C (2008) APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase. Curr Biol 18:1649-1658
    • (2008) Curr Biol , vol.18 , pp. 1649-1658
    • Floyd, S.1    Pines, J.2    Lindon, C.3
  • 71
    • 79551542895 scopus 로고    scopus 로고
    • The nuclear scaffold protein SAF-A is required for kinetochore- microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles
    • 21242313 1:CAS:528:DC%2BC3MXisFOqu7c%3D
    • Ma N, Matsunaga S, Morimoto A, Sakashita G, Urano T, Uchiyama S, Fukui K (2011) The nuclear scaffold protein SAF-A is required for kinetochore- microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles. J Cell Sci 124:394-404
    • (2011) J Cell Sci , vol.124 , pp. 394-404
    • Ma, N.1    Matsunaga, S.2    Morimoto, A.3    Sakashita, G.4    Urano, T.5    Uchiyama, S.6    Fukui, K.7
  • 72
    • 34247615185 scopus 로고    scopus 로고
    • GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases
    • 17488622 1:CAS:528:DC%2BD2sXlsVajtLg%3D
    • Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM (2007) GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell 12:699-712
    • (2007) Dev Cell , vol.12 , pp. 699-712
    • Birkenfeld, J.1    Nalbant, P.2    Bohl, B.P.3    Pertz, O.4    Hahn, K.M.5    Bokoch, G.M.6
  • 74
    • 26944442735 scopus 로고    scopus 로고
    • The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A
    • 16246726 1:CAS:528:DC%2BD2MXht1SntrfM
    • Zhao ZS, Lim JP, Ng YW, Lim L, Manser E (2005) The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell 20:237-249
    • (2005) Mol Cell , vol.20 , pp. 237-249
    • Zhao, Z.S.1    Lim, J.P.2    Ng, Y.W.3    Lim, L.4    Manser, E.5
  • 75
    • 0034717818 scopus 로고    scopus 로고
    • TPX2, a novel xenopus MAP involved in spindle pole organization
    • 10871281 1:CAS:528:DC%2BD3cXksVKnsrw%3D
    • Wittmann T, Wilm M, Karsenti E, Vernos I (2000) TPX2, a novel xenopus MAP involved in spindle pole organization. J Cell Biol 149:1405-1418
    • (2000) J Cell Biol , vol.149 , pp. 1405-1418
    • Wittmann, T.1    Wilm, M.2    Karsenti, E.3    Vernos, I.4
  • 76
    • 1542365225 scopus 로고    scopus 로고
    • Regulation of Xenopus Aurora A activation by TPX2
    • 14701852 1:CAS:528:DC%2BD2cXhs1Onu7s%3D
    • Eyers PA, Maller JL (2004) Regulation of Xenopus Aurora A activation by TPX2. J Biol Chem 279:9008-9015
    • (2004) J Biol Chem , vol.279 , pp. 9008-9015
    • Eyers, P.A.1    Maller, J.L.2
  • 78
    • 0037446847 scopus 로고    scopus 로고
    • A novel mechanism for activation of the protein kinase Aurora A
    • 12699628 1:CAS:528:DC%2BD3sXjtVKhu7k%3D
    • Eyers PA, Erikson E, Chen LG, Maller JL (2003) A novel mechanism for activation of the protein kinase Aurora A. Curr Biol 13:691-697
    • (2003) Curr Biol , vol.13 , pp. 691-697
    • Eyers, P.A.1    Erikson, E.2    Chen, L.G.3    Maller, J.L.4
  • 79
    • 0037135979 scopus 로고    scopus 로고
    • Human TPX2 is required for targeting Aurora-A kinase to the spindle
    • 12177045 1:CAS:528:DC%2BD38XmsVSntbo%3D
    • Kufer TA, Sillje HH, Korner R, Gruss OJ, Meraldi P, Nigg EA (2002) Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol 158:617-623
    • (2002) J Cell Biol , vol.158 , pp. 617-623
    • Kufer, T.A.1    Sillje, H.H.2    Korner, R.3    Gruss, O.J.4    Meraldi, P.5    Nigg, E.A.6
  • 80
    • 0037341906 scopus 로고    scopus 로고
    • A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
    • 12577065 1:CAS:528:DC%2BD3sXitFKmsb8%3D
    • Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y (2003) A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 5:242-248
    • (2003) Nat Cell Biol , vol.5 , pp. 242-248
    • Tsai, M.Y.1    Wiese, C.2    Cao, K.3    Martin, O.4    Donovan, P.5    Ruderman, J.6    Prigent, C.7    Zheng, Y.8
  • 81
    • 84855494872 scopus 로고    scopus 로고
    • Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic
    • 22094468 1:CAS:528:DC%2BC38XjslyntQ%3D%3D
    • Dodson CA, Bayliss R (2012) Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic. J Biol Chem 287:1150-1157
    • (2012) J Biol Chem , vol.287 , pp. 1150-1157
    • Dodson, C.A.1    Bayliss, R.2
  • 82
    • 79951778220 scopus 로고    scopus 로고
    • Two TPX2-dependent switches control the activity of Aurora A
    • 21347367 1:CAS:528:DC%2BC3MXitlyjtrk%3D
    • Xu X, Wang X, Xiao Z, Li Y, Wang Y (2011) Two TPX2-dependent switches control the activity of Aurora A. PLoS One 6:e16757
    • (2011) PLoS One , vol.6 , pp. 16757
    • Xu, X.1    Wang, X.2    Xiao, Z.3    Li, Y.4    Wang, Y.5
  • 83
    • 67650061988 scopus 로고    scopus 로고
    • Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks
    • 19359241 1:CAS:528:DC%2BD1MXmsFyqu7w%3D
    • Scutt PJ, Chu ML, Sloane DA, Cherry M, Bignell CR, Williams DH, Eyers PA (2009) Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks. J Biol Chem 284:15880-15893
    • (2009) J Biol Chem , vol.284 , pp. 15880-15893
    • Scutt, P.J.1    Chu, M.L.2    Sloane, D.A.3    Cherry, M.4    Bignell, C.R.5    Williams, D.H.6    Eyers, P.A.7
  • 86
    • 0141429171 scopus 로고    scopus 로고
    • Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
    • 13678582 1:CAS:528:DC%2BD3sXntlalt7c%3D
    • Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114:585-598
    • (2003) Cell , vol.114 , pp. 585-598
    • Hirota, T.1    Kunitoku, N.2    Sasayama, T.3    Marumoto, T.4    Zhang, D.5    Nitta, M.6    Hatakeyama, K.7    Saya, H.8
  • 87
    • 79953129453 scopus 로고    scopus 로고
    • Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome
    • 21402878 1:CAS:528:DC%2BC3MXls1Oisb8%3D
    • Sabino D, Brown NH, Basto R (2011) Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome. J Cell Sci 124:1156-1166
    • (2011) J Cell Sci , vol.124 , pp. 1156-1166
    • Sabino, D.1    Brown, N.H.2    Basto, R.3
  • 88
    • 0029891787 scopus 로고    scopus 로고
    • Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae
    • 8668148 1:CAS:528:DyaK28XjvVWntr8%3D
    • Law SF, Estojak J, Wang B, Mysliwiec T, Kruh G, Golemis EA (1996) Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol Cell Biol 16:3327-3337
    • (1996) Mol Cell Biol , vol.16 , pp. 3327-3337
    • Law, S.F.1    Estojak, J.2    Wang, B.3    Mysliwiec, T.4    Kruh, G.5    Golemis, E.A.6
  • 90
    • 77950605242 scopus 로고    scopus 로고
    • CAS proteins in normal and pathological cell growth control
    • 19937461 1:CAS:528:DC%2BC3cXivFakt78%3D
    • Tikhmyanova N, Little JL, Golemis EA (2010) CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci 67:1025-1048
    • (2010) Cell Mol Life Sci , vol.67 , pp. 1025-1048
    • Tikhmyanova, N.1    Little, J.L.2    Golemis, E.A.3
  • 91
    • 0031416275 scopus 로고    scopus 로고
    • Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: Potential relevance to neoplastic lymphohematopoietic cells
    • 9498705 1:CAS:528:DC%2BD3cXis1arsL4%3D
    • Astier A, Manie SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS (1997) Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. Leuk Lymphoma 28:65-72
    • (1997) Leuk Lymphoma , vol.28 , pp. 65-72
    • Astier, A.1    Manie, S.N.2    Law, S.F.3    Canty, T.4    Haghayghi, N.5    Druker, B.J.6    Salgia, R.7    Golemis, E.A.8    Freedman, A.S.9
  • 92
    • 0036153173 scopus 로고    scopus 로고
    • Dissection of HEF1-dependent functions in motility and transcriptional regulation
    • 11801728 1:CAS:528:DC%2BD38XovVeisA%3D%3D
    • Fashena SJ, Einarson MB, O'Neill GM, Patriotis C, Golemis EA (2002) Dissection of HEF1-dependent functions in motility and transcriptional regulation. J Cell Sci 115:99-111
    • (2002) J Cell Sci , vol.115 , pp. 99-111
    • Fashena, S.J.1    Einarson, M.B.2    O'Neill, G.M.3    Patriotis, C.4    Golemis, E.A.5
  • 94
    • 79959735228 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells
    • rs5
    • Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA (2011) Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal 4:rs5
    • (2011) Sci Signal , vol.4
    • Kettenbach, A.N.1    Schweppe, D.K.2    Faherty, B.K.3    Pechenick, D.4    Pletnev, A.A.5    Gerber, S.A.6
  • 95
    • 33645220356 scopus 로고    scopus 로고
    • HEF1-aurora A interactions: Points of dialog between the cell cycle and cell attachment signaling networks
    • 16479169 1:CAS:528:DC%2BD28Xkslaqtbo%3D
    • Pugacheva EN, Golemis EA (2006) HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle 5:384-391
    • (2006) Cell Cycle , vol.5 , pp. 384-391
    • Pugacheva, E.N.1    Golemis, E.A.2
  • 96
    • 33644868709 scopus 로고    scopus 로고
    • Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle
    • 16394104 1:CAS:528:DC%2BD28XltlSqtLw%3D
    • Dadke D, Jarnik M, Pugacheva EN, Singh MK, Golemis EA (2006) Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell 17:1204-1217
    • (2006) Mol Biol Cell , vol.17 , pp. 1204-1217
    • Dadke, D.1    Jarnik, M.2    Pugacheva, E.N.3    Singh, M.K.4    Golemis, E.A.5
  • 97
    • 25444455576 scopus 로고    scopus 로고
    • Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination
    • 16166645 1:CAS:528:DC%2BD2MXhtVKqsLfL
    • Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD (2005) Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol 25:8656-8668
    • (2005) Mol Cell Biol , vol.25 , pp. 8656-8668
    • Sankaran, S.1    Starita, L.M.2    Groen, A.C.3    Ko, M.J.4    Parvin, J.D.5
  • 98
    • 42049096542 scopus 로고    scopus 로고
    • Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
    • 18378770 1:CAS:528:DC%2BD1cXks1Gkuro%3D
    • Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G (2008) Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol 181:65-78
    • (2008) J Cell Biol , vol.181 , pp. 65-78
    • Seki, A.1    Coppinger, J.A.2    Du, H.3    Jang, C.Y.4    Yates III, J.R.5    Fang, G.6
  • 100
    • 0028304675 scopus 로고
    • Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation
    • 8007975 1:CAS:528:DyaK2cXkslGhsr8%3D
    • Francisco L, Wang W, Chan CS (1994) Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol 14:4731-4740
    • (1994) Mol Cell Biol , vol.14 , pp. 4731-4740
    • Francisco, L.1    Wang, W.2    Chan, C.S.3
  • 101
    • 2942590333 scopus 로고    scopus 로고
    • Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
    • 15173575 1:CAS:528:DC%2BD2cXltFKks7k%3D
    • Satinover DL, Leach CA, Stukenberg PT, Brautigan DL (2004) Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl Acad Sci U S A 101:8625-8630
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8625-8630
    • Satinover, D.L.1    Leach, C.A.2    Stukenberg, P.T.3    Brautigan, D.L.4
  • 102
    • 0035824660 scopus 로고    scopus 로고
    • Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle
    • 11551964 1:CAS:528:DC%2BD3MXptVymt7k%3D
    • Katayama H, Zhou H, Li Q, Tatsuka M, Sen S (2001) Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 276:46219-46224
    • (2001) J Biol Chem , vol.276 , pp. 46219-46224
    • Katayama, H.1    Zhou, H.2    Li, Q.3    Tatsuka, M.4    Sen, S.5
  • 103
    • 78650745657 scopus 로고    scopus 로고
    • Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
    • 21187329 1:CAS:528:DC%2BC3MXis1Wjtg%3D%3D
    • Zeng K, Bastos RN, Barr FA, Gruneberg U (2010) Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol 191:1315-1332
    • (2010) J Cell Biol , vol.191 , pp. 1315-1332
    • Zeng, K.1    Bastos, R.N.2    Barr, F.A.3    Gruneberg, U.4
  • 104
    • 84860284549 scopus 로고    scopus 로고
    • Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89
    • 22451695 1:CAS:528:DC%2BC38XlsVChur8%3D
    • Reboutier D, Troadec MB, Cremet JY, Fukasawa K, Prigent C (2012) Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89. J Cell Biol 197:19-26
    • (2012) J Cell Biol , vol.197 , pp. 19-26
    • Reboutier, D.1    Troadec, M.B.2    Cremet, J.Y.3    Fukasawa, K.4    Prigent, C.5
  • 106
    • 0346497760 scopus 로고    scopus 로고
    • Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3
    • 14724178 1:CAS:528:DC%2BD2cXotFOhsQ%3D%3D
    • Sarkissian M, Mendez R, Richter JD (2004) Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Gene Dev 18:48-61
    • (2004) Gene Dev , vol.18 , pp. 48-61
    • Sarkissian, M.1    Mendez, R.2    Richter, J.D.3
  • 107
    • 79955913373 scopus 로고    scopus 로고
    • A translational regulator, PUM2, promotes both protein stability and kinase activity of Aurora-A
    • 21589936 1:CAS:528:DC%2BC3MXmt1ejtb8%3D
    • Huang YH, Wu CC, Chou CK, Huang CY (2011) A translational regulator, PUM2, promotes both protein stability and kinase activity of Aurora-A. PLoS One 6:e19718
    • (2011) PLoS One , vol.6 , pp. 19718
    • Huang, Y.H.1    Wu, C.C.2    Chou, C.K.3    Huang, C.Y.4
  • 108
    • 54049088105 scopus 로고    scopus 로고
    • RASSF1A interacts with and activates the mitotic kinase Aurora-A
    • 18641684 1:CAS:528:DC%2BD1cXht1Cms7rF
    • Liu L, Guo C, Dammann R, Tommasi S, Pfeifer GP (2008) RASSF1A interacts with and activates the mitotic kinase Aurora-A. Oncogene 27:6175-6186
    • (2008) Oncogene , vol.27 , pp. 6175-6186
    • Liu, L.1    Guo, C.2    Dammann, R.3    Tommasi, S.4    Pfeifer, G.P.5
  • 109
    • 78149332043 scopus 로고    scopus 로고
    • Golgi partitioning controls mitotic entry through Aurora-A kinase
    • 20844084 1:CAS:528:DC%2BC3cXhsFWhs7vP
    • Persico A, Cervigni RI, Barretta ML, Corda D, Colanzi A (2010) Golgi partitioning controls mitotic entry through Aurora-A kinase. Mol Biol Cell 21:3708-3721
    • (2010) Mol Biol Cell , vol.21 , pp. 3708-3721
    • Persico, A.1    Cervigni, R.I.2    Barretta, M.L.3    Corda, D.4    Colanzi, A.5
  • 110
    • 20344387214 scopus 로고    scopus 로고
    • Conditional transgenic system for mouse aurora a kinase: Degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein
    • 15923640 1:CAS:528:DC%2BD2MXlt1Oru7s%3D
    • Fukuda T, Mishina Y, Walker MP, DiAugustine RP (2005) Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein. Mol Cell Biol 25:5270-5281
    • (2005) Mol Cell Biol , vol.25 , pp. 5270-5281
    • Fukuda, T.1    Mishina, Y.2    Walker, M.P.3    Diaugustine, R.P.4
  • 111
    • 0034213929 scopus 로고    scopus 로고
    • Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway
    • 10851084 1:CAS:528:DC%2BD3cXkt12rtL0%3D
    • Honda K, Mihara H, Kato Y, Yamaguchi A, Tanaka H, Yasuda H, Furukawa K, Urano T (2000) Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 19:2812-2819
    • (2000) Oncogene , vol.19 , pp. 2812-2819
    • Honda, K.1    Mihara, H.2    Kato, Y.3    Yamaguchi, A.4    Tanaka, H.5    Yasuda, H.6    Furukawa, K.7    Urano, T.8
  • 112
    • 0034609753 scopus 로고    scopus 로고
    • The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
    • 11039908 1:CAS:528:DC%2BD3cXns1emu7c%3D
    • Walter AO, Seghezzi W, Korver W, Sheung J, Lees E (2000) The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 19:4906-4916
    • (2000) Oncogene , vol.19 , pp. 4906-4916
    • Walter, A.O.1    Seghezzi, W.2    Korver, W.3    Sheung, J.4    Lees, E.5
  • 113
    • 81055139468 scopus 로고    scopus 로고
    • Structural insights into anaphase-promoting complex function and mechanism
    • 22084387 1:CAS:528:DC%2BC38XhtVertQ%3D%3D
    • Barford D (2011) Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci 366:3605-3624
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 3605-3624
    • Barford, D.1
  • 116
    • 0036714512 scopus 로고    scopus 로고
    • Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
    • 12208850 1:CAS:528:DC%2BD38XntFOitLc%3D
    • Littlepage LE, Ruderman JV (2002) Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Gene Dev 16:2274-2285
    • (2002) Gene Dev , vol.16 , pp. 2274-2285
    • Littlepage, L.E.1    Ruderman, J.V.2
  • 118
    • 0034654399 scopus 로고    scopus 로고
    • The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
    • 10733526 1:CAS:528:DC%2BD3cXisVShu7o%3D
    • Pfleger CM, Kirschner MW (2000) The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Gene Dev 14:655-665
    • (2000) Gene Dev , vol.14 , pp. 655-665
    • Pfleger, C.M.1    Kirschner, M.W.2
  • 120
    • 0037160088 scopus 로고    scopus 로고
    • Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase
    • 12244051 1:CAS:528:DC%2BD38Xosl2ksLo%3D
    • Kiat LS, Hui KM, Gopalan G (2002) Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. J Biol Chem 277:45558-45565
    • (2002) J Biol Chem , vol.277 , pp. 45558-45565
    • Kiat, L.S.1    Hui, K.M.2    Gopalan, G.3
  • 121
    • 35348851301 scopus 로고    scopus 로고
    • Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A
    • 17452972 1:CAS:528:DC%2BD2sXhtFCkt7vI
    • Lim SK, Gopalan G (2007) Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. Oncogene 26:6593-6603
    • (2007) Oncogene , vol.26 , pp. 6593-6603
    • Lim, S.K.1    Gopalan, G.2
  • 122
    • 34147181752 scopus 로고    scopus 로고
    • Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway
    • 17125467 1:CAS:528:DC%2BD2sXksFCiur8%3D
    • Lim SK, Gopalan G (2007) Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Biochem J 403:119-127
    • (2007) Biochem J , vol.403 , pp. 119-127
    • Lim, S.K.1    Gopalan, G.2
  • 123
    • 47949089393 scopus 로고    scopus 로고
    • AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta
    • 18391981 1:CAS:528:DC%2BD1cXovV2ktrc%3D
    • Fumoto K, Lee PC, Saya H, Kikuchi A (2008) AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta. Oncogene 27:4478-4487
    • (2008) Oncogene , vol.27 , pp. 4478-4487
    • Fumoto, K.1    Lee, P.C.2    Saya, H.3    Kikuchi, A.4
  • 125
    • 66749118526 scopus 로고    scopus 로고
    • Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics
    • 19395863 1:CAS:528:DC%2BD1MXptFehtbo%3D
    • Lorenzo C, Liao Q, Hardwicke MA, Ducommun B (2009) Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics. Cell Cycle 8:1733-1737
    • (2009) Cell Cycle , vol.8 , pp. 1733-1737
    • Lorenzo, C.1    Liao, Q.2    Hardwicke, M.A.3    Ducommun, B.4
  • 126
    • 77953591215 scopus 로고    scopus 로고
    • The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogenesis
    • 20168084
    • Yamada M, Hirotsune S, Wynshaw-Boris A (2010) The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogenesis. Cell Adh Migr 4:180-184
    • (2010) Cell Adh Migr , vol.4 , pp. 180-184
    • Yamada, M.1    Hirotsune, S.2    Wynshaw-Boris, A.3
  • 127
    • 53649104927 scopus 로고    scopus 로고
    • Localization of aurora A and aurora B kinases during interphase: Role of the N-terminal domain
    • 18802402 1:CAS:528:DC%2BD1cXhsVOgsrvM
    • Rannou Y, Troadec MB, Petretti C, Hans F, Dutertre S, Dimitrov S, Prigent C (2008) Localization of aurora A and aurora B kinases during interphase: role of the N-terminal domain. Cell Cycle 7:3012-3020
    • (2008) Cell Cycle , vol.7 , pp. 3012-3020
    • Rannou, Y.1    Troadec, M.B.2    Petretti, C.3    Hans, F.4    Dutertre, S.5    Dimitrov, S.6    Prigent, C.7
  • 128
    • 1842583754 scopus 로고    scopus 로고
    • Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2
    • 15068791 1:CAS:528:DC%2BD2cXjsFeqsbc%3D
    • Kemp CA, Kopish KR, Zipperlen P, Ahringer J, O'Connell KF (2004) Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell 6:511-523
    • (2004) Dev Cell , vol.6 , pp. 511-523
    • Kemp, C.A.1    Kopish, K.R.2    Zipperlen, P.3    Ahringer, J.4    O'Connell, K.F.5
  • 130
    • 34250758641 scopus 로고    scopus 로고
    • HEF1-dependent Aurora A activation induces disassembly of the primary cilium
    • 17604723 1:CAS:528:DC%2BD2sXotV2hsL0%3D
    • Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA (2007) HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-1363
    • (2007) Cell , vol.129 , pp. 1351-1363
    • Pugacheva, E.N.1    Jablonski, S.A.2    Hartman, T.R.3    Henske, E.P.4    Golemis, E.A.5
  • 131
    • 79959410384 scopus 로고    scopus 로고
    • Aurora A kinase activity influences calcium signaling in kidney cells
    • 21670214 1:CAS:528:DC%2BC3MXnvFWqu7s%3D
    • Plotnikova OV, Pugacheva EN, Golemis EA (2011) Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol 193:1021-1032
    • (2011) J Cell Biol , vol.193 , pp. 1021-1032
    • Plotnikova, O.V.1    Pugacheva, E.N.2    Golemis, E.A.3
  • 132
    • 79957887714 scopus 로고    scopus 로고
    • A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos
    • 21572421
    • Toya M, Terasawa M, Nagata K, Iida Y, Sugimoto A (2011) A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos. Nat Cell Biol 13:708-714
    • (2011) Nat Cell Biol , vol.13 , pp. 708-714
    • Toya, M.1    Terasawa, M.2    Nagata, K.3    Iida, Y.4    Sugimoto, A.5
  • 133
    • 70350418719 scopus 로고    scopus 로고
    • Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions
    • 19690050 1:CAS:528:DC%2BD1MXhtlSitLzK
    • Ogawa H, Ohta N, Moon W, Matsuzaki F (2009) Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions. J Cell Sci 122:3242-3249
    • (2009) J Cell Sci , vol.122 , pp. 3242-3249
    • Ogawa, H.1    Ohta, N.2    Moon, W.3    Matsuzaki, F.4
  • 134
    • 52949141884 scopus 로고    scopus 로고
    • Modulation of kinase-inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX-680 and with TPX2
    • 18662907 1:CAS:528:DC%2BD1cXht1Cit7rM
    • Zhao B, Smallwood A, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick RB, Lai Z (2008) Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci 17:1791-1797
    • (2008) Protein Sci , vol.17 , pp. 1791-1797
    • Zhao, B.1    Smallwood, A.2    Yang, J.3    Koretke, K.4    Nurse, K.5    Calamari, A.6    Kirkpatrick, R.B.7    Lai, Z.8
  • 135
    • 0034604639 scopus 로고    scopus 로고
    • Regulated targeting of a protein kinase into an intact flagellum. An aurora/Ipl1p-like protein kinase translocates from the cell body into the flagella during gamete activation in chlamydomonas
    • 10807915 1:CAS:528:DC%2BD3cXls12lsb0%3D
    • Pan J, Snell WJ (2000) Regulated targeting of a protein kinase into an intact flagellum. An aurora/Ipl1p-like protein kinase translocates from the cell body into the flagella during gamete activation in chlamydomonas. J Biol Chem 275:24106-24114
    • (2000) J Biol Chem , vol.275 , pp. 24106-24114
    • Pan, J.1    Snell, W.J.2
  • 136
    • 1642406286 scopus 로고    scopus 로고
    • An aurora kinase is essential for flagellar disassembly in Chlamydomonas
    • 15030766 1:CAS:528:DC%2BD2cXis1KmsLs%3D
    • Pan J, Wang Q, Snell WJ (2004) An aurora kinase is essential for flagellar disassembly in Chlamydomonas. Dev Cell 6:445-451
    • (2004) Dev Cell , vol.6 , pp. 445-451
    • Pan, J.1    Wang, Q.2    Snell, W.J.3
  • 137
    • 42049111410 scopus 로고    scopus 로고
    • Cell cycle-dependent ciliogenesis and cancer
    • 18381407 1:CAS:528:DC%2BD1cXktVyqtLc%3D
    • Plotnikova OV, Golemis EA, Pugacheva EN (2008) Cell cycle-dependent ciliogenesis and cancer. Cancer Res 68:2058-2061
    • (2008) Cancer Res , vol.68 , pp. 2058-2061
    • Plotnikova, O.V.1    Golemis, E.A.2    Pugacheva, E.N.3
  • 138
    • 1542289920 scopus 로고    scopus 로고
    • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases
    • 14670976 1:CAS:528:DC%2BD2cXhsFejsLk%3D
    • Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S (2004) Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem 279:7685-7691
    • (2004) J Biol Chem , vol.279 , pp. 7685-7691
    • Brush, M.H.1    Guardiola, A.2    Connor, J.H.3    Yao, T.P.4    Shenolikar, S.5
  • 141
    • 38649120238 scopus 로고    scopus 로고
    • 2+ underlies flagellar excision in Chlamydomonas reinhardtii
    • 18086284 1:CAS:528:DC%2BD1cXisFSnu78%3D
    • 2+ underlies flagellar excision in Chlamydomonas reinhardtii. Plant J 53:401-413
    • (2008) Plant J , vol.53 , pp. 401-413
    • Wheeler, G.L.1    Joint, I.2    Brownlee, C.3
  • 144
    • 67249091839 scopus 로고    scopus 로고
    • Polycystic kidney disease
    • 18947299 1:CAS:528:DC%2BD1MXitlyntLc%3D
    • Harris PC, Torres VE (2009) Polycystic kidney disease. Annu Rev Med 60:321-337
    • (2009) Annu Rev Med , vol.60 , pp. 321-337
    • Harris, P.C.1    Torres, V.E.2
  • 146
    • 0242330123 scopus 로고    scopus 로고
    • Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
    • 14580337 1:CAS:528:DC%2BD3sXovVKjtb0%3D
    • Bayliss R, Sardon T, Vernos I, Conti E (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell 12:851-862
    • (2003) Mol Cell , vol.12 , pp. 851-862
    • Bayliss, R.1    Sardon, T.2    Vernos, I.3    Conti, E.4
  • 147
    • 52949141884 scopus 로고    scopus 로고
    • Modulation of kinase-inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX-680 and with TPX2
    • 18662907 1:CAS:528:DC%2BD1cXht1Cit7rM
    • Zhao B, Smallwood A, Yang J, Koretke K, Nurse K, Calamari A, Kirkpatrick RB, Lai Z (2008) Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci 17:1791-1797
    • (2008) Protein Sci , vol.17 , pp. 1791-1797
    • Zhao, B.1    Smallwood, A.2    Yang, J.3    Koretke, K.4    Nurse, K.5    Calamari, A.6    Kirkpatrick, R.B.7    Lai, Z.8
  • 149
    • 77950878509 scopus 로고    scopus 로고
    • Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: Insights into selectivity and drug design
    • 20067443 1:CAS:528:DC%2BC3cXjtFyntr8%3D
    • Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, Bayliss R (2010) Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design. Biochem J 427:19-28
    • (2010) Biochem J , vol.427 , pp. 19-28
    • Dodson, C.A.1    Kosmopoulou, M.2    Richards, M.W.3    Atrash, B.4    Bavetsias, V.5    Blagg, J.6    Bayliss, R.7
  • 150
    • 75349091799 scopus 로고    scopus 로고
    • Defining the conserved internal architecture of a protein kinase
    • 19879387 1:CAS:528:DC%2BC3cXhs1ynu74%3D
    • Kornev AP, Taylor SS (2010) Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta 1804:440-444
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 440-444
    • Kornev, A.P.1    Taylor, S.S.2
  • 152
    • 70450228455 scopus 로고    scopus 로고
    • A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2
    • 19801554 1:CAS:528:DC%2BD1MXhsVCjtLfN
    • Bibby RA, Tang C, Faisal A, Drosopoulos K, Lubbe S, Houlston R, Bayliss R, Linardopoulos S (2009) A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. J Biol Chem 284:33177-33184
    • (2009) J Biol Chem , vol.284 , pp. 33177-33184
    • Bibby, R.A.1    Tang, C.2    Faisal, A.3    Drosopoulos, K.4    Lubbe, S.5    Houlston, R.6    Bayliss, R.7    Linardopoulos, S.8
  • 154
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    • 9771714 1:CAS:528:DyaK1cXms1eis78%3D
    • Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S (1998) Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20:189-193
    • (1998) Nat Genet , vol.20 , pp. 189-193
    • Zhou, H.1    Kuang, J.2    Zhong, L.3    Kuo, W.L.4    Gray, J.W.5    Sahin, A.6    Brinkley, B.R.7    Sen, S.8
  • 155
    • 78650185393 scopus 로고    scopus 로고
    • Estrogen-induced aurora kinase-A (AURKA) gene expression is activated by GATA-3 in estrogen receptor-positive breast cancer cells
    • 21761347 1:CAS:528:DC%2BC3cXotVeht7o%3D
    • Jiang S, Katayama H, Wang J, Li SA, Hong Y, Radvanyi L, Li JJ, Sen S (2010) Estrogen-induced aurora kinase-A (AURKA) gene expression is activated by GATA-3 in estrogen receptor-positive breast cancer cells. Horm Cancer 1:11-20
    • (2010) Horm Cancer , vol.1 , pp. 11-20
    • Jiang, S.1    Katayama, H.2    Wang, J.3    Li, S.A.4    Hong, Y.5    Radvanyi, L.6    Li, J.J.7    Sen, S.8
  • 156
    • 53849129538 scopus 로고    scopus 로고
    • Downregulation of Aurora-A overrides estrogen-mediated growth and chemoresistance in breast cancer cells
    • 18469155 1:CAS:528:DC%2BD1cXhtlWit7fJ
    • Lee HH, Zhu Y, Govindasamy KM, Gopalan G (2008) Downregulation of Aurora-A overrides estrogen-mediated growth and chemoresistance in breast cancer cells. Endocr Relat Cancer 15:765-775
    • (2008) Endocr Relat Cancer , vol.15 , pp. 765-775
    • Lee, H.H.1    Zhu, Y.2    Govindasamy, K.M.3    Gopalan, G.4
  • 158
    • 80051962870 scopus 로고    scopus 로고
    • Biology of Aurora A kinase: Implications in cancer manifestation and therapy
    • Karthigeyan D, Prasad SB, Shandilya J, Agrawal S, Kundu TK (2011) Biology of Aurora A kinase: implications in cancer manifestation and therapy. Med Res Rev 31(5):757-793
    • (2011) Med Res Rev , vol.31 , Issue.5 , pp. 757-793
    • Karthigeyan, D.1    Prasad, S.B.2    Shandilya, J.3    Agrawal, S.4    Kundu, T.K.5
  • 159
    • 84860316904 scopus 로고    scopus 로고
    • IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer
    • 22483753 1:CAS:528:DC%2BC38XlsFGnsr0%3D
    • Yin N, Shi J, Wang D, Tong T, Wang M, Fan F, Zhan Q (2012) IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer. Biochem Biophys Res Commun 421:64-69
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 64-69
    • Yin, N.1    Shi, J.2    Wang, D.3    Tong, T.4    Wang, M.5    Fan, F.6    Zhan, Q.7
  • 161
    • 84863568236 scopus 로고    scopus 로고
    • CHFR: A key checkpoint component implicated in a wide range of cancers
    • 22159584 1:CAS:528:DC%2BC38Xmt1Glt7o%3D
    • Sanbhnani S, Yeong FM (2012) CHFR: a key checkpoint component implicated in a wide range of cancers. Cell Mol Life Sci 69:1669-1687
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1669-1687
    • Sanbhnani, S.1    Yeong, F.M.2
  • 163
    • 76649120544 scopus 로고    scopus 로고
    • Aurora kinase inhibitors - Rising stars in cancer therapeutics?
    • 20124450 1:CAS:528:DC%2BC3cXhslekt7w%3D
    • Dar AA, Goff LW, Majid S, Berlin J, El-Rifai W (2010) Aurora kinase inhibitors - rising stars in cancer therapeutics? Mol Cancer Ther 9:268-278
    • (2010) Mol Cancer Ther , vol.9 , pp. 268-278
    • Dar, A.A.1    Goff, L.W.2    Majid, S.3    Berlin, J.4    El-Rifai, W.5
  • 165
    • 0038341158 scopus 로고    scopus 로고
    • The Aurora kinases: Role in cell transformation and tumorigenesis
    • 12884918
    • Katayama H, Brinkley WR, Sen S (2003) The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22:451-464
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 451-464
    • Katayama, H.1    Brinkley, W.R.2    Sen, S.3
  • 166
    • 11144225241 scopus 로고    scopus 로고
    • Aurora-A - A guardian of poles
    • 15630414 1:CAS:528:DC%2BD2MXlvVen
    • Marumoto T, Zhang D, Saya H (2005) Aurora-A - a guardian of poles. Nat Rev Cancer 5:42-50
    • (2005) Nat Rev Cancer , vol.5 , pp. 42-50
    • Marumoto, T.1    Zhang, D.2    Saya, H.3
  • 167
    • 79952447362 scopus 로고    scopus 로고
    • Aurora-A kinase inhibitor scaffolds and binding modes
    • 21147253 1:CAS:528:DC%2BC3MXjs1WrtLk%3D
    • Yan A, Wang L, Xu S, Xu J (2011) Aurora-A kinase inhibitor scaffolds and binding modes. Drug Discov Today 16:260-269
    • (2011) Drug Discov Today , vol.16 , pp. 260-269
    • Yan, A.1    Wang, L.2    Xu, S.3    Xu, J.4
  • 168
    • 47549118837 scopus 로고    scopus 로고
    • Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice
    • 18372918 1:CAS:528:DC%2BD1cXosFGitr8%3D
    • Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M, Saya H (2008) Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice. Oncogene 27:4305-4314
    • (2008) Oncogene , vol.27 , pp. 4305-4314
    • Zhang, D.1    Shimizu, T.2    Araki, N.3    Hirota, T.4    Yoshie, M.5    Ogawa, K.6    Nakagata, N.7    Takeya, M.8    Saya, H.9
  • 169
    • 0029881977 scopus 로고    scopus 로고
    • Abnormal centrosome amplification in the absence of p53
    • 8596939 1:CAS:528:DyaK28XhvVWmsb4%3D
    • Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF (1996) Abnormal centrosome amplification in the absence of p53. Science 271:1744-1747
    • (1996) Science , vol.271 , pp. 1744-1747
    • Fukasawa, K.1    Choi, T.2    Kuriyama, R.3    Rulong, S.4    Vande Woude, G.F.5
  • 172
    • 0037009435 scopus 로고    scopus 로고
    • Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function
    • 12198151 1:CAS:528:DC%2BD38Xms1Knurs%3D
    • Chen SS, Chang PC, Cheng YW, Tang FM, Lin YS (2002) Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J 21:4491-4499
    • (2002) EMBO J , vol.21 , pp. 4491-4499
    • Chen, S.S.1    Chang, P.C.2    Cheng, Y.W.3    Tang, F.M.4    Lin, Y.S.5
  • 173
    • 33846811519 scopus 로고    scopus 로고
    • Crosstalk between Aurora-A and p53: Frequent deletion or downregulation of Aurora-A in tumors from p53 null mice
    • 17292827 1:CAS:528:DC%2BD2sXitVartLY%3D
    • Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM, Gray JW, Cai WW, Balmain A (2007) Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell 11:161-173
    • (2007) Cancer Cell , vol.11 , pp. 161-173
    • Mao, J.H.1    Wu, D.2    Perez-Losada, J.3    Jiang, T.4    Li, Q.5    Neve, R.M.6    Gray, J.W.7    Cai, W.W.8    Balmain, A.9
  • 175
    • 33750464049 scopus 로고    scopus 로고
    • EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
    • 17069461
    • Cai QL, Knight JS, Verma SC, Zald P, Robertson ES (2006) EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog 2:e116
    • (2006) PLoS Pathog , vol.2 , pp. 116
    • Cai, Q.L.1    Knight, J.S.2    Verma, S.C.3    Zald, P.4    Robertson, E.S.5
  • 176
    • 84863583787 scopus 로고    scopus 로고
    • Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation
    • 22396649 1:CAS:528:DC%2BC38Xjs12rsL0%3D
    • Cai Q, Xiao B, Si H, Cervini A, Gao J, Lu J, Upadhyay SK, Verma SC, Robertson ES (2012) Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation. PLoS Pathog 8:e1002566
    • (2012) PLoS Pathog , vol.8 , pp. 1002566
    • Cai, Q.1    Xiao, B.2    Si, H.3    Cervini, A.4    Gao, J.5    Lu, J.6    Upadhyay, S.K.7    Verma, S.C.8    Robertson, E.S.9
  • 178
    • 79960943596 scopus 로고    scopus 로고
    • Aurora-A interacts with AP-2alpha and down regulates its transcription activity
    • 21829699 1:CAS:528:DC%2BC3MXhtV2ju77N
    • Zou L, Sun Y, Wang M, Zhan Q (2011) Aurora-A interacts with AP-2alpha and down regulates its transcription activity. PloS One 6:e23110
    • (2011) PloS One , vol.6 , pp. 23110
    • Zou, L.1    Sun, Y.2    Wang, M.3    Zhan, Q.4
  • 179
    • 33847724638 scopus 로고    scopus 로고
    • Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha
    • 17308110 1:CAS:528:DC%2BD2sXhvVWqtLs%3D
    • Briassouli P, Chan F, Savage K, Reis-Filho JS, Linardopoulos S (2007) Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res 67:1689-1695
    • (2007) Cancer Res , vol.67 , pp. 1689-1695
    • Briassouli, P.1    Chan, F.2    Savage, K.3    Reis-Filho, J.S.4    Linardopoulos, S.5
  • 180
    • 79960012417 scopus 로고    scopus 로고
    • Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFkB pathway
    • 21623171 1:CAS:528:DC%2BC38Xktlelsw%3D%3D
    • Chefetz I, Holmberg JC, Alvero AB, Visintin I, Mor G (2011) Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFkB pathway. Cell Cycle 10:2206-2214
    • (2011) Cell Cycle , vol.10 , pp. 2206-2214
    • Chefetz, I.1    Holmberg, J.C.2    Alvero, A.B.3    Visintin, I.4    Mor, G.5
  • 181
    • 33749605644 scopus 로고    scopus 로고
    • Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells
    • 1:CAS:528:DC%2BD28XhtVylsL3K
    • Yang H, He L, Kruk P, Nicosia SV, Cheng JQ (2006) Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. J Int Cancer 119:2304-2312
    • (2006) J Int Cancer , vol.119 , pp. 2304-2312
    • Yang, H.1    He, L.2    Kruk, P.3    Nicosia, S.V.4    Cheng, J.Q.5
  • 183
    • 20144373746 scopus 로고    scopus 로고
    • Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening
    • 15637052 1:CAS:528:DC%2BD2MXitVCit7w%3D
    • Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY (2005) Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem 280:9013-9022
    • (2005) J Biol Chem , vol.280 , pp. 9013-9022
    • Wu, J.C.1    Chen, T.Y.2    Yu, C.T.3    Tsai, S.J.4    Hsu, J.M.5    Tang, M.J.6    Chou, C.K.7    Lin, W.J.8    Yuan, C.J.9    Huang, C.Y.10
  • 184
    • 2342533921 scopus 로고    scopus 로고
    • Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival
    • 15126347 1:CAS:528:DC%2BD2cXjs1ehtrs%3D
    • Neben K, Korshunov A, Benner A, Wrobel G, Hahn M, Kokocinski F, Golanov A, Joos S, Lichter P (2004) Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival. Cancer Res 64:3103-3111
    • (2004) Cancer Res , vol.64 , pp. 3103-3111
    • Neben, K.1    Korshunov, A.2    Benner, A.3    Wrobel, G.4    Hahn, M.5    Kokocinski, F.6    Golanov, A.7    Joos, S.8    Lichter, P.9
  • 185
    • 33644770126 scopus 로고    scopus 로고
    • Correlations between c-myc gene copy-number and clinicopathological parameters of ovarian tumours
    • 16458500 1:CAS:528:DC%2BD28Xit1Ciuro%3D
    • Dimova I, Raitcheva S, Dimitrov R, Doganov N, Toncheva D (2006) Correlations between c-myc gene copy-number and clinicopathological parameters of ovarian tumours. Eur J Cancer 42:674-679
    • (2006) Eur J Cancer , vol.42 , pp. 674-679
    • Dimova, I.1    Raitcheva, S.2    Dimitrov, R.3    Doganov, N.4    Toncheva, D.5
  • 186
    • 34547135182 scopus 로고    scopus 로고
    • Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy
    • 17634533 1:CAS:528:DC%2BD2sXnvVCiuro%3D
    • Lassmann S, Shen Y, Jutting U, Wiehle P, Walch A, Gitsch G, Hasenburg A, Werner M (2007) Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy. Clin Cancer Res 13:4083-4091
    • (2007) Clin Cancer Res , vol.13 , pp. 4083-4091
    • Lassmann, S.1    Shen, Y.2    Jutting, U.3    Wiehle, P.4    Walch, A.5    Gitsch, G.6    Hasenburg, A.7    Werner, M.8
  • 189
    • 1642556824 scopus 로고    scopus 로고
    • Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells
    • 14744757 1:CAS:528:DC%2BD2cXmsVWksg%3D%3D
    • Yang H, Ou CC, Feldman RI, Nicosia SV, Kruk PA, Cheng JQ (2004) Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res 64:463-467
    • (2004) Cancer Res , vol.64 , pp. 463-467
    • Yang, H.1    Ou, C.C.2    Feldman, R.I.3    Nicosia, S.V.4    Kruk, P.A.5    Cheng, J.Q.6
  • 191
    • 60149085428 scopus 로고    scopus 로고
    • The aurora kinase A regulates GSK-3beta in gastric cancer cells
    • 19060929 1:CAS:528:DC%2BD1cXhsVKlt7rI
    • Dar AA, Belkhiri A, El-Rifai W (2009) The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene 28:866-875
    • (2009) Oncogene , vol.28 , pp. 866-875
    • Dar, A.A.1    Belkhiri, A.2    El-Rifai, W.3
  • 193
    • 79958117200 scopus 로고    scopus 로고
    • Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells
    • 21557940 1:CAS:528:DC%2BC3MXnsVShsLw%3D
    • Sumi K, Tago K, Kasahara T, Funakoshi-Tago M (2011) Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells. FEBS Lett 585:1884-1890
    • (2011) FEBS Lett , vol.585 , pp. 1884-1890
    • Sumi, K.1    Tago, K.2    Kasahara, T.3    Funakoshi-Tago, M.4
  • 194
    • 84861531111 scopus 로고    scopus 로고
    • Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma
    • 21963848 1:CAS:528:DC%2BC3MXht1Gqs7nF
    • Torchia EC, Caulin C, Acin S, Terzian T, Kubick BJ, Box NF, Roop DR (2012) Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene 31:2680-2690
    • (2012) Oncogene , vol.31 , pp. 2680-2690
    • Torchia, E.C.1    Caulin, C.2    Acin, S.3    Terzian, T.4    Kubick, B.J.5    Box, N.F.6    Roop, D.R.7
  • 197
    • 84866730145 scopus 로고    scopus 로고
    • Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo
    • doi: 10.1016/j.ejca.2011.12.028
    • Arai R, Tsuda M, Watanabe T, Ose T, Obuse C, Maenaka K, Minami A, Ohba Y (2012) Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. Eur J Cancer. doi: 10.1016/j.ejca.2011.12.028
    • (2012) Eur J Cancer.
    • Arai, R.1    Tsuda, M.2    Watanabe, T.3    Ose, T.4    Obuse, C.5    Maenaka, K.6    Minami, A.7    Ohba, Y.8
  • 199
    • 16344376622 scopus 로고    scopus 로고
    • Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer
    • 15839305 1:CAS:528:DC%2BD2MXjtFSrtbw%3D
    • Hu W, Kavanagh JJ, Deaver M, Johnston DA, Freedman RS, Verschraegen CF, Sen S (2005) Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncol Res 15:49-57
    • (2005) Oncol Res , vol.15 , pp. 49-57
    • Hu, W.1    Kavanagh, J.J.2    Deaver, M.3    Johnston, D.A.4    Freedman, R.S.5    Verschraegen, C.F.6    Sen, S.7
  • 204
    • 78649908015 scopus 로고    scopus 로고
    • Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma
    • 20937525 1:CAS:528:DC%2BC3cXhsFWqtb%2FP
    • Lassus H, Staff S, Leminen A, Isola J, Butzow R (2011) Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma. Gynecol Oncol 120:11-17
    • (2011) Gynecol Oncol , vol.120 , pp. 11-17
    • Lassus, H.1    Staff, S.2    Leminen, A.3    Isola, J.4    Butzow, R.5
  • 207
    • 79957883089 scopus 로고    scopus 로고
    • AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma
    • 21441901 1:CAS:528:DC%2BC3MXmvFyjt78%3D
    • Yang F, Guo X, Yang G, Rosen DG, Liu J (2011) AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma. Mod Pathol 24:836-845
    • (2011) Mod Pathol , vol.24 , pp. 836-845
    • Yang, F.1    Guo, X.2    Yang, G.3    Rosen, D.G.4    Liu, J.5
  • 212
    • 40849130815 scopus 로고    scopus 로고
    • Aurora kinase expression in colorectal adenocarcinoma: Correlations with clinicopathological features, p16 expression, and telomerase activity
    • 18284933 1:CAS:528:DC%2BD1cXjtlCjsbo%3D
    • Lam AK, Ong K, Ho YH (2008) Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity. Hum Pathol 39:599-604
    • (2008) Hum Pathol , vol.39 , pp. 599-604
    • Lam, A.K.1    Ong, K.2    Ho, Y.H.3
  • 213
    • 84856912673 scopus 로고    scopus 로고
    • Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer
    • 22240781 1:CAS:528:DC%2BC38XisVGqurk%3D
    • Dotan E, Meropol NJ, Zhu F, Zambito F, Bove B, Cai KQ, Godwin AK, Golemis EA, Astsaturov I, Cohen SJ (2012) Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer. Br J Cancer 106:748-755
    • (2012) Br J Cancer , vol.106 , pp. 748-755
    • Dotan, E.1    Meropol, N.J.2    Zhu, F.3    Zambito, F.4    Bove, B.5    Cai, K.Q.6    Godwin, A.K.7    Golemis, E.A.8    Astsaturov, I.9    Cohen, S.J.10
  • 216
    • 51649095478 scopus 로고    scopus 로고
    • Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer
    • 18628459 1:CAS:528:DC%2BD1cXosFGit7k%3D
    • Nadler Y, Camp RL, Schwartz C, Rimm DL, Kluger HM, Kluger Y (2008) Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer. Clin Cancer Res 14:4455-4462
    • (2008) Clin Cancer Res , vol.14 , pp. 4455-4462
    • Nadler, Y.1    Camp, R.L.2    Schwartz, C.3    Rimm, D.L.4    Kluger, H.M.5    Kluger, Y.6
  • 218
    • 17844381081 scopus 로고    scopus 로고
    • Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK
    • 1:CAS:528:DC%2BD2MXjvFWjsL4%3D
    • Lo YL, Yu JC, Chen ST, Yang HC, Fann CS, Mau YC, Shen CY (2005) Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK. J Int Cancer 115:276-283
    • (2005) J Int Cancer , vol.115 , pp. 276-283
    • Lo, Y.L.1    Yu, J.C.2    Chen, S.T.3    Yang, H.C.4    Fann, C.S.5    Mau, Y.C.6    Shen, C.Y.7
  • 219
    • 30544438805 scopus 로고    scopus 로고
    • Polymorphisms of the AURKA (STK15/Aurora Kinase) gene and breast cancer risk (United States)
    • 16411056
    • Cox DG, Hankinson SE, Hunter DJ (2006) Polymorphisms of the AURKA (STK15/Aurora Kinase) gene and breast cancer risk (United States). Cancer Causes Control 17:81-83
    • (2006) Cancer Causes Control , vol.17 , pp. 81-83
    • Cox, D.G.1    Hankinson, S.E.2    Hunter, D.J.3
  • 220
    • 40649091864 scopus 로고    scopus 로고
    • Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC)
    • 18043979
    • Ogawa E, Takenaka K, Katakura H, Adachi M, Otake Y, Toda Y, Kotani H, Manabe T, Wada H, Tanaka F (2008) Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC). Ann Surg Oncol 15:547-554
    • (2008) Ann Surg Oncol , vol.15 , pp. 547-554
    • Ogawa, E.1    Takenaka, K.2    Katakura, H.3    Adachi, M.4    Otake, Y.5    Toda, Y.6    Kotani, H.7    Manabe, T.8    Wada, H.9    Tanaka, F.10
  • 221
    • 79959646086 scopus 로고    scopus 로고
    • Aurora kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation
    • 21718475 1:CAS:528:DC%2BC3MXpt12gtrs%3D
    • Lo Iacono M, Monica V, Saviozzi S, Ceppi P, Bracco E, Papotti M, Scagliotti GV (2011) Aurora kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. J Transl Med 9:100
    • (2011) J Transl Med , vol.9 , pp. 100
    • Lo Iacono, M.1    Monica, V.2    Saviozzi, S.3    Ceppi, P.4    Bracco, E.5    Papotti, M.6    Scagliotti, G.V.7
  • 222
    • 33847284072 scopus 로고    scopus 로고
    • Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians
    • 16926177 1:CAS:528:DC%2BD2sXhs1Srsr0%3D
    • Gu J, Gong Y, Huang M, Lu C, Spitz MR, Wu X (2007) Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians. Carcinogenesis 28:350-355
    • (2007) Carcinogenesis , vol.28 , pp. 350-355
    • Gu, J.1    Gong, Y.2    Huang, M.3    Lu, C.4    Spitz, M.R.5    Wu, X.6
  • 224
    • 33748991178 scopus 로고    scopus 로고
    • Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma
    • 16951231 1:CAS:528:DC%2BD28XovF2gs7c%3D
    • Reiter R, Gais P, Jutting U, Steuer-Vogt MK, Pickhard A, Bink K, Rauser S, Lassmann S, Hofler H, Werner M, Walch A (2006) Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma. Clin Cancer Res 12:5136-5141
    • (2006) Clin Cancer Res , vol.12 , pp. 5136-5141
    • Reiter, R.1    Gais, P.2    Jutting, U.3    Steuer-Vogt, M.K.4    Pickhard, A.5    Bink, K.6    Rauser, S.7    Lassmann, S.8    Hofler, H.9    Werner, M.10    Walch, A.11
  • 230
    • 84867071565 scopus 로고    scopus 로고
    • Targeting aurora a kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism
    • doi: 10.1002/ijc.27579
    • Kelly KR, Nawrocki ST, Espitia CM, Zhang M, Yang JJ, Padmanabhan S, Ecsedy J, Giles FJ, Carew JS (2012) Targeting aurora a kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism. Int J Cancer. doi: 10.1002/ijc.27579
    • (2012) Int J Cancer
    • Kelly, K.R.1    Nawrocki, S.T.2    Espitia, C.M.3    Zhang, M.4    Yang, J.J.5    Padmanabhan, S.6    Ecsedy, J.7    Giles, F.J.8    Carew, J.S.9
  • 232
    • 84858118200 scopus 로고    scopus 로고
    • Phase 2 trial of alisertib (MLN8237), an investigational, potent inhibitor of Aurora A kinase (AAK), in patients (pts) with aggressive B- and T-cell non-hodgkin lymphoma (NHL)
    • Friedberg J, Mahadevan D, Jung J, Persky DO, Lossos IS, Danaee H, Zhou X, Leonard EJ, Bernstein SH (2011) Phase 2 trial of alisertib (MLN8237), an investigational, potent inhibitor of Aurora A kinase (AAK), in patients (pts) with aggressive B- and T-cell non-hodgkin lymphoma (NHL). ASH Ann Meet Abstr 118:95
    • (2011) ASH Ann Meet Abstr , vol.118 , pp. 95
    • Friedberg, J.1    Mahadevan, D.2    Jung, J.3    Persky, D.O.4    Lossos, I.S.5    Danaee, H.6    Zhou, X.7    Leonard, E.J.8    Bernstein, S.H.9
  • 233
    • 80054070897 scopus 로고    scopus 로고
    • Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer
    • 21920801 1:CAS:528:DC%2BC3MXhtlaksLfF
    • Mehra R, Serebriiskii IG, Dunbrack RL Jr, Robinson MK, Burtness B, Golemis EA (2011) Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer. Drug Resist Updat 14:260-279
    • (2011) Drug Resist Updat , vol.14 , pp. 260-279
    • Mehra, R.1    Serebriiskii, I.G.2    Dunbrack, Jr.R.L.3    Robinson, M.K.4    Burtness, B.5    Golemis, E.A.6
  • 234
    • 84873727147 scopus 로고    scopus 로고
    • Phase III study of investigational MLN8237 (alisertib) versus investigator's choice in patients (pts) with relapsed/refractory (rel/ref) peripheral T-cell lymphoma (PTCL)
    • abstr TPS8110
    • O'Connor O, Leonard EJ, Benaim E (2012) Phase III study of investigational MLN8237 (alisertib) versus investigator's choice in patients (pts) with relapsed/refractory (rel/ref) peripheral T-cell lymphoma (PTCL). J Clin Oncol 30(suppl); abstr TPS8110. http://www.asco.org/ASCOv2/Meetings/ Abstract?&vmview=abst-detail-view&conflD=114&abstractID=93843
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • O'Connor, O.1    Leonard, E.J.2    Benaim, E.3
  • 237
    • 79957501125 scopus 로고    scopus 로고
    • Human cancers express mutator phenotypes: Origin, consequences and targeting
    • 21593786 1:CAS:528:DC%2BC3MXmtleltbg%3D
    • Loeb LA (2011) Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer 11:450-457
    • (2011) Nat Rev Cancer , vol.11 , pp. 450-457
    • Loeb, L.A.1
  • 244
    • 10644227569 scopus 로고    scopus 로고
    • Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215
    • 15469940 1:CAS:528:DC%2BD2cXhtVCktbfO
    • Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ (2004) Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem 279:52175-52182
    • (2004) J Biol Chem , vol.279 , pp. 52175-52182
    • Liu, Q.1    Kaneko, S.2    Yang, L.3    Feldman, R.I.4    Nicosia, S.V.5    Chen, J.6    Cheng, J.Q.7
  • 245
    • 0035839605 scopus 로고    scopus 로고
    • PEg2 aurora-A kinase, histone H3 phosphorylation, and chromosome assembly in Xenopus egg extract
    • 11402032 1:CAS:528:DC%2BD3MXmtFehs7c%3D
    • Scrittori L, Hans F, Angelov D, Charra M, Prigent C, Dimitrov S (2001) pEg2 aurora-A kinase, histone H3 phosphorylation, and chromosome assembly in Xenopus egg extract. J Biol Chem 276:30002-30010
    • (2001) J Biol Chem , vol.276 , pp. 30002-30010
    • Scrittori, L.1    Hans, F.2    Angelov, D.3    Charra, M.4    Prigent, C.5    Dimitrov, S.6
  • 246
    • 21644465065 scopus 로고    scopus 로고
    • Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1
    • 15966895 1:CAS:528:DC%2BD2MXpvF2lsbk%3D
    • Sasayama T, Marumoto T, Kunitoku N, Zhang D, Tamaki N, Kohmura E, Saya H, Hirota T (2005) Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1. Genes Cells 10:627-638
    • (2005) Genes Cells , vol.10 , pp. 627-638
    • Sasayama, T.1    Marumoto, T.2    Kunitoku, N.3    Zhang, D.4    Tamaki, N.5    Kohmura, E.6    Saya, H.7    Hirota, T.8
  • 247
    • 84861389543 scopus 로고    scopus 로고
    • LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy
    • 22492986 1:CAS:528:DC%2BC38XnsVWjsbo%3D
    • Johnson EO, Chang KH, Ghosh S, Venkatesh C, Giger K, Low PS, Shah K (2012) LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy. J Cell Sci 125:1204-1216
    • (2012) J Cell Sci , vol.125 , pp. 1204-1216
    • Johnson, E.O.1    Chang, K.H.2    Ghosh, S.3    Venkatesh, C.4    Giger, K.5    Low, P.S.6    Shah, K.7
  • 248
    • 0041885288 scopus 로고    scopus 로고
    • Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells
    • 12939255 1:CAS:528:DC%2BD3sXntFeqs7Y%3D
    • Terada Y, Uetake Y, Kuriyama R (2003) Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. J Cell Biol 162:757-763
    • (2003) J Cell Biol , vol.162 , pp. 757-763
    • Terada, Y.1    Uetake, Y.2    Kuriyama, R.3
  • 250
    • 79961152605 scopus 로고    scopus 로고
    • PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer
    • 21807936 1:CAS:528:DC%2BC3MXhtlWitbnK
    • Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K (2011) PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer. J Cell Sci 124:2711-2722
    • (2011) J Cell Sci , vol.124 , pp. 2711-2722
    • Johnson, E.O.1    Chang, K.H.2    De Pablo, Y.3    Ghosh, S.4    Mehta, R.5    Badve, S.6    Shah, K.7
  • 252
    • 79551587720 scopus 로고    scopus 로고
    • Cytoscape 2.8: New features for data integration and network visualization
    • (Oxford, England)
    • Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T (2011) Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics (Oxford, England) 27:431-432
    • (2011) Bioinformatics , vol.27 , pp. 431-432
    • Smoot, M.E.1    Ono, K.2    Ruscheinski, J.3    Wang, P.L.4    Ideker, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.