Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4491-4499

  Chen, Shih Shun ^a   Chang, Pi Chu ^a   Cheng, Yu Wen ^a   Tang, Fen Mei ^a   Lin, Young Sun ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Aurora box; Centrosome amplification; Oncogenic kinase; P53; STK15

Indexed keywords

PROTEIN P53; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CENTROSOME; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; TRANSACTIVATION;

3T3 CELLS; ANIMALS; BINDING SITES; CENTROSOME; GENES, P53; GENES, REPORTER; HUMANS; K562 CELLS; MICE; ONCOGENE PROTEINS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA;

EID: 0037009435     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf409     Document Type: Article

References (49)

1. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons
2. p53 expression during normal tissue regeneration in response to acute cutaneous injury in swine
3. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
4. The intracellular distribution of the transformation-associated protein p53 in adenovirus-transformed rodent cells
5. c-abl is involved in the association of p53 and trk A
6. Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes
7. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
8. A movable and regulable inactivation function within the central region of a temperature-sensitive p53 mutant
9. 1 arrest following transient inhibition of the mitotic spindle
10. Gas1-induced growth suppression requires a transactivation-independent p53 function
11. Definition of a consensus binding site for p53
12. p53: A glimpse at the puppet behind the shadow play
13. Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain
14. Abnormal centrosome amplification in the absence of p53
15. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
16. The complexity of p53 modulation: Emerging patterns from divergent signals
17. Aurora/Ipllp-related kinases, a new oncogenic family of mitotic serine-threonine kinases
18. The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability
19. p53 mediated apoptosis in HeLa cells: Transcription dependent and independent mechanisms
20. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
21. Transcriptional regulation by p53: Functional interactions among multiple regulatory domains
22. Antagonism between members of the CNC-bZIP family and the immediate-early protein IE2 of human cytomegalovirus
23. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
24. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
25. A transactivation-deficient mouse model provides insights into Trp53 regulation and function
26. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max
27. p53: Puzzle and paradigm
28. Functional analysis and intracellular localization of p53 modified by SUMO-1
29. Cyclin-dependent kinase control of centrosome duplication
30. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
31. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: Suppression by BAG-1
32. -/- cells
33. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein
34. Oncogenic potential of the adenovirus E4orf6 protein
35. p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines and a human primary culture: An immunofluorescence study
36. p53 in tumor progression: Life, death and everything
37. Centrosome multiplication accompanies a transient clustering of polyploid cells during tissue repair
38. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication
39. Oncogenic Ras blocks cell cycle progression and inhibits p34cdc2 kinase in activated Xenopus egg extracts
40. A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1
41. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
42. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
43. Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: Potential role of Ser315 phosphorylation-dependent centrosome binding of p53
44. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipll-like midbody-associated protein mitotic kinase in human cancer cells
45. Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53
46. Inhibition of hTAFII32-binding implicated in the transcriptional repression by central regions of mutant p53 proteins
47. 1/S cell cycle checkpoint control
48. Adenovirus serotype determines association and localization of the large EIB tumor antigen with cellular tumor antigen p53 in transformed cells
49. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation