A cancer-associated Aurora a mutant is mislocalized and misregulated due to loss of interaction with TPX2

Journal of Biological Chemistry

Volumn 284, Issue 48, 2009, Pages 33177-33184

  Bibby, Rachel Ann ^a   Tang, Chan ^a   Faisal, Amir ^a   Drosopoulos, Konstantinos ^a   Lubbe, Steven ^a   Houlston, Richard ^a   Bayliss, Richard ^a   Linardopoulos, Spiros ^a,b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b Breakthrough Breast Cancer Research Centre ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; CANCER-ASSOCIATED MUTATIONS; CATALYTIC DOMAINS; CELLULAR ACTIVITIES; CHROMOSOMAL ABNORMALITIES; COLON CANCER; DIFFERENT MECHANISMS; HUMAN CANCER; KINASE ACTIVITY; MICROSATELLITE INSTABILITY; MISLOCALIZATION; MUTANT PROTEINS; NORMAL TISSUE; PROTEIN EXPRESSIONS; PROTEIN KINASE; SOMATIC MUTATION; STRUCTURAL BASIS; WILD TYPES;

LAWS AND LEGISLATION; PROTEINS; TUMORS;

PLANTS (BOTANY);

AURORA A KINASE; MYC PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TPX2; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CENTROSOME; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SOMATIC MUTATION;

BASE SEQUENCE; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, MOLECULAR; MUTATION; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 70450228455     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.032722     Document Type: Article

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