Aurora-A Kinase Regulates Telomerase Activity through c-Myc in Human Ovarian and Breast Epithelial Cells

Cancer Research

Volumn 64, Issue 2, 2004, Pages 463-467

  Yang, Hua ^a   Chen Ou, Chien ^a   Feldman, Richard I ^b   Nicosia, Santo V ^a   Kruk, Patricia A ^a   Cheng, Jin Q ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; MESSENGER RNA; MYC PROTEIN; PROTEIN SERINE THREONINE KINASE; RNA DIRECTED DNA POLYMERASE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BREAST CANCER; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KNOCKOUT GENE; MALIGNANT TRANSFORMATION; ONCOGENE C MYC; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RNA INTERFERENCE;

BREAST; CELL CYCLE PROTEINS; CELL LINE; DNA PRIMERS; DNA-BINDING PROTEINS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; KINETICS; OVARY; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TELOMERASE; TRANSCRIPTION, GENETIC; XENOPUS PROTEINS;

EID: 1642556824     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2907     Document Type: Article

References (33)

1. Dutertre, S., Descamps, S., and Prigent, C. On the role of aurora-A in centrosome function. Oncogene, 21: 6175-6183, 2002.
2. Tanner, M. M., Grenman, S., Koul, A., Johannsson, O., Meltzer, P., Pejovic, T., Borg, A., and Isola, J. J. Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin. Cancer Res., 6: 1833-1839, 2000.
3. Gritsko, T. M., Coppola, D., Paciga, J. E., Yang, L., Sun, M., Shelley, S. A., Fiorica, J. V., Nicosia, S. V., and Cheng, J. Q. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin. Cancer Res., 9: 1420-1426, 2003.
4. Anand, S., Penrhyn-Lowe, S., and Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to taxol. Cancer Cell, 3: 51-62, 2003.
5. Zhou, H., Kuang, J., Zhong, L., Kuo, W. L., Gray, J. W., Sahin, A., Brinkley, B. R., and Sen, S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet., 20: 189-193, 1998.
6. Goepfert, T. M., Adigun, Y. E., Zhong, L., Gay, J., Medina, D., and Brinkley, W. R. Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res., 62: 4115-4122, 2002.
7. Broccoli, D., and Godwin, A. K. Telomere length changes in human cancer. Methods Mol. Med., 68: 271-278, 2002.
8. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E. Extension of life-span by introduction of telomerase into normal human cells. Science (Wash. DC), 279: 349-352, 1998.
9. Shay, J. W., and Wright, W. E. Telomerase activity in human cancer. Curr. Opin. Oncol., 8: 66-71, 1996.
10. Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., and Cech, T. R. Telomerase catalytic subunit homologs from fission yeast and human. Science (Wash. DC), 277: 955-959, 1997.
11. Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., and Weinberg, R. A. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell, 90: 785-795, 1997.
12. Morales, C. P., Holt, S. E., Ouellette, M., Kaur, K. J., Yan, Y., Wilson, K. S., White, M. A., Wright, W. E., and Shay, J. W. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet., 21: 115-118, 1999.
13. Zhu, J., Wang, H., Bishop, J. M., and Blackburn, E. H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA, 96: 3723-3728, 1999.
14. Delhommeau, F., Thierry, A., Feneux, D., Lauret, E., Leclercq, E., Courtier, M. H., Sainteny, F., Vainchenker, W., and Bennaceur-Griscelli, A. Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. Oncogene, 21: 8262-8271, 2002.
15. Saretzki, G. Telomerase inhibition as cancer therapy. Cancer Lett., 194: 209-219, 2003.
16. Alfonso-De Matte, M. Y., Yang, H., Evans, M. S., Cheng, J. Q., and Kruk, P. A. Telomerase is regulated by c-Jun NH2-terminal kinase in ovarian surface epithelial cells. Cancer Res., 62: 4575-4578, 2002.
17. Lassus, P., Opitz-Araya, X., and Lazehnik, Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science (Wash. DC), 297: 1352-1354, 2002.
18. Dan, H. C., Sun, M., Yang, L., Feldman, R. I., Sui, X. M., Ou, C. C., Nellist, M., Yeung, R. S., Halley, D. J. J., Nicosia, S. V., Pledger, W. J., and Cheng, J. Q. Regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J. Biol. Chem., 277: 35364-35370, 2002.
19. Broccoli, D., Godley, L. A., Donehower, L. A., Varmus, H. E., and de Lange, T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol. Cell. Biol. 16: 3765-3772, 1996.
20. Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., and Inoue, M. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res., 59: 551-557, 1999.
21. Lin, S. Y., and Elledge, S. J. Multiple tumor suppressor pathways negatively regulate telomerase. Cell, 113: 881-889, 2003.
22. Kang, S. S., Kwon, T., Kwon, D. Y., and Do, S. I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem., 274: 13085-13090, 1999.
23. Li, H., Zhao, L., Yang, Z., Funder, J. W., und Liu, J. P. Telomerase is controlled by protein kinase Cα in human breast cancer cells. J. Biol. Chem., 273: 33436-33442, 1998.
24. Kimura, M., Kotani, S., Hattori, T., Sumi, N., Yoshioka, T., Todokoro, K., and Okano, Y. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ip11. J. Biol. Chem., 272: 13766-13771, 1997.
25. Scrittori, L., Hans, F., Angelov, D., Charra, M., Prigent, C., and Dimitrov, S. pEg2 aurora-A kinase, histone H3 phosphorylation, and chromosome assembly in Xenopus egg extract. J. Biol. Chem., 276: 30002-30010, 2001.
26. Hsu, J. Y., Sun, Z. W., Li, X., Reuben, M., Tatchell, K., Bishop, D. K., Grushcow, J. M., Brame, C. J., Caldwell, J. A., Hunt, D. F., Lin, R., Smith, M. M., and Allis, C. D. Mitotic phosphorylation of histone H3 is governed by Ip11/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell, 102: 279-291, 2000.
27. Huang, Y. S., Jung, M. Y., Sarkissian, M., and Richter, J. D. N-Methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and αCaMKII mRNA polyadenylation at synapses. EMBO J., 21: 2139-2148, 2002.
28. Giet, R., McLean, D., Descamps, S., Lee, M. J., Raff, J. W., Prigent, C., and Glover, D. M. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell Biol., 156: 437-451, 2002.
29. Castro, A., Mandart, E., Lorca, T., and Galas, S. Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes. J. Biol. Chem., 278: 2236-2241, 2003.
30. Kufer, T. A., Sillje, H. H., Korner, R., Gruss, O. J., Meraldi, P., and Nigg, E. A. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J. Cell Biol., 158: 617-623, 2002.
31. Kyo, S., Takakura, M., Taira, T., Kanaya, T., Itoh, H., Yutsudo, M., Ariga, H., and Inoue, M. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res., 28: 669-677, 2000.
32. Gunes, C., Lichtsteiner, S., Vasserot, A. P., and Englert, C. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res., 60: 2116-2121, 2000.
33. Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., and Inoue, M. Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT. Nucleic Acids Res., 28: 2557-2562, 2000.