The Aurora kinase family in cell division and cancer

Biochimica et Biophysica Acta - Reviews on Cancer

Volumn 1786, Issue 1, 2008, Pages 60-72

  Vader, Gerben ^a   Lens, Susanne M A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Aurora; Cancer; Cell division; Checkpoint; Mitosis

Indexed keywords

AURORA A KINASE; AURORA B KINASE; PROTEIN AURORA C KINASE; UNCLASSIFIED DRUG;

ANAPHASE; CELL CYCLE; CELL DIVISION; CENTROSOME; CHROMOSOME CONDENSATION; CYTOKINESIS; ENZYME ACTIVITY; HUMAN; IN VIVO STUDY; MITOSIS; MITOSIS SPINDLE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SISTER CHROMATID;

ANAPHASE; CELL DIVISION; CENTROSOME; CHROMATIDS; CYTOKINESIS; ENZYME ACTIVATION; HUMANS; MITOSIS; MITOTIC SPINDLE APPARATUS; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES;

MAMMALIA;

EID: 51649095569     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbcan.2008.07.003     Document Type: Review

References (219)

1. Pines J., and Rieder C.L. Re-staging mitosis: a contemporary view of mitotic progression. Nat. Cell Biol. 3 (2001) E3-6
2. van de Weerdt B.C., and Medema R.H. Polo-like kinases: a team in control of the division. Cell Cycle 5 (2006) 853-864
3. O'Connell M.J., Krien M.J., and Hunter T. Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol. 13 (2003) 221-228
4. Gold M.G., Barford D., and Komander D. Lining the pockets of kinases and phosphatases. Curr. Opin. Struct. Biol. 16 (2006) 693-701
5. Glover D.M., Leibowitz M.H., McLean D.A., and Parry H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81 (1995) 95-105
6. Chan C.S., and Botstein D. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135 (1993) 677-691
7. Francisco L., Wang W., and Chan C.S. Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol. Cell. Biol. 14 (1994) 4731-4740
8. Petersen J., Paris J., Willer M., Philippe M., and Hagan I.M. The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation. J. Cell. Sci. 114 (2001) 4371-4384
9. Kimura M., Kotani S., Hattori T., Sumi N., Yoshioka T., Todokoro K., and Okano Y. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J. Biol. Chem. 272 (1997) 13766-13771
10. Tanaka M., Ueda A., Kanamori H., Ideguchi H., Yang J., Kitajima S., and Ishigatsubo Y. Cell-cycle-dependent regulation of human Aurora A transcription is mediated by periodic repression of E4TF1. J. Biol. Chem. 277 (2002) 10719-10726
11. Kimura M., Uchida C., Takano Y., Kitagawa M., and Okano Y. Cell cycle-dependent regulation of the human Aurora B promoter. Biochem. Biophys. Res. Commun. 316 (2004) 930-936
12. Wang I.C., Chen Y.J., Hughes D., Petrovic V., Major M.L., Park H.J., Tan Y., Ackerson T., and Costa R.H. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol. Cell. Biol. 25 (2005) 10875-10894
13. Tang C.J., Chuang C.K., Hu H.M., and Tang T.K. The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (Aurora-C) kinase gene. J. Biol. Chem. 276 (2001) 19631-19639
14. Wittmann T., Wilm M., Karsenti E., and Vernos I. TPX2, a novel Xenopus MAP involved in spindle pole organization. J. Cell. Biol. 149 (2000) 1405-1418
15. Kufer T.A., Sillje H.H., Korner R., Gruss O.J., Meraldi P., and Nigg E.A. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J. Cell. Biol. 158 (2002) 617-623
16. Bayliss R., Sardon T., Vernos I., and Conti E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12 (2003) 851-862
17. Eyers P.A., Erikson E., Chen L.G., and Maller J.L. A novel mechanism for activation of the protein kinase Aurora A. Curr. Biol. 13 (2003) 691-697
18. Tsai M.Y., and Zheng Y. Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly. Curr. Biol. 15 (2005) 2156-2163
19. Hirota T., Kunitoku N., Sasayama T., Marumoto T., Zhang D., Nitta M., Hatakeyama K., and Saya H. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114 (2003) 585-598
20. Hutterer A., Berdnik D., Wirtz-Peitz F., Zigman M., Schleiffer A., and Knoblich J.A. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev. Cell 11 (2006) 147-157
21. Berdnik D., and Knoblich J.A. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr. Biol. 12 (2002) 640-647
22. Pugacheva E.N., and Golemis E.A. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat. Cell. Biol. 7 (2005) 937-946
23. Satinover D.L., Leach C.A., Stukenberg P.T., and Brautigan D.L. Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 8625-8630
24. Sessa F., Mapelli M., Ciferri C., Tarricone C., Areces L.B., Schneider T.R., Stukenberg P.T., and Musacchio A. Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol. Cell 18 (2005) 379-391
25. Kelly A.E., Sampath S.C., Maniar T.A., Woo E.M., Chait B.T., and Funabiki H. Chromosomal enrichment and activation of the Aurora B pathway are coupled to spatially regulate spindle assembly. Dev. Cell 12 (2007) 31-43
26. Vader G., Medema R.H., and Lens S.M. The chromosomal passenger complex: guiding Aurora-B through mitosis. J. Cell. Biol. 173 (2006) 833-837
27. Jelluma N., Brenkman A.B., van den Broek N.J., Cruijsen C.W., van Osch M.H., Lens S.M., Medema R.H., and Kops G.J. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell 132 (2008) 233-246
28. Zachos G., Black E.J., Walker M., Scott M.T., Vagnarelli P., Earnshaw W.C., and Gillespie D.A. Chk1 is required for spindle checkpoint function. Dev. Cell 12 (2007) 247-260
29. Han Z., Riefler G.M., Saam J.R., Mango S.E., and Schumacher J.M. The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Curr. Biol. 15 (2005) 894-904
30. Riefler G.M., Dent S.Y., and Schumacher J.M. Tousled-mediated activation of Aurora B kinase does not require tousled kinase activity in vivo. J. Biol. Chem. 283 (2008) 12763-12768
31. Rosasco-Nitcher S.E., Lan W., Khorasanizadeh S., and Stukenberg P.T. Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science 319 (2008) 469-472
32. Sasai K., Katayama H., Stenoien D.L., Fujii S., Honda R., Kimura M., Okano Y., Tatsuka M., Suzuki F., Nigg E.A., Earnshaw W.C., Brinkley W.R., and Sen S. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil. Cytoskelet. 59 (2004) 249-263
33. Li X., Sakashita G., Matsuzaki H., Sugimoto K., Kimura K., Hanaoka F., Taniguchi H., Furukawa K., and Urano T. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. 279 (2004) 47201-47211
34. Taguchi S., Honda K., Sugiura K., Yamaguchi A., Furukawa K., and Urano T. Degradation of human Aurora-A protein kinase is mediated by hCdh1. FEBS Lett. 519 (2002) 59-65
35. Nguyen H.G., Chinnappan D., Urano T., and Ravid K. Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol. Cell. Biol. 25 (2005) 4977-4992
36. Arlot-Bonnemains Y., Klotzbucher A., Giet R., Uzbekov R., Bihan R., and Prigent C. Identification of a functional destruction box in the Xenopus laevis Aurora-A kinase pEg2. FEBS Lett. 508 (2001) 149-152
37. Crane R., Kloepfer A., and Ruderman J.V. Requirements for the destruction of human Aurora-A. J. Cell. Sci. 117 (2004) 5975-5983
38. Littlepage L.E., and Ruderman J.V. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev. 16 (2002) 2274-2285
39. Stewart S., and Fang G. Destruction box-dependent degradation of Aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. Cancer Res. 65 (2005) 8730-8735
40. Sumara I., Quadroni M., Frei C., Olma M.H., Sumara G., Ricci R., and Peter M. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev. Cell 12 (2007) 887-900
41. Ramadan K., Bruderer R., Spiga F.M., Popp O., Baur T., Gotta M., and Meyer H.H. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature 450 (2007) 1258-1262
42. Zhao Z.S., Lim J.P., Ng Y.W., Lim L., and Manser E. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol. Cell 20 (2005) 237-249
43. De Luca M., Lavia P., and Guarguaglini G. A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle 5 (2006) 296-303
44. Petretti C., Savoian M., Montembault E., Glover D.M., Prigent C., and Giet R. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. EMBO Rep. 7 (2006) 418-424
45. Terada Y., Uetake Y., and Kuriyama R. Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. J. Cell. Biol. 162 (2003) 757-763
46. Mori D., Yano Y., Toyo-oka K., Yoshida N., Yamada M., Muramatsu M., Zhang D., Saya H., Toyoshima Y.Y., Kinoshita K., Wynshaw-Boris A., and Hirotsune S. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol. Cell. Biol. 27 (2007) 352-367
47. Toji S., Yabuta N., Hosomi T., Nishihara S., Kobayashi T., Suzuki S., Tamai K., and Nojima H. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells 9 (2004) 383-397
48. Abe Y., Ohsugi M., Haraguchi K., Fujimoto J., and Yamamoto T. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett. 580 (2006) 782-788
49. Barros T.P., Kinoshita K., Hyman A.A., and Raff J.W. Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J. Cell. Biol. 170 (2005) 1039-1046
50. Giet R., McLean D., Descamps S., Lee M.J., Raff J.W., Prigent C., and Glover D.M. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell. Biol. 156 (2002) 437-451
51. Hannak E., Kirkham M., Hyman A.A., and Oegema K. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J. Cell. Biol. 155 (2001) 1109-1116
52. Liu Q., and Ruderman J.V. Aurora A, mitotic entry, and spindle bipolarity. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 5811-5816
53. Roghi C., Giet R., Uzbekov R., Morin N., Chartrain I., Le Guellec R., Couturier A., Doree M., Philippe M., and Prigent C. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J. Cell. Sci. 111 Pt 5 (1998) 557-572
54. Giet R., Uzbekov R., Cubizolles F., Le Guellec K., and Prigent C. The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. J. Biol. Chem. 274 (1999) 15005-15013
55. Khodjakov A., Cole R.W., Oakley B.R., and Rieder C.L. Centrosome-independent mitotic spindle formation in vertebrates. Curr. Biol. 10 (2000) 59-67
56. Maiato H., Rieder C.L., and Khodjakov A. Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. J. Cell. Biol. 167 (2004) 831-840
57. Carazo-Salas R.E., Guarguaglini G., Gruss O.J., Segref A., Karsenti E., and Mattaj I.W. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400 (1999) 178-181
58. Wilde A., and Zheng Y. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science 284 (1999) 1359-1362
59. Kalab P., Weis K., and Heald R. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295 (2002) 2452-2456
60. Kalab P., Pralle A., Isacoff E.Y., Heald R., and Weis K. Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature 440 (2006) 697-701
61. Caudron M., Bunt G., Bastiaens P., and Karsenti E. Spatial coordination of spindle assembly by chromosome-mediated signaling gradients. Science 309 (2005) 1373-1376
62. Nachury M.V., Maresca T.J., Salmon W.C., Waterman-Storer C.M., Heald R., and Weis K. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104 (2001) 95-106
63. Wiese C., Wilde A., Moore M.S., Adam S.A., Merdes A., and Zheng Y. Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science 291 (2001) 653-656
64. Wilde A., Lizarraga S.B., Zhang L., Wiese C., Gliksman N.R., Walczak C.E., and Zheng Y. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat. Cell. Biol. 3 (2001) 221-227
65. Blower M.D., Nachury M., Heald R., and Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 121 (2005) 223-234
66. Ribbeck K., Groen A.C., Santarella R., Bohnsack M.T., Raemaekers T., Kocher T., Gentzel M., Gorlich D., Wilm M., Carmeliet G., Mitchison T.J., Ellenberg J., Hoenger A., and Mattaj I.W. NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol. Biol. Cell 17 (2006) 2646-2660
67. Gruss O.J., Carazo-Salas R.E., Schatz C.A., Guarguaglini G., Kast J., Wilm M., Le Bot N., Vernos I., Karsenti E., and Mattaj I.W. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell 104 (2001) 83-93
68. Koffa M.D., Casanova C.M., Santarella R., Kocher T., Wilm M., and Mattaj I.W. HURP is part of a Ran-dependent complex involved in spindle formation. Curr. Biol. 16 (2006) 743-754
69. Satinover D.L., Brautigan D.L., and Stukenberg P.T. Aurora-A kinase and inhibitor-2 regulate the cyclin threshold for mitotic entry in Xenopus early embryonic cell cycles. Cell Cycle 5 (2006) 2268-2274
70. Macurek L., Lindqvist A., Lim D., Lampson M.A., Klompmaker R., Freire R., Clouin C., Taylor S.S., Yaffe M.B., and Medema R.H. Polo-like kinase-1 is activated by Aurora A to promote checkpoint recovery. Nature AOP, 9 July (2008) 10.1038/nature07185
71. Seki A., Coppinger J.A., Jang C.Y., Yates J.R., and Fang G. Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry. Science 320 (2008) 1655-1658
72. van Vugt M.A., Bras A., and Medema R.H. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol. Cell 15 (2004) 799-811
73. van Vugt M.A., Bras A., and Medema R.H. Restarting the cell cycle when the checkpoint comes to a halt. Cancer Res. 65 (2005) 7037-7040
74. Cazales M., Schmitt E., Montembault E., Dozier C., Prigent C., and Ducommun B. CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage. Cell Cycle 4 (2005) 1233-1238
75. Lindqvist A., Kallstrom H., Lundgren A., Barsoum E., and Rosenthal C.K. Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome. J. Cell Biol. 171 (2005) 35-45
76. Christensen S.T., Pedersen L.B., Schneider L., and Satir P. Sensory cilia and integration of signal transduction in human health and disease. Traffic 8 (2007) 97-109
77. Pugacheva E.N., and Golemis E.A. HEF1-Aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle 5 (2006) 384-391
78. Swedlow J.R., and Hirano T. The making of the mitotic chromosome: modern insights into classical questions. Mol. Cell 11 (2003) 557-569
79. Hirano T. At the heart of the chromosome: SMC proteins in action. Nat. Rev., Mol. Cell Biol. 7 (2006) 311-322
80. Giet R., and Glover D.M. Drosophila Aurora B kinase is required for histone H3 phosphorylation and Condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J. Cell Biol. 152 (2001) 669-682
81. Maddox P.S., Portier N., Desai A., and Oegema K. Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 15097-15102
82. Lipp J.J., Hirota T., Poser I., and Peters J.M. Aurora B controls the association of Condensin I but not Condensin II with mitotic chromosomes. J. Cell. Sci. 120 (2007) 1245-1255
83. Takemoto A., Murayama A., Katano M., Urano T., Furukawa K., Yokoyama S., Yanagisawa J., Hanaoka F., and Kimura K. Analysis of the role of Aurora B on the chromosomal targeting of Condensin I. Nucleic Acids Res. 35 (2007) 2403-2412
84. Losada A., Hirano M., and Hirano T. Cohesin release is required for sister chromatid resolution, but not for Condensin-mediated compaction, at the onset of mitosis. Genes Dev. 16 (2002) 3004-3016
85. Morishita J., Matsusaka T., Goshima G., Nakamura T., Tatebe H., and Yanagida M. Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair. Genes Cells 6 (2001) 743-763
86. Ono T., Fang Y., Spector D.L., and Hirano T. Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Mol. Biol. Cell 15 (2004) 3296-3308
87. Adams R.R., Maiato H., Earnshaw W.C., and Carmena M. Essential roles of Drosophila inner centromere protein (INCENP) and Aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J. Cell Biol. 153 (2001) 865-880
88. Hsu J.Y., Sun Z.W., Li X., Reuben M., Tatchell K., Bishop D.K., Grushcow J.M., Brame C.J., Caldwell J.A., Hunt D.F., Lin R., Smith M.M., and Allis C.D. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102 (2000) 279-291
89. Wei Y., Mizzen C.A., Cook R.G., Gorovsky M.A., and Allis C.D. Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 7480-7484
90. Mellone B.G., Ball L., Suka N., Grunstein M.R., Partridge J.F., and Allshire R.C. Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3. Curr. Biol. 13 (2003) 1748-1757
91. Hirota T., Lipp J.J., Toh B.H., and Peters J.M. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 438 (2005) 1176-1180
92. Fischle W., Tseng B.S., Dormann H.L., Ueberheide B.M., Garcia B.A., Shabanowitz J., Hunt D.F., Funabiki H., and Allis C.D. Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 438 (2005) 1116-1122
93. Nasmyth K., and Haering C.H. The structure and function of SMC and kleisin complexes. Annu. Rev. Biochem. 74 (2005) 595-648
94. Nasmyth K., Peters J.M., and Uhlmann F. Splitting the chromosome: cutting the ties that bind sister chromatids. Novartis Found Symp. 237 (2001) 113-133 discussion 133-118, 158-163
95. Waizenegger I.C., Hauf S., Meinke A., and Peters J.M. Two distinct pathways remove mammalian Cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell 103 (2000) 399-410
96. Sumara I., Vorlaufer E., Stukenberg P.T., Kelm O., Redemann N., Nigg E.A., and Peters J.M. The dissociation of Cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol. Cell 9 (2002) 515-525
97. Gimenez-Abian J.F., Sumara I., Hirota T., Hauf S., Gerlich D., de la Torre C., Ellenberg J., and Peters J.M. Regulation of sister chromatid cohesion between chromosome arms. Curr. Biol. 14 (2004) 1187-1193
98. Kerrebrock A.W., Moore D.P., Wu J.S., and Orr-Weaver T.L. Mei-S332, a Drosophila protein required for sister-chromatid Cohesion, can localize to meiotic centromere regions. Cell 83 (1995) 247-256
99. Kitajima T.S., Kawashima S.A., and Watanabe Y. The conserved kinetochore protein Shugoshin protects centromeric cohesion during meiosis. Nature 427 (2004) 510-517
100. Riedel C.G., Katis V.L., Katou Y., Mori S., Itoh T., Helmhart W., Galova M., Petronczki M., Gregan J., Cetin B., Mudrak I., Ogris E., Mechtler K., Pelletier L., Buchholz F., Shirahige K., and Nasmyth K. Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature 441 (2006) 53-61
101. Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., and Watanabe Y. Shugoshin collaborates with protein phosphatase 2A to protect Cohesin. Nature 441 (2006) 46-52
102. Hauf S., Roitinger E., Koch B., Dittrich C.M., Mechtler K., and Peters J.M. Dissociation of Cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol. 3 (2005) e69
103. Tang Z., Shu H., Qi W., Mahmood N.A., Mumby M.C., and Yu H. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev. Cell 10 (2006) 575-585
104. Salic A., Waters J.C., and Mitchison T.J. Vertebrate Shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell 118 (2004) 567-578
105. McGuinness B.E., Hirota T., Kudo N.R., Peters J.M., and Nasmyth K. Shugoshin prevents dissociation of Cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol. 3 (2005) e86
106. Dai J., Sullivan B.A., and Higgins J.M. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. Dev. Cell 11 (2006) 741-750
107. Resnick T.D., Satinover D.L., MacIsaac F., Stukenberg P.T., Earnshaw W.C., Orr-Weaver T.L., and Carmena M. INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev. Cell 11 (2006) 57-68
108. Nonaka N., Kitajima T., Yokobayashi S., Xiao G., Yamamoto M., Grewal S.I., and Watanabe Y. Recruitment of Cohesin to heterochromatic regions by Swi6/HP1 in fission yeast. Nat. Cell Biol. 4 (2002) 89-93
109. Bernard P., Maure J.F., Partridge J.F., Genier S., Javerzat J.P., and Allshire R.C. Requirement of heterochromatin for cohesion at centromeres. Science 294 (2001) 2539-2542
110. Sampath S.C., Ohi R., Leismann O., Salic A., Pozniakovski A., and Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118 (2004) 187-202
111. Zhang X., Lan W., Ems-McClung S.C., Stukenberg P.T., and Walczak C.E. Aurora B phosphorylates multiple sites on MCAK to spatially and temporally regulate its function. Mol. Biol. Cell (2008) 3264-3276
112. Tulu U.S., Fagerstrom C., Ferenz N.P., and Wadsworth P. Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr. Biol. 16 (2006) 536-541
113. Gadea B.B., and Ruderman J.V. Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4493-4498
114. Cleveland D.W., Mao Y., and Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112 (2003) 407-421
115. Kline-Smith S.L., Sandall S., and Desai A. Kinetochore-spindle microtubule interactions during mitosis. Curr. Opin. Cell Biol. 17 (2005) 35-46
116. Maiato H., DeLuca J., Salmon E.D., and Earnshaw W.C. The dynamic kinetochore-microtubule interface. J. Cell. Sci. 117 (2004) 5461-5477
117. Roos U.P. Light and electron microscopy of rat kangaroo cells in mitosis. III. Patterns of chromosome behavior during prometaphase. Chromosoma 54 (1976) 363-385
118. Tanaka T.U., Rachidi N., Janke C., Pereira G., Galova M., Schiebel E., Stark M.J., and Nasmyth K. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108 (2002) 317-329
119. Tanaka T.U. Chromosome bi-orientation on the mitotic spindle. Philos. Trans. R. Soc. Lond. B, Biol. Sci. 360 (2005) 581-589
120. Cheeseman I.M., Anderson S., Jwa M., Green E.M., Kang J., Yates III J.R., Chan C.S., Drubin D.G., and Barnes G. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111 (2002) 163-172
121. Lampson M.A., Renduchitala K., Khodjakov A., and Kapoor T.M. Correcting improper chromosome-spindle attachments during cell division. Nat. Cell Biol. 6 (2004) 232-237
122. Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K., Wordeman L., and Swedlow J.R. Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6 (2004) 253-268
123. Lan W., Zhang X., Kline-Smith S.L., Rosasco S.E., Barrett-Wilt G.A., Shabanowitz J., Hunt D.F., Walczak C.E., and Stukenberg P.T. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr. Biol. 14 (2004) 273-286
124. Ohi R., Sapra T., Howard J., and Mitchison T.J. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol. Biol. Cell 15 (2004) 2895-2906
125. Cheeseman I.M., Chappie J.S., Wilson-Kubalek E.M., and Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127 (2006) 983-997
126. DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., and Salmon E.D. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127 (2006) 969-982
127. Cimini D., Howell B., Maddox P., Khodjakov A., Degrassi F., and Salmon E.D. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153 (2001) 517-527
128. Cimini D., Moree B., Canman J.C., and Salmon E.D. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J. Cell. Sci. 116 (2003) 4213-4225
129. Salmon E.D., Cimini D., Cameron L.A., and DeLuca J.G. Merotelic kinetochores in mammalian tissue cells. Philos. Trans. R. Soc. Lond., B Biol. Sci. 360 (2005) 553-568
130. Cimini D., Wan X., Hirel C.B., and Salmon E.D. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr. Biol. 16 (2006) 1711-1718
131. Knowlton A.L., Lan W., and Stukenberg P.T. Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr. Biol. 16 (2006) 1705-1710
132. Ohi R., Coughlin M.L., Lane W.S., and Mitchison T.J. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev. Cell 5 (2003) 309-321
133. Huang H., Feng J., Famulski J., Rattner J.B., Liu S.T., Kao G.D., Muschel R., Chan G.K., and Yen T.J. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J. Cell Biol. 177 (2007) 413-424
134. Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat. Rev., Mol. Cell Biol. 8 (2007) 379-393
135. Rieder C.L., Schultz A., Cole R., and Sluder G. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127 (1994) 1301-1310
136. Rieder C.L., Cole R.W., Khodjakov A., and Sluder G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 130 (1995) 941-948
137. Li R., and Murray A.W. Feedback control of mitosis in budding yeast. Cell 66 (1991) 519-531
138. Hoyt M.A., Totis L., and Roberts B.T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66 (1991) 507-517
139. Weiss E., and Winey M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132 (1996) 111-123
140. Sudakin V., Ganoth D., Dahan A., Heller H., Hershko J., Luca F.C., Ruderman J.V., and Hershko A. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6 (1995) 185-197
141. King R.W., Peters J.M., Tugendreich S., Rolfe M., Hieter P., and Kirschner M.W. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81 (1995) 279-288
142. Irniger S., Piatti S., Michaelis C., and Nasmyth K. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81 (1995) 269-278
143. Irniger S., and Nasmyth K. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. J. Cell. Sci. 110 Pt 13 (1997) 1523-1531
144. Ciosk R., Zachariae W., Michaelis C., Shevchenko A., Mann M., and Nasmyth K. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93 (1998) 1067-1076
145. Shirayama M., Toth A., Galova M., and Nasmyth K. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402 (1999) 203-207
146. Visintin R., Prinz S., and Amon A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278 (1997) 460-463
147. Peters J.M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev., Mol. Cell Biol. 7 (2006) 644-656
148. Sudakin V., Chan G.K., and Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154 (2001) 925-936
149. Shannon K.B., Canman J.C., and Salmon E.D. Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension. Mol. Biol. Cell 13 (2002) 3706-3719
150. Skoufias D.A., Andreassen P.R., Lacroix F.B., Wilson L., and Margolis R.L. Mammalian Mad2 and Bub1/BubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 4492-4497
151. Waters J.C., Chen R.H., Murray A.W., and Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell. Biol. 141 (1998) 1181-1191
152. Li X., and Nicklas R.B. Mitotic forces control a cell-cycle checkpoint. Nature 373 (1995) 630-632
153. Nicklas R.B. How cells get the right chromosomes. Science 275 (1997) 632-637
154. Pinsky B.A., and Biggins S. The spindle checkpoint: tension versus attachment. Trends Cell Biol. 15 (2005) 486-493
155. Biggins S., and Murray A.W. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 15 (2001) 3118-3129
156. Ditchfield C., Johnson V.L., Tighe A., Ellston R., Haworth C., Johnson T., Mortlock A., Keen N., and Taylor S.S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161 (2003) 267-280
157. Hauf S., Cole R.W., LaTerra S., Zimmer C., Schnapp G., Walter R., Heckel A., van Meel J., Rieder C.L., and Peters J.M. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161 (2003) 281-294
158. Lens S.M., Wolthuis R.M., Klompmaker R., Kauw J., Agami R., Brummelkamp T., Kops G., and Medema R.H. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. Embo J. 22 (2003) 2934-2947
159. Carvalho A., Carmena M., Sambade C., Earnshaw W.C., and Wheatley S.P. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J. Cell. Sci. 116 (2003) 2987-2998
160. Vader G., Cruijsen C.W., van Harn T., Vromans M.J., Medema R.H., and Lens S.M. The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions. Mol. Biol. Cell 18 (2007) 4553-4564
161. Pinsky B.A., Kung C., Shokat K.M., and Biggins S. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat. Cell Biol. 8 (2006) 78-83
162. Kallio M.J., McCleland M.L., Stukenberg P.T., and Gorbsky G.J. Inhibition of Aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr. Biol. 12 (2002) 900-905
163. Vigneron S., Prieto S., Bernis C., Labbe J.C., Castro A., and Lorca T. Kinetochore localization of spindle checkpoint proteins: who controls whom?. Mol. Biol. Cell 15 (2004) 4584-4596
164. Petersen J., and Hagan I.M. S. pombe aurora kinase/Survivin is required for chromosome condensation and the spindle checkpoint attachment response. Curr. Biol. 13 (2003) 590-597
165. King E.M., Rachidi N., Morrice N., Hardwick K.G., and Stark M.J. Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Genes Dev. 21 (2007) 1163-1168
166. Elowe S., Hummer S., Uldschmid A., Li X., and Nigg E.A. Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev. 21 (2007) 2205-2219
167. King J.M., and Nicklas R.B. Tension on chromosomes increases the number of kinetochore microtubules but only within limits. J. Cell. Sci. 113 Pt 21 (2000) 3815-3823
168. Terada Y., Tatsuka M., Suzuki F., Yasuda Y., Fujita S., and Otsu M. AIM-1: a mammalian midbody-associated protein required for cytokinesis. Embo J. 17 (1998) 667-676
169. Kaitna S., Pasierbek P., Jantsch M., Loidl J., and Glotzer M. The Aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous chromosomes during meiosis. Curr. Biol. 12 (2002) 798-812
170. Severson A.F., Hamill D.R., Carter J.C., Schumacher J., and Bowerman B. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Curr. Biol. 10 (2000) 1162-1171
171. Higuchi T., and Uhlmann F. Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature 433 (2005) 171-176
172. Buvelot S., Tatsutani S.Y., Vermaak D., and Biggins S. The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly. J. Cell Biol. 160 (2003) 329-339
173. Glotzer M. The molecular requirements for cytokinesis. Science 307 (2005) 1735-1739
174. Piekny A., Werner M., and Glotzer M. Cytokinesis: welcome to the Rho zone. Trends Cell Biol. 15 (2005) 651-658
175. Yuce O., Piekny A., and Glotzer M. An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170 (2005) 571-582
176. Nishimura Y., and Yonemura S. Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J. Cell. Sci. 119 (2006) 104-114
177. Zhao W.M., and Fang G. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13158-13163
178. Lehner C.F. The pebble gene is required for cytokinesis in Drosophila. J. Cell. Sci. 103 Pt 4 (1992) 1021-1030
179. Tatsumoto T., Xie X., Blumenthal R., Okamoto I., and Miki T. Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J. Cell Biol. 147 (1999) 921-928
180. Kaitna S., Mendoza M., Jantsch-Plunger V., and Glotzer M. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr. Biol. 10 (2000) 1172-1181
181. Guse A., Mishima M., and Glotzer M. Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis. Curr. Biol. 15 (2005) 778-786
182. Minoshima Y., Kawashima T., Hirose K., Tonozuka Y., Kawajiri A., Bao Y.C., Deng X., Tatsuka M., Narumiya S., May Jr. W.S., Nosaka T., Semba K., Inoue T., Satoh T., Inagaki M., and Kitamura T. Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell 4 (2003) 549-560
183. Goto H., Yasui Y., Kawajiri A., Nigg E.A., Terada Y., Tatsuka M., Nagata K., and Inagaki M. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J. Biol. Chem. 278 (2003) 8526-8530
184. Murata-Hori M., Fumoto K., Fukuta Y., Iwasaki T., Kikuchi A., Tatsuka M., and Hosoya H. Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora/Ipl1p-related kinase from rat. J. Biochem. (Tokyo) 128 (2000) 903-907
185. Kawajiri A., Yasui Y., Goto H., Tatsuka M., Takahashi M., Nagata K., and Inagaki M. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol. Biol. Cell 14 (2003) 1489-1500
186. Norden C., Mendoza M., Dobbelaere J., Kotwaliwale C.V., Biggins S., and Barral Y. The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage. Cell 125 (2006) 85-98
187. Bernard M., Sanseau P., Henry C., Couturier A., and Prigent C. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. Genomics 53 (1998) 406-409
188. Kimura M., Matsuda Y., Yoshioka T., and Okano Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. J. Biol. Chem. 274 (1999) 7334-7340
189. Tang C.J., Lin C.Y., and Tang T.K. Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Dev. Biol. 290 (2006) 398-410
190. Yan X., Cao L., Li Q., Wu Y., Zhang H., Saiyin H., Liu X., Zhang X., Shi Q., and Yu L. Aurora C is directly associated with Survivin and required for cytokinesis. Genes Cells 10 (2005) 617-626
191. Chen H.L., Tang C.J., Chen C.Y., and Tang T.K. Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. J. Biomed. Sci. 12 (2005) 297-310
192. Tseng T.C., Chen S.H., Hsu Y.P., and Tang T.K. Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 17 (1998) 823-833
193. Kimmins S., Crosio C., Kotaja N., Hirayama J., Monaco L., Hoog C., van Duin M., Gossen J.A., and Sassone-Corsi P. Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol. Endocrinol. 21 (2007) 726-739
194. Dieterich K., Soto Rifo R., Faure A.K., Hennebicq S., Ben Amar B., Zahi M., Perrin J., Martinez D., Sele B., Jouk P.S., Ohlmann T., Rousseaux S., Lunardi J., and Ray P.F. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Nat. Genet. 39 (2007) 661-665
195. Katayama H., Brinkley W.R., and Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 22 (2003) 451-464
196. Bischoff J.R., Anderson L., Zhu Y., Mossie K., Ng L., Souza B., Schryver B., Flanagan P., Clairvoyant F., Ginther C., Chan C.S., Novotny M., Slamon D.J., and Plowman G.D. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Embo J. 17 (1998) 3052-3065
197. Zhou H., Kuang J., Zhong L., Kuo W.L., Gray J.W., Sahin A., Brinkley B.R., and Sen S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20 (1998) 189-193
198. Meraldi P., Honda R., and Nigg E.A. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. Embo J. 21 (2002) 483-492
199. Anand S., Penrhyn-Lowe S., and Venkitaraman A.R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cells 3 (2003) 51-62
200. Tatsuka M., Sato S., Kitajima S., Suto S., Kawai H., Miyauchi M., Ogawa I., Maeda M., Ota T., and Takata T. Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis. Oncogene 24 (2005) 1122-1127
201. Ewart-Toland A., Briassouli P., de Koning J.P., Mao J.H., Yuan J., Chan F., MacCarthy-Morrogh L., Ponder B.A., Nagase H., Burn J., Ball S., Almeida M., Linardopoulos S., and Balmain A. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat. Genet. 34 (2003) 403-412
202. Mao J.H., Wu D., Perez-Losada J., Jiang T., Li Q., Neve R.M., Gray J.W., Cai W.W., and Balmain A. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cells 11 (2007) 161-173
203. Willis A.E. Translational control of growth factor and proto-oncogene expression. Int. J. Biochem. Cell Biol. 31 (1999) 73-86
204. Katayama H., Sasai K., Kawai H., Yuan Z.M., Bondaruk J., Suzuki F., Fujii S., Arlinghaus R.B., Czerniak B.A., and Sen S. Phosphorylation by Aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat. Genet. 36 (2004) 55-62
205. Liu Q., Kaneko S., Yang L., Feldman R.I., Nicosia S.V., Chen J., and Cheng J.Q. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J. Biol. Chem. 279 (2004) 52175-52182
206. Shao S., Wang Y., Jin S., Song Y., Wang X., Fan W., Zhao Z., Fu M., Tong T., Dong L., Fan F., Xu N., and Zhan Q. Gadd45a interacts with Aurora-A and inhibits its kinase activity. J. Biol. Chem. 281 (2006) 28943-28950
207. Eyers P.A., and Maller J.L. Regulation of Xenopus Aurora A activation by TPX2. J. Biol. Chem. 279 (2004) 9008-9015
208. Chen S.S., Chang P.C., Cheng Y.W., Tang F.M., and Lin Y.S. Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. Embo J. 21 (2002) 4491-4499
209. Lee C.Y., Andersen R.O., Cabernard C., Manning L., Tran K.D., Lanskey M.J., Bashirullah A., and Doe C.Q. Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 20 (2006) 3464-3474
210. Wang H., Somers G.W., Bashirullah A., Heberlein U., Yu F., and Chia W. Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 20 (2006) 3453-3463
211. Ota T., Suto S., Katayama H., Han Z.B., Suzuki F., Maeda M., Tanino M., Terada Y., and Tatsuka M. Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res. 62 (2002) 5168-5177
212. Kanda A., Kawai H., Suto S., Kitajima S., Sato S., Takata T., and Tatsuka M. Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation. Oncogene 24 (2005) 7266-7272
213. Taylor S., and Peters J.M. Polo and Aurora kinases: lessons derived from chemical biology. Curr. Opin. Cell Biol. 20 (2008) 77-84
214. Harrington E.A., Bebbington D., Moore J., Rasmussen R.K., Ajose-Adeogun A.O., Nakayama T., Graham J.A., Demur C., Hercend T., Diu-Hercend A., Su M., Golec J.M., and Miller K.M. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat. Med. 10 (2004) 262-267
215. Ganem N.J., and Pellman D. Limiting the proliferation of polyploid cells. Cell 131 (2007) 437-440
216. Manfredi M.G., Ecsedy J.A., Meetze K.A., Balani S.K., Burenkova O., Chen W., Galvin K.M., Hoar K.M., Huck J.J., LeRoy P.J., Ray E.T., Sells T.B., Stringer B., Stroud S.G., Vos T.J., Weatherhead G.S., Wysong D.R., Zhang M., Bolen J.B., and Claiborne C.F. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 4106-4111
217. Hoar K., Chakravarty A., Rabino C., Wysong D., Bowman D., Roy N., and Ecsedy J.A. MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol. Cell. Biol. 27 (2007) 4513-4525
218. Girdler F., Gascoigne K.E., Eyers P.A., Hartmuth S., Crafter C., Foote K.M., Keen N.J., and Taylor S.S. Validating Aurora B as an anti-cancer drug target. J. Cell. Sci. 119 (2006) 3664-3675
219. Girdler F., Sessa F., Patercoli S., Villa F., Musacchio A., and Taylor S. Molecular basis of drug resistance in aurora kinases. Chem. Biol. 15 (2008) 552-562