Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo

European Journal of Cancer

Volumn 48, Issue 15, 2012, Pages 2417-2430

  Arai, Ryuta ^a   Tsuda, Masumi ^a   Watanabe, Takuya ^a   Ose, Toyoyuki ^b   Obuse, Chikashi ^b   Maenaka, Katsumi ^b   Minami, Akio ^a   Ohba, Yusuke ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Aurora kinases; Src family kinase; SU6656; Synergy; Synovial sarcoma

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; AURORA A KINASE; AURORA B KINASE; AURORA C KINASE; HISTONE H3; PROTEIN P53; PROTEIN TYROSINE KINASE; TOZASERTIB; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CHEMOTAXIS; DRUG EFFICACY; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROGEN BOND; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNOVIAL SARCOMA; TUMOR CELL; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN-SERINE-THREONINE KINASES; SARCOMA, SYNOVIAL; SRC-FAMILY KINASES; SULFONAMIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84866730145     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.12.028     Document Type: Article

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