Human TPX2 is required for targeting Aurora-A kinase to the spindle

Journal of Cell Biology

Volumn 158, Issue 4, 2002, Pages 617-623

  Kufer, Thomas A ^a   Silljé, Herman H W ^a   Körner, Roman ^a   Gruss, Oliver J ^b   Meraldi, Patrick ^a   Nigg, Erich A ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Aurora A; Mitosis; siRNA; Spindle; TPX2

Indexed keywords

AURORA A KINASE; CELL PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TPX2; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SISTER CHROMATID;

CELL CYCLE PROTEINS; ENZYME ACTIVATION; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; RNA, UNTRANSLATED; SUBSTRATE SPECIFICITY; XENOPUS PROTEINS;

EID: 0037135979     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200204155     Document Type: Article

References (25)

1. The Aurora/Ip11p kinase family: Regulators of chromosome segregation and cytokinesis
2. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
3. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
4. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
5. Aurora/Ip11p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
6. The Xenopus laevis aurora/Ip11p-related kinase pEg2 participates in the srability of the bipolar mitoric spindle
7. The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XIEg5
8. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
9. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
10. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity
11. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans
12. p100: A novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M
13. The mitotic spindle: A self-made machine
14. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(-/-) cells
15. Mitotic kinases as regulators of cell division and its checkpoints
16. Probability-based protein identification by searching sequence databases using mass spectrometry data
17. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
18. A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos
19. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
20. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels
21. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
22. The spindle: A dynamic assembly of microtubules and motors
23. TPX2, a novel Xenopus MAP involved in spindle pole organization
24. Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
25. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation