HURP Is Part of a Ran-Dependent Complex Involved in Spindle Formation

Current Biology

Volumn 16, Issue 8, 2006, Pages 743-754

  Koffa, Maria D ^a   Casanova, Claudia M ^a   Santarella, Rachel ^a   Köcher, Thomas ^a   Wilm, Matthias ^a   Mattaj, Iain W ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

CELLBIO

Indexed keywords

AURORA KINASE; DLG7 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; RAN PROTEIN; TUMOR PROTEIN; XENOPUS PROTEIN; XMAP215 PROTEIN, XENOPUS;

ANIMAL; ARTICLE; CHROMOSOME SEGREGATION; HELA CELL; HUMAN; IMMUNOLOGY; METABOLISM; MICROTUBULE; MITOSIS SPINDLE; PHYSIOLOGY; XENOPUS;

ANIMALS; CHROMOSOME SEGREGATION; HELA CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOTIC SPINDLE APPARATUS; MULTIPROTEIN COMPLEXES; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RAN GTP-BINDING PROTEIN; XENOPUS; XENOPUS PROTEINS;

EID: 33646024346     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.03.056     Document Type: Article

References (36)

1. Carazo-Salas R.E., Guarguaglini G., Gruss O.J., Segref A., Karsenti E., and Mattaj I.W. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400 (1999) 178-181
2. Askjaer P., Galy V., Hannak E., and Mattaj I.W. Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol. Biol. Cell 13 (2002) 4355-4370
3. Bamba C., Bobinnec Y., Fukuda M., and Nishida E. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr. Biol. 12 (2002) 503-507
4. Kalab P., Pu R.T., and Dasso M. The ran GTPase regulates mitotic spindle assembly. Curr. Biol. 9 (1999) 481-484
5. Zhang C., Hughes M., and Clarke P.R. Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. J. Cell Sci. 112 (1999) 2453-2461
6. Wilde A., and Zheng Y. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science 284 (1999) 1359-1362
7. Ohba T., Nakamura M., Nishitani H., and Nishimoto T. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science 284 (1999) 1356-1358
8. Gruss O.J., Carazo-Salas R.E., Schatz C.A., Guarguaglini G., Kast J., Wilm M., Le Bot N., Vernos I., Karsenti E., and Mattaj I.W. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell 104 (2001) 83-93
9. Schatz C.A., Santarella R., Hoenger A., Karsenti E., Mattaj I.W., Gruss O.J., and Carazo-Salas R.E. Importin alpha-regulated nucleation of microtubules by TPX2. EMBO J. 22 (2003) 2060-2070
10. Gruss O.J., Wittmann M., Yokoyama H., Pepperkok R., Kufer T., Sillje H., Karsenti E., Mattaj I.W., and Vernos I. Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nat. Cell Biol. 4 (2002) 871-879
11. Nachury M.V., Maresca T.J., Salmon W.C., Waterman-Storer C.M., Heald R., and Weis K. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104 (2001) 95-106
12. Blower M.D., Nachury M., Heald R., and Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 121 (2005) 223-234
13. Enos A.P., and Morris N.R. Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans. Cell 60 (1990) 1019-1027
14. Hagan I., and Yanagida M. Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature 356 (1992) 74-76
15. Sawin K.E., LeGuellec K., Philippe M., and Mitchison T.J. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature 359 (1992) 540-543
16. Kashina A.S., Baskin R.J., Cole D.G., Wedaman K.P., Saxton W.M., and Scholey J.M. A bipolar kinesin. Nature 379 (1996) 270-272
17. Kapitein L.C., Peterman E.J., Kwok B.H., Kim J.H., Kapoor T.M., and Schmidt C.F. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435 (2005) 114-118
18. Miyamoto D.T., Perlman Z.E., Burbank K.S., Groen A.C., and Mitchison T.J. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J. Cell Biol. 167 (2004) 813-818
19. Wilde A., Lizarraga S.B., Zhang L., Wiese C., Gliksman N.R., Walczak C.E., and Zheng Y. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat. Cell Biol. 3 (2001) 221-227
20. Tsou A.P., Yang C.W., Huang C.Y., Yu R.C., Lee Y.C., Chang C.W., Chen B.R., Chung Y.F., Fann M.J., Chi C.W., et al. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene 22 (2003) 298-307
21. Carmena M., and Earnshaw W.C. The cellular geography of aurora kinases. Nat. Rev. Mol. Cell Biol. 4 (2003) 842-854
22. Bayliss R., Sardon T., Vernos I., and Conti E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12 (2003) 851-862
23. Eyers P.A., Erikson E., Chen L.G., and Maller J.L. A novel mechanism for activation of the protein kinase Aurora A. Curr. Biol. 13 (2003) 691-697
24. Tsai M.Y., Wiese C., Cao K., Martin O., Donovan P., Ruderman J., Prigent C., and Zheng Y. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat. Cell Biol. 5 (2003) 242-248
25. Popov A.V., and Karsenti E. Stu2p and XMAP215: turncoat microtubule-associated proteins?. Trends Cell Biol. 13 (2003) 547-550
26. Popov A.V., Severin F., and Karsenti E. XMAP215 is required for the microtubule-nucleating activity of centrosomes. Curr. Biol. 12 (2002) 1326-1330
27. Kinoshita K., Habermann B., and Hyman A.A. XMAP215: a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol. 12 (2002) 267-273
28. Bischoff F.R., Klebe C., Kretschmer J., Wittinghofer A., and Ponstingl H. RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc. Natl. Acad. Sci. USA 91 (1994) 2587-2591
29. Bischoff J.R., Anderson L., Zhu Y., Mossie K., Ng L., Souza B., Schryver B., Flanagan P., Clairvoyant F., Ginther C., et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17 (1998) 3052-3065
30. Meraldi P., and Nigg E.A. Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J. Cell Sci. 114 (2001) 3749-3757
31. Hsu J.M., Lee Y.C., Yu C.T., and Huang C.Y. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J. Biol. Chem. 279 (2004) 32592-32602
32. Kunitoku N., Sasayama T., Marumoto T., Zhang D., Honda S., Kobayashi O., Hatakeyama K., Ushio Y., Saya H., and Hirota T. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev. Cell 5 (2003) 853-864
33. Yu C.T., Hsu J.M., Lee Y.C., Tsou A.P., Chou C.K., and Huang C.Y. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell. Biol. 25 (2005) 5789-5800
34. Nedelec F. Computer simulations reveal motor properties generating stable antiparallel microtubule interactions. J. Cell Biol. 158 (2002) 1005-1015
35. Mitchison T.J. Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360 (2005) 623-629
36. Anand S., Penrhyn-Lowe S., and Venkitaraman A.R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3 (2003) 51-62