Aurora-A: The maker and breaker of spindle poles

Journal of Cell Science

Volumn 120, Issue 17, 2007, Pages 2987-2996

  Barr, Alexis R ^a   Gergely, Fanni ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Centrosome; Mitosis; Spindle

Indexed keywords

AURORA A KINASE;

BINDING AFFINITY; CELL DIVISION; CELL FATE; CENTROSOME; DNA REPLICATION; ENZYME ACTIVITY; HUMAN; MICROTUBULE ASSEMBLY; MITOSIS; MOLECULAR BIOLOGY; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN PROCESSING; PROTEIN TARGETING; SPINDLE POLE BODY;

ANIMALS; CELL CYCLE PROTEINS; CENTROSOME; HUMANS; MITOSIS; MITOTIC SPINDLE APPARATUS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES;

EID: 34948901399     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.013136     Document Type: Note

References (121)

1. Abe, Y., Ohsugi, M., Haraguchi, K., Fujimoto, J. and Yamamoto, T. (2006). LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett. 580, 782-788.
2. Anand, S., Penrhyn-Lowe, S. and Venkitaraman, A. R. (2003). AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3, 51-62.
3. Andrews, P. D., Knatko, E., Moore, W. J. and Swedlow, J. R. (2003). Mitotic mechanics: the auroras come into view. Curr. Opin. Cell Biol. 15, 672-683.
4. Azimzadeh, J. and Bornens, M. (2007). Structure and duplication of the centrosome. J. Cell Sci. 120, 2139-2142.
5. Barros, T. P., Kinoshita, K., Hyman, A. A. and Raff, J. W. (2005). Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J. Cell Biol. 170, 1039-1046.
6. Bayliss, R., Sardon, T., Vernos, I. and Conti, E. (2003). Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12, 851-862.
7. Bellanger, J. M. and Gonczy, P. (2003). TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos. Curr. Biol. 13, 1488-1498.
8. Berdnik, D. and Knoblich, J. A. (2002). Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr. Biol. 12, 640-647.
9. Bernard, M., Sanseau, P., Henry, C., Couturier, A. and Prigent, C. (1998). Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipll that maps on chromosome 19ql3.3-ter. Genomics 53, 406-409.
10. Bischoff, J. R., Anderson, L., Zhu, Y., Mossie, K., Ng, L., Souza, B., Schryver, B., Flanagan, P., Clairvoyant F., Ginther, C. et al. (1998). A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065.
11. Budde, P. P. and Heald, R. (2003). Centrosomes and kinetochores, who needs 'Em? The role of noncentromeric chromatin in spindle assembly. Curr. Top. Dev. Biol. 56, 85-113.
12. Cassimeris, L. and Morabito, J. (2004). TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15, 1580-1590.
13. Castro, A., Mandart, E., Lorca, T. and Galas, S. (2003). Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes. J. Biol. Chem. 278, 2236-2241.
14. Cazales, M., Schmitt, E., Montembault, E., Dozier, C., Prigent, C. and Ducommun, B. (2005). CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage. Cell Cycle 4, 1233-1238.
15. Cheeseman, I. M., Anderson, S., Jwa, M., Green, E. M., Kang, J., Yates, J. R., 3rd, Chan, C. S., Drubin, D. G. and Barnes, G. (2002). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipllp. Cell 111, 163-172.
16. Compton, D. A. (2000). Spindle assembly in animal cells. Annu. Rev. Biochem. 69, 95-114.
17. De Luca, M., Lavia, P. and Guarguaglini, G. (2006). A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle 5, 296-303.
18. De Souza, C. P., Ellem, K. A. and Gabrielli, B. G. (2000). Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. Exp. Cell Res. 257, 11-21.
19. Dutertre, S., Cazales, M., Quaranta, M., Froment, C., Trabut, V., Dozier, C., Mirey, G., Bouche, J. P., Theis-Febvre, N., Schmitt, E. et al. (2004). Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J. Cell Sci. 117, 2523-2531.
20. Ewart-Toland, A., Briassouli, P., de Koning, J. P., Mao, J. H., Yuan, J., Chan, F., MacCarthy-Morrogh, L., Ponder, B. A., Nagase, H., Burn, J. et al. (2003). Identification of Stk6/STKl5 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat. Genet. 34, 403412.
21. Eyers, P. A., Erikson, E., Chen, L. G. and Maller, J. L. (2003). A novel mechanism for activation of the protein kinase Aurora A. Curr. Biol. 13, 691-697.
22. Garrett, S., Auer, K., Compton, D. A. and Kapoor, T. M. (2002). hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Curr. Biol. 12, 2055-2059.
23. Gergely, F. (2002). Centrosomal TACCtics. BioEssays 24, 915-925.
24. Gergely, F., Kidd, D., Jeffers, K., Wakefield, J. G. and Raff, J. W. (2000). D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. EMBO J. 19, 241-252.
25. Gergely, F., Draviam, V. M. and Raff, J. W. (2003). The ch-TOG/ XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev. 17, 336-341.
26. Giet, R., Uzbekov, R., Cubizolles, F., Le Guellec, K. and Prigent, C. (1999). The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. J. Biol. Chem. 274, 15005-15013.
27. Giet, R., McLean, D., Descamps, S., Lee, M. J., Raff, J. W., Prigent, C. and Glover, D. M. (2002). Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell Biol. 156, 437-451.
28. Giet, R., Petretti, C. and Prigent, C. (2005). Aurora kinases, aneupioidy and cancer, a coincidence or a real link? Trends Cell Biol. 15, 241-250.
29. Girdler, R, Gascoigne, K. E., Eyers, P. A., Hartmuth, S., Crafter, C., Foote, K. M., Keen, N. J. and Taylor, S. S. (2006). Validating Aurora B as an anti-cancer drug target. J. Cell Sci. 119, 3664-3675.
30. Glover, D. M., Leibowitz, M. H., McLean, D. A. and Parry, H. (1995). Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81, 95-105.
31. Gruss, O. J., Carazo-Salas, R. E., Schatz, C. A., Guarguaglini, G., Kast, J., Wilm, M., Le Bot, N., Vernos, I., Karsenti, E. and Mattaj, I. W. (2001). Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell 104, 83-93.
32. Hachet, V., Canard, C. and Gonczy, P. (2007). Centrosomes promote timely mitotic entry in C. elegans embryos. Dev. Cell 12, 531-541.
33. Hannak, E., Kirkham, M., Hyman, A. A. and Oegema, K. (2001). Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J. Cell Biol. 155, 1109-1116.
34. Harborth, J., Elbashir, S. M., Bechert, K., Tuschl, T. and Weber, K. (2001). Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci. 114, 4557-4565.
35. Harel, A. and Forbes, D. J. (2004). Importin beta: conducting a much larger cellular symphony. Mol. Cell 16, 319-330.
36. Hirota, T., Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Nitta, M., Hatakeyama, K. and Saya, H. (2003). Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114, 585-598.
37. Honda, K., Mihara, H., Kato, Y., Yamaguchi, A., Tanaka, H., Yasuda, H., Furukawa, K. and Urano, T. (2000). Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 19, 2812-2819.
38. Huang, Y. S., Jung, M. Y., Sarkissian, M. and Richter, J. D. (2002). N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphofyladon and alpha CaMKII mRNA polyadenylation at synapses. EMBO J 21, 2139-2148.
39. Hutterer, A., Berdnik, D., Wirtz-Peitz, F., Zigman, M., Schleiffer, A. and Knoblich, J. A. (2006). Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev. Cell 11, 147-157.
40. Jackman, M., Lindon, C., Nigg, E. A. and Pines, J. (2003). Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5, 143-148.
41. Joseph, J. (2006). Ran at a glance. J. Cell Sci. 119, 3481-3484.
42. Kalab, P., Pralle, A., Isacoff, E. Y., Heald, R. and Weis, K. (2006). Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature 440, 697-701.
43. Kamath, R. S., Fraser, A. G., Dong, Y., Poulin, G., Durbin, R., Gotta, M., Kanapin, A., Le Bot, N., Moreno, S., Sohrmann, M. et al. (2003). Systematic functional analysis of the Caenorhabditis elegans genorne using RNAi. Nature 421, 231-237.
44. Kapitein, L. C., Peterman, E. J., Kwok, B. H., Kim, J. H., Kapoor, T. M. and Schmidt, C. F. (2005). The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435, 114-118.
45. Karsenti, E. and Vernos, I. (2001). The mitotic spindle: a self-made machine. Science 294, 543-547.
46. Katayama, H., Zhou H., Li, Q., Tatsuka M. and Sen, S. (2001). Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J. Biol. Chem. 276, 46219-46224.
47. Keen, N. and Taylor, S. (2004). Aurora-kinase inhibitors as anticancer agents. Nat. Rev. Cancer 4, 927-936.
48. Khodjakov, A. and Rieder, C. L. (1999). The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. J. Cell Biol. 146, 585-596.
49. Kimmins, S., Crosio, C., Kotaja, N., Hirayama, J., Monaco, L., Hoog, C., van Duin, M., Gossen, J. A. and Sassone-Corsi, P. (2007). Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol. Endocrinol. 21, 726-739.
50. Kimura, M., Kotani, S., Hattori, T., Sumi, N., Yoshioka, T., Todokoro, K. and Okano, Y. (1997). Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipll. J. Biol. Chem. 272, 13766-13771.
51. Kimura, M., Matsuda, Y., Yoshioka, T. and Okano, Y. (1999). Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipll-related protein kinase, AIK3. J. Biol. Chem. 274, 7334-7340.
52. Kinoshita, K., Arnal, I., Desai, A., Drechsel, D. N. and Hyman, A. A. (2001). Reconstitution of physiological microtubule dynamics using purified components. Science 294, 1340-1343.
53. Kinoshita, K., Noetzel, T. L., Pelletier, L., Mechtler, K., Drechsel, D. N., Schwager, A., Lee, M., Raff, J. W. and Hyman, A. A. (2005). Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. J. Cell Biol. 170, 1047-1055.
54. Koffa, M. D., Casanova, C. M., Santarella, R., Kocher, T., Wilm, M. and Mattaj, I. W. (2006). HURP is part of a Ran-dependent complex involved in spindle formation. Curr. Biol. 16, 743-754.
55. Kramer, A., Mailand, N., Lukas, C., Syljuasen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. and Lukas, J. (2004). Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk 1 kinase. Nat. Cell Biol. 6, 884-891.
56. Kufer, T. A., Sillje, H. H., Korner, R., Gruss, O. J., Meraldi, P. and Nigg, E. A. (2002). Human TPX2 is required for targeting Aurora-A kinase to the spindle. J. Cell Biol. 158, 617-623.
57. Lane, H. A. and Nigg, E. A. (1996). Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plkl) in the functional maturation of mitotic centrosomes. J. Cell Biol. 135, 1701-1713.
58. Le Bot, N., Tsai, M. C., Andrews, R. K. and Ahringer, J. (2003). TAC-1, a regulator of microtubule length in the C. elegans embryo. Curr. Biol. 13, 1499-1505.
59. Lee, C. Y., Andersen, R. O., Cabernard, C., Manning, L., Tran, K. D., Lanskey, M. J., Bashirullah, A. and Doe, C. Q. (2006). Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 20, 3464-3474.
60. Lee, M. J., Gergely, F., Jeffers, K., Peak-Chew, S. Y. and Ruff, J. W. (2001). Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour. Nat. Cell Biol. 3, 643-649.
61. Lenart, F., Petronczki, M., Steegmaier, M., Di Fiore, B., Lipp, J. J., Hoffmann, M., Rettig, W. J., Kraut, N. and Peters, J. M. (2007). The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr. Biol. 17, 304-315.
62. LeRoy, P. J., Hunter, J. J., Hoar, K. M., Burke, K. E., Shinde, V., Ruan, J., Bowman, D., Galvin, K. and Ecsedy, J. A. (2007). Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. Cancer Res. 67, 5362-5370.
63. Lindon, C. and Pines, J. (2004). Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells. J. Cell Biol. 164, 233-241.
64. Littlepage, L. E., Wu, H., Andresson, T., Deanehan, J. K., Amundadottir, L. T. and Ruderman, J. V. (2002). Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. Proc. Natl. Acad Sci. USA, 99, 15440-15445.
65. Ling Q. and Ruderman, J. V. (2006). Aurora A, mitotic entry, and spindle bipolarity. Proc. Natl. Acad Sci. USA 103, 5811-5816.
66. Manfredi, M. G., Ecsedy, J. A., Meetze, K. A., Balani, S. K, Burenkova, O., Chen, W., Galvin, K. M., Hoar, K. M., Huck, J. J., LeRoy, F. J. et al. (2007). Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc. Natl. Acad. Sci. USA 104, 4106-4111.
67. Manning, A. L. and Compton, D. A. (2007). Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells. Curr Biol. 17, 260-265.
68. Marumoto, T., Hirota, T., Morisaki, T., Kunitoku, N., Zhang, D., Ichikawa, Y., Sasayama, T., Kuninaka, S., Mimori, T., Tamaki, N. et al. (2002). Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells 7, 1173-1182.
69. Marumoto, T., Honda, S., Hara, T., Nitta, M., Hirota, T., Kohmura, E. and Saya, H. (2003). Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol. Chem. 278, 51786-51795.
70. Maton, G., Thibier, C., Castro, A., Lorca, T., Prigent, C. and Jessus, C. (2003). Cdc2-cyclin B triggers H3 kinase activation of Aurora-A in Xenopus oocytes. J. Biol. Chem. 278, 21439-21449.
71. Mayer, T. U., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L. and Mitchison, T. J. (1999). Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974.
72. Megraw, T. L., Li, K., Kao, L. R. and Kaufman, T. C. (1999). The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. Development 126, 2829-2839.
73. Mendez, R., Hake, L. E., Andresson, T., Littlepage, L. E., Ruderman, J. V. and Richter, J. D. (2000a). Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404, 302-307.
74. Mendez, R., Murthy, K. G., Ryan, K., Manley, J. L. and Richter, J. D. (2000b). Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol. Cell 6, 1253-1259.
75. Meraldi, F., Honda, R. and Nigg, E. A. (2002). Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J. 21, 483-492.
76. Mori, D., Yano, Y., Toyo-oka, K., Yoshida, N., Yamada, M., Muramatsu, M., Zhang, D., Saya H., Toyoshima, Y. Y., Kinoshita, K. et al. (2007). NDELI phosphorylation by Aurora-A kinase is essential for centrosonal maturation, separation, and TACC3 recruitment. Mol. Cell. Biol. 27, 352-367.
77. Motegi, F., Velarde, N. V., Piano, F. and Sugimoto, A. (2006). Two phases of astral microtubule activity during cytokinesis in C. elegans embryos. Dev. Cell 10, 509-520.
78. Nachury, M. V., Maresca, T. J., Salmon, W. C., Waterman-Storer, C. M., Heald, R. and Weis, K. (2001). Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104, 95-106.
79. Nigg, E. A. (2001). Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2, 21-32.
80. Nigg, E. A. (2007). Centrosome duplication: of rules and licenses. Trends Cell Biol. 17, 215-221.
81. O'Connell, C. B. and Khodjakov, A. L. (2007). Cooperative mechanisms of mitotic spindle formation. J. Cell Sci. 120, 1717-1722.
82. Peset, L, Seiler, J., Sardon, T., Bejarano, L. A., Rybina, S. and Vernos, I. (2005). Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis. J. Cell Biol. 170, 1057-1066.
83. Petretti, C., Savoian, M., Montembault, E., Glover, D. M., Prigent, C. and Giet, R. (2006). The PITSLRE/CDK1 I p58 protein kinase promotes centrosome maturation and bipolar spindle formation. EMBO Rep. 7, 418-424.
84. Piehl, M., Tulu, U. S., Wadsworth, P. and Cassimeris, L. (2004). Centrosome maturation: measurement of microtubule nucleation throughout the cell cycle by using GFP-tagged EB1. Proc. Natl. Acad. Sci. USA 101, 1584-1588.
85. Pines, J. and Rieder, C. L. (2001). Re-staging mitosis: a contemporary view of mitotic progression. Nat. Cell Biol. 3, E3-E6.
86. Portier, N., Audhya, A., Maddox, P. S., Green, R. A., Dammermann, A., Desai, A. and Oegema, K. (2007). A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev. Cell 12, 515-529.
87. Pratt, S. J,. Epple, H., Ward, M., Feng, Y., Braga, V. M. and Longmore, G. D. (2005). The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168, 813-824.
88. Pugacheva, E. N. and Golemis, E. A. (2005). The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat. Cell Biol. 7, 937-946.
89. Rattner, J. B. and Berns, M. W. (1976). Distribution of microtubules during centriole separation in rat kangaroo (Potorous) cells. Cytobios 15, 37-43.
90. Rieder, C. L. and Alexander, S. P. (1990). Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J. Cell Biol. 110, 81-95.
91. Roghi, C., Giet R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Couturier, A., Doree, M., Philippe, M. and Prigent, C. (1998). The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle mirotubules and is involved in bipolar mitotic spindle assembly. J. Cell Sci. 111, 557-572.
92. Rosenblatt, J., Cramer, L. P., Baum, B. and McGee, K. M. (2004). Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly. Cell 117, 361-372.
93. Sarkissian, M., Mendez, R. and Richter, J. D. (2004). Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Genes Dev. 18, 48-61.
94. Sauer, G., Korner, R., Hanisch, A., Ries, A., Nigg, E. A. and Sillje, H. H. (2005). Proteome analysis of the human mitotic spindle. Mol. Cell. Proteomics 4, 35-43.
95. Schumacher, J. M., Ashcroft, N., Donovan, P. J. and Golden, A. (1998). A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos. Development 125, 4391-4402.
96. Sen, S., Zhou, H. and White, R. A. (1997). A putative serine/ threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14, 2195-2200.
97. Sillje, H. H., Nagel, S., Korner, R. and Nigg, E. A. (2006). HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr. Biol. 16, 731-742.
98. Sonnichsen, B., Koski, L. B., Walsh, A., Marschall, P., Neumann, B., Brehm, M., Alleaume, A. M., Artelt, J., Bettencourt, P., Cassin, E. et al. (2005). Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434, 462-469.
99. Srayko, M., Quintin, S., Schwager, A. and Hyman, A. A. (2003). Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules. Curr. Biol. 13, 1506-1511.
100. Srayko, M., Kaya, A., Stamford, J. and Hyman, A. A. (2005). Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo. Dev. Cell 9, 223-236.
101. Stebbins-Boaz, B., Cao, Q., de Moor, C. H., Mendez, R. and Richter, J. D. (1999). Maskin is a CPEB-associated factor that transiently interacts with e1F-4E. Mol. Cell 4, 1017-1027.
102. Stenoien, D. L., Sen, S., Mancini, M. A. and Brinkley, B. R. (2003). Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil. Cytoskeleton 55, 144-146
103. Sunkel, C. E. and Glover, D. M. (1988). polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell Sci. 89, 25-38.
104. Taguchi, S., Honda, K., Sugiura, K., Yamaguchi, A., Furukawa, K. and Urano, T. (2002). Degradation of human Aurora-A protein kinase is mediated by hCdh1. FEBS Lett. 519, 59-65.
105. Tang, C. J., Lin, C. Y. and Tang, T. K. (2006). Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Dev. Biol. 290, 398-410.
106. Tay, J., Hodgman, R. and Richter, J. D. (2000). The control of cyclin B1 mRNA translation during mouse oocyte maturation. Dev. Biol. 221, 1-9.
107. Terada, Y., Uetake, Y. and Kuriyama, R. (2003). Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. J. Cell Biol. 162, 757-763.
108. Toji, S., Yabuta, N., Hosomi, T., Nishihara, S., Kobayashi, T., Suzuki, S., Tamai, K. and Nojima, H. (2004). The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells 9, 383-397.
109. Tsai, M. Y. and Zheng, Y. (2005). Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGT?-induced spindle assembly. Curr. Biol. 15, 2156-2163.
110. Tseng, T. C., Chen, S. H., Hsu, Y. P. and Tang, T. K. (1998). Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 17, 823-833.
111. Vagnarelli, P. and Earnshaw, W. C. (2004). Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma 113, 211-222.
112. Walczak, C. E., Vernos, I., Mitchison, T. J., Karsenti, E. and Heald, R. (1998). A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr. Biol. 8, 903-913.
113. Walter, A. O., Seghezzi, W., Korver, W., Sheung, J. and Lees, E. (2000). The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 19, 4906-4916.
114. Wang, H., Somers, G. W., Bashirullah, A., Heberlein, U., Yu, F. and Chia, W. (2006). Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 20, 3453-3463.
115. Waters, J. C., Cole, R. W. and Rieder, C. L. (1993). The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster. J. Cell Biol. 122, 361-372.
116. Whitehead, C. M., Winkfein, R. J. and Rattner, J. B. (1996). The relationship of HsEg5 and the actin cytoskeleton to centrosome separation. Cell Motil. Cytoskeleton 35, 298-308.
117. Wiese, C., Wilde, A., Moore, M. S., Adam, S. A., Merdes, A. and Zheng, Y. (2001). Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science 291, 653-656.
118. Wittmann, T., Wilm, M., Karsenti, E. and Vernos, I. (2000). TPX2, A novel xenopus MAP involved in spindle pole organization. J. Cell Biol. 149, 1405-1418.
119. Zhang, D., Hirota, T., Marumoto, T., Shimizu, M., Kunitoku, N., Sasayama, T., Arima, Y., Feng, L., Suzuki, M., Takeya, M. et al. (2004). Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 23, 8720-8730.
120. Zhao, Z. S., Lim, J. F., Ng, Y. W., Lim, L. and Manser, E. (2005). The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol. Cell 20, 237-249.
121. Zhou, H., Kuang, J., Zhong, L., Kuo, W. L., Gray, J. W., Sahin, A., Brinkley, B. R. and Sen, S. (1998). Tumour amplified kinase STK15/ BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189-193.