Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora a kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 10, 2007, Pages 4106-4111

  Manfredi, Mark G ^a   Ecsedy, Jeffrey A ^a   Meetze, Kristan A ^a   Balani, Suresh K ^a   Burenkova, Olga ^a   Chen, Wei ^a   Galvin, Katherine M ^a   Hoar, Kara M ^a   Huck, Jessica J ^a   LeRoy, Patrick J ^a   Ray, Emily T ^a   Sells, Todd B ^a   Stringer, Bradley ^a   Stroud, Stephen G ^a   Vos, Tricia J ^a   Weatherhead, Gabriel S ^a   Wysong, Deborah R ^a   Zhang, Mengkun ^a   Bolen, Joseph B ^a   Claiborne, Christopher F ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Apoptosis; Cancer; Mitosis

Indexed keywords

4 [[9 CHLORO 7 (2,6 DIFLUOROPHENYL) 5H PYRIMIDO[5,4 D][2]BENZAZEPIN 2 YL]AMINO]BENZOIC ACID; ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA KINASE INHIBITOR; BENZOIC ACID DERIVATIVE; MLN 8054; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; AURORA KINASE; BENZAZEPINE DERIVATIVE; ENZYME INHIBITOR; MLN8054; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SOLID TUMOR; TUMOR CELL LINE; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; DISEASE COURSE; DRUG ANTAGONISM; NUDE MOUSE; ORAL DRUG ADMINISTRATION;

MUS MUSCULUS;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BENZAZEPINES; CELL LINE, TUMOR; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 34247259822     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608798104     Document Type: Article

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