Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

Nature Genetics

Volumn 34, Issue 4, 2003, Pages 403-412

  Ewart Toland, Amanda ^a   Briassouli, Paraskevi ^b   De Koning, John P ^a,g   Mao, Jian Hua ^a   Yuan, Jinwei ^a   Chan, Florence ^b   MacCarthy Morrogh, Lucy ^b   Ponder, Bruce A J ^c   Nagase, Hiroki ^d   Burn, John ^e   Ball, Sarah ^e,h   Almeida, Maria ^e   Linardopoulos, Spiros ^b   Balmain, Allan ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^h UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

UBE2N ENZYME; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANEUPLOIDY; ANIMAL CELL; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENICITY; CENTROSOME; COLON TUMOR; GENE; GENE AMPLIFICATION; GENE IDENTIFICATION; GENE MAPPING; GENE OVEREXPRESSION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN CELL; LINKAGE ANALYSIS; MITOSIS; MOUSE; NONHUMAN; PENETRANCE; PRIORITY JOURNAL; RAT; STK15 GENE; STK6 GENE; TUMOR SUSCEPTIBILITY GENE; TWO HYBRID SYSTEM;

ANEUPLOIDY; ANIMALS; CELL DIVISION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 20; CROSSES, GENETIC; GENE AMPLIFICATION; HAPLOTYPES; HUMANS; LIGASES; MICE; MICE, INBRED STRAINS; MURIDAE; ONCOGENES; PHYSICAL CHROMOSOME MAPPING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SKIN NEOPLASMS; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN-CONJUGATING ENZYMES; VARIATION (GENETICS);

ANIMALIA; MUS; MUS MUSCULUS; MUS SPRETUS; MUSCULUS;

EID: 0042093747     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1220     Document Type: Article

References (39)

1. Balmain, A., Ponder, B.A.J. & Gray, J. The genetics and genomics of cancer. Nat. Genet. 33, 238-244 (2003).
2. Ponder, B.A. Cancer genetics. Nature 411, 336-341 (2001).
3. Fijneman, R.J., de Vries, S.S., Jansen, R.C. & Demant, P. Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat. Genet. 14, 465-467 (1996).
4. Balmain, A. & Nagase, H. Cancer resistance genes in mice: models for the study of tumour modifiers. Trends Genet. 14, 139-144 (1998).
5. Dietrich, W.F. et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75, 631-639 (1993).
6. Nagase, H. et al. Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat. Genet. 10, 424-429 (1995).
7. Cormier, R.T. et al. The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene 19, 3182-3192 (2000).
8. Nagase, H., Mao, J.H. & Balmain, A. A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc. Natl. Acad. Sci. USA 96, 15032-15037 (1999).
9. Iwabuchi, H. et al. Genetic analysis of benign, low-grade, and high-grade ovarian tumors. Cancer Res. 55, 6172-6180 (1995).
10. Kallioniemi, A. et al. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl. Acad. Sci. USA 91, 2156-2160 (1994).
11. Korn, W.M. et al. Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Genes Chromosomes Cancer 25, 82-90 (1999).
12. Tanner, M.M. et al. Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin. Cancer Res. 6, 1833-1839 (2000).
13. Collins, C. et al. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma, Proc. Natl. Acad. Sci. USA 95, 8703-8708 (1998).
14. Albertson, D.G. et al Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat. Genet. 25, 144-146 (2000).
15. Bischoff, J.R. et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065 (1998).
16. Zhou, H. et al, Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189-193 (1998).
17. Sen, S., Zhou, H. & White, R.A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14, 2195-2200 (1997).
18. Cardon, L.R. & Bell, J.I. Association study designs for complex diseases. Nat. Rev. Genet. 2, 91-99 (2001).
19. Berry, R. et al. Evidence for a prostate cancer-susceptibility locus on chromosome 20. Am. J. Hum. Genet. 67, 82-91 (2000).
20. Dahlman, I. et al. Parameters for reliable results in genetic association studies in common disease. Nat. Genet. 30, 149-150 (2002).
21. Reich, D.E. et al. Linkage disequilibrium in the human genome. Nature 411, 199-204 (2001).
22. Bischoff, J.R. & Plowman, G.D. The Aurora/lpl1p kinase family regulators of chromosome segregation and cytokinesis. Trends Cell Biol. 9, 454-459 (1999).
23. Nigg, E.A. Centrosome aberrations: cause or consequence of cancer progression? Nat. Rev. Cancer 2, 815-825 (2002).
24. Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature 386, 623-627 (1997).
25. Giet, R. & Prigent, C. Aurora/lpl1p related kinases a new oncongenic family of mitotic serine threonine kinases. J. Cell Sci. 112, 3591-3601 (1999).
26. McKenna, S. et al. Noncovalent interaction between ubiquitin and the human DNA repair protein MMS2 is required for Ubc13-mediated polyubiquitination. J. Biol. Chem. 276, 40120-40126 (2001).
27. Antoch, M.P. et al. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89, 655-667 (1997).
28. Miyoshi, Y., Iwao, K., Egawa, C. & Noguchi, S. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int. J. Cancer 92, 370-373 (2001).
29. Romanov, S.R. et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409, 633-637 (2001).
30. Aldaz, C.M., Trono, D., Larcher, F., Slaga, T.J. & Conti, C.J. Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol. Carcinog. 2, 22-26 (1989).
31. Kemp, C.J., Fee, F. & Balmain, A. Allelotype analysis of mouse skin tumors using polymorphic microsatellites: sequential genetic alterations on chromosomes 6, 7, and 11. Cancer Res. 53, 6022-6027 (1993).
32. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425-479 (1998).
33. -/- cells. EMBO J. 21, 483-492 (2002).
34. Ruivenkamp, C.A. et al. Ptprj is a candidate for the mouse colon cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nat. Genet. 31, 295-300 (2002).
35. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).
36. Snijders, A.M. et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat. Genet. 29, 263-264 (2001).
37. Segraves, R., Albertson, D. & Pinkel, D. Comparative genomic hybridization using BAC genomic microarrays. in DNA Arrays: A Laboratory Manual (ed. Bowtell, D.A.S.J.) 380-385 (Cold Spring Harbor Laboratory Press, New York, 2002).
38. Pinkel, D.E.A. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat. Genet. 20, 207-211 (1998).
39. Jain, A.N. et al. Fully automatic quantification of microarray image data. Genome Res. 12, 325-332 (2002).