LIMK2 is a crucial regulator and effector of Aurora-Akinase-mediated malignancy

Journal of Cell Science

Volumn 125, Issue 5, 2012, Pages 1204-1216

  Johnson, Emmanuel O ^a   Chang, Kuei Hua ^a   Ghosh, Soumitra ^a   Venkatesh, Chelvam ^a   Giger, Katie ^a   Low, Philip S ^a   Shah, Kavita ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Aurora A kinase; Breast cancer; Chemical genetic; LIMK2; Prostate cancer

Indexed keywords

AURORA A KINASE; BRCA1 PROTEIN; LIM KINASE 2; PLECKSTRIN HOMOLOGY LIKE DOMAIN FAMILY A MEMBER 1; PROTEIN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CANCER CELL; CARCINOGENESIS; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CHEMOTAXIS; COLONY FORMATION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; FEMALE; HEK293 CELLS; HUMANS; LIM KINASES; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

MUS MUSCULUS;

EID: 84861389543     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.092304     Document Type: Article

References (38)

1. Carol, H., Boehm, I., Reynolds, C. P., Kang, M. H., Maris, J. M., Morton, C. L., Gorlick, R., Kolb, E. A., Keir, S. T., Wu, J. et al. (2011). Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. Cancer Chemother. Pharmacol. 5, 1291-1304.
2. Chang, K. H., Multani, P. S., Sun, K H., Vincent, F., de Pablo, Y., Ghosh, S., Gupta, R., Lee, H. P., Lee, H. G., Smith, M. A. and Shah, K. (2011). Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Mol. Biol. Cell 124, 2711-2722.
3. Cowley, D. O., Rivera-Perez, J. A., Schliekelman, M., He, Y. J., Oliver, T. G., Lu, L., O'Quinn, R., Salmon, E. D., Magnuson, T. and Van Dyke, T. (2009). Aurora-A kinase is essential for bipolar spindle formation and early development. Mol. Cell Biol. 29, 1059-1071.
4. Cox, D. G., Hankinson, S. E. and Hunter, D. J. (2006). Polymorphisms of the AURKA (STK15/Aurora Kinase) gene and breast cancer risk. Cancer Causes Control 17, 81-83.
5. Cronin, M., Sangli, C., Liu, M. L., Pho, M., Dutta, D., Nguyen, A., Jeong, J., Wu, J., Langone, K. C. and Watson, D. (2007). Analytical validation of the Oncotype DX genomic diagnostic test for recurrence prognosis and therapeutic response prediction in node-negative, estrogen receptor-positive breast cancer. Clin. Chem. 53, 1084-1091.
6. Dai, Q., Cai, Q. Y., Shu, X. O., Ewart-Toland, A., Wen, W. Q., Balmain, A., Gao, Y. T. and Zheng, W. (2004). Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 13, 2065-2070.
7. Ferrari, S., Marin, O., Pagano, M. A., Meggio, F., Hess, D., El-Shemerly, M., Krystyniak, A. and Pinna, L. A. (2005). Aurora-A site specificity: a study with synthetic peptide substrates. Biochem. J. 390, 293-302.
8. Goyal, P., Pandey, D. and Siess, W. (2006). Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. J. Biol. Chem. 281, 25223-25230.
9. Hirota, T., Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Nitta, M., Hatakeyama, K. and Saya, H. (2003). Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114, 585-598.
10. Honda, K., Mihara, H., Kato, Y., Yamaguchi, A., Tanaka, H., Yasuda, H, Furukawa, K. and Urano, T. (2000). Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 19, 2812-2819.
11. Jang, M. S., Sul, J. W., Choi, B. J., Lee, S. J., Suh, J. H., Kim, N. S., Kim, W. H., Lim, D. S., Lee, C. W. et al. (2008). Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1. Curr. Biol. 18, 1649-1658.
12. Johnson, E. J., Chang, K. H., de Pablo, Y., Ghosh, S., Mehta, R., Badve, S. and Shah, K. (2011). PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer. J. Cell Science 124, 2711-2722.
13. Katayama, H., Zhou, H., Li, Q., Tatsuka, M. and Sen, S. (2001). Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J. Biol. Chem. 276, 46219-4624.
14. Kim, S. and Shah, K. (2007). Dissecting yeast Hog1 MAP kinase pathway using a chemical genetic approach. FEBS Lett. 581, 1209-1216.
15. Lee, E. C., Frolov, A., Li, R., Ayala, G. and Greenberg, N. M. (2006). Targeting Aurora kinases for the treatment of prostate cancer. Cancer Res. 66, 4996-5002.
16. Mao, J. H., Wu, D., Perez-Losada, J., Jiang, T., Li, Q., Neve, R. M., Gray, J. W., Cai, W. W. and Balmain, A. (2007). Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell. 11, 161-173.
17. Miyoshi, Y., Iwao, K., Egawa, C. and Noguchi, S. (2001). Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int. J. Cancer 92, 370-373.
18. Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T. M., Luo, B., Grenier, J. K. et al. (2006). A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298.
19. Mountzios, G., Terpos, E. and Dimopoulos, M. A. (2008). Aurora kinases as targets for cancer therapy. Cancer Treat. Rev. 34, 175-182.
20. Nadler, Y., Camp, R. L., Schwartz, C., Rimm, D. L. and Kluger, H. M. (2008). Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer. Clin. Cancer Res. 14, 4455-4462.
21. Qu, Y., Zhang, L., Mao, M., Zhao, F., Huang, X., Yang, C., Xiong, Y. and Mu, D. (2008). Effects of DNAzymes targeting Aurora kinase A on the growth of human prostate cancer. Cancer Gene Ther. 15, 517-525.
22. Scott, R. W. and Olson, M. F. (2007) LIM kinases: function, regulation and association with human disease. J. Mol. Med. 85, 555-568.
23. Shah, K. and Shokat, K. M. (2002). A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem. Biol. 9, 35-47.
24. Shah, K. and Shokat, K. M. (2003). A chemical genetic approach for the identification of direct substrates of protein kinases. Methods Mol. Biol. 233, 253-271.
25. Shah, K. and Vincent, F. (2005). Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol. Biol. Cell 16, 5418-5432.
26. Shah, K., Liu, Y., Deirmengian, C. and Shokat, K. M. (1997). Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc. Natl. Acad. Sci. USA 94, 3565-3570.
27. Sumi, T., Matsumoto, K., Takai, Y. and Nakamura, T. (1999). Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J. Cell Biol. 147, 1519-1532.
28. Sumi, T., Matsumoto, K. and Nakamura, T. (2001a). Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J. Biol. Chem. 276, 670-676.
29. Sumi, T., Matsumoto, K., Shibuya, A. and Nakamura, T. (2001b) Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J. Biol. Chem. 276, 23092-23096.
30. Sun, K. H., de Pablo, Y., Vincent, F., Johnson, E. O., Chavers, A. K. and Shah, K. (2008a). Novel genetic tools reveal Cdk59s major role in Golgi fragmentation in Alzheimer's disease. Mol. Biol. Cell 19, 3052-3069.
31. Sun, K. H., de Pablo, Y., Vincent, F. and Shah, K. (2008b). Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction. J. Neurochem. 107, 265-278.
32. Sun, K. H., Lee, H. G., Smith, M. A. and Shah, K. (2009). Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease. Mol. Biol. Cell. 20, 4611-4619.
33. Suyama, E., Wadhwa, R., Kawasaki, H., Yaguchi, T., Kaul, S. C., Nakajima, M. and Taira, K. (2004). LIM kinase-2 targeting as a possible anti-metastasis therapy. J. Gene. Med. 6, 357-363.
34. Tanaka, T., Kimura, M., Matsunaga, K., Fukada, D., Mori, H. and Okano, Y. (1999). Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res. 59, 2041-2044.
35. Takahashi, H., Koshimizu, U., Miyazaki, J. and Nakamura, T. (2002). Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene. Dev. Biol. 241, 259-272.
36. Venoux, M., Basbous, J., Berthenet, C., Prigent, C., Fernandez, A., Lamb, N. J. and Rouquier, S. (2008). ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Hum. Mol. Genet. 17, 215-224.
37. Vlecken, D. H. and Bagowski, C. P. (2009). LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells. Zebrafish 6, 433-439.
38. Wang, X., Zhou, Y. X., Qiao, W., Tominaga, Y., Ouchi, M., Ouchi, T., Deng, C. X. (2006). Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 25, 7148-7158.