-
1
-
-
0035235736
-
Mitotic kinases as regulators of cell division and its checkpoints
-
Nigg, E. A. Mitotic kinases as regulators of cell division and its checkpoints. Nature Rev. Mol. Cell Biol. 2, 21-32 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol.
, vol.2
, pp. 21-32
-
-
Nigg, E.A.1
-
2
-
-
8744313990
-
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C
-
Li, X. et al. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. 279, 47201-47211 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47201-47211
-
-
Li, X.1
-
3
-
-
0033652421
-
Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1
-
Hu, H. M., Chuang, C. K., Lee, M. J., Tseng, T. C. & Tang, T. K. Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1. DNA Cell Biol. 19, 679-688 (2000).
-
(2000)
DNA Cell Biol.
, vol.19
, pp. 679-688
-
-
Hu, H.M.1
Chuang, C.K.2
Lee, M.J.3
Tseng, T.C.4
Tang, T.K.5
-
4
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff, J. R. et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052-3065 (1998). Demonstrates that Aurora A is overexpressed in more than 50% of primary colorectal cancers, and that overexpression of Aurora A transforms rodent fibroblasts.
-
(1998)
EMBO J.
, vol.17
, pp. 3052-3065
-
-
Bischoff, J.R.1
-
5
-
-
0031714080
-
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
-
Zhou, H. et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nature Genet. 20, 189-193 (1998).
-
(1998)
Nature Genet.
, vol.20
, pp. 189-193
-
-
Zhou, H.1
-
6
-
-
0034025874
-
Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer
-
Tanner, M. M. et al. Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin. Cancer Res. 6, 1833-1839 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1833-1839
-
-
Tanner, M.M.1
-
7
-
-
0036807853
-
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers
-
Watanabe, T. et al. Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers. Jpn J. Cancer Res. 93, 1114-1122 (2002).
-
(2002)
Jpn. J. Cancer Res.
, vol.93
, pp. 1114-1122
-
-
Watanabe, T.1
-
8
-
-
4444239881
-
The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer
-
Rojanala, S. et al. The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer. Mol. Cancer Ther. 3, 451-457 (2004).
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 451-457
-
-
Rojanala, S.1
-
9
-
-
0033135640
-
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast
-
Tanaka, T. et al. Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res. 59, 2041-2044 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 2041-2044
-
-
Tanaka, T.1
-
10
-
-
0033756439
-
Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers
-
Takahashi, T. et al. Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers. Jpn J. Cancer Res. 91, 1007-1014 (2000).
-
(2000)
Jpn. J. Cancer Res.
, vol.91
, pp. 1007-1014
-
-
Takahashi, T.1
-
11
-
-
0037386929
-
Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer
-
Gritsko, T. M. et al. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin. Cancer Res. 9, 1420-1426 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1420-1426
-
-
Gritsko, T.M.1
-
12
-
-
0037343237
-
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
-
Li, D. et al. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin. Cancer Res. 9, 991-997 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 991-997
-
-
Li, D.1
-
13
-
-
0033532869
-
Mitotic kinase expression and colorectal cancer progression
-
Katayama, H. et al. Mitotic kinase expression and colorectal cancer progression. J. Natl Cancer Inst. 91, 1160-1162 (1999).
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 1160-1162
-
-
Katayama, H.1
-
14
-
-
0032213515
-
Multinuclearity and increased ploidy caused by overexpression of the aurora- and IpI-like midbody-associated protein mitotic kinase in human cancer cells
-
Tatsuka, M. et al. Multinuclearity and increased ploidy caused by overexpression of the aurora- and IpI-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. 58, 4811-4816 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 4811-4816
-
-
Tatsuka, M.1
-
15
-
-
0037105758
-
Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability
-
Ota, T. et al. Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. Cancer Res. 62, 5168-5177 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5168-5177
-
-
Ota, T.1
-
16
-
-
0033548619
-
Cell cycle-dependent expression and centrosome localization of a third human aurora/IpI1-related protein kinase, AIK3
-
Kimura, M., Matsuda, Y., Yoshioka, T. & Okano, Y. Cell cycle-dependent expression and centrosome localization of a third human aurora/IpI1-related protein kinase, AIK3. J. Biol. Chem. 274, 7334-7340 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7334-7340
-
-
Kimura, M.1
Matsuda, Y.2
Yoshioka, T.3
Okano, Y.4
-
17
-
-
0035945342
-
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans
-
Hannak, E., Kirkham, M., Hyman, A. A. & Oegema, K. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J. Cell Biol. 155, 1109-1116 (2001).
-
(2001)
J. Cell Biol.
, vol.155
, pp. 1109-1116
-
-
Hannak, E.1
Kirkham, M.2
Hyman, A.A.3
Oegema, K.4
-
18
-
-
0037017398
-
Drosophila Aurora a kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
-
Giet, R. et al. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell Biol. 156, 437-451 (2002).
-
(2002)
J. Cell Biol.
, vol.156
, pp. 437-451
-
-
Giet, R.1
-
19
-
-
0037117408
-
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis
-
Berdnik, D. & Knoblich, J. A. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr. Biol. 12, 640-647 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 640-647
-
-
Berdnik, D.1
Knoblich, J.A.2
-
20
-
-
0141429171
-
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
-
Hirota, T. et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114, 585-598 (2003).
-
(2003)
Cell
, vol.114
, pp. 585-598
-
-
Hirota, T.1
-
21
-
-
0042420427
-
TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos
-
Bellanger, J. M. & Gonczy, P. TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos. Curr. Biol. 13, 1488-1498 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 1488-1498
-
-
Bellanger, J.M.1
Gonczy, P.2
-
22
-
-
0345256340
-
TACC1-chTOG-Aurora A protein complex in breast cancer
-
Conte, N. et al. TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene 22, 8102-8116 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 8102-8116
-
-
Conte, N.1
-
23
-
-
0347324949
-
Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells
-
Marumoto, T. et al. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J. Biol. Chem. 278, 51786-51795 (2003). References 20 and 23 describe the subcellular localization of Aurora-A during the cell cycle and show that Aurora-A activity is required for execution of various mitotic events, such as mitotic entry, centrosome maturation, centrosome separation, chromosome alignment and cytokinesis.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51786-51795
-
-
Marumoto, T.1
-
24
-
-
0033591432
-
The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XIEg5
-
Giet, R., Uzbekov, R., Cubizolles, F., Le Guellec, K. & Prigent, C. The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XIEg5. J. Biol. Chem. 274, 15005-15013 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15005-15013
-
-
Giet, R.1
Uzbekov, R.2
Cubizolles, F.3
Le Guellec, K.4
Prigent, C.5
-
25
-
-
3042734502
-
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition
-
Dutertre, S. et al. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J. Cell Sci. 117, 2523-2531 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 2523-2531
-
-
Dutertre, S.1
-
26
-
-
0037428388
-
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with α-catenin
-
Marie, H. et al. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with α-catenin. J. Biol. Chem. 278, 1220-1228 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1220-1228
-
-
Marie, H.1
-
27
-
-
0031938231
-
The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
-
Roghi, C. et al. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J. Cell Sci. 111, 557-572 (1998).
-
(1998)
J. Cell Sci.
, vol.111
, pp. 557-572
-
-
Roghi, C.1
-
28
-
-
0037341906
-
A Ran signaling pathway mediated by the mitotic kinase Aurora A in spindle assembly
-
Tsai, M. Y. et al. A Ran signaling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nature Cell Biol. 5, 242-248 (2003).
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 242-248
-
-
Tsai, M.Y.1
-
29
-
-
0033528994
-
The ran GTPase regulates mitotic spindle assembly
-
Kalab, P., Pu, R. T. & Dasso, M. The ran GTPase regulates mitotic spindle assembly. Curr. Biol. 9, 481-484 (1999).
-
(1999)
Curr. Biol.
, vol.9
, pp. 481-484
-
-
Kalab, P.1
Pu, R.T.2
Dasso, M.3
-
30
-
-
0033536178
-
Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
-
Carazo-Salas, R. E. et al. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400, 178-181 (1999).
-
(1999)
Nature
, vol.400
, pp. 178-181
-
-
Carazo-Salas, R.E.1
-
31
-
-
0032476724
-
Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
-
Witmann, T., Boleti, H., Antony, C., Karsenti, E. & Vernos, I. Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J. Cell Biol. 143, 673-685 (1998).
-
(1998)
J. Cell Biol.
, vol.143
, pp. 673-685
-
-
Witmann, T.1
Boleti, H.2
Antony, C.3
Karsenti, E.4
Vernos, I.5
-
32
-
-
0035913964
-
The mitotic spindle: A self-made machine
-
Karsenti, E. & Vernos, I. The mitotic spindle: a self-made machine. Science 294, 543-547 (2001).
-
(2001)
Science
, vol.294
, pp. 543-547
-
-
Karsenti, E.1
Vernos, I.2
-
33
-
-
0034717818
-
TPX2, a novel xenopus MAP involved in spindle pole organization
-
Wittmann, T., Wilm, M., Karsenti, E. & Vernos, I. TPX2, A novel xenopus MAP involved in spindle pole organization. J. Cell Biol. 149, 1405-1418 (2000).
-
(2000)
J. Cell Biol.
, vol.149
, pp. 1405-1418
-
-
Wittmann, T.1
Wilm, M.2
Karsenti, E.3
Vernos, I.4
-
34
-
-
18844464851
-
hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division
-
Garrett, S., Auer, K., Compton, D. A. & Kapoor, T. M. hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Curr. Biol. 12, 2055-2059 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 2055-2059
-
-
Garrett, S.1
Auer, K.2
Compton, D.A.3
Kapoor, T.M.4
-
35
-
-
0037135979
-
Human TPX2 is required for targeting Aurora-A kinase to the spindle
-
Kufer, T. A. et al. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J. Cell Biol. 158, 617-623 (2002).
-
(2002)
J. Cell Biol.
, vol.158
, pp. 617-623
-
-
Kufer, T.A.1
-
36
-
-
0037446847
-
A novel mechanism for activation of the protein kinase Aurora A
-
Eyers, P. A., Erikson, E., Chen, L. G. & Maller, J. L. A novel mechanism for activation of the protein kinase Aurora A. Curr. Biol. 13, 691-697 (2003). References 35 and 36 show that TPX2 interacts with and is phosphorylated by Aurora-A, and acts as an activator of Aurora-A.
-
(2003)
Curr. Biol.
, vol.13
, pp. 691-697
-
-
Eyers, P.A.1
Erikson, E.2
Chen, L.G.3
Maller, J.L.4
-
37
-
-
0034631960
-
The Xenopus laevis aurora/Ip11 p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle
-
Giet, R. & Prigent, C. The Xenopus laevis aurora/Ip11 p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle. Exp. Cell Res. 258, 145-151 (2000).
-
(2000)
Exp. Cell Res.
, vol.258
, pp. 145-151
-
-
Giet, R.1
Prigent, C.2
-
38
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
-
Ditchfield, C. et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161, 267-280 (2003).
-
(2003)
J. Cell Biol.
, vol.161
, pp. 267-280
-
-
Ditchfield, C.1
-
39
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf, S. et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161, 281-294 (2003).
-
(2003)
J. Cell Biol.
, vol.161
, pp. 281-294
-
-
Hauf, S.1
-
40
-
-
0344845010
-
Mitotic mechanics: The auroras come into view
-
Andrews, P. D., Knatko, E., Moore, W. J. & Swedlow, J. R. Mitotic mechanics: the auroras come into view. Curr. Opin. Cell Biol. 15, 672-683 (2003).
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 672-683
-
-
Andrews, P.D.1
Knatko, E.2
Moore, W.J.3
Swedlow, J.R.4
-
41
-
-
10744225982
-
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
-
Kunitoku, N. et al. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev. Cell 5, 853-864 (2003).
-
(2003)
Dev. Cell
, vol.5
, pp. 853-864
-
-
Kunitoku, N.1
-
42
-
-
0034644473
-
Signaling to chromatin through histone modifications
-
Cheung, P., Allis, C. D. & Sassone-Corsi, P. Signaling to chromatin through histone modifications. Cell 103, 263-271 (2000).
-
(2000)
Cell
, vol.103
, pp. 263-271
-
-
Cheung, P.1
Allis, C.D.2
Sassone-Corsi, P.3
-
43
-
-
0035945340
-
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
-
Zeitlin, S. G., Shelby, R. D. & Sullivan, K. F. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J. Cell Biol. 155, 1147-1157 (2001).
-
(2001)
J. Cell Biol.
, vol.155
, pp. 1147-1157
-
-
Zeitlin, S.G.1
Shelby, R.D.2
Sullivan, K.F.3
-
45
-
-
0037586498
-
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
-
Anand, S., Penrhyn-Lowe, S. & Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3, 51-62 (2003). Reports that overexpression of Aurora-A disrupts the spindle checkpoint, resulting in resistance to apoptosis induced by paclitaxel in a human cancer cell line.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
Penrhyn-Lowe, S.2
Venkitaraman, A.R.3
-
46
-
-
9944220985
-
Cre-IoxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models
-
Zhang, D. et al. Cre-IoxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 23, 8720-8730 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 8720-8730
-
-
Zhang, D.1
-
47
-
-
0034213929
-
Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway
-
Honda, K. et al. Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 19, 2812-2819 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2812-2819
-
-
Honda, K.1
-
48
-
-
12244301635
-
The D-Box-activating domain (DAD) is a new proteorysis signal that stimulates the silent D-Box sequence of Aurora-A
-
Castro, A. et al. The D-Box-activating domain (DAD) is a new proteorysis signal that stimulates the silent D-Box sequence of Aurora-A. EMBO Rep. 3, 1209-1214 (2002).
-
(2002)
EMBO Rep.
, vol.3
, pp. 1209-1214
-
-
Castro, A.1
-
49
-
-
1642361744
-
Overexpression and amplification of Aurora-A in hepatocellular carcinoma
-
Jeng, Y. M., Peng, S. Y., Lin, C. Y. & Hsu, H. C. Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin. Cancer Res. 10, 2065-2071 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 2065-2071
-
-
Jeng, Y.M.1
Peng, S.Y.2
Lin, C.Y.3
Hsu, H.C.4
-
50
-
-
17744384260
-
Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation
-
Sakakura, C. et al. Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br. J. Cancer 84, 824-831 (2001).
-
(2001)
Br. J. Cancer
, vol.84
, pp. 824-831
-
-
Sakakura, C.1
-
51
-
-
0037099531
-
Centrosome amplication and overexpression of aurora A are early events in rat mammary carcinogenesis
-
Goepfert, T. M. et al. Centrosome amplication and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res. 62, 4115-4122 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4115-4122
-
-
Goepfert, T.M.1
-
52
-
-
0035342595
-
Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers
-
Miyoshi, Y., Iwao, K., Egawa, C. & Noguchi, S. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int. J. Cancer 92, 370-373 (2001).
-
(2001)
Int. J. Cancer
, vol.92
, pp. 370-373
-
-
Miyoshi, Y.1
Iwao, K.2
Egawa, C.3
Noguchi, S.4
-
53
-
-
18644380150
-
Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells
-
Marumoto, T. et al. Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells 7, 1173-1182 (2002).
-
(2002)
Genes Cells
, vol.7
, pp. 1173-1182
-
-
Marumoto, T.1
-
54
-
-
0345304925
-
Aurora A overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer
-
Jiang, Y., Zhang, Y., Lees, E. & Seghezzi, W. Aurora A overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 22, 8293-8301 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 8293-8301
-
-
Jiang, Y.1
Zhang, Y.2
Lees, E.3
Seghezzi, W.4
-
55
-
-
0024406882
-
Model for the genetic evolution of human solid tumors
-
Shackney, S. E. et al. Model for the genetic evolution of human solid tumors. Cancer Res. 49, 3344-3354 (1989).
-
(1989)
Cancer Res.
, vol.49
, pp. 3344-3354
-
-
Shackney, S.E.1
-
56
-
-
0029658664
-
L and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
-
L and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev. 10, 2621-2631 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 2621-2631
-
-
Minn, A.J.1
Boise, L.H.2
Thompson, C.B.3
-
57
-
-
0031931414
-
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
-
Lanni, J. S. & Jacks, T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18, 1055-1064 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1055-1064
-
-
Lanni, J.S.1
Jacks, T.2
-
58
-
-
7744233719
-
Stuck in division or passing through; what happens when cells cannot satisfy the spindle assembly checkpoint
-
Rieder, C. L. & Maiato, H. Stuck in division or passing through; what happens when cells cannot satisfy the spindle assembly checkpoint. Dev. Cell 7, 637-651 (2004).
-
(2004)
Dev. Cell
, vol.7
, pp. 637-651
-
-
Rieder, C.L.1
Maiato, H.2
-
59
-
-
0034767429
-
Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1
-
Andreassen, P. R., Lohez, O. D., Lacroix, F. B. & Margolis, R. L. Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol. Biol. Cell 12, 1315-1328 (2001).
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1315-1328
-
-
Andreassen, P.R.1
Lohez, O.D.2
Lacroix, F.B.3
Margolis, R.L.4
-
60
-
-
0037373258
-
G1 tetraploidy checkpoint and the suppression of tumorigenesis
-
Margolis, R. L., Lohez, O. D. & Andreassen, P. R. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J. Cell Biochem. 88, 673-683 (2003).
-
(2003)
J. Cell Biochem.
, vol.88
, pp. 673-683
-
-
Margolis, R.L.1
Lohez, O.D.2
Andreassen, P.R.3
-
61
-
-
0030929838
-
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
-
Di Leonardo, A. et al. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 57, 1013-1019 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 1013-1019
-
-
Di Leonardo, A.1
-
62
-
-
0032005132
-
p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest
-
Khan, S. H. & Wahl, G. M. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res. 68, 396-401 (1998).
-
(1998)
Cancer Res.
, vol.68
, pp. 396-401
-
-
Khan, S.H.1
Wahl, G.M.2
-
63
-
-
0033178452
-
p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells
-
Casenghi, M. et al. p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells. Exp. Cell Res. 250, 339-350 (1999).
-
(1999)
Exp. Cell Res.
, vol.250
, pp. 339-350
-
-
Casenghi, M.1
-
64
-
-
0032952584
-
Waf1/Cip1 inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
-
Waf1/Cip1 inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell. Biol. 19, 205-215 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 205-215
-
-
Stewart, Z.A.1
Leach, S.D.2
Pietenpol, J.A.3
-
65
-
-
4644281946
-
Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy
-
Vogel, C., Kienitz, A., Hofmann, I., Muller, R. & Bastians, H. Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene 23, 6845-6853 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 6845-6853
-
-
Vogel, C.1
Kienitz, A.2
Hofmann, I.3
Muller, R.4
Bastians, H.5
-
66
-
-
0037009435
-
Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function
-
Chen, S. S., Chang, P. C., Cheng, Y. W., Tang, F. M. & Lin, Y. S. Suppression of the STK15 oncogenic activity requires a transactivation- independent p53 function. EMBO J. 21, 4491-4499 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 4491-4499
-
-
Chen, S.S.1
Chang, P.C.2
Cheng, Y.W.3
Tang, F.M.4
Lin, Y.S.5
-
67
-
-
9144251019
-
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of P53
-
Katayama, H. et al. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of P53. Nature Genet. 36, 55-62 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 55-62
-
-
Katayama, H.1
-
68
-
-
10644227569
-
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine-215
-
doi:10.1074/jbc.M406802200
-
Liu, Q. et al. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine-215. J. Biol. Chem. 6 Oct 2004 (doi:10.1074/jbc.M406802200).
-
J. Biol. Chem.
-
-
Liu, Q.1
-
69
-
-
0042093747
-
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
-
Ewart-Toland, A. et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nature Genet. 34, 403-412 (2003).
-
(2003)
Nature Genet.
, vol.34
, pp. 403-412
-
-
Ewart-Toland, A.1
-
70
-
-
4944245357
-
STK15 polymorphisms and association with risk of invasive ovarian cancer
-
DiCioccio, R. A. et al. STK15 polymorphisms and association with risk of invasive ovarian cancer. Cancer Epidemiol. Biomarkers Prev. 13, 1589-1594 (2004).
-
(2004)
Cancer Epidemiol. Biomarkers Prev.
, vol.13
, pp. 1589-1594
-
-
DiCioccio, R.A.1
-
71
-
-
8844250780
-
STK15 polymorphism and breast cancer risk in a population-based study
-
Egan, K. M. et al. STK15 polymorphism and breast cancer risk in a population-based study. Carcinogenesis 25, 2149-2153 (2004).
-
(2004)
Carcinogenesis
, vol.25
, pp. 2149-2153
-
-
Egan, K.M.1
-
72
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington, E. A. et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Med. 10, 262-267 (2004). Describes a small-molecule inhibitor of Aurora kinases, VX-680, that blocks cell-cycle progression and induces apoptosis in various human tumour cell types, both in vitro and in vivo.
-
(2004)
Nature Med.
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
-
73
-
-
2342624020
-
Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint
-
Dutertre, S. & Prigent, C. Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint. Mol. Interv. 3, 127-130 (2003).
-
(2003)
Mol. Interv.
, vol.3
, pp. 127-130
-
-
Dutertre, S.1
Prigent, C.2
-
74
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein, B. & Kinzler, K. W. Cancer genes and the pathways they control. Nature Med. 10, 789-799 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
75
-
-
1642556824
-
Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells
-
Yang, H. et al. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res. 64, 463-467 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 463-467
-
-
Yang, H.1
-
76
-
-
0030946109
-
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast IpI1
-
Kimura, M. et al. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast IpI1. J. Biol. Chem. 272, 13766-13771 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13766-13771
-
-
Kimura, M.1
-
77
-
-
0033231927
-
The Aurora/IpI1p kinase family: Regulators of chromosome segregation and cytokinesis
-
Bischoff, J. R. & Plowman, G. D. The Aurora/IpI1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol. 9, 454-459 (1999).
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 454-459
-
-
Bischoff, J.R.1
Plowman, G.D.2
-
78
-
-
0028938482
-
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
-
Glover, D. M., Leibowitz, M. H., McLean, D. A. & Parry, H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81, 95-105 (1995).
-
(1995)
Cell
, vol.81
, pp. 95-105
-
-
Glover, D.M.1
Leibowitz, M.H.2
McLean, D.A.3
Parry, H.4
-
79
-
-
0033612557
-
Sli15 associates with the IpI1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae
-
Kim, J. H., Kang, J. S. & Chan, C. S. Sli15 associates with the IpI1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 145, 1381-1394 (1999).
-
(1999)
J. Cell Biol.
, vol.145
, pp. 1381-1394
-
-
Kim, J.H.1
Kang, J.S.2
Chan, C.S.3
-
80
-
-
0034618724
-
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
-
Adams, R. R. et al. INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr. Biol. 10, 1075-1078 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1075-1078
-
-
Adams, R.R.1
-
81
-
-
0034609747
-
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
-
Kaitna, S., Mendoza, M., Jantsch-Plunger, V. & Glotzer, M. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr. Biol. 10, 1172-1181 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1172-1181
-
-
Kaitna, S.1
Mendoza, M.2
Jantsch-Plunger, V.3
Glotzer, M.4
-
82
-
-
0032472915
-
AIM-1: A mammalian midbody-associated protein required for cytokinesis
-
Terada, Y. et al. AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J. 17, 667-676 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 667-676
-
-
Terada, Y.1
-
83
-
-
0035911159
-
Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
-
Giet, R. & Glover, D. M. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J. Cell Biol. 152, 669-682 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 669-682
-
-
Giet, R.1
Glover, D.M.2
-
84
-
-
0034609763
-
The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis
-
Severson, A. F., Hamill, D. R., Carter, J. C., Schumacher, J. & Bowerman, B. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Curr. Biol. 10, 1162-1171 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1162-1171
-
-
Severson, A.F.1
Hamill, D.R.2
Carter, J.C.3
Schumacher, J.4
Bowerman, B.5
-
85
-
-
0034536903
-
Myosin il regulatory light chain as a novel substrate for AIM-1, an aurora/IpI1p-related kinase from rat
-
Murata-Hori, M. et al. Myosin il regulatory light chain as a novel substrate for AIM-1, an aurora/IpI1p-related kinase from rat. J. Biochem. (Tokyo) 128, 903-907 (2000).
-
(2000)
J. Biochem. (Tokyo)
, vol.128
, pp. 903-907
-
-
Murata-Hori, M.1
-
86
-
-
0037424487
-
Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process
-
Goto, H. et al. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J. Biol. Chem. 278, 8626-6630 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8626-16630
-
-
Goto, H.1
-
87
-
-
0038371015
-
Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase
-
Kawajiri, A. et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol. Biol. Cell 14, 1489-1500 (2003).
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 1489-1500
-
-
Kawajiri, A.1
-
88
-
-
0037387766
-
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis
-
Minoshima, Y. et al. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell 4, 549-560 (2003).
-
(2003)
Dev. Cell
, vol.4
, pp. 549-560
-
-
Minoshima, Y.1
-
89
-
-
0035931757
-
Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells
-
Kawasaki, A. et al. Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells. J. Cell Biol. 152, 275-287 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 275-287
-
-
Kawasaki, A.1
-
90
-
-
3843052430
-
Megakaryocytes express functional Aurora-B kinase in endomitosis
-
Geddis, A. E. & Kaushansky, K. Megakaryocytes express functional Aurora-B kinase in endomitosis. Blood 104, 1017-1024 (2004).
-
(2004)
Blood
, vol.104
, pp. 1017-1024
-
-
Geddis, A.E.1
Kaushansky, K.2
-
91
-
-
0034673706
-
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA
-
Mendez, R. et al. Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404, 302-307 (2000).
-
(2000)
Nature
, vol.404
, pp. 302-307
-
-
Mendez, R.1
-
92
-
-
0037462726
-
Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes
-
Castro, A., Mandart E., Lorca, T. & Galas, S. Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes. J. Biol. Chem. 278, 2236-2241 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2236-2241
-
-
Castro, A.1
Mandart, E.2
Lorca, T.3
Galas, S.4
-
93
-
-
0035824660
-
Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle
-
Katayama, H., Zhou, H., Li, Q., Tatsuka, M. & Sen, S. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J. Biol. Chem. 276, 46219-46224 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46219-46224
-
-
Katayama, H.1
Zhou, H.2
Li, Q.3
Tatsuka, M.4
Sen, S.5
-
94
-
-
0037008684
-
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity
-
Bishop, J. D. & Schumacher, J. M. Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J. Biol. Chem. 277, 27577-27580 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27577-27580
-
-
Bishop, J.D.1
Schumacher, J.M.2
-
95
-
-
0037092044
-
The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenoitiabditis elegans meiosis
-
Rogers, E., Bishop, J. D., Waddle, J. A., Schumacher, J. M. & Lin, R. The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenoitiabditis elegans meiosis. J. Cell Biol. 157, 219-129 (2002).
-
(2002)
J. Cell Biol.
, vol.157
, pp. 219-1129
-
-
Rogers, E.1
Bishop, J.D.2
Waddle, J.A.3
Schumacher, J.M.4
Lin, R.5
-
96
-
-
1542290607
-
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity
-
Lan, W. et al. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr. Biol. 14, 273-286 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 273-286
-
-
Lan, W.1
-
97
-
-
0037189527
-
Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins
-
Gigoux, V., L'Hoste, S., Raynaud, F., Camonis, J. & Garbay, C. Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. J. Biol. Chem. 277, 23742-23746 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23742-23746
-
-
Gigoux, V.1
L'Hoste, S.2
Raynaud, F.3
Camonis, J.4
Garbay, C.5
-
98
-
-
0037115829
-
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1
-
Du, J. & Hannon, G. J. The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acids Res. 30, 5465-5475 (2002).
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 5465-5475
-
-
Du, J.1
Hannon, G.J.2
-
99
-
-
0036714512
-
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
-
Littlepage, L. E. & Ruderman, J. V. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev. 16, 2274-2285 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 2274-2285
-
-
Littlepage, L.E.1
Ruderman, J.V.2
|