Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

Journal of Cell Biology

Volumn 155, Issue 7, 2001, Pages 1109-1115

  Hannak, Eva ^a,b   Kirkham, Matthew ^a   Hyman, Anthony A ^a   Oegema, Karen ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Cancer; Cell cycle; Microtubule; Mitosis

Indexed keywords

ALPHA TUBULIN; AURORA A KINASE; CELL ENZYME; CELL PROTEIN; GAMMA TUBULIN; PROTEIN CEGRIP; PROTEIN ZYG 9; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL CYCLE; CELL MATURATION; CELL NUCLEUS MEMBRANE; CELL SEPARATION; CENTROSOME; CONTROLLED STUDY; ENZYME ACTIVITY; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS RATE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CENTROSOME; MICROSCOPY, FLUORESCENCE; NOCODAZOLE; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; TUBULIN;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 0035945342     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200108051     Document Type: Article

References (21)

1. The Aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis
2. Centriole and centrosome dynamics during the embryonic cell cycles that follow the formation of the cellular blastoderm in Drosophila
3. Metaphase arrest with centromere separation in polo mutants of Drosophila
4. Regulating centrosomes by protein phosphorylation
5. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
6. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
7. Polo-like kinases: A team that plays throughout mitosis
8. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase
9. Centrosome dynamics in early embryos of Caenorhabditis elegans
10. The sudden recruitment of γ-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle do not require microtubules
11. Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression
12. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
13. ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meiotic and mitotic spindle poles
14. Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression
15. Cell division: Mitotic kinases as regulators of cell division and its checkpoints
16. Functional analysis of kinetochore assembly in C. elegans
17. Regulating the onset of mitosis
18. Centrosome maturation
19. The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
20. A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in C. elegans embryos
21. Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles