메뉴 건너뛰기




Volumn 1243, Issue 1, 2011, Pages 54-68

Diabetes, cancer, and metformin: Connections of metabolism and cell proliferation

Author keywords

Cancer; Diabetes; Insulin resistance; Metformin

Indexed keywords

FAS LIGAND; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; GROWTH HORMONE RECEPTOR; HEMOGLOBIN A1C; INSULIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53; SOMATOMEDIN C RECEPTOR; SULFONYLUREA; TRANSCRIPTION FACTOR FOXO; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84255178432     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.06285.x     Document Type: Article
Times cited : (161)

References (138)
  • 1
    • 77957102090 scopus 로고
    • A statistical study in cancer death-rates
    • Maynard, G. 1910. A statistical study in cancer death-rates. Biometrika 7: 276-304.
    • (1910) Biometrika , vol.7 , pp. 276-304
    • Maynard, G.1
  • 3
    • 65549157490 scopus 로고    scopus 로고
    • Impact of diabetes mellitus on complications and outcomes of adjuvant chemotherapy in older patients with breast cancer
    • Srokowski, T.P., S. Fang, G.N. Hortobagyi & S.H. Giordano. 2009. Impact of diabetes mellitus on complications and outcomes of adjuvant chemotherapy in older patients with breast cancer. J. Clin. Oncol. 27: 2170-2176.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2170-2176
    • Srokowski, T.P.1    Fang, S.2    Hortobagyi, G.N.3    Giordano, S.H.4
  • 4
    • 58049192725 scopus 로고    scopus 로고
    • Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis
    • Barone, B.B., H.C. Yeh, C.F. Snyder, et al. 2008. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA 300: 2754-2764.
    • (2008) JAMA , vol.300 , pp. 2754-2764
    • Barone, B.B.1    Yeh, H.C.2    Snyder, C.F.3
  • 5
    • 2942520997 scopus 로고    scopus 로고
    • Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    • Coughlin, S.S., E.E. Calle, L.R. Teras, et al. 2004. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am. J. Epidemiol. 159: 1160-1167.
    • (2004) Am. J. Epidemiol. , vol.159 , pp. 1160-1167
    • Coughlin, S.S.1    Calle, E.E.2    Teras, L.R.3
  • 6
    • 0029017953 scopus 로고
    • Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis
    • Everhart, J. & D. Wright. 1995. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA 273: 1605-1609.
    • (1995) JAMA , vol.273 , pp. 1605-1609
    • Everhart, J.1    Wright, D.2
  • 7
    • 21244485747 scopus 로고    scopus 로고
    • Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
    • Huxley, R., A. Ansary-Moghaddam, A. Berrington de Gonzalez, et al. 2005. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br. J. Cancer 92: 2076-2083.
    • (2005) Br. J. Cancer , vol.92 , pp. 2076-2083
    • Huxley, R.1    Ansary-Moghaddam, A.2    Berrington de Gonzalez, A.3
  • 8
    • 34249948987 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of endometrial cancer: a meta-analysis
    • Friberg, E., N. Orsini, C.S. Mantzoros & A. Wolk. 2007. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia 50: 1365-1374.
    • (2007) Diabetologia , vol.50 , pp. 1365-1374
    • Friberg, E.1    Orsini, N.2    Mantzoros, C.S.3    Wolk, A.4
  • 9
    • 33644759114 scopus 로고    scopus 로고
    • The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence
    • El-Serag, H.B., H. Hampel & F. Javadi. 2006. The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin. Gastroenterol. Hepatol. 4: 369-380.
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 369-380
    • El-Serag, H.B.1    Hampel, H.2    Javadi, F.3
  • 10
    • 33750930105 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of bladder cancer: a meta-analysis
    • Larsson, S.C., N. Orsini, K. Brismar & A. Wolk. 2006. Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia 49: 2819-2823.
    • (2006) Diabetologia , vol.49 , pp. 2819-2823
    • Larsson, S.C.1    Orsini, N.2    Brismar, K.3    Wolk, A.4
  • 11
    • 79952856558 scopus 로고    scopus 로고
    • Diabetes and risk of bladder cancer: evidence from a case-control study in New England
    • MacKenzie, T., M.S. Zens, A. Ferrara, et al. 2010. Diabetes and risk of bladder cancer: evidence from a case-control study in New England. Cancer 117: 1552-1556.
    • (2010) Cancer , vol.117 , pp. 1552-1556
    • MacKenzie, T.1    Zens, M.S.2    Ferrara, A.3
  • 12
    • 79954631858 scopus 로고    scopus 로고
    • Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies
    • Larsson, S.C. & A. Wolk. 2011. Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies. Diabetologia 54: 1013-1018.
    • (2011) Diabetologia , vol.54 , pp. 1013-1018
    • Larsson, S.C.1    Wolk, A.2
  • 13
    • 27944450832 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of colorectal cancer: a meta-analysis
    • Larsson, S.C., N. Orsini & A. Wolk. 2005. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J. Natl. Cancer Inst. 97: 1679-1687.
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 1679-1687
    • Larsson, S.C.1    Orsini, N.2    Wolk, A.3
  • 14
    • 34547127614 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of breast cancer: a meta-analysis
    • Larsson, S.C., C.S. Mantzoros & A. Wolk. 2007. Diabetes mellitus and risk of breast cancer: a meta-analysis. Int. J. Cancer 121: 856-862.
    • (2007) Int. J. Cancer , vol.121 , pp. 856-862
    • Larsson, S.C.1    Mantzoros, C.S.2    Wolk, A.3
  • 15
    • 79951960884 scopus 로고    scopus 로고
    • Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis
    • Peairs, K.S., B.B. Barone, C.F. Snyder, et al. 2011. Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J. Clin. Oncol. 29: 40-46.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 40-46
    • Peairs, K.S.1    Barone, B.B.2    Snyder, C.F.3
  • 16
    • 33845328853 scopus 로고    scopus 로고
    • A meta-analysis of diabetes mellitus and the risk of prostate cancer
    • Kasper, J.S. & E. Giovannucci. 2006. A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol. Biomarkers Prev. 15: 2056-2062.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 2056-2062
    • Kasper, J.S.1    Giovannucci, E.2
  • 17
    • 3142729250 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of prostate cancer: a meta-analysis
    • Bonovas, S., K. Filioussi & A. Tsantes. 2004. Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia 47: 1071-1078.
    • (2004) Diabetologia , vol.47 , pp. 1071-1078
    • Bonovas, S.1    Filioussi, K.2    Tsantes, A.3
  • 18
    • 84255201758 scopus 로고    scopus 로고
    • National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, Centers for Disease Control and Prevention; 2011.
    • National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Centers for Disease Control and Prevention; 2011.
    • (2011)
  • 19
    • 77955517441 scopus 로고    scopus 로고
    • Diabetes and cancer: a consensus report
    • Giovannucci, E., D.M. Harlan, M.C. Archer, et al. 2010. Diabetes and cancer: a consensus report. Diabetes Care 33: 1674-1685.
    • (2010) Diabetes Care , vol.33 , pp. 1674-1685
    • Giovannucci, E.1    Harlan, D.M.2    Archer, M.C.3
  • 20
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study
    • Martin, B.C., J.H. Warram, A.S. Krolewski, et al. 1992. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340: 925-929.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3
  • 21
    • 78651338445 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2011
    • American Diabetes Association.
    • American Diabetes Association. 2011. Standards of medical care in diabetes-2011. Diabetes Care 34(Suppl 1): S11-S61.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 1
  • 22
    • 0015011783 scopus 로고
    • Influence of nutritional factors on prevalence of diabetes
    • West, K.M. & J.M. Kalbfleisch. 1971. Influence of nutritional factors on prevalence of diabetes. Diabetes 20: 99-108.
    • (1971) Diabetes , vol.20 , pp. 99-108
    • West, K.M.1    Kalbfleisch, J.M.2
  • 23
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle E.E., C. Rodriguez, K. Walker-Thurmond & M.J. Thun. 2003. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 348: 1625-1638.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 24
    • 84255201759 scopus 로고    scopus 로고
    • Chapter 36 in. 2nd ed. Springer. New York
    • Poretsky, L. 2010. Chapter 36 in Principles of Diabetes. 2nd ed. Springer. New York.
    • (2010) Principles of Diabetes
    • Poretsky, L.1
  • 26
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker, S.L., S.R. Majumdar, P. Veugelers & J.A. Johnson. 2006. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 27
    • 68449094354 scopus 로고    scopus 로고
    • Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group
    • Colhoun, H.M. 2009. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia 52: 1755-1765.
    • (2009) Diabetologia , vol.52 , pp. 1755-1765
    • Colhoun, H.M.1
  • 28
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie, C.J., C.D. Poole & E.A. Gale. 2009. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 52: 1766-1777.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 29
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
    • Libby, G., L.A. Donnelly, P.T. Donnan, et al. 2009. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 32: 1620-1625.
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3
  • 30
    • 77953539812 scopus 로고    scopus 로고
    • Long-term metformin use is associated with decreased risk of breast cancer
    • Bodmer, M., C. Meier, S. Krahenbuhl, et al. 2010. Long-term metformin use is associated with decreased risk of breast cancer. Diabetes Care 33: 1304-1308.
    • (2010) Diabetes Care , vol.33 , pp. 1304-1308
    • Bodmer, M.1    Meier, C.2    Krahenbuhl, S.3
  • 31
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine, A.J. & A.M. Puzio-Kuter. 2010. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330: 1340-1344.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 32
    • 79959694931 scopus 로고    scopus 로고
    • An extended Myc network contributes to glucose homeostasis in cancer and diabetes
    • Peterson, C.W. & D.E. Ayer. 2011. An extended Myc network contributes to glucose homeostasis in cancer and diabetes. Front. Biosci. 17: 2206-2223.
    • (2011) Front. Biosci. , vol.17 , pp. 2206-2223
    • Peterson, C.W.1    Ayer, D.E.2
  • 33
    • 79954988230 scopus 로고    scopus 로고
    • Associations between adipokines and obesity-related cancer
    • Paz-Filho, G., E.L. Lim, M.L. Wong & J. Licinio. 2011. Associations between adipokines and obesity-related cancer. Front. Biosci. 16: 1634-1650.
    • (2011) Front. Biosci. , vol.16 , pp. 1634-1650
    • Paz-Filho, G.1    Lim, E.L.2    Wong, M.L.3    Licinio, J.4
  • 34
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis, R.J. & T. Cheng. 2010. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29: 313-324.
    • (2010) Oncogene , vol.29 , pp. 313-324
    • DeBerardinis, R.J.1    Cheng, T.2
  • 36
    • 33645507592 scopus 로고    scopus 로고
    • Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo
    • Tran, T.T., D. Naigamwalla, A.I. Oprescu, et al. 2006. Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo. Endocrinology 147: 1830-1837.
    • (2006) Endocrinology , vol.147 , pp. 1830-1837
    • Tran, T.T.1    Naigamwalla, D.2    Oprescu, A.I.3
  • 37
    • 58549084793 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    • Gunter, M.J., D.R. Hoover, H. Yu, et al. 2009. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. J. Natl. Cancer Inst. 101: 48-60.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 48-60
    • Gunter, M.J.1    Hoover, D.R.2    Yu, H.3
  • 38
    • 0036138579 scopus 로고    scopus 로고
    • Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study
    • Goodwin, P.J., M. Ennis, K.I. Pritchard, et al. 2002. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J. Clin. Oncol. 20: 42-51.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 42-51
    • Goodwin, P.J.1    Ennis, M.2    Pritchard, K.I.3
  • 39
    • 1842866389 scopus 로고    scopus 로고
    • A prospective study of plasma C-peptide and colorectal cancer risk in men
    • Ma, J., E. Giovannucci, M. Pollak, et al. 2004. A prospective study of plasma C-peptide and colorectal cancer risk in men. J. Natl. Cancer Inst. 96: 546-553.
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 546-553
    • Ma, J.1    Giovannucci, E.2    Pollak, M.3
  • 40
    • 16444376296 scopus 로고    scopus 로고
    • A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women
    • Wei, E.K., J. Ma, M.N. Pollak, et al. 2005. A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiol. Biomarkers Prev. 14: 850-855.
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , pp. 850-855
    • Wei, E.K.1    Ma, J.2    Pollak, M.N.3
  • 41
    • 70349251631 scopus 로고    scopus 로고
    • Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer
    • Albanes, D., S.J. Weinstein, M.E. Wright, et al. 2009. Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer. J. Natl. Cancer Inst. 101: 1272-1279.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1272-1279
    • Albanes, D.1    Weinstein, S.J.2    Wright, M.E.3
  • 42
    • 33846614678 scopus 로고    scopus 로고
    • Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women
    • Eliassen, A.H., S.S. Tworoger, C.S. Mantzoros, et al. 2007. Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women. Cancer Epidemiol. Biomarkers Prev. 16: 161-164.
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 161-164
    • Eliassen, A.H.1    Tworoger, S.S.2    Mantzoros, C.S.3
  • 43
    • 76549136489 scopus 로고    scopus 로고
    • Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
    • Novosyadlyy, R., D.E. Lann, A. Vijayakumar, et al. 2010. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res. 70: 741-751.
    • (2010) Cancer Res. , vol.70 , pp. 741-751
    • Novosyadlyy, R.1    Lann, D.E.2    Vijayakumar, A.3
  • 44
    • 0018904425 scopus 로고
    • Association between serum insulin, serum somatomedin and liver receptors for human growth hormone in streptozotocin diabetes
    • Baxter, RC., A.S. Brown & J.R. Turtle. 1980. Association between serum insulin, serum somatomedin and liver receptors for human growth hormone in streptozotocin diabetes. Horm. Metab. Res. 12: 377-381.
    • (1980) Horm. Metab. Res. , vol.12 , pp. 377-381
    • Baxter, R.C.1    Brown, A.S.2    Turtle, J.R.3
  • 46
    • 70450255319 scopus 로고    scopus 로고
    • Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies
    • Chen, W., S. Wang, T. Tian, et al. 2009. Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies. Eur. J. Hum. Genet. 17: 1668-1675.
    • (2009) Eur. J. Hum. Genet. , vol.17 , pp. 1668-1675
    • Chen, W.1    Wang, S.2    Tian, T.3
  • 47
    • 77449111832 scopus 로고    scopus 로고
    • Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies
    • Rinaldi, S., R. Cleveland, T. Norat, et al. 2010. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies. Int. J. Cancer 126: 1702-1715.
    • (2010) Int. J. Cancer , vol.126 , pp. 1702-1715
    • Rinaldi, S.1    Cleveland, R.2    Norat, T.3
  • 48
    • 53749097826 scopus 로고    scopus 로고
    • Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies
    • W83-W88
    • Roddam, A.W., N.E Allen, P. Appleby, et al. 2008. Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. Ann. Intern. Med. 149: 461-471, W83-W88.
    • (2008) Ann. Intern. Med. , vol.149 , pp. 461-471
    • Roddam, A.W.1    Allen, N.E.2    Appleby, P.3
  • 49
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    • Renehan, A.G., M. Zwahlen, C. Minder, et al. 2004. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363: 1346-1353.
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3
  • 50
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu, Y., S. Yakar, L. Zhao, et al. 2002. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res. 62: 1030-1035.
    • (2002) Cancer Res. , vol.62 , pp. 1030-1035
    • Wu, Y.1    Yakar, S.2    Zhao, L.3
  • 51
    • 0030727705 scopus 로고    scopus 로고
    • Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
    • Dunn, S.E., F.W. Kari, J. French, et al. 1997. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res. 57: 4667-4672.
    • (1997) Cancer Res. , vol.57 , pp. 4667-4672
    • Dunn, S.E.1    Kari, F.W.2    French, J.3
  • 52
    • 0025066641 scopus 로고
    • Elevated insulin receptor content in human breast cancer
    • Papa, V., V. Pezzino, A. Costantino, et al. 1990. Elevated insulin receptor content in human breast cancer. J. Clin. Invest. 86: 1503-1510.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1503-1510
    • Papa, V.1    Pezzino, V.2    Costantino, A.3
  • 53
    • 0030679620 scopus 로고    scopus 로고
    • Insulin receptor expression and clinical outcome in node-negative breast cancer
    • Mathieu, M.C., G.M. Clark, D.C. Allred, et al. 1997. Insulin receptor expression and clinical outcome in node-negative breast cancer. Proc. Assoc. Am. Physicians 109: 565-571.
    • (1997) Proc. Assoc. Am. Physicians , vol.109 , pp. 565-571
    • Mathieu, M.C.1    Clark, G.M.2    Allred, D.C.3
  • 54
    • 34848834225 scopus 로고    scopus 로고
    • Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer
    • Mulligan, A.M., F.P. O'Malley, M. Ennis, et al. 2007. Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Breast Cancer Res. Treat. 106: 39-47.
    • (2007) Breast Cancer Res. Treat. , vol.106 , pp. 39-47
    • Mulligan, A.M.1    O'Malley, F.P.2    Ennis, M.3
  • 55
    • 0033134117 scopus 로고    scopus 로고
    • Human insulin receptor and insulin signaling proteins in hepatic disease
    • Spector, S.A., E.T. Olson, A.A. Gumbs, et al. 1999. Human insulin receptor and insulin signaling proteins in hepatic disease. J. Surg. Res. 83: 32-35.
    • (1999) J. Surg. Res. , vol.83 , pp. 32-35
    • Spector, S.A.1    Olson, E.T.2    Gumbs, A.A.3
  • 56
    • 58149339692 scopus 로고    scopus 로고
    • Insulin receptor expression by human prostate cancers
    • Cox, M.E., M.E. Gleave, M. Zakikhani, et al. 2009. Insulin receptor expression by human prostate cancers. Prostate 69: 33-40.
    • (2009) Prostate , vol.69 , pp. 33-40
    • Cox, M.E.1    Gleave, M.E.2    Zakikhani, M.3
  • 57
    • 79955488988 scopus 로고    scopus 로고
    • A pathobiological role of the insulin receptor in chronic lymphocytic leukemia
    • Saiya-Cork, K., R. Collins, B. Parkin, et al. 2011. A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. Clin. Cancer Res. 17: 2679-2692.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2679-2692
    • Saiya-Cork, K.1    Collins, R.2    Parkin, B.3
  • 58
    • 77956049616 scopus 로고    scopus 로고
    • Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807
    • Dinchuk, J.E., C. Cao, F. Huang, et al. 2010. Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807. Endocrinology 151: 4123-4132.
    • (2010) Endocrinology , vol.151 , pp. 4123-4132
    • Dinchuk, J.E.1    Cao, C.2    Huang, F.3
  • 59
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
    • Ulanet, D.B., D.L. Ludwig, C.R. Kahn & D. Hanahan. 2010. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc. Natl. Acad. Sci. USA 107: 10791-10798.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 60
    • 33846458639 scopus 로고    scopus 로고
    • Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    • Zhang, H., A.M. Pelzer, D.T. Kiang & D. Yee. 2007. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res. 67: 391-397.
    • (2007) Cancer Res. , vol.67 , pp. 391-397
    • Zhang, H.1    Pelzer, A.M.2    Kiang, D.T.3    Yee, D.4
  • 61
    • 77958067823 scopus 로고    scopus 로고
    • Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer
    • Buck, E., P.C. Gokhale, S. Koujak, et al. 2010. Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer. Mol. Cancer Ther. 9: 2652-2664.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2652-2664
    • Buck, E.1    Gokhale, P.C.2    Koujak, S.3
  • 62
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine, A.J., Z. Feng, T.W. Mak, et al. 2006. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev. 20: 267-275.
    • (2006) Genes Dev. , vol.20 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3
  • 63
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn, D.M., D.B. Shackelford, D.F. Egan, et al. 2008. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30: 214-226.
    • (2008) Mol. Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 64
    • 41849150779 scopus 로고    scopus 로고
    • FOXOs, cancer and regulation of apoptosis
    • Fu, Z. & D.J. Tindall. 2008. FOXOs, cancer and regulation of apoptosis. Oncogene 27: 2312-2319.
    • (2008) Oncogene , vol.27 , pp. 2312-2319
    • Fu, Z.1    Tindall, D.J.2
  • 65
    • 33748194240 scopus 로고    scopus 로고
    • Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway
    • Smolewski, P. 2006. Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 17: 487-494.
    • (2006) Anticancer Drugs , vol.17 , pp. 487-494
    • Smolewski, P.1
  • 66
    • 0142150204 scopus 로고    scopus 로고
    • Involvement of the Akt/PKB signaling pathway with disease processes
    • Sen, P., S. Mukherjee, D. Ray & S. Raha. 2003. Involvement of the Akt/PKB signaling pathway with disease processes. Mol. Cell Biochem. 253: 241-246.
    • (2003) Mol. Cell Biochem. , vol.253 , pp. 241-246
    • Sen, P.1    Mukherjee, S.2    Ray, D.3    Raha, S.4
  • 67
    • 79955518863 scopus 로고    scopus 로고
    • Metabolic status rather than cell cycle signals control quiescence entry and exit
    • Laporte, D., A. Lebaudy, A. Sahin, et al. 2011. Metabolic status rather than cell cycle signals control quiescence entry and exit. J. Cell Biol. 192: 949-957.
    • (2011) J. Cell Biol. , vol.192 , pp. 949-957
    • Laporte, D.1    Lebaudy, A.2    Sahin, A.3
  • 68
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. 1956. On the origin of cancer cells. Science 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 69
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu, P.P. & D.M. Sabatini. 2008. Cancer cell metabolism: Warburg and beyond. Cell 134: 703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 70
    • 79953776342 scopus 로고    scopus 로고
    • Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials
    • Johnson, J.A. & S.L. Bowker. 2011. Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 54: 25-31.
    • (2011) Diabetologia , vol.54 , pp. 25-31
    • Johnson, J.A.1    Bowker, S.L.2
  • 71
    • 33847650108 scopus 로고    scopus 로고
    • Prospective study of hyperglycemia and cancer risk
    • Stattin, P., O. Bjor, P. Ferrari, et al. 2007. Prospective study of hyperglycemia and cancer risk. Diabetes Care 30: 561-567.
    • (2007) Diabetes Care , vol.30 , pp. 561-567
    • Stattin, P.1    Bjor, O.2    Ferrari, P.3
  • 72
    • 77951835127 scopus 로고    scopus 로고
    • Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry
    • Yang, X., G.T. Ko, W.Y. So, et al. 2010. Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry. Diabetes 59: 1254-1260.
    • (2010) Diabetes , vol.59 , pp. 1254-1260
    • Yang, X.1    Ko, G.T.2    So, W.Y.3
  • 73
    • 0037152340 scopus 로고    scopus 로고
    • Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression
    • Okumura, M., M. Yamamoto, H. Sakuma, et al. 2002. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochim. Biophys. Acta 1592: 107-1016.
    • (2002) Biochim. Biophys. Acta , vol.1592 , pp. 107-1016
    • Okumura, M.1    Yamamoto, M.2    Sakuma, H.3
  • 74
    • 78651272050 scopus 로고    scopus 로고
    • High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells
    • Liu, H., Q. Ma & J. Li. 2011. High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells. Mol. Cell Biochem. 347: 95-101.
    • (2011) Mol. Cell Biochem. , vol.347 , pp. 95-101
    • Liu, H.1    Ma, Q.2    Li, J.3
  • 75
    • 33744918297 scopus 로고    scopus 로고
    • Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation
    • Nunez, N.P., W.J. Oh, J. Rozenberg, et al. 2006. Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation. Cancer Res. 66: 5469-5476.
    • (2006) Cancer Res. , vol.66 , pp. 5469-5476
    • Nunez, N.P.1    Oh, W.J.2    Rozenberg, J.3
  • 76
    • 0015296174 scopus 로고
    • Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction
    • Heuson, J.C. & N. Legros. 1972. Influence of insulin deprivation on growth of the 7, 12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction. Cancer Res. 32: 226-232.
    • (1972) Cancer Res. , vol.32 , pp. 226-232
    • Heuson, J.C.1    Legros, N.2
  • 77
    • 60249085118 scopus 로고    scopus 로고
    • Mitochondria in cancer: not just innocent bystanders
    • Frezza, C. & E. Gottlieb. 2009. Mitochondria in cancer: not just innocent bystanders. Semin. Cancer Biol. 19: 4-11.
    • (2009) Semin. Cancer Biol. , vol.19 , pp. 4-11
    • Frezza, C.1    Gottlieb, E.2
  • 78
    • 12944262229 scopus 로고    scopus 로고
    • Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
    • Macheda, M.L., S. Rogers & J.D. Best. 2005. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J. Cell Physiol. 202: 654-662.
    • (2005) J. Cell Physiol. , vol.202 , pp. 654-662
    • Macheda, M.L.1    Rogers, S.2    Best, J.D.3
  • 79
    • 0030750652 scopus 로고    scopus 로고
    • GLUT1 glucose transporter expression in benign and malignant thyroid nodules
    • Haber, R.S., K.R. Weiser, A. Pritsker, et al. 1997. GLUT1 glucose transporter expression in benign and malignant thyroid nodules. Thyroid 7: 363-367.
    • (1997) Thyroid , vol.7 , pp. 363-367
    • Haber, R.S.1    Weiser, K.R.2    Pritsker, A.3
  • 80
    • 0032762469 scopus 로고    scopus 로고
    • Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases
    • Kurata, T., T. Oguri, T. Isobe, et al. 1999. Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Jpn. J. Cancer Res. 90: 1238-1243.
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 1238-1243
    • Kurata, T.1    Oguri, T.2    Isobe, T.3
  • 81
    • 0025075721 scopus 로고
    • Over-expression of facilitative glucose transporter genes in human cancer
    • Yamamoto, T., Y. Seino, H. Fukumoto, et al. 1990. Over-expression of facilitative glucose transporter genes in human cancer. Biochem. Biophys. Res. Commun. 170: 223-230.
    • (1990) Biochem. Biophys. Res. Commun. , vol.170 , pp. 223-230
    • Yamamoto, T.1    Seino, Y.2    Fukumoto, H.3
  • 82
    • 0029554059 scopus 로고
    • GLUT1 expression in human breast carcinoma: correlation with known prognostic markers
    • Younes, M., R.W. Brown, D.R. Mody, et al. 1995. GLUT1 expression in human breast carcinoma: correlation with known prognostic markers. Anticancer Res. 15: 2895-2898.
    • (1995) Anticancer Res. , vol.15 , pp. 2895-2898
    • Younes, M.1    Brown, R.W.2    Mody, D.R.3
  • 83
    • 0030821269 scopus 로고    scopus 로고
    • Expression of the human erythrocyte glucose transporter Glut1 in cutaneous neoplasia
    • Baer, S.C., L. Casaubon, M. Younes. 1997. Expression of the human erythrocyte glucose transporter Glut1 in cutaneous neoplasia. J. Am. Acad. Dermatol. 37: 575-577.
    • (1997) J. Am. Acad. Dermatol. , vol.37 , pp. 575-577
    • Baer, S.C.1    Casaubon, L.2    Younes, M.3
  • 84
    • 0028833042 scopus 로고
    • Immunohistochemical localization of glucose transporters in human renal cell carcinoma
    • Nagase, Y., K. Takata, N. Moriyama, et al. 1995. Immunohistochemical localization of glucose transporters in human renal cell carcinoma. J. Urol. 153: 798-801.
    • (1995) J. Urol. , vol.153 , pp. 798-801
    • Nagase, Y.1    Takata, K.2    Moriyama, N.3
  • 85
    • 0027483861 scopus 로고
    • Expression of facilitative glucose transporter isoforms in human brain tumors
    • Nagamatsu, S., H. Sawa, A. Wakizaka & T. Hoshino. 1993. Expression of facilitative glucose transporter isoforms in human brain tumors. J. Neurochem. 61: 2048-2053.
    • (1993) J. Neurochem. , vol.61 , pp. 2048-2053
    • Nagamatsu, S.1    Sawa, H.2    Wakizaka, A.3    Hoshino, T.4
  • 86
    • 0032972781 scopus 로고    scopus 로고
    • Glucose uptake in the human gastric cancer cell line, MKN28, is increased by insulin stimulation
    • Noguchi, Y., S. Sato, D. Marat, et al. 1999. Glucose uptake in the human gastric cancer cell line, MKN28, is increased by insulin stimulation. Cancer Lett. 140: 69-74.
    • (1999) Cancer Lett. , vol.140 , pp. 69-74
    • Noguchi, Y.1    Sato, S.2    Marat, D.3
  • 87
    • 0036846196 scopus 로고    scopus 로고
    • PAX3/forkhead homolog in rhabdomyosarcoma oncoprotein activates glucose transporter 4 gene expression in vivo and in vitro
    • Armoni, M., M.J. Quon, G. Maor, et al. 2002. PAX3/forkhead homolog in rhabdomyosarcoma oncoprotein activates glucose transporter 4 gene expression in vivo and in vitro. J. Clin. Endocrinol. Metab. 87: 5312-5324.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 5312-5324
    • Armoni, M.1    Quon, M.J.2    Maor, G.3
  • 88
    • 0031978209 scopus 로고    scopus 로고
    • Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage
    • Ito, T., Y. Noguchi, S. Satoh, et al. 1998. Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage. Mod. Pathol. 11: 437-443.
    • (1998) Mod. Pathol. , vol.11 , pp. 437-443
    • Ito, T.1    Noguchi, Y.2    Satoh, S.3
  • 89
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • Schwartzenberg-Bar-Yoseph, F., M. Armoni & E. Karnieli. 2004. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res. 64: 2627-2633.
    • (2004) Cancer Res. , vol.64 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 90
    • 79952717399 scopus 로고    scopus 로고
    • Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells
    • Cifuentes, M., M.A. Garcia, P.M. Arrabal, et al. 2011. Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells. J. Cell Physiol. 226: 1425-1432.
    • (2011) J. Cell Physiol. , vol.226 , pp. 1425-1432
    • Cifuentes, M.1    Garcia, M.A.2    Arrabal, P.M.3
  • 91
    • 0033798639 scopus 로고    scopus 로고
    • Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression
    • Ding, X.Z., D.M. Fehsenfeld, L.O. Murphy, et al. 2000. Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression. Pancreas 21: 310-320.
    • (2000) Pancreas , vol.21 , pp. 310-320
    • Ding, X.Z.1    Fehsenfeld, D.M.2    Murphy, L.O.3
  • 92
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • Bensaad, K., A. Tsuruta, M.A. Selak, et al. 2006. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126: 107-120.
    • (2006) Cell , vol.126 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3
  • 93
    • 43049139541 scopus 로고    scopus 로고
    • p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    • Kawauchi, K., K. Araki, K. Tobiume & N. Tanaka. 2008. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat. Cell Biol. 10: 611-618.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 611-618
    • Kawauchi, K.1    Araki, K.2    Tobiume, K.3    Tanaka, N.4
  • 94
    • 79952280229 scopus 로고    scopus 로고
    • p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • Jiang, P., W. Du, X. Wang, et al. 2011. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat. Cell Biol. 13: 310-316.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3
  • 95
    • 79952749503 scopus 로고    scopus 로고
    • Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    • Sun, Q., X. Chen, J. Ma, et al. 2011. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc. Natl. Acad. Sci. USA 108: 4129-4134.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 4129-4134
    • Sun, Q.1    Chen, X.2    Ma, J.3
  • 96
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta, S., M. Wetterling, M. Lehrke, et al. 2000. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 60: 916-921.
    • (2000) Cancer Res. , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3
  • 97
    • 0030921103 scopus 로고    scopus 로고
    • c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
    • Shim, H., C. Dolde, B.C. Lewis, et al. 1997. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. USA 94: 6658-6663.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6658-6663
    • Shim, H.1    Dolde, C.2    Lewis, B.C.3
  • 99
    • 79954537559 scopus 로고    scopus 로고
    • Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    • Martinez-Outschoorn, U.E., M. Prisco, A. Ertel, et al. 2011. Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle 10: 1271-1286.
    • (2011) Cell Cycle , vol.10 , pp. 1271-1286
    • Martinez-Outschoorn, U.E.1    Prisco, M.2    Ertel, A.3
  • 100
    • 0030667884 scopus 로고    scopus 로고
    • Dual effects of weight and weight gain on breast cancer risk
    • Huang, Z., S.E. Hankinson, G.A. Colditz, et al. 1997. Dual effects of weight and weight gain on breast cancer risk. JAMA 278: 1407-1411.
    • (1997) JAMA , vol.278 , pp. 1407-1411
    • Huang, Z.1    Hankinson, S.E.2    Colditz, G.A.3
  • 101
    • 72549099341 scopus 로고    scopus 로고
    • Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome
    • Pugeat, M, N. Nader, K. Hogeveen, et al. 2010. Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome. Mol. Cell Endocrinol. 316: 53-59.
    • (2010) Mol. Cell Endocrinol. , vol.316 , pp. 53-59
    • Pugeat, M.1    Nader, N.2    Hogeveen, K.3
  • 102
    • 34547956513 scopus 로고    scopus 로고
    • Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line
    • Eertmans, F, W. Dhooge, O. De Wever, et al. 2007. Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line. J. Cell Physiol. 212: 583-590.
    • (2007) J. Cell Physiol. , vol.212 , pp. 583-590
    • Eertmans, F.1    Dhooge, W.2    De Wever, O.3
  • 103
    • 79955790378 scopus 로고    scopus 로고
    • Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-alpha and -beta via the IGF-1 and the insulin receptors in breast cancer cells
    • Richardson, A.E., N. Hamilton, W. Davis, et al. 2011. Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-alpha and -beta via the IGF-1 and the insulin receptors in breast cancer cells. Growth Factors 29: 82-93.
    • (2011) Growth Factors , vol.29 , pp. 82-93
    • Richardson, A.E.1    Hamilton, N.2    Davis, W.3
  • 104
    • 79956348919 scopus 로고    scopus 로고
    • Metabolic syndrome and the risk of breast cancer in postmenopausal women
    • Epub ahead of Print].
    • Rosato, V., C. Bosetti, R. Bosetti, et al. 2011. Metabolic syndrome and the risk of breast cancer in postmenopausal women. Ann. Oncol. [Epub ahead of Print]. doi:.
    • (2011) Ann. Oncol
    • Rosato, V.1    Bosetti, C.2    Bosetti, R.3
  • 105
    • 79953295548 scopus 로고    scopus 로고
    • Metabolic syndrome and endometrial cancer risk
    • Rosato, V., A. Zucchetto, C. Bosetti, et al. 2011. Metabolic syndrome and endometrial cancer risk. Ann. Oncol. 22: 884-889.
    • (2011) Ann. Oncol. , vol.22 , pp. 884-889
    • Rosato, V.1    Zucchetto, A.2    Bosetti, C.3
  • 106
    • 0344641797 scopus 로고
    • The influence of the degree of caloric restriction on the formation of skin tumors and hepatomas in mice
    • Tannenbaum, A. & H. Silverstone. 1949. The influence of the degree of caloric restriction on the formation of skin tumors and hepatomas in mice. Cancer Res. 9: 724-727.
    • (1949) Cancer Res. , vol.9 , pp. 724-727
    • Tannenbaum, A.1    Silverstone, H.2
  • 107
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in rhesus monkeys
    • Colman, R.J., R.M. Anderson, S.C. Johnson, et al. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
    • (2009) Science , vol.325 , pp. 201-204
    • Colman, R.J.1    Anderson, R.M.2    Johnson, S.C.3
  • 108
    • 45549106969 scopus 로고    scopus 로고
    • Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels
    • Moore, T., S. Carbajal, L. Beltran, et al. 2008. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. Cancer Res. 68: 3680-3688.
    • (2008) Cancer Res. , vol.68 , pp. 3680-3688
    • Moore, T.1    Carbajal, S.2    Beltran, L.3
  • 109
    • 74049092809 scopus 로고    scopus 로고
    • Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
    • Hursting, S.D., S.M. Smith, L.M. Lashinger, et al. 2010. Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis 31: 83-89.
    • (2010) Carcinogenesis , vol.31 , pp. 83-89
    • Hursting, S.D.1    Smith, S.M.2    Lashinger, L.M.3
  • 110
    • 79951700516 scopus 로고    scopus 로고
    • Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry
    • Yang, X., W.Y. So, R.C. Ma, et al. 2011. Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry. Diabetes Care 34: 375-380.
    • (2011) Diabetes Care , vol.34 , pp. 375-380
    • Yang, X.1    So, W.Y.2    Ma, R.C.3
  • 111
    • 77954559516 scopus 로고    scopus 로고
    • Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma
    • Donadon, V., M. Balbi, F. Valent & A. Avogaro. 2010. Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma. World J. Gastroenterol. 16: 3025-3032.
    • (2010) World J. Gastroenterol. , vol.16 , pp. 3025-3032
    • Donadon, V.1    Balbi, M.2    Valent, F.3    Avogaro, A.4
  • 112
    • 80052965511 scopus 로고    scopus 로고
    • Incidence of malignancies in patients with diabetes mellitus and correlation with treatment modalities in a large Israeli health maintenance organization: a historical cohort study
    • Buchs, A.E. & B.G. Silverman. 2011. Incidence of malignancies in patients with diabetes mellitus and correlation with treatment modalities in a large Israeli health maintenance organization: a historical cohort study. Metabolism. 60: 1379-1385.
    • (2011) Metabolism , vol.60 , pp. 1379-1385
    • Buchs, A.E.1    Silverman, B.G.2
  • 113
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
    • Decensi, A., M. Puntoni, P. Goodwin, et al. 2010. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev. Res. (Phila) 3: 1451-1461.
    • (2010) Cancer Prev. Res. (Phila) , vol.3 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 114
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans, J.M., L.A. Donnelly, A.M. Emslie-Smith, et al. 2005. Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305.
    • (2005) BMJ , vol.330 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3
  • 115
    • 75149179169 scopus 로고    scopus 로고
    • Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16
    • Landman, G.W., N. Kleefstra, K.J. van Hateren, et al. 2010. Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care 33: 322-326.
    • (2010) Diabetes Care , vol.33 , pp. 322-326
    • Landman, G.W.1    Kleefstra, N.2    van Hateren, K.J.3
  • 116
    • 79951708837 scopus 로고    scopus 로고
    • Metformin and cancer occurrence in insulin-treated type 2 diabetic patients
    • Monami, M., C. Colombi, D. Balzi, et al. 2011. Metformin and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care 34: 129-131.
    • (2011) Diabetes Care , vol.34 , pp. 129-131
    • Monami, M.1    Colombi, C.2    Balzi, D.3
  • 117
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • Jiralerspong, S., S.L. Palla, S.H. Giordano, et al. 2009. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J. Clin. Oncol. 27: 3297-3302.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3297-3302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3
  • 118
    • 80053504259 scopus 로고    scopus 로고
    • Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients
    • [Epub ahead of Print].
    • He, X.X., S.M. Tu, M.H. Lee & S.C. Yeung. 2011. Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients. Ann. Oncol. [Epub ahead of Print]. doi:.
    • (2011) Ann. Oncol
    • He, X.X.1    Tu, S.M.2    Lee, M.H.3    Yeung, S.C.4
  • 119
    • 80052968453 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and medications for type 2 diabetes mellitus are associated with risk for and mortality from cancer in a German primary care cohort
    • Baur, D.M., J. Klotsche, O.P. Hamnvik, et al. 2010. Type 2 diabetes mellitus and medications for type 2 diabetes mellitus are associated with risk for and mortality from cancer in a German primary care cohort. Metabolism. 60: 1363-1371.
    • (2010) Metabolism , vol.60 , pp. 1363-1371
    • Baur, D.M.1    Klotsche, J.2    Hamnvik, O.P.3
  • 120
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
    • Hadad, S., T. Iwamoto, L. Jordan, et al. 2011. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res. Treat. 128: 783-794.
    • (2011) Breast Cancer Res. Treat , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3
  • 121
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El-Mir, M.Y., V. Nogueira, E. Fontaine, et al. 2000. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J. Biol. Chem. 275: 223-228.
    • (2000) J. Biol. Chem. , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3
  • 122
    • 58149354390 scopus 로고    scopus 로고
    • Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
    • Zhuang, Y. & W.K. Miskimins. 2008. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. J. Mol. Signal. 3: 18-28.
    • (2008) J. Mol. Signal. , vol.3 , pp. 18-28
    • Zhuang, Y.1    Miskimins, W.K.2
  • 123
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani, M., R. Dowling, I.G. Fantus, et al. 2006. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66: 10269-10273.
    • (2006) Cancer Res. , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3
  • 124
    • 47249088612 scopus 로고    scopus 로고
    • In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
    • Gotlieb, W.H., J. Saumet, M.C. Beauchamp, et al. 2008. In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecol. Oncol. 110: 246-250.
    • (2008) Gynecol. Oncol. , vol.110 , pp. 246-250
    • Gotlieb, W.H.1    Saumet, J.2    Beauchamp, M.C.3
  • 125
    • 79959764729 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
    • Ben Sahra, I., C. Regazzetti, G. Robert, et al. 2011. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res. 71: 4366-4372.
    • (2011) Cancer Res , vol.71 , pp. 4366-4372
    • Ben Sahra, I.1    Regazzetti, C.2    Robert, G.3
  • 126
    • 44849099894 scopus 로고    scopus 로고
    • The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
    • Ben Sahra, I., K. Laurent, A. Loubat, et al. 2008. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27: 3576-3586.
    • (2008) Oncogene , vol.27 , pp. 3576-3586
    • Ben Sahra, I.1    Laurent, K.2    Loubat, A.3
  • 127
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz, M., S. Hebrard, J. Leclerc, et al. 2010. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J. Clin. Invest. 120: 2355-2369.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hebrard, S.2    Leclerc, J.3
  • 128
    • 69249222515 scopus 로고    scopus 로고
    • Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism
    • Ota, S., K. Horigome, T. Ishii, et al. Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. Biochem. Biophys. Res. Commun. 388: 311-316.
    • Biochem. Biophys. Res. Commun. , vol.388 , pp. 311-316
    • Ota, S.1    Horigome, K.2    Ishii, T.3
  • 129
    • 77949493599 scopus 로고    scopus 로고
    • Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    • Caton, P.W., N.K. Nayuni, J. Kieswich, et al. 2010. Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J. Endocrinol. 205: 97-106.
    • (2010) J. Endocrinol. , vol.205 , pp. 97-106
    • Caton, P.W.1    Nayuni, N.K.2    Kieswich, J.3
  • 130
    • 77953589054 scopus 로고    scopus 로고
    • Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
    • Algire, C., L. Amrein, M. Zakikhani, et al. 2010. Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocr. Relat. Cancer 17: 351-360.
    • (2010) Endocr. Relat. Cancer , vol.17 , pp. 351-360
    • Algire, C.1    Amrein, L.2    Zakikhani, M.3
  • 131
    • 60549102941 scopus 로고    scopus 로고
    • Insulin-lowering effects of metformin in women with early breast cancer
    • Goodwin, P.J., K.I. Pritchard, M. Ennis, et al. 2008. Insulin-lowering effects of metformin in women with early breast cancer. Clin. Breast Cancer 8: 501-505.
    • (2008) Clin. Breast Cancer , vol.8 , pp. 501-505
    • Goodwin, P.J.1    Pritchard, K.I.2    Ennis, M.3
  • 132
    • 77955770568 scopus 로고    scopus 로고
    • Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
    • Zakikhani, M., M.J. Blouin, E. Piura & M.N. Pollak. 2010. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res. Treat. 123: 271-279.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 271-279
    • Zakikhani, M.1    Blouin, M.J.2    Piura, E.3    Pollak, M.N.4
  • 133
    • 69249162223 scopus 로고    scopus 로고
    • Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth
    • Kisfalvi, K., G. Eibl, J. Sinnett-Smith & E. Rozengurt. 2009. Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res. 69: 6539-6545.
    • (2009) Cancer Res. , vol.69 , pp. 6539-6545
    • Kisfalvi, K.1    Eibl, G.2    Sinnett-Smith, J.3    Rozengurt, E.4
  • 134
    • 77956150294 scopus 로고    scopus 로고
    • Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase
    • Brown, K.A., N.I. Hunger, M. Docanto & E.R. Simpson. 2010. Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast Cancer Res. Treat. 123: 591-596.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 591-596
    • Brown, K.A.1    Hunger, N.I.2    Docanto, M.3    Simpson, E.R.4
  • 135
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch, H.A., D. Iliopoulos, P.N. Tsichlis & K. Struhl. 2009. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 69: 7507-7511.
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 136
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos, D., H.A. Hirsch & K. Struhl. 2011. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 71: 3196-3201.
    • (2011) Cancer Res. , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 137
    • 77957005003 scopus 로고    scopus 로고
    • Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
    • Vazquez-Martin, A., C. Oliveras-Ferraros, S. Cufi, et al. 2010. Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status. Cell Cycle 9: 3807-3814.
    • (2010) Cell Cycle , vol.9 , pp. 3807-3814
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Cufi, S.3
  • 138
    • 79954460690 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
    • Vazquez-Martin, A., C. Oliveras-Ferraros, S. Del Barco, et al. 2011. The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells. Breast Cancer Res. Treat. 126: 355-364.
    • (2011) Breast Cancer Res. Treat. , vol.126 , pp. 355-364
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Del Barco, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.