Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

Gastroenterology

Volumn 142, Issue 7, 2012, Pages

  Din, Farhat V N ^a   Valanciute, Asta ^a   Houde, Vanessa P ^b   Zibrova, Daria ^b   Green, Kevin A ^b   Sakamoto, Kei ^b   Alessi, Dario R ^b   Dunlop, Malcolm G ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Chemoprevention; Colon Cancer; Oncogene; Tumor Suppressor

Indexed keywords

ACETYLSALICYLIC ACID; BIOLOGICAL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; NUCLEOTIDE; PHENFORMIN; PROTEIN KINASE B; PROTEIN S6; S6 KINASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL; CASE REPORT; COLORECTAL CANCER; CONTROLLED STUDY; DRUG DOSE ESCALATION; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FIBROBLAST; GENE SILENCING; HUMAN; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECTUM MUCOSA; SIGNAL TRANSDUCTION; TREATMENT DURATION;

EID: 84861648941     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.02.050     Document Type: Article

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