The caloric restriction paradigm: Implications for healthy human aging

American Journal of Human Biology

Volumn 24, Issue 2, 2012, Pages 101-106

  Anderson, Rozalyn M ^a,b   Weindruch, Richard ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL; ARTICLE; CALORIC INTAKE; CALORIC RESTRICTION; HUMAN; LONGEVITY; PHYSIOLOGY;

AGING; ANIMALS; CALORIC RESTRICTION; ENERGY INTAKE; HUMANS; LONGEVITY;

EID: 84863403169     PISSN: 10420533     EISSN: 15206300     Source Type: Journal    
DOI: 10.1002/ajhb.22243     Document Type: Article

References (66)

1. Anderson RM, Weindruch R. 2010. Metabolic reprogramming, caloric restriction and aging. Trends Endocrinol Metab 21: 134-141.
2. Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R. 2008a. Short-term consumption of a resveratrol-containing nutracuetical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol 43: 859-866.
3. Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. 2008b. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One 3: e2264.
4. Black A, Allison DB, Shapses SA, Tilmont EM, Handy AM, Ingram DK, Roth GS, Lane MA. 2001. Calorie restriction and skeletal mass in rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body size. J Gerontol A Biol Sci Med Sci 56: B98-B107.
5. Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC. 2003. Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci 58: 212-219.
6. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. 2009. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458: 1056-1060.
7. Cartwright MJ, Tchkonia T, Kirkland JL. 2007. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp Gerontol 42: 463-471.
8. Chan YC, Suzuki M, Yamamoto S. 1997. Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan. J Am Coll Nutr 16: 229-235.
9. Clement K, Langin D. 2007. Regulation of inflammation-related genes in human adipose tissue. J Intern Med 262: 422-430.
10. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
11. Colman RJ, Lane MA, Binkley N, Wegner FH, Kemnitz JW. 1999a. Skeletal effects of aging in male rhesus monkeys. Bone 24: 17-23.
12. Colman RJ, Ramsey JJ, Roecker EB, Havighurst T, Hudson JC, Kemnitz JW. 1999b. Body fat distribution with long-term dietary restriction in adult male rhesus macaques. J Gerontol A Biol Sci Med Sci 54: B283-B290.
13. Das M, Gabriely I, Barzilai N. 2004. Caloric restriction, body fat and ageing in experimental models. Obes Rev 5: 13-19.
14. De Lorenzo MS, Baljinnyam E, Vatner DE, Abarzua P, Vatner SF, Rabson AB. 2011. Caloric restriction reduces growth of mammary tumors and metastases. Carcinogenesis 32: 1381-1387.
15. de Magalhaes JP, Curado J, Church GM. 2009. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25: 875-881.
16. Eckel RH, Grundy SM, Zimmet PZ. 2005. The metabolic syndrome. Lancet 365: 1415-1428.
17. Edwards IJ, Rudel LL, Terry JG, Kemnitz JW, Weindruch R, Cefalu WT. 1998. Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans. J Gerontol A Biol Sci Med Sci 53: B443-B448.
18. Feige JN, Auwerx J. 2007. Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol 17: 292-301.
19. Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J. 2008. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8: 347-358.
20. Fontana L, Meyer TE, Klein S, Holloszy JO. 2004. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 101: 6659-6663.
21. Fontana L, Partridge L, Longo VD. 2010. Extending healthy life span-from yeast to humans. Science 328: 321-326.
22. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO. 2007. Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab 293: E197-E202.
23. Gresl TA, Colman RJ, Roecker EB, Havighurst TC, Huang Z, Allison DB, Bergman RN, Kemnitz JW. 2001. Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr. Am J Physiol Endocrinol Metab 281: E757-E765.
24. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
25. Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E;Pennington CALERIE Team. 2006. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 295: 1539-1548.
26. Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R. 2006. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr 136: 343-352.
27. Higami Y, Pugh TD, Page GP, Allison DB, Prolla TA, Weindruch R. 2004. Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. FASEB J 18: 415-417.
28. Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444: 860-867.
29. Jazwinski SM. 2000. Metabolic control and ageing. Trends Genet 16: 506-511.
30. Jiang W, Zhu Z, Thompson HJ. 2008. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res 68: 5492-5499.
31. Kagawa Y. 1978. Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians. Prev Med 7: 205-217.
32. Kemnitz JW, Roecker EB, Weindruch R, Elson DF, Baum ST, Bergman RN. 1994. Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol 266(4, Part 1): E540-E547.
33. Kennedy BK, Steffen KK, Kaeberlein M. 2007. Ruminations on dietary restriction and aging. Cell Mol Life Sci 64: 1323-1328.
34. Lago F, Dieguez C, Gomez-Reino J, Gualillo O. 2007. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev 18: 313-325.
35. Lane MA, Ball SS, Ingram DK, Cutler RG, Engel J, Read V, Roth GS. 1995. Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. Am J Physiol 268(5, Part 1): E941-E948.
36. Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA. 2002. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci USA 99: 14988-14993.
37. Lee CK, Klopp RG, Weindruch R, Prolla TA. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390-1393.
38. Lee CK, Weindruch R, Prolla TA. 2000. Gene-expression profile of the ageing brain in mice. Nat Genet 25: 294-297.
39. Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, Greenway FL, Williamson DA, Smith SR, Ravussin E. 2008. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis 203: 206-213.
40. Longo VD, Kennedy BK. 2006. Sirtuins in aging and age-related disease. Cell 126: 257-268.
41. Mattison JA, Roth GS, Lane MA, Ingram DK. 2007. Dietary restriction in aging nonhuman primates. Interdiscip Top Gerontol 35: 137-158.
42. McCay CM, Crowell MF, Maynard LA. 1935. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr 10: 63-79.
43. McKiernan SH, Colman RJ, Lopez M, Beasley TM, Aiken JM, Anderson RM, Weindruch R. 2011. Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle. Exp Gerontol 46: 23-29.
44. Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L. 2006. Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol 47: 398-402.
45. Nemoto S, Fergusson MM, Finkel T. 2005. SIRT1 functionally interacts with the metabolic regulator and transcriptional co-activator PGC-1[alpha]. J Biol Chem 280: 16456-16460.
46. Park SK, Prolla TA. 2005. Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Res Rev 4: 55-65.
47. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8: 157-168.
48. Putman CT, Kiricsi M, Pearcey J, MacLean IM, Bamford JA, Murdoch GK, Dixon WT, Pette D. 2003. AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions. J Physiol 551 (Part 1): 169-178.
49. Racette SB, Weiss EP, Villareal DT, Arif H, Steger-May K, Schechtman KB, Fontana L, Klein S, Holloszy JO. 2006. One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J Gerontol A Biol Sci Med Sci 61: 943-950.
50. Redman LM, Heilbronn LK, Martin CK, Alfonso A, Smith SR, Ravussin E. 2007. Effect of calorie restriction with or without exercise on body composition and fat distribution. J Clin Endocrinol Metab 92: 865-872.
51. Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P. 2008. Metabolic adaptations through the PGC-1α and SIRT1 pathways. FEBS Lett 582: 46-53.
52. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. 2005. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434: 113-118.
53. Roth GS, Ingram DK, Black A, Lane MA. 2000. Effects of reduced energy intake on the biology of aging: the primate model. Eur J Clin Nutr 54 (Suppl 3): S15-S20.
54. Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ. 2009. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326: 140-144.
55. Sinclair DA. 2005. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 126: 987-1002.
56. Suzuki M, Wilcox BJ, Wilcox CD. 2001. Implications from and for food cultures for cardiovascular disease: longevity. Asia Pac J Clin Nutr 10: 165-171.
57. Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P. 2011. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14: 612-622.
58. Weindruch R, Walford RL, Fligiel S, Guthrie D. 1986. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 116: 641-654.
59. Weindruch RH, Walford RL. 1988. The retardation of aging and disease by dietary restriction. Springfield, IL: Charles C. Thomas.
60. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO. 2006. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr 84: 1033-1042.
61. Wisse BE. 2004. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15: 2792-2800.
62. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. 1999. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic co-activator PGC-1. Cell 98: 115-124.
63. Wullschleger S, Loewith R, Hall MN. 2006. TOR signaling in growth and metabolism. Cell 124: 471-484.
64. Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I. 2010. FoxO1 is involved in the antineoplastic effect of calorie restriction. Aging Cell 9: 372-382.
65. Zahn JM, Poosala S, Owen AB, Ingram DK, Lustig A, Carter A, Weeraratna AT, Taub DD, Gorospe M, Mazan-Mamczarz K, Lakatta EG, Boheler KR, Xu X, Mattson MP, Falco G, Ko MS, Schlessinger D, Firman J, Kummerfeld SK, Wood WHIII, Zonderman AB, Kim SK, Becker KG. 2007. AGEMAP: a gene expression database for aging in mice. PLoS Genet 3: e201.
66. Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. 2002. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 99: 15983-15987.