Comparing adiposity profiles in three mouse models with altered GH signaling

Growth Hormone and IGF Research

Volumn 14, Issue 4, 2004, Pages 309-318

  Berryman, Darlene E ^a   List, Edward O ^a   Coschigano, Karen T ^a   Behar, Kevin ^b   Kim, Jason K ^b   Kopchick, John J ^a,c  

^a OHIO UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OHIO UNIVERSITY   (United States)

Author keywords

Adiponectin; Adiposity; Body composition; Bovine growth hormone transgenic; Growth hormone antagonist; Growth hormone receptor knockout; Leptin

Indexed keywords

ADIPONECTIN; GROWTH HORMONE; GROWTH HORMONE ANTIBODY; GROWTH HORMONE RECEPTOR; LEPTIN; RECOMBINANT GROWTH HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BODY COMPOSITION; BODY FAT; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; DWARFISM; FEMALE; FOOD INTAKE; GENE EXPRESSION; GROWTH HORMONE DEFICIENCY; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE INHIBITION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIPID METABOLISM; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; SUBCUTANEOUS FAT; WEIGHT GAIN;

EID: 3042815659     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ghir.2004.02.005     Document Type: Article

References (59)

1. Gianotti L. Broglio F. Ramunni J. Lanfranco F. Gauna C. Benso A. Zanello M. Arvat E. Ghigo E. The activity of GH/IGF-I axis in anorexia nervosa and in obesity: a comparison with normal subjects and patients with hypopituitarism or critical illness Eat Weight Disord. 3 1998 64-70
2. Salomon F. Cuneo R.C. Hesp R. Sonksen P.H. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency N. Engl. J. Med. 321 1989 1797-1803
3. De Boer H. Blok G.J. Voerman H.J. De Vries P.M. van der Veen E.A. Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis J. Clin. Endocrinol. Metab. 75 1992 833-837
4. Binnerts A. Deurenberg P. Swart G.R. Wilson J.H. Lamberts S.W. Body composition in growth hormone-deficient adults Am. J. Clin. Nutr. 55 1992 918-923
5. Bengtsson B.A. Brummer R.J. Eden S. Bosaeus I. Lindstedt G. Body composition in acromegaly: the effect of treatment Clin. Endocrinol. (Oxford) 31 1989 481-490
6. Yang S. Bjorntorp P. Liu X. Eden S. Growth hormone treatment of hypophysectomized rats increases catecholamine-induced lipolysis and the number of beta-adrenergic receptors in adipocytes: no differences in the effects of growth hormone on different fat depots Obes. Res. 4 1996 471-478
7. Gause I. Eden S. Hormonal regulation of growth hormone binding and responsiveness in adipose tissue and adipocytes of hypophysectomized rats J. Endocrinol. 105 1985 331-337
8. Hausman D.B. Hausman G.J. Martin R.J. Endocrine regulation of fetal adipose tissue metabolism in the pig: interaction of porcine growth hormone and thyroxine Obes. Res. 7 1999 76-82
9. Blackburn A. Schmitt A. Schmidt P. Wanke R. Hermanns W. Brem G. Wolf E. Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice Transgenic Res. 6 1997 213-222
10. Chen X.L. Lee K. Hartzell D.L. Dean R.G. Hausman G.J. McGraw R.A. Della-Fera M.A. Baile C.A. Adipocyte insensitivity to insulin in growth hormone-transgenic mice Biochem. Biophys. Res. Commun. 283 2001 933-937
11. Searle T.W. Murray J.D. Baker P.J. Effect of increased production of growth hormone on body composition in mice: transgenic versus control J. Endocrinol. 132 1992 285-291
12. Kaps M. Moura A.S. Safranski T.J. Lamberson W.R. Components of growth in mice hemizygous for a MT/bGH transgene J. Anim. Sci. 77 1999 1148-1154
13. Solomon M.B. Pursel V.G. Paroczay E.W. Bolt D.J. Lipid composition of carcass tissue from transgenic pigs expressing a bovine growth hormone gene J. Anim. Sci. 72 1994 1242-1246
14. Costa C. Solanes G. Visa J. Bosch F. Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus Faseb. J. 12 1998 1455-1460
15. Pursel V.G. Wall R.J. Solomon M.B. Bolt D.J. Murray J.E. Ward K.A. Transfer of an ovine metallothionein-ovine growth hormone fusion gene into swine J. Anim. Sci. 75 1997 2208-2214
16. Knapp J.R. Chen W.Y. Turner N.D. Byers F.M. Kopchick J.J. Growth patterns and body composition of transgenic mice expressing mutated bovine somatotropin genes J. Anim. Sci. 72 1994 2812-2819
17. Turner N.D. Knapp J.R. Byers F.M. Kopchick J.J. Expression of mutant bovine growth hormone genes in mice perturbs age- related nutrient utilization patterns J. Nutr. 128 1998 520-524
18. Donahue L.R. Beamer W.G. Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4 J. Endocrinol. 136 1993 91-104
19. Lall S. Tung L.Y. Ohlsson C. Jansson J.O. Dickson S.L. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues Biochem. Biophys. Res. Commun. 280 2001 132-138
20. Ng F.M. Jiang W.J. Gianello R. Pitt S. Roupas P. Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats J. Mol. Endocrinol. 25 2000 287-298
21. Heffernan M. Summers R.J. Thorburn A. Ogru E. Gianello R. Jiang W.J. Ng F.M. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice Endocrinology 142 2001 5182-5189
22. Coschigano K.T. Holland A.N. Riders M.E. List E.O. Flyvbjerg A. Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin and IGF-1 levels and increased lifespan Endocrinology 144 2003 3799-3810
23. Zhou Y. Xu B.C. Maheshwari H.G. He L. Reed M. Lozykowski M. Okada S. Cataldo L. Coschigano K. Wagner T.E. Baumann G. Kopchick J.J. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse) Proc. Natl. Acad. Sci. USA 94 1997 13215-13220
24. Coschigano K.T. Clemmons D. Bellush L.L. Kopchick J.J. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice Endocrinology 141 2000 2608-2613
25. Dominici F.P. Arostegui Diaz G. Bartke A. Kopchick J.J. Turyn D. Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice J. Endocrinol. 166 2000 579-590
26. Hauck S.J. Hunter W.S. Danilovich N. Kopchick J.J. Bartke A. Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse Exp. Biol. Med. (Maywood) 226 2001 552 558
27. Chen W.Y. White M.E. Wagner T.E. Kopchick J.J. Functional antagonism between endogenous mouse growth hormone (GH) and a GH analog results in dwarf transgenic mice Endocrinology 129 1991 1402-1408
28. Chen W.Y. Chen N. Yun J. Wagner T.E. Kopchick J.J. In vitro and in vivo studies of the antagonistic effects of human growth hormone analogs J. Biol. Chem. 269 1994 15892-15897
29. Balbis A. Dellacha J.M. Calandra R.S. Bartke A. Turyn D. Down regulation of masked and unmasked insulin receptors in the liver of transgenic mice expressing bovine growth hormone gene Life Sci. 51 1992 771-778
30. McGrane M.M. de Vente J. Yun J. Bloom J. Park E. Wynshaw-Boris A. Wagner T. Rottman F.M. Hanson R.W. Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice J. Biol. Chem. 263 1988 11443-11451
31. Considine R.V. Sinha M.K. Heiman M.L. Kriauciunas A. Stephens T.W. Nyce M.R. Ohannesian J.P. Marco C.C. McKee L.J. Bauer T.L. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans N. Engl. J. Med. 334 1996 292-295
32. Frederich R.C. Hamann A. Anderson S. Lollmann B. Lowell B.B. Flier J.S. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action Nat. Med. 1 1995 1311-1314
33. Maffei M. Fei H. Lee G.H. Dani C. Leroy P. Zhang Y. Proenca R. Negrel R. Ailhaud G. Friedman J.M. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus Proc. Natl. Acad. Sci. USA 92 1995 6957-6960
34. Hu E. Liang P. Spiegelman B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity J. Biol. Chem. 271 1996 10697-10703
35. Yamauchi T. Kamon J. Waki H. Terauchi Y. Kubota N. Hara K. Mori Y. Ide T. Murakami K. Tsuboyama-Kasaoka N. Ezaki O. Akanuma Y. Gavrilova O. Vinson C. Reitman M.L. Kagechika H. Shudo K. Yoda M. Nakano Y. Tobe K. Nagai R. Kimura S. Tomita M. Froguel P. Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nat. Med. 7 2001 941-946
36. Arita Y. Kihara S. Ouchi N. Takahashi M. Maeda K. Miyagawa J. Hotta K. Shimomura I. Nakamura T. Miyaoka K. Kuriyama H. Nishida M. Yamashita S. Okubo K. Matsubara K. Muraguchi M. Ohmoto Y. Funahashi T. Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem. Biophys. Res. Commun. 257 1999 79-83
37. Nam S.Y. Lobie P.E. The mechanism of effect of growth hormone on preadipocyte and adipocyte function Obes. Rev. 1 2000 73-86
38. Li Y. Knapp J.R. Kopchick J.J. Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice Exp. Biol. Med. (Maywood) 228 2003 207-215
39. Flint D.J. Gardner M.J. Influence of growth hormone deficiency on growth and body composition in rats: site-specific effects upon adipose tissue development J. Endocrinol. 137 1993 203-211
40. Kadim I.T. McCutcheon S.N. Purchas R.W. Wickham G.A. Manipulation of adult body composition by treatment of the neonatal rat with growth hormone and prolactin Growth Regul. 6 1996 201-205
41. Bengtsson B.A. Eden S. Lonn L. Kvist H. Stokland A. Lindstedt G. Bosaeus I. Tolli J. Sjostrom L. Isaksson O.G. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH J. Clin. Endocrinol. Metab. 76 1993 309-317
42. Roemmich J.N. Rogol A.D. Hormonal changes during puberty and their relationship to fat distribution Am. J. Human Biol. 11 1999 209-224
43. Johannsson G. Marin P. Lonn L. Ottosson M. Stenlof K. Bjorntorp P. Sjostrom L. Bengtsson B.A. Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure J. Clin. Endocrinol. Metab. 82 1997 727-734
44. Pomp D. Oberbauer A.M. Murray J.D. Development of obesity following inactivation of a growth hormone transgene in mice Transgenic Res. 5 1996 13-23
45. Oberbauer A.M. Stern J.S. Johnson P.R. Horwitz B.A. German J.B. Phinney S.D. Beermann D.H. Pomp D. Murray J.D. Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype Growth Dev. Aging 61 1997 169-179
46. Laron Z. Klinger B. Body fat in Laron syndrome patients: effect of insulin-like growth factor I treatment Horm. Res. 40 1993 16-22
47. Moura A.S. Spiers D.E. Lamberson W.R. Thermogenic activity of growth hormone transgenic mice Growth Dev. Aging 62 1998 149-159
48. Weyer C. Funahashi T. Tanaka S. Hotta K. Matsuzawa Y. Pratley R.E. Tataranni P.A. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia J. Clin. Endocrinol. Metab. 86 2001 1930-1935
49. Yang W.S. Lee W.J. Funahashi T. Tanaka S. Matsuzawa Y. Chao C.L. Chen C.L. Tai T.Y. Chuang L.M. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin J. Clin. Endocrinol. Metab. 86 2001 3815-3819
50. Berg A.H. Combs T.P. Du X. Brownlee M. Scherer P.E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat. Med. 7 2001 947-953
51. Tschritter O. Fritsche A. Thamer C. Haap M. Shirkavand F. Rahe S. Staiger H. Maerker E. Haring H. Stumvoll M. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism Diabetes 52 2003 239-243
52. T. Higashimori, H.-J. Kim, K.T. Coschigano, S.-Y. Park, H. Choi, J.J. Kopchick, G.I. Shulman, and J.K. Kim, American Diabetes Association 63rd Scientific Sessions, 2003 (Abstract), New Orleans, LA, p.2337-PO
53. Silha J.V. Krsek M. Hana V. Marek J. Jezkova J. Weiss V. Murphy L.J. Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance Clin. Endocrinol. (Oxford) 58 2003 736-742
54. Trayhurn P. Thomas M.E. Duncan J.S. Rayner D.V. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (oblob) mice FEBS Lett. 368 1995 488-490
55. Isozaki O. Tsushima T. Miyakawa M. Nozoe Y. Demura H. Seki H. Growth hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats J. Endocrinol. 161 1999 511-516
56. Rauch F. Westermann F. Englaro P. Blum W.F. Schonau E. Serum leptin is suppressed by growth hormone therapy in growth hormone-deficient children Horm. Res. 50 1998 18-21
57. Saad M.F. Khan A. Sharma A. Michael R. Riad-Gabriel M.G. Boyadjian R. Jinagouda S.D. Steil G.M. Kamdar V. Physiological insulinemia acutely modulates plasma leptin Diabetes 47 1998 544-549
58. Saladin R. De Vos P. Guerre-Millo M. Leturque A. Girard J. Staels B. Auwerx J. Transient increase in obese gene expression after food intake or insulin administration Nature 377 1995 527-529
59. Havel P.J. Leptin production and action: relevance to energy balance in humans Am. J. Clin. Nutr. 67 1998 355-356