Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 4, 2012, Pages

  Steinbaugh, Michael J ^a   Sun, Liou Y ^b,c   Bartke, Andrzej ^d   Miller, Richard A ^a,b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caloric restriction; Crowded litter; Nrf2; Rapamycin

Indexed keywords

(S) 2 HYDROXY ACID OXIDASE; CYTOCHROME P450; MESSENGER RNA; METALLOTHIONEIN; QUERCETIN; RAPAMYCIN; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2; UNSPECIFIC MONOOXYGENASE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DETOXIFICATION; DIET RESTRICTION; DIET THERAPY; ENZYME ACTIVATION; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; LIFE EXTENSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA ISOLATION; TREATMENT DURATION; XENOBIOTIC METABOLISM; XENOBIOTIC METABOLIZING ENZYME GENE;

ANIMALS; ANTIOXIDANTS; CALORIC RESTRICTION; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FLAVINS; GENE EXPRESSION REGULATION; HYDROQUINONES; LIVER; LONGEVITY; MALE; METALLOTHIONEIN; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES; SIROLIMUS; UP-REGULATION; XENOBIOTICS;

EID: 84865108931     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00110.2012     Document Type: Article

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