Direct bioanalytical sample injection with 2D LC-MS

Bioanalysis

Volumn 4, Issue 22, 2012, Pages 2737-2756

  Cassiano, Nm ^a   Barreiro, Jc ^a   Oliveira, Rv ^a   Cass, Qb ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; 4,4' ISOPROPYLIDENEDIPHENOL; ABACAVIR; AMITRIPTYLINE; ANTIBIOTIC AGENT; BUSULFAN; CIPROFLOXACIN; CYCLOPHOSPHAMIDE; DESIPRAMINE; DICLOFENAC; ENROFLOXACIN; ESTROGEN; EVEROLIMUS; IMIPRAMINE; INDINAVIR; MK 0752; NEVIRAPINE; NORMETADRENALIN; NORTRIPTYLINE; PHENOL DERIVATIVE; RAPAMYCIN; RIFAXIMIN; ROFECOXIB; SERTRALINE; SITAGLIPTIN; TELCAGEPANT; TESTOSTERONE; TRICLOCARBAN; TRICLOSAN; UNINDEXED DRUG;

BIOASSAY; CATION EXCHANGE; CHROMATOGRAPHY; EXTRACTION; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; ONLINE SYSTEM; PROTEOMICS; REVIEW; SOLID PHASE MICROEXTRACTION;

ANIMALS; CHROMATOGRAPHY, LIQUID; EQUIPMENT DESIGN; HUMANS; MASS SPECTROMETRY; PROTEOME; PROTEOMICS;

EID: 84870482160     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.226     Document Type: Review

References (178)

1. Cox J, Mann M. Quantitative, high-resolution proteomics for data-driven systems biology. Annu. Rev. Biochem. 80, 273-299 (2011).
2. Tomas R, Kleparnik K, Foret F. Multidimensional liquid phase separations for mass spectrometry. J. Sep. Sci. 31(11), 1964-1979 (2008). (Pubitemid 352003181)
3. Shushan B. A review of clinical diagnostic applications of liquid chromatography- tandem mass spectrometry. Mass Spectrom. Rev. 29(6), 930-944 (2010).
4. Xu RN, Fan L, Rieser MJ, El-Shourbagy TA. Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS. J. Pharm. Biomed. Anal. 44(2), 342-355 (2007). (Pubitemid 46880094)
5. Schoenmakers P, Marriott P, Beens J. Nomenclature and conventions in comprehensive multidimensional chromatography. LC GC Eur. 16(6), 335-339 (2003). (Pubitemid 38553051)
6. Hogendoorn E, van Zoonen P, Hernandez F. The versatility of coupled-column LC. LC GC Eur. 16(12A), 44-51 (2003).
7. Snyder LR, Dolan JW, Carr PW. The hydrophobic-subtraction model of reversed-phase column selectivity. J. Chromatogr. A 1060(1-2), 77-116 (2004). (Pubitemid 39573277)
8. Marchand DH, Snyder LR, Dolan JW. Characterization and applications of reversed-phase column selectivity based on the hydrophobic-subtraction model. J. Chromatogr. A 1191(1-2), 2-20 (2008). (Pubitemid 351635751)
9. Marchand DH, Croes K, Dolan JW, Snyder LR. Column selectivity in reversed-phase liquid chromatography. VII. Cyanopropyl columns. J. Chromatogr. A 1062(1), 57-64 (2005). (Pubitemid 39647557)
10. Marchand DH, Snyder LR. Anion-exchange behavior of several alkylsilica reversed-phase columns. J. Chromatogr. A 1209(1-2), 104-110 (2008).
11. Marchand DH, Carr PW, McCalley DV, Neue UD, Dolan JW, Snyder LR. Contributions to reversed-phase column selectivity. II. Cation exchange. J. Chromatogr. A 1218(40), 7110-7129 (2011).
12. Carr PW, Dolan JW, Neue UD, Snyder LR. Contributions to reversed-phase column selectivity. I. Steric interaction. J. Chromatogr. A 1218(13), 1724-1742 (2011).
13. Dolan JW, Snyder LR. Selecting an "orthogonal" column during high-performance liquid chromatographic method development for samples that may contain non-ionized solutes. J. Chromatogr. A 1216(16), 3467-3472 (2009).
14. Zhang Y, Carr PW. A visual approach to stationary phase selectivity classification based on the Snyder-Dolan hydrophobic- subtraction model. J. Chromatogr. A 1216(39), 6685-6694 (2009).
15. Snyder LR, Carr PW, Dolan JW, Majors RE. New horizons in reversed-phase chromatography selectivity. LC GC Eur. 23(6), 314-326 (2010).
16. Simpkins SW, Bedard JW, Groskreutz SR, Swenson MM, Liskutin TE, Stoll DR. Targeted three-dimensional liquid chromatography: a versatile tool for quantitative trace analysis in complex matrices. J. Chromatogr. A 1217(49), 7648-7660 (2010).
17. Dinh NP, Jonsson T, Irgum K. Probing the interaction mode in hydrophilic interaction chromatography. J. Chromatogr. A 1218(35), 5880-5891 (2011).
18. Pellett J, Lukulay P, Mao Y et al. "Orthogonal" separations for reversed-phase liquid chromatography. J. Chromatogr. A 1101(1-2), 122-135 (2006). (Pubitemid 41785543)
19. Stoll DR, Li XP, Wang XO, Carr PW, Porter SEG, Rutan SC. Fast, comprehensive two-dimensional liquid chromatography. J. Chromatogr. A 1168(1-2), 3-43 (2007). (Pubitemid 47488336)
20. Al Bakain R, Rivals I, Sassiat P et al. Comparison of different statistical approaches to evaluate the orthogonality of chromatographic separations: application to reverse phase systems. J. Chromatogr. A 1218(20), 2963-2975 (2011).
21. Gilar M, Olivova P, Daly AE, Gebler JC. Orthogonality of separation in two-dimensional liquid chromatography. Anal. Chem. 77(19), 6426-6434 (2005). (Pubitemid 41436983)
22. Blumberg L, Klee MS. A critical look at the definition of multidimensional separations. J. Chromatogr. A 1217(1), 99-103 (2010).
23. Malerod H, Lundanes E, Greibrokk T. Recent advances in on-line multidimensional liquid chromatography. Anal. Methods 2(2), 110-122 (2010).
24. Cassiano NM, Lima VV, Oliveira RV, de Pietro AC, Cass QB. Development of restricted-access media supports and their application to the direct analysis of biological fluid samples via high-performance liquid chromatography. Anal. Bioanal. Chem. 384(7-8), 1462-1469 (2006).
25. Cassiano NM, Barreiro JC, Moraes MC, Oliveira RV, Cass QB. Restricted access media supports for direct high-throughput analysis of biological fluid samples: review of recent applications. Bioanalysis 1(3), 577-594 (2009).
26. Jandera P. Stationary phases for hydrophilic interaction chromatography, their characterization and implementation into multidimensional chromatography concepts. J. Sep. Sci. 31(9), 1421-1437 (2008). (Pubitemid 351890771)
27. Unger KK, Ditz R, Machtejevas E, Skudas R. Liquid chromatography - Its development and key role in life science applications. Angew. Chem. Int. Ed. Engl. 49(13), 2300-2312 (2010).
28. Sadilek P, Satinsky D, Solich P. Using restricted-access materials and column switching in high-performance liquid chromatography for direct analysis of biologically-active compounds in complex matrices. Trends Analyt. Chem. 26(5), 375-384 (2007). (Pubitemid 46694007)
29. Cass QB, Gomes RF, Calafatti SA, Pedrazolli J. Determination of amoxycillin in human plasma by direct injection and coupled-column high-performance liquid chromatography. J. Chromatogr. A 987(1-2), 235-241 (2003). (Pubitemid 36140100)
30. Rogatsky E, Braaten K, Cruikshank G, Jayatillake H, Zheng B, Stein DT. Flow inconsistency: the evil twin of column switching-hardware aspects. J. Chromatogr. A 1216(45), 7721-7727 (2009).
31. Yu Z, Westerlund D. Influence of mobile phase conditions on the clean-up effect of restricted-access media precolumns for plasma samples injected in a column-switching system. Chromatographia 44(11-12), 589-594 (1997). (Pubitemid 27277934)
32. Cassiano NM, Barreiro JC, Martins LRR, Oliveira RV, Cass QB. Chromatographic methods validation for analysis of small molecules in biological matrices. Quim. Nova 32(4), 1021-1030 (2009).
33. Kuklenyik Z, Calafat AM, Barr JR, Pirkle JL. Design of online solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) hyphenated systems for quantitative analysis of small organic compounds in biological matrices. J. Sep. Sci. 34(24), 3606-3618 (2011).
34. Committee for Medicinal Products for Human Use, European Medicines Agency. Guideline on Bioanalytical Method Validation. London, UK (2011).
35. Gomes RF, Cassiano NM, Pedrazzoli J, Cass QB. Two-dimensional chromatography method applied to the enantiomeric determination of lansoprazole in human plasma by direct sample injection. Chirality 22(1), 35-41 (2010).
36. Guiochon G, Marchetti N, Mriziq K, Shalliker R A. Implementations of two-dimensional liquid chromatography. J. Chromatogr. A 1189(1-2), 109-168 (2008).
37. Potts LW, Carr PW. Approximate and exact equations for peak capacity in isocratic high-pressure liquid chromatography. Anal. Chem. 83(20), 7614-7615 (2011).
38. Stoll DR, Wang XL, Carr PW. Comparison of the practical resolving power of one- and two-dimensional high-performance liquid chromatography analysis of metabolomic samples. Anal. Chem. 80(1), 268-278 (2008). (Pubitemid 351448431)
39. Li XP, Stoll DR, Carr PW. Equation for peak capacity estimation in two-dimensional liquid chromatography. Anal. Chem. 81(2), 845-850 (2009).
40. Stoll DR. Guidelines for bioanalytical 2D chromatography method development and implementation. Bioanalysis 2(1), 105-122 (2010).
41. Gu HW, Huang Y, Filgueira M, Carr PW. Effect of first dimension phase selectivity in online comprehensive two dimensional liquid chromatography (LC × LC). J. Chromatogr. A 1218(38), 6675-6687 (2011).
42. Donato P, Cacciola F, Sommella E et al. Online comprehensive RPLC × RPLC with mass spectrometry detection for the analysis of proteome samples. Anal. Chem. 83(7), 2485-2491 (2011).
43. Stoll DR. Recent progress in online, comprehensive two-dimensional high-performance liquid chromatography for non-proteomic applications. Anal. Bioanal. Chem. 397(3), 979-986 (2010).
44. Cao LW, Yu DH, Wang XL, Ke YX, Jin Y, Liang XM. The development of an evaluation method for capture columns used in two-dimensional liquid chromatography. Anal. Chim. Acta 706(1), 184-190 (2011).
45. Potts LW, Stoll DR, Li XP, Carr PW. The impact of sampling time on peak capacity and analysis speed in on-line comprehensive two-dimensional liquid chromatography. J. Chromatogr. A 1217(36), 5700-5709 (2010).
46. Cacciola F, Delmonte P, Jaworska K, Dugo P, Mondello L, Rader JI. Employing ultra high pressure liquid chromatography as the second dimension in a comprehensive two-dimensional system for analysis of Stevia rebaudiana extracts. J. Chromatogr. A 1218(15), 2012-2018 (2011).
47. Cacciola F, Jandera P, Mondello L. Temperature effects on separation on zirconia columns: Applications to one- and two-dimensional LC separations of phenolic antioxidants. J. Sep. Sci. 30(4), 462-474 (2007). (Pubitemid 46510560)
48. Stoll DR, Cohen JD, Carr PW. Fast, comprehensive online two-dimensional high performance liquid chromatography through the use of high temperature ultra-fast gradient elution reversed-phase liquid chromatography. J. Chromatogr. A 1122(1-2), 123-137 (2006). (Pubitemid 44041369)
49. Russo M, Cacciola F, Bonaccorsi I, Dugo P, Mondello L. Determination of flavanones in Citrus juices by means of one- and two-dimensional liquid chromatography. J. Sep. Sci. 34(6), 681-687 (2011).
50. Alexander AJ, Ma LJ. Comprehensive two-dimensional liquid chromatography separations of pharmaceutical samples using dual fused-core columns in the 2nd dimension. J. Chromatogr. A 1216(9), 1338-1345 (2009).
51. Tanaka N, Kimura H, Tokuda D et al. Simple and comprehensive two-dimensional reversed-phase HPLC using monolithic silica columns. Anal. Chem. 76(5), 1273-1281 (2004). (Pubitemid 38280473)
52. Kimura H, Tanigawa T, Morisaka H et al. Simple 2D-HPLC using a monolithic silica column for peptide separation. J. Sep. Sci. 27(10-11), 897-904 (2004). (Pubitemid 39136475)
53. Donato P, Cacciola F, Mondello L, Dugo P. Comprehensive chromatographic separations in proteomics. J. Chromatogr. A 1218(49), 8777-8790 (2011).
54. Mondello L, Donato P, Cacciola F, Fanali C, Dugo P. RP-LC × RP-LC analysis of a tryptic digest using a combination of totally porous and partially porous stationary phases. J. Sep. Sci. 33(10), 1454-1461 (2010).
55. Cacciola F, Jandera P, Hajdu Z, Cesla P, Mondello L. Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. J. Chromatogr. A 1149(1), 73-87 (2007). (Pubitemid 46627630)
56. Jandera P, Hajek T, Cesla P. Effects of the gradient profile, sample volume and solvent on the separation in very fast gradients, with special attention to the second-dimension gradient in comprehensive two-dimensional liquid chromatography. J. Chromatogr. A 1218(15), 1995-2006 (2011).
57. Liu A, Tweed J, Wujcik CE. Investigation of an on-line two-dimensional chromatographic approach for peptide analysis in plasma by LC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(20-21), 1873-1881 (2009).
58. Blahova E, Jandera P, Cacciola F, Mondello L. Two-dimensional and serial column reversed-phase separation of phenolic antioxidants on octadecyl-, polyethyleneglycol-, and pentafluorophenylpropyl-silica columns. J. Sep. Sci. 29(4), 555-566 (2006).
59. Bedani F, Kok WT, Janssen HG. A theoretical basis for parameter selection and instrument design in comprehensive size-exclusion chromatography × liquid chromatography. J. Chromatogr. A 1133(1-2), 126-134 (2006). (Pubitemid 44604375)
60. Sommella E, Cacciola F, Donato P, Dugo P, Campiglia P, Mondello L. Development of an online capillary comprehensive 2D-LC system for the analysis of proteome samples. J. Sep. Sci. 35(4), 530-533 (2012).
61. Kong RPW, Siu SO, Lee SSM, Lo C, Chu IK. Development of online high-/low-pH reversed-phase-reversed-phase two-dimensional liquid chromatography for shotgun proteomics: a reversed-phase-strong cation exchange-reversed-phase approach. J. Chromatogr. A 1218(23), 3681-3688 (2011).
62. Temporini C, Dolcini L, Abee A et al. Development of an integrated chromatographic system for on-line digestion and characterization of phosphorylated proteins. J. Chromatogr. A 1183(1-2), 65-75 (2008).
63. Millea KA, Kass IJ, Cohen SA, Krull IS, Gebler JC, Berger SJ. Evaluation of multidimensional (ion-exchange/reversed-phase) protein separations using linear and step gradients in the first dimension. J. Chromatogr. A 1079(1-2), 287-298 (2005). (Pubitemid 40813210)
64. Kajdan T, Cortes H, Kuppannan K, Young SA. Development of a comprehensive multidimensional liquid chromatography system with tandem mass spectrometry detection for detailed characterization of recombinant proteins. J. Chromatogr. A 1189(1-2), 183-195 (2008).
65. Mihailova A, Malerod H, Wilson SR et al. Improving the resolution of neuropeptides in rat brain with on-line HILIC-RP compared with on-line SCX-RP. J. Sep. Sci. 31(3), 459-467 (2008). (Pubitemid 351351178)
66. Francois I, Sandra K, Sandra P. Comprehensive liquid chromatography: fundamental aspects and practical considerations - a review. Anal. Chim. Acta 641(1-2), 14-31 (2009).
67. Zhang JA, Lanham KA, Peterson RE, Heideman W, Li LJ. Characterization of the adult zebrafish cardiac proteome using online pH gradient strong cation exchange-RP 2D LC coupled with ESI MS/MS. J. Sep. Sci. 33(10), 1462-1471 (2010).
68. Hu L, Boos K-S, Ye M, Wu RA, Zou H. Selective on-line serum peptide extraction and multidimensional separation by coupling a restricted-access material-based capillary trap column with nanoliquid chromatography- tandem mass spectrometry. J. Chromatogr. A 1216(28), 5377-5384 (2009).
69. Francois I, Cabooter D, Sandra K, Lynen F, Desmet G, Sandra P. Tryptic digest analysis by comprehensive reversed phase x two reversed phase liquid chromatography (RP-LC × 2RP-LC) at different pH's. J. Sep. Sci. 32(8), 1137-1144 (2009).
70. Siu SO, Lam MPY, Lau E, Kong RPW, Lee SMY, Chu IK. Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics. Proteomics 11(11), 2308-2319 (2011).
71. Lam MPY, Lau E, Siu SO et al. Online combination of reversed-phase/ reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples. Electrophoresis 32(21), 2930-2940 (2011).
72. Zhou F, Cardoza JD, Ficarro SB, Adelmant GO, Lazaro JB, Marto JA. Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage. J. Proteome Res. 9(12), 6242-6255 (2010).
73. Zhou F, Sikorski TW, Ficarro SB, Webber JT, Marto JA. Online nanoflow reversed phase-strong anion exchange-reversed phase liquid chromatography-tandem mass spectrometry platform for efficient and in-depth proteome sequence analysis of complex organisms. Anal. Chem. 83(18), 6996-7005 (2011).
74. Temporini C, Calleri E, Cabrera K, Felix G, Massolini G. On-line multi-enzymatic approach for improved sequence coverage in protein analysis. J. Sep. Sci. 32(8), 1120-1128 (2009).
75. Julka S, Folkenroth J, Young SA. Two dimensional liquid chromatography- ultraviolet/mass spectrometric (2D LC-UV/MS) analyses for quantitation of intact proteins in complex biological matrices. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879(22), 2057-2063 (2011).
76. Tran BQ, Loftheim H, Reubsaet L, Lundanes E, Greibrokk T. On-line multitasking analytical proteomics: how to separate, reduce, alkylate and digest whole proteins in an on-line multidimensional chromatography system coupled to MS. J. Sep. Sci. 31(16-17), 2913-2923 (2008).
77. Tran BQ, Pepaj M, Lundanes E, Greibrokk T. On-line method for identification of native proteins using pH-gradient SAX chromatography and reversed phase chromatography-mass spectrometry of tryptic peptides. J. Liq. Chromatogr. Relat. Technol. 31(10), 1387-1411 (2008). (Pubitemid 351574465)
78. Sobhi HR, Vatansever B, Wortmann A, Grouzmann E, Rochat B. Generic approach for the sensitive absolute quantification of large undigested peptides in plasma using a particular liquid chromatography-mass spectrometry setup. J. Chromatogr. A 1218(47), 8536-8543 (2011).
79. Groskreutz SR, Swenson MM, Secor LB, Stoll DR. Selective comprehensive multi-dimensional separation for resolution enhancement in high performance liquid chromatography. Part I: principles and instrumentation. J. Chromatogr. A 1228, 31-40 (2012).
80. Groskreutz SR, Swenson MM, Secor LB, Stoll DR. Selective comprehensive multidimensional separation for resolution enhancement in high performance liquid chromatography. Part II: applications. J. Chromatogr. A 1228, 41-50 (2012).
81. Souverain S, Rudaz S, Veuthey JL. Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 801(2), 141-156 (2004). (Pubitemid 38130063)
82. Kataoka H, Saito K. Recent advances in column switching sample preparation in bioanalysis. Bioanalysis 4(7), 809-832 (2012).
83. Moura F, de Almeida FG, Lopes BR, Cass QB. Quantification of ampicilin in bovine milk by coupled-column ultrahigh-performance liquid chromatography- tandem mass spectrometry. J. Sep. Sci. 35(19), 2615-2620 (2012).
84. Santos-Neto AJ, Bergquist J, Lancas FM, Sjoberg PJR. Simultaneous analysis of five antidepressant drugs using direct injection of biofluids in a capillary restricted-access media-liquid chromatography-tandem mass spectrometry system. J. Chromatogr. A 1189(1-2), 514-522 (2008).
85. Buszewski B, Noga S. Hydrophilic interaction liquid chromatography (HILIC) - a powerful separation technique. Anal. Bioanal. Chem. 402(1), 231-247 (2012).
86. Rodriguez-Gonzalo E, Garcia-Gomez D, Carabias-Martinez R. Development and validation of a hydrophilic interaction chromatography-tandem mass spectrometry method with on-line polar extraction for the analysis of urinary nucleosides. Potential application in clinical diagnosis. J. Chromatogr. A 1218(50), 9055-9063 (2011).
87. Novakova L, Vlckova H. A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation. Anal. Chim. Acta 656(1-2), 8-35 (2009).
88. Rudewicz PJ. Turbulent flow bioanalysis in drug metabolism and pharmacokinetics. Bioanalysis 3(14), 1663-1671 (2011).
89. Nunez O, Gallart-Ayala H, Martins CPB, Lucci P. New trends in fast liquid chromatography for food and environmental analysis. J. Chromatogr. A 1228, 298-323 (2012).
90. Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal. Bioanal. Chem. 400(5), 1359-1366 (2011).
91. Schebb NH, Inceoglu B, Rose T, Wagner K, Hammock BD. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography- electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Anal. Methods 3(2), 420-428 (2011).
92. Mueller DM, Rentsch KM. Sensitive quantification of sirolimus and everolimus by LC-MS/MS with online sample cleanup. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(13-14), 1007-1012 (2010).
93. Xin GZ, Zhou JL, Qi LW et al. Turbulent-flow chromatography coupled on-line to fast high-performance liquid chromatography and mass spectrometry for simultaneous determination of verticine, verticinone and isoverticine in rat plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(3-4), 435-441 (2010).
94. Kataoka H, Saito K. Recent advances in SPME techniques in biomedical analysis. J. Pharm. Biomed. Anal. 54(5), 926-950 (2011).
95. Moliner-Martinez Y, Molins-Legua C, Verdu- Andres J, Herraez-Hernandez R, Campins- Falco P. Advantages of monolithic over particulate columns for multiresidue analysis of organic pollutants by in-tube solid-phase microextraction coupled to capillary liquid chromatography. J. Chromatogr. A 1218(37), 6256-6262 (2011).
96. Saito K, Yagi K, Ishizaki A, Kataoka H. Determination of anabolic steroids in human urine by automated in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 52(5), 727-733 (2010).
97. Kataoka H, Inoue R, Yagi K, Saito K. Determination of nicotine, cotinine, and related alkaloids in human urine and saliva by automated in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 49(1), 108-114 (2009).
98. Kumazawa T, Saeki K, Yanagisawa I et al. Automated on-line in-tube solid-phase microextraction coupled with HPLC-MS/MS for the determination of butyrophenone derivatives in human plasma. Anal. Bioanal. Chem. 394(4), 1161-1170 (2009).
99. He JG, Liu Z, Ren LB et al. On-line coupling of in-tube boronate affinity solid phase microextraction with high performance liquid chromatography- electrospray ionization tandem mass spectrometry for the determination of cis-diol biomolecules. Talanta 82(1), 270-276 (2010).
100. Zheng MM, Wang ST, Hu WK, Feng YQ. In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma. J. Chromatogr. A 1217(48), 7493-7501 (2010).
101. Zheng MM, Ruan GD, Feng YQ. Evaluating polymer monolith in-tube solid-phase microextraction coupled to liquid chromatography-quadrupole time-of-flight mass spectrometry for reliable quantification and confirmation of quinolone antibacterials in edible animal food. J. Chromatogr. A 1216(44), 7510-7519 (2009).
102. The Commission of the European Communities. Commission Decision 2002/657/ EC of 12 August 2002 Implementing Council Directive 96/23/EC Concerning the Performance of Analytical Methods and the Interpretation of Results. Official Journal of the European Communities, Luxembourg City, Luxembourg (2002).
103. Zheng MM, Zhang MY, Feng YQ. Polymer monolith microextraction online coupled to hydrophilic interaction chromatography-mass spectrometry for analysis of beta(2)-agonist in human urine. J. Sep. Sci. 32(11), 1965-1974 (2009).
104. Shah KA, Peoples MC, Halquist MS, Rutan SC, Karnes HT. Microfluidic direct injection method for analysis of urinary 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanol (NNAL) using molecularly imprinted polymers coupled on-line with LC-MS/MS. J. Pharm. Biomed. Anal. 54(2), 368-378 (2011).
105. Motoyama A, Yates Jr. Multidimensional LC separations in shotgun proteomics. Anal. Chem. 80(19), 7187-7193 (2008).
106. Sandra K, Moshir M, D'hondt F et al. Highly efficient peptide separations in proteomics: part 2: bi- and multidimensional liquid-based separation techniques. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(11-12), 1019-1039 (2009).
107. Dugo P, Cacciola F, Kumm T, Dugo G, Mondello L. Comprehensive multidimensional liquid chromatography: theory and applications. J. Chromatogr. A 1184(1-2), 353-368 (2008). (Pubitemid 351296208)
108. Pol J, Hyotylainen T. Comprehensive two-dimensional liquid chromatography coupled with mass spectrometry. Anal. Bioanal. Chem. 391(1), 21-31 (2008).
109. Horvatovich P, Hoekman B, Govorukhina N, Bischoff R. Multidimensional chromatography coupled to mass spectrometry in analysing complex proteomics samples. J. Sep. Sci. 33(10), 1421-1437 (2010).
110. Cho W, Jung K, Regnier FE. Screening antibody and immunosorbent selectivity by two-dimensional liquid chromatography- MS/MS (2D LC-MS/MS). J. Sep. Sci. 33(10), 1438-1447 (2010).
111. Lasaosa M, Delmotte N, Huber CG, Melchior K, Heinzle E, Tholey A. A 2D reversed-phase x ion-pair reversed-phase HPLC-MALDI TOF/TOF-MS approach for shotgun proteome analysis. Anal. Bioanal. Chem. 393(4), 1245-1256 (2009).
112. Zhang X, Fang AQ, Riley CP, Wang M, Regnier FE, Buck C. Multi-dimensional liquid chromatography in proteomics - a review. Anal. Chim. Acta 664(2), 101-113 (2010).
113. Horvath K, Fairchild JN, Guiochon G. Detection issues in two-dimensional on-line chromatography. J. Chromatogr. A 1216(45), 7785-7792 (2009).
114. Whailova A, Karaszewski B, Faergestad EM et al. Two-dimensional LC-MS/MS in detection of peptides in hypothalamus of the rat subjected to hypoxic stress. J. Sep. Sci. 31(3), 468-479 (2008). (Pubitemid 351351179)
115. Ralhan R, Desouza LV, Matta A et al. Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry. Mol. Cell. Proteomics 7(6), 1162-1173 (2008). (Pubitemid 351943962)
116. Dowell JA, Frost DC, Zhang J, Li LJ. Comparison of two-dimensional fractionation techniques for shotgun proteomics. Anal. Chem. 80(17), 6715-6723 (2008).
117. Dai J, Wang LS, Wu YB et al. Fully automatic separation and identification of phosphopeptides by continuous pH-gradient anion exchange online coupled with reversed-phase liquid chromatography-mass spectrometry. J. Proteome Res. 8(1), 133-141 (2009).
118. Machtejevas E, Marko-Varga G, Lindberg C, Lubda D, Hendriks R, Unger KK. Profiling of endogenous peptides by multidimensional liquid chromatography: on-line automated sample cleanup for biomarker discovery in human urine. J. Sep. Sci. 32(13), 2223-2232 (2009).
119. Francois I, de Villiers A, Tienpont B, David F, Sandra P. Comprehensive two-dimensional liquid chromatography applying two parallel columns in the second dimension. J. Chromatogr. A 1178(1-2), 33-42 (2008). (Pubitemid 350299037)
120. Lam MPY, Siu SO, Lau E et al. Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization. Anal. Bioanal. Chem. 398(2), 791-804 (2010).
121. Benesch JLP, Ruotolo BT. Mass spectrometry: come of age for structural and dynamical biology. Curr. Opin. Struct. Biol. 21(5), 641-649 (2011).
122. Himmelsbach M. 10 years of MS instrumental developments - impact on LC- MS/MS in clinical chemistry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 883, 3-17 (2012).
123. Jiwan JLH, Wallemacq P, Herent MF. HPLC-high resolution mass spectrometry in clinical laboratory? Clin. Biochem. 44(1), 136-147 (2011).
124. Youdim KA, Saunders KC. A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(17-18), 1326-1336 (2010).
125. Josephs JL. HRMS: current usage, future directions and the promise of integration with unified data streams suited to post-acquisition mining. Bioanalysis 4(5), 471-476 (2012).
126. Ramanathan R, Korfmacher W. The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena. Bioanalysis 4(5), 467-469 (2012).
127. El-Aneed A, Cohen A, Banoub J. Mass spectrometry, review of the basics: Electrospray, MALDI, and commonly used mass analyzers. Appl. Spectrosc. Rev. 44(3), 210-230 (2009).
128. Huang MZ, Cheng SC, Cho YT, Shiea J. Ambient ionization mass spectrometry: A tutorial. Anal. Chim. Acta 702(1), 1-15 (2011).
129. Sikanen T, Franssila S, Kauppila TJ, Kostiainen R, Kotiaho T, Ketola RA. Microchip technology in mass spectrometry. Mass Spectrom. Rev. 29(3), 351-391 (2010).
130. Yang H, Luk VN, Abelgawad M, Barbulovic- Nad I, Wheeler AR. A world-to-chip interface for digital microfluidics. Anal. Chem. 81(3), 1061-1067 (2009).
131. Guo X, Lankmayr E. Multidimensional approaches in LC and MS for phospholipid bioanalysis. Bioanalysis 2(6), 1109-1123 (2010).
132. Zhang X, Fang A, Riley CP, Wang M, Regnier FE, Buck C. Multi-dimensional liquid chromatography in proteomics - a review. Anal. Chim. Acta 664(2), 101-113 (2010).
133. Tolonen A, Turpeinen M, Pelkonen A. Liquid chromatography-mass spectrometry in in vitro drug metabolite screening. Drug Discov. Today 14(3-4), 120-133 (2009).
134. Ranasinghe A, Ramanathan R, Jemal M, D'arienzo CJ, Humphreys WG, Olah TV. Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS. Bioanalysis 4(5), 511-528 (2012).
135. Liang Y, Wang G, Xie L, Sheng L. Recent development in liquid chromatography-mass spectrometry and emerging technologies for metabolite identification. Curr. Drug Metab. 12(4), 329-344 (2011).
136. Trufelli H, Palma P, Famiglini G, Cappielo A. An overview of matrix effects in liquid chromatography-mass spectrometry. Mass Spectrom. Rev. 30(3), 491-509 (2011).
137. Kostiainen R, Kauppila TJ. Effect of eluent on the ionization process in liquid chromatography-mass spectrometry. J. Chromatogr. A 1216(4), 685-699 (2009).
138. Wong SHP, Cooks RG. Ion trap mass spectrometry. Curr. Sep. 16(3), 85-92 (1997).
139. Douglas DJ. Linear quadrupoles in mass spectrometry. Mass Spectrom. Rev. 28(6), 937-960 (2009).
140. Jonscher KR, Yates Jr. The quadrupole ion trap mass spectrometer - a small solution to a big challenge. Anal. Biochem. 244(1), 1-15 (1997). (Pubitemid 27030518)
141. Hopfgartner G, Varesio E, Tschappat V, Grivet C, Bourgogne E, Leuthold LA. Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules. J. Mass Spectrom. 39(8), 845-855 (2004). (Pubitemid 39173091)
142. Zhou X, Ye X, Calafat AM. Automated on-line column-switching HPLC-MS/MS method for the quantification of triclocarban and its oxidative metabolites in human urine and serum. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 881-882, 27-33 (2012).
143. Ye X, Zhou X, Needham LL, Calafat AM. In vitro oxidation of bisphenol A: is bisphenol A catechol a suitable biomarker for human exposure to bisphenol A? Anal. Bioanal. Chem. 399(3), 1071-1079 (2011).
144. Rao RN, Vali RM, Shinde DD. On-line 2D-LC-ESI/MS/MS determination of rifaximin in rat serum. Biomed. Chromatogr. 23(11), 1145-1150 (2009).
145. Rao RN, Shinde DD. Two-dimensional LC-MS/MS determination of antiretroviral drugs in rat serum and urine. J. Pharm. Biomed. Anal. 50(5), 994-999 (2009).
146. Ye X, Tao LJ, Needham LL, Calafat AM. Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum. Talanta 76(4), 865-871 (2008).
147. Ye X, Bishop AM, Needham LL, Calafat AM. Automated on-line column-switchning HPLC-MS/MS method with peak focusing for measuring parcabens, triclosan, and other environmental phenols in human milk. Anal. Chim. Acta 622(1-2), 150-156 (2008).
148. Mueller DM, Rentsch KM. Online extraction toxicological MS(n) screening system for serum and heparinized plasma and comparison of screening results between plasma and urine in the context of clinical data. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 883, 189-197 (2012).
149. Mueller DM, Duretz B, Espourteille FA, Rentsch KM. Development of a fully automated toxicological LC-MS(n) screening system in urine using online extraction with turbulent flow chromatography. Anal. Bioanal. Chem. 400(1), 89-100 (2011).
150. Scigelova M, Makarov A. Advances in bioanalytical LC-MS using the Orbitrap™ mass analyzer. Bioanalysis 1(4), 741-754 (2009).
151. Xian F, Hendrickson CL, Marshall AG. High resolution mass spectrometry. Anal. Chem. 84(2), 708-719 (2012).
152. Yates JR, Ruse CI, Nakorchevsky A. Proteomics by mass spectrometry: approaches, advances, and applications. Annu. Rev. Biomed. Eng. 11, 49-79 (2009).
153. Campbell JL, Le Blanc JCY. Using high-resolution quadrupole TOF technology in DMPK analyses. Bioanalysis 4(5), 487-500 (2012).
154. Dillen L, Cools W, Vereyken L et al. Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides. Bioanalysis 4(5), 565-579 (2012).
155. Plumb RS, Fujimoto G, Mather J et al. Comparison of the quantification of a therapeutic protein using nominal and accurate mass MS/MS. Bioanalysis 4(5), 605-615 (2012).
156. Gil GC, Brennan J, Throckmorton DJ, Branda SS, Chirica GS. Automated
157. Zhi WB, Sharma A, Purohit S et al. Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays. Mol. Cell. Proteomics 10(11), 10 (2011).
158. Barreiro JC, Vanzolini KL, Cass QB. Direct injection of native aqueous matrices by achiral-chiral chromatography ion trap mass spectrometry for simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions. J. Chromatogr. A 1218(20), 2865-2870 (2011).
159. Inoue K, Ikemura A, Tsuruta Y, Tsutsumiuchi K, Hino T, Oka H. On-line solid-phase extraction LC-MS/MS for the determination of Ac-SDKP peptide in human plasma from hemodialysis patients. Biomed. Chromatogr. 26(2), 137-141 (2012).
160. Reska M, Ochsmann E, Kraus T, Schettgen T. Accurate quantification of mercapturic acids of styrene (PHEMAs) in human urine with direct sample injection using automated column-switching high-performance liquid chromatography coupled with tandem mass spectrometry. Anal. Bioanal. Chem. 397(8), 3563-3574 (2010).
161. Rao RN, Kumar KN, Shinde DD. Determination of rat plasma levels of sertraline enantiomers using direct injection with achiral-chiral column switching by LC-ESI-MS/MS. J. Pharm. Biomed. Anal. 52(3), 398-405 (2010).
162. Rodriguez-Gonzalo E, Garcia-Gomez D, Carabias-Martinez R. Development and validation of a method for the detection and confirmation of biomarkers of exposure in human urine by means of restricted access material-liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1217(1), 40-48 (2010).
163. Schettgen T, Musiol A, Alt A, Ochsmann E, Kraus T. A method for the quantification of biomarkers of exposure to acrylonitrile and 1,3-butadiene in human urine by column-switching liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 393(3), 969-981 (2009).
164. Schettgen T, Musiol A, Alt A, Kraus T. Fast determination of urinary S-phenylmercapturic acid (S-PMA) and S-benzylmercapturic acid (S-BMA) by column-switching liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 863(2), 283-292 (2008).
165. Friedrich G, Rose T, Wawkuschewski A et al. Determination of testosterone metabolites in rat hepatocytes with and without cryopreservation by on-line SPE column-switching LC and MS detection. Chromatographia 67(1-2), 31-39 (2008).
166. Liu M, Yan W, Lin JM, Hashi Y, Liu LB, Wei Y. On-line liquid chromatography-mass spectrometry with dilution line to achieve large volume urine injection for the improvement of sensitivity. J. Chromatogr. A 1198, 87-94 (2008).
167. He X, Kozak M. Development of a liquid chromatography-tandem mass spectrometry method for plasma-free metanephrines with ion-pairing turbulent flow online extraction. Anal. Bioanal. Chem. 402(9), 3003-3010 (2012).
168. Perez F, Llorca M, Farre M, Barcelo D. Automated analysis of perfluorinated compounds in human hair and urine samples by turbulent flow chromatography coupled to tandem mass spectrometry. Anal. Bioanal. Chem. 402(7), 2369-2378 (2012).
169. Harlan R, Clarke W, Di Bussolo JM, Kozak M, Straseski J, Meany DL. An automated turbulent flow liquid chromatography-isotope dilution mass spectrometry (LC-IDMS) method for quantitation of serum creatinine. Clin. Chim. Acta 411(21-22), 1728-1734 (2010).
170. Bunch DR, Heideloff C, Ritchie JC, Wang SH. A fast and simple assay for busulfan in serum or plasma by liquid chromatography-tandem mass spectrometry using turbulent flow online extraction technology. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(31), 3255-3258 (2010).
171. Stolker AAM, Peters RJB, Zuiderent R, Dibussolo JM, Martins CPB. Fully automated screening of veterinary drugs in milk by turbulent flow chromatography and tandem mass spectrometry. Anal. Bioanal. Chem. 397(7), 2841-2849 (2010).
172. Bai F, Tagen M, Colotta C, Miller L, Fouladi M, Stewart CF. Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC- ESI-MS/MS). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(25), 2348-2352 (2010).
173. Breaud AR, Harlan R, Di Bussolo JM, McMillin GA, Clarke W. A rapid and fully-automated method for the quantitation of tricyclic antidepressants in serum using turbulent-flow liquid chromatography-tandem mass spectrometry. Clin. Chim. Acta 411(11-12), 825-832 (2010).
174. Verdirame M, Veneziano M, Alfieri A, Di Marco A, Monteagudo E, Bonelli F. Turbulent flow chromatography TFC-tandem mass spectrometry supporting in vitro/vivo studies of NCEs in high throughput fashion. J. Pharm. Biomed. Anal. 51(4), 834-841 (2010).
175. Krebber R, Hoffend FJ, Ruttmann F. Simple and rapid determination of enrofloxacin and ciprofloxacin in edible tissues by turbulent flow chromatography-tandem mass spectrometry (TFC-MS/MS). Anal. Chim. Acta 637(1-2), 208-213 (2009).
176. Bai F, Fraga CH, Tagen M, Schaiquevich P, Hagedorn N, Stewart CF. Simultaneous determination of cyclophosphamide and carboxyethylphosphoramide mustard in human plasma using online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/ MS). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(18-19), 1709-1715 (2009).
177. Xu Y, Willson KJ, Anderson MDG, Musson DG, Miller-Stein CM, Woolf EJ. Elimination of diastereomer interference to determine telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(16-17), 1634-1642 (2009).
178. Zeng W, Musson DG, Fisher AL et al. Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry. J. Pharm. Biomed. Anal. 46(3), 534-542 (2008).