Turbulent Flow Chromatography TFC-tandem mass spectrometry supporting in vitro/vivo studies of NCEs in high throughput fashion

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 4, 2010, Pages 834-841

  Verdirame, Maria ^a   Veneziano, Maria ^a   Alfieri, Anna ^a   Di Marco, Annalise ^a   Monteagudo, Edith ^a   Bonelli, Fabio ^a  

^a Merck Research Laboratories   (Italy)

Author keywords

On line extraction; TFC LC MS MS

Indexed keywords

ACETONITRILE; HYMECROMONE; PLASMA PROTEIN; UMBELLIFERONE;

ANIMAL CELL; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG METABOLISM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; NONHUMAN; ONLINE ANALYSIS; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TURBULENT FLOW CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY; EQUIPMENT DESIGN; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ONLINE SYSTEMS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 72149117656     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.10.005     Document Type: Article

References (20)

1. Herman J.L. Rapid Commun. Mass Spectrom. 16 (2002) 421-426
2. Zeng W., Wang A.Q., Fisher A.L., and Musson D.G. Rapid Commun. Mass Spectrom. 17 (2003) 2475-2482
3. Zeng W., Fisher A.L., Musson D.G., and Wang A.Q. J. Chromatogr. B 806 (2004) 177-183
4. Takino M., Daishima S., and Nakahara T. Rapid Commun. Mass Spectrom. 17 (2003) 383-390
5. Chassaing C., Stafford H., Luckwell J., Wright A., and Edington A. Chromatographia 62 (2005) 17-24
6. Grant R.P., Cameron C., and Mackenzie-McMurter S. Rapid Commun. Mass Spectrom. 16 (2002) 1785-1792
7. Herman J.L. Int. J. Mass Spectrom. 238 (2004) 107-117
8. Herman J.L. Rapid Commun. Mass Spectrom. 19 (2005) 696-700
9. Krebber R., Hoffend F.J., and Ruttmann F. Anal. Chim. Acta 637 (2009) 208-213
10. H.M. Quinn, J.J. Takarewski, Int. Pat., WO 97/16724, 1997.
11. Edge T. Bioanalytical separations. In: Wilson I.G. (Ed). Handbook of Analytical separations (2003), Elsevier Science, B.V. p. 91, chapter 4
12. Edge T. Chromatogr. Sep. Technol. (CAST) 23 (2002) 10-16
13. Zeng W., Musson D.G., Fisher A.L., and Wang A.Q. Rapid Commun. Mass Spectrom. 20 (2006) 1169-1175
14. Ong V.S., Cook K.L., Kosara C.M., and Brubaker W.F. Int. J. Mass Spectrom. 238 (2004) 139-152
15. Sadagopan N., Pabst B., and Cohen L. J. Chromatogr. B 820 (2005) 59-67
16. Zimmer D., Pickard V., Czembor W., and Müller C. J. Chromatogr. A 854 (1999) 23-35
17. FDA. Guidance for Industry: Bioanalytical Method Validation (May 2001), US Department of Health and Human Services
18. Matuszewski B., Constanzer M., and Chavez-Eng C.M. Anal. Chem. 75 (2003) 3019-3030
19. Lim H.K., Chan K.W., Sisenwine S., and Scatina J.A. Anal. Chem. 73 (2001) 2140-2146
20. Smalley J., Marino A.M., Xin B., Olah T., and Balimane P.V. J. Chromatogr. B 854 (2007) 260-267