메뉴 건너뛰기




Volumn 4, Issue 5, 2012, Pages 487-500

Using high-resolution quadrupole TOF technology in DMPK analyses

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; BIOTRANSFORMATION; DATA ANALYSIS SOFTWARE; INTERMETHOD COMPARISON; ION MOBILITY SPECTROMETRY; IONIZATION; LIMIT OF QUANTITATION; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; QUADRUPOLE MASS SPECTROMETRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; REVIEW; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 84858427546     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.14     Document Type: Review
Times cited : (31)

References (64)
  • 1
    • 79958695977 scopus 로고    scopus 로고
    • High-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures
    • Kormacher W. High-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures. Bioanalysis 3, 1169-1171 (2011
    • (2011) Bioanalysis , vol.3 , pp. 1169-1171
    • Kormacher, W.1
  • 2
    • 79958110797 scopus 로고    scopus 로고
    • It is time for a paradigm shift in drug discovery bioanalysis: From SRM to HRMS
    • Ramanathan R, Jemal M, Ramagiri S et al. It is time for a paradigm shift in drug discovery bioanalysis: From SRM to HRMS. J. Mass Spectrom. 46, 595-601 (2011
    • (2011) J. Mass Spectrom. , vol.46 , pp. 595-601
    • Ramanathan, R.1    Jemal, M.2    Ramagiri, S.3
  • 3
    • 0242293695 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics in drug discovery: A primer for bioanalytical chemists, Part I
    • Gunaratna C. Drug metabolism and pharmacokinetics in drug discovery: A primer for bioanalytical chemists, Part I. Curr. Sep. 19, 17-23 (2000
    • (2000) Curr. Sep. , vol.19 , pp. 17-23
    • Gunaratna, C.1
  • 4
    • 0010596116 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics in drug discovery: A primer for bioanalytical chemists, Part II
    • Gunaratna C. Drug metabolism and pharmacokinetics in drug discovery: A primer for bioanalytical chemists, Part II. Curr. Sep. 19, 87-92 (2001
    • (2001) Curr. Sep. , vol.19 , pp. 87-92
    • Gunaratna, C.1
  • 5
    • 80052505619 scopus 로고    scopus 로고
    • Accurate-mass instrumentation should not always be the first-and-only choice for MS in the drug metabolism environment
    • Weston DJ, Beattie IG. Accurate-mass instrumentation should not always be the first-and-only choice for MS in the drug metabolism environment. Bioanalysis 3, 1795-1798 (2011
    • (2011) Bioanalysis , vol.3 , pp. 1795-1798
    • Weston, D.J.1    Beattie, I.G.2
  • 6
    • 80052599296 scopus 로고    scopus 로고
    • Targeted quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: An evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile modes
    • Xia Y-Q, Lau J, Olah T, Jemal M. Targeted quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: An evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile modes. Rapid Commun. Mass Spectrom. 25, 2863-2878 (2011
    • (2011) Rapid Commun. Mass Spectrom. , vol.25 , pp. 2863-2878
    • Xia, Y-.Q.1    Lau, J.2    Olah, T.3    Jemal, M.4
  • 7
    • 79959958529 scopus 로고    scopus 로고
    • Performance characteristics of a new hybrid quadrupole time-of-flight tandem mass spectrometer (TripleTOF 5600
    • Andrews GL, Simons BL, Young JB, Hawkridge AM, Muddiman DC. Performance characteristics of a new hybrid quadrupole time-of-flight tandem mass spectrometer (TripleTOF 5600). Anal. Chem. 83, 5442-5446 (2011
    • (2011) Anal. Chem. , vol.83 , pp. 5442-5446
    • Andrews, G.L.1    Simons, B.L.2    Young, J.B.3    Hawkridge, A.M.4    Muddiman, D.C.5
  • 8
    • 0034852208 scopus 로고    scopus 로고
    • An introduction to quadrupole-time-of-flight mass spectrometry
    • Chernushevich IV, Loboda AV, Thomson BA. An introduction to quadrupole-time-of-flight mass spectrometry. J. Mass Spectrom. 36, 849-865 (2001).
    • (2001) J. Mass Spectrom. , vol.36 , pp. 849-865
    • Chernushevich, I.V.1    Loboda, A.V.2    Thomson, B.A.3
  • 9
    • 0028064214 scopus 로고
    • Reflecting time-of-flight mass spectrometer with an electrospray ion source and orthogonal extraction
    • Verentchikov AN, Ens W, Standing KG. Reflecting time-of-flight mass spectrometer with an electrospray ion source and orthogonal extraction. Anal. Chem. 66, 126-133 (1994
    • (1994) Anal. Chem. , vol.66 , pp. 126-133
    • Verentchikov, A.N.1    Ens, W.2    Standing, K.G.3
  • 10
    • 0000081497 scopus 로고
    • On the detection of large organic ions by secondary electron production
    • Hedin A, Hkansson P, Sundqvist BUR. On the detection of large organic ions by secondary electron production. Int. J. Mass Spectrom. 75, 275-289 (1987
    • (1987) Int. J. Mass Spectrom. , vol.75 , pp. 275-289
    • Hedin, A.1    Hkansson, P.2    Sundqvist, B.U.R.3
  • 11
    • 0037689628 scopus 로고
    • Secondary electron emission induced by impact of low-velocity molecular ions on a microchannel plate
    • Geno PW, Macfarlane RD. Secondary electron emission induced by impact of low-velocity molecular ions on a microchannel plate. Int. J. Mass Spectrom. 92, 195-210 (1989
    • (1989) Int. J. Mass Spectrom. , vol.92 , pp. 195-210
    • Geno, P.W.1    Macfarlane, R.D.2
  • 12
    • 0042918465 scopus 로고    scopus 로고
    • Mass selective blanking in a compact multiple reflection time-of-flight mass spectrometer
    • Hohl M, Wurz P, Scherer S, Altwegg K, Balsiger H. Mass selective blanking in a compact multiple reflection time-of-flight mass spectrometer. Int. J. Mass Spectrom. 188, 189-197 (1999
    • (1999) Int. J. Mass Spectrom. , vol.188 , pp. 189-197
    • Hohl, M.1    Wurz, P.2    Scherer, S.3    Altwegg, K.4    Balsiger, H.5
  • 14
    • 0032216568 scopus 로고    scopus 로고
    • Multi-anode detection in electrospray ionization time-of-flight mass spectrometry
    • Barbacci DC, Russell DH, Schultz JA et al. Multi-anode detection in electrospray ionization time-of-flight mass spectrometry.J. Am. Soc. Mass Spectrom. 9, 1328-1333 (1998
    • (1998) J. Am. Soc. Mass Spectrom. , vol.9 , pp. 1328-1333
    • Barbacci, D.C.1    Russell, D.H.2    Schultz, J.A.3
  • 15
    • 0029877652 scopus 로고    scopus 로고
    • Increasing the increasing the dynamic range of a transient recorder by using two analog-to-digital converters
    • Beavis RC. Increasing the increasing the dynamic range of a transient recorder by using two analog-to-digital converters. J. Am. Soc. Mass Spectrom. 7, 107-113 (1996
    • (1996) J. Am. Soc. Mass Spectrom. , vol.7 , pp. 107-113
    • Beavis, R.C.1
  • 16
    • 0042697374 scopus 로고    scopus 로고
    • Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry
    • Hopfgartner G, Bourgogne E. Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry. Mass Spectrom. Rev. 22, 195-214 (2003).
    • (2003) Mass Spectrom. Rev. , vol.22 , pp. 195-214
    • Hopfgartner, G.1    Bourgogne, E.2
  • 17
    • 33645721632 scopus 로고    scopus 로고
    • Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins
    • Anderson L, Hunter CL. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol. Cell. Proteom. 5, 573-588 (2006
    • (2006) Mol. Cell. Proteom. , vol.5 , pp. 573-588
    • Anderson, L.1    Hunter, C.L.2
  • 18
    • 63049090914 scopus 로고    scopus 로고
    • How specific is my SRM? The issue of precursor and product ion redundancy
    • Sherman J, McKay MJ, Ashman K, Molloy MP. How specific is my SRM? The issue of precursor and product ion redundancy. Proteomics 9, 1120-1123 (2009
    • (2009) Proteomics , vol.9 , pp. 1120-1123
    • Sherman, J.1    McKay, M.J.2    Ashman, K.3    Molloy, M.P.4
  • 19
    • 79953122848 scopus 로고    scopus 로고
    • Peptide and protein analysis by mass spectrometry: Challenges and opportunities for the discovery environment
    • Campbell JL, Le Blanc JCY. Peptide and protein analysis by mass spectrometry: Challenges and opportunities for the discovery environment. Bioanalysis 3, 645-657 (2011
    • (2011) Bioanalysis , vol.3 , pp. 645-657
    • Campbell, J.L.1    Le Blanc, J.C.Y.2
  • 21
    • 0034652244 scopus 로고    scopus 로고
    • Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS
    • Zhang N, Fountain ST, Bi H, Rossi DT. Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS. Anal. Chem. 72, 800-806 (2000
    • (2000) Anal. Chem. , vol.72 , pp. 800-806
    • Zhang, N.1    Fountain, S.T.2    Bi, H.3    Rossi, D.T.4
  • 22
    • 25144468977 scopus 로고    scopus 로고
    • All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
    • Wrona M, Mauriala T, Bateman KP, Mortishire-Smith RJ, O'Connor D. 'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid Commun. Mass Spectrom. 19, 2597-2602 (2005).
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 2597-2602
    • Wrona, M.1    Mauriala, T.2    Bateman, K.P.3    Mortishire-Smith, R.J.4    O'Connor, D.5
  • 23
    • 25144438177 scopus 로고    scopus 로고
    • Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
    • Mortishire-Smith RJ, O'Connor D, Castro-Perez JM, Kirby J. Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun. Mass Spectrom. 19, 2659-2670 (2005
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 2659-2670
    • Mortishire-Smith, R.J.1    O'Connor, D.2    Castro-Perez, J.M.3    Kirby, J.4
  • 24
    • 84858389394 scopus 로고    scopus 로고
    • Large-molecule bioanalysis using QTOF without pre-digestion and its data processing challenges
    • Ramagiri S, Garofolo F. Large-molecule bioanalysis using QTOF without pre-digestion and its data processing challenges. Bioanalysis 4(5), 529-540 (2012
    • (2012) Bioanalysis , vol.4 , Issue.5 , pp. 529-540
    • Ramagiri, S.1    Garofolo, F.2
  • 25
    • 0242521617 scopus 로고    scopus 로고
    • A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses
    • Zhang H, Zhang D, Ray K. A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses. J. Mass Spectrom. 38, 1110-1112 (2003
    • (2003) J. Mass Spectrom. , vol.38 , pp. 1110-1112
    • Zhang, H.1    Zhang, D.2    Ray, K.3
  • 26
    • 67650494794 scopus 로고    scopus 로고
    • Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry
    • Zhang H, Zhang D, Ray K, Zhu M. Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry. J. Mass Spectrom. 44, 999-1016 (2009
    • (2009) J. Mass Spectrom. , vol.44 , pp. 999-1016
    • Zhang, H.1    Zhang, D.2    Ray, K.3    Zhu, M.4
  • 28
    • 80155167738 scopus 로고    scopus 로고
    • Evaluation of a high-throughput online solid phase extraction-tandem mass spectrometry system for in vivo bioanalytical studies
    • Jian W, Romm MV, Edom RW, Miller VP, LaMarr WA, Weng N. Evaluation of a high-throughput online solid phase extraction-tandem mass spectrometry system for in vivo bioanalytical studies. Anal. Chem. 83, 8259-8266 (2011
    • (2011) Anal. Chem. , vol.83 , pp. 8259-8266
    • Jian, W.1    Romm, M.V.2    Edom, R.W.3    Miller, V.P.4    LaMarr, W.A.5    Weng, N.6
  • 29
    • 71649089437 scopus 로고    scopus 로고
    • Analyzing protein drugs
    • Kelmsley J. Analyzing protein drugs. Chem. Eng. News 87, 20-23 (2009
    • (2009) Chem. Eng. News , vol.87 , pp. 20-23
    • Kelmsley, J.1
  • 30
    • 0001198225 scopus 로고
    • Mechanistic interpretation of the dependence of charge state distributions on analyte concentrations in electrospray ionization mass spectrometry
    • Wang G, Cole RB. Mechanistic interpretation of the dependence of charge state distributions on analyte concentrations in electrospray ionization mass spectrometry. Anal. Chem. 67, 2892-2900 (1995
    • (1995) Anal. Chem. , vol.67 , pp. 2892-2900
    • Wang, G.1    Cole, R.B.2
  • 33
    • 79951901773 scopus 로고    scopus 로고
    • Can MS fully exploit the benefits of fast chromatography?
    • Hopfgartner G. Can MS fully exploit the benefits of fast chromatography? Bioanalysis 3, 121-123 (2011
    • (2011) Bioanalysis , vol.3 , pp. 121-123
    • Hopfgartner, G.1
  • 34
    • 84858411340 scopus 로고    scopus 로고
    • Mass defect triggered information dependent acquisition
    • Bloomfield N, Le Blanc Y. Mass defect triggered information dependent acquisition. US7589318. September 15 (2009
    • (2009) US7589318. September , vol.15
    • Bloomfield, N.1    Le Blanc, Y.2
  • 40
    • 41549139685 scopus 로고    scopus 로고
    • High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies
    • Tiller PR, Yu S, Castro-Perez J, Fillgrove KL; Baillie TA. High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies. Rapid Commun. Mass Spectrom. 22, 1053-1061 (2008
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 1053-1061
    • Tiller, P.R.1    Yu, S.2    Castro-Perez, J.3    Fillgrove, K.L.4    Baillie, T.A.5
  • 41
    • 34248572197 scopus 로고    scopus 로고
    • MSE with mass defect filtering for in vitro and in vivo metabolite identification
    • Bateman KP, Castro-Perez J, Wrona M et al. MSE with mass defect filtering for in vitro and in vivo metabolite identification. Rapid Commun. Mass Spectrom. 21, 1485-1496 (2007
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 1485-1496
    • Bateman, K.P.1    Castro-Perez, J.2    Wrona, M.3
  • 42
    • 63449106748 scopus 로고    scopus 로고
    • Generic dealkylation: A tool for increasing the hit-rate of metabolite rationalization and automatic customization of mass defect filters
    • Mortishire-Smith RJ, Castro-Perez JM, Yu K et al. Generic dealkylation: A tool for increasing the hit-rate of metabolite rationalization and automatic customization of mass defect filters. Rapid Commun. Mass Spectrom. 23, 939-948 (2009
    • (2009) Rapid Commun. Mass Spectrom. , vol.23 , pp. 939-948
    • Mortishire-Smith, R.J.1    Castro-Perez, J.M.2    Yu, K.3
  • 46
    • 67650901565 scopus 로고    scopus 로고
    • Validated quantitation method for a peptide in rat serum using liquid chromatography/high-field asymmetric waveform ion mobility spectrometry
    • Klaassen T, Szwandt S, Kapron JT, Roemer A. Validated quantitation method for a peptide in rat serum using liquid chromatography/high-field asymmetric waveform ion mobility spectrometry. Rapid Commun. Mass Spectrom. 23, 2301-2306 (2009
    • (2009) Rapid Commun. Mass Spectrom. , vol.23 , pp. 2301-2306
    • Klaassen, T.1    Szwandt, S.2    Kapron, J.T.3    Roemer, A.4
  • 47
    • 0001542973 scopus 로고    scopus 로고
    • Combined ion mobility/time-of-flight mass spectrometry study of electrospray-generated ions
    • Guevremont R, Siu KWM, Wang J, Ding L. Combined ion mobility/time-of- flight mass spectrometry study of electrospray-generated ions. Anal. Chem. 69, 3959-3965 (1997
    • (1997) Anal. Chem. , vol.69 , pp. 3959-3965
    • Guevremont, R.1    Siu, K.W.M.2    Wang, J.3    Ding, L.4
  • 48
    • 33646571543 scopus 로고    scopus 로고
    • Structural identification of highly polar nontarget contaminants in drinking water by ESI-FAIMS-Q-TOF-MS
    • Sultan J, Gabryelski W. Structural identification of highly polar nontarget contaminants in drinking water by ESI-FAIMS-Q-TOF-MS. Anal. Chem. 78, 2905-2917 (2006
    • (2006) Anal. Chem. , vol.78 , pp. 2905-2917
    • Sultan, J.1    Gabryelski, W.2
  • 49
    • 77149134996 scopus 로고    scopus 로고
    • Control of chemical effects in the separation process of a differential mobility mass spectrometer system
    • Schneider BB, Covey TR, Coy SL, Krylov EV, Nazarov EG. Control of chemical effects in the separation process of a differential mobility mass spectrometer system. Eur. J. Mass Spectrom. 16, 57-71 (2010
    • (2010) Eur. J. Mass Spectrom. , vol.16 , pp. 57-71
    • Schneider, B.B.1    Covey, T.R.2    Coy, S.L.3    Krylov, E.V.4    Nazarov, E.G.5
  • 50
    • 77749302232 scopus 로고    scopus 로고
    • Chemical effects in the separation process of a differential mobility/mass spectrometer system
    • Schneider BB, Covey TR, Coy SL, Krylov EV, Nazarov EG. Chemical effects in the separation process of a differential mobility/mass spectrometer system. Anal. Chem. 82, 1867-1880 (2010
    • (2010) Anal. Chem. , vol.82 , pp. 1867-1880
    • Schneider, B.B.1    Covey, T.R.2    Coy, S.L.3    Krylov, E.V.4    Nazarov, E.G.5
  • 53
    • 33846811132 scopus 로고    scopus 로고
    • An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument
    • Pringle SD, Giles K, Wildgoose JL et al. An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. Int. J. Mass Spectrom. 261, 1-12 (2007
    • (2007) Int. J. Mass Spectrom. , vol.261 , pp. 1-12
    • Pringle, S.D.1    Giles, K.2    Wildgoose, J.L.3
  • 54
    • 60149101752 scopus 로고    scopus 로고
    • Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry
    • Chan ECY, New LS, Yap CW, Goh LT. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 23, 384-394 (2009
    • (2009) Rapid Commun. Mass Spectrom. , vol.23 , pp. 384-394
    • Chan, E.C.Y.1    New, L.S.2    Yap, C.W.3    Goh, L.T.4
  • 57
    • 41849105800 scopus 로고    scopus 로고
    • Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates
    • Bagal D, Zhang H, Schnier PD. Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates. Anal. Chem. 80, 2408-2418 (2008
    • (2008) Anal. Chem. , vol.80 , pp. 2408-2418
    • Bagal, D.1    Zhang, H.2    Schnier, P.D.3
  • 58
    • 33745276848 scopus 로고    scopus 로고
    • Implementation of ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer
    • Xia Y, Chrisman PA, Erickson DE et al. Implementation of ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer. Anal. Chem. 78, 4146-4154 (2006
    • (2006) Anal. Chem. , vol.78 , pp. 4146-4154
    • Xia, Y.1    Chrisman, P.A.2    Erickson, D.E.3
  • 59
    • 42949096464 scopus 로고    scopus 로고
    • Rapidly alternating transmission mode electron-transfer dissociation and collisional activation for the characterization of polypeptide ions
    • Han H, Xia Y, Yang M, McLuckey SA. Rapidly alternating transmission mode electron-transfer dissociation and collisional activation for the characterization of polypeptide ions. Anal. Chem. 80, 3492-3497 (2008
    • (2008) Anal. Chem. , vol.80 , pp. 3492-3497
    • Han, H.1    Xia, Y.2    Yang, M.3    McLuckey, S.A.4
  • 60
    • 77954794218 scopus 로고    scopus 로고
    • Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS
    • Williams JP, Brown JM, Campuzano I, Sadler PJ. Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS). Chem. Commun. 46, 5458-5460 (2010
    • (2010) Chem. Commun. , vol.46 , pp. 5458-5460
    • Williams, J.P.1    Brown, J.M.2    Campuzano, I.3    Sadler, P.J.4
  • 62
    • 0037365932 scopus 로고    scopus 로고
    • Big physics, small doses: The use of AMS and PET in human microdosing of development drugs
    • Lappin G, Garner RC. Big physics, small doses: The use of AMS and PET in human microdosing of development drugs. Nat. Rev. Drug Discovery 2, 233-240 (2003
    • (2003) Nat. Rev. Drug Discovery , vol.2 , pp. 233-240
    • Lappin, G.1    Garner, R.C.2
  • 64
    • 34548324267 scopus 로고    scopus 로고
    • The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
    • Marchetti S, Schellens JHM. The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials. Br. J. Cancer 97, 577-581 (2007).
    • (2007) Br. J. Cancer , vol.97 , pp. 577-581
    • Marchetti, S.1    Schellens, J.H.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.