Turbulent-flow chromatography coupled on-line to fast high-performance liquid chromatography and mass spectrometry for simultaneous determination of verticine, verticinone and isoverticine in rat plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 3-4, 2010, Pages 435-441

  Xin, Gui Zhong ^a   Zhou, Jian Liang ^a   Qi, Lian Wen ^a   Li, Chang Yin ^a   Liu, Peng ^a   Li, Hui Jun ^a   Wen, Xiao dong ^a   Li, Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Isoverticine; Pharmacokinetic study; Traditional Chinese medicines; Turbulent flow chromatography; Verticine; Verticinone

Indexed keywords

ACCURACY AND PRECISION; AGILENT; CHEMICAL MARKERS; COLUMN SWITCHING; FAST HPLC; FAST HPLC-MS; FLOW EXTRACTION; FLOW PROPERTIES; FRITILLARIA; HIGH THROUGHPUT; HIGH-FLOW RATE; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; ON-LINE EXTRACTION COLUMNS; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PHARMACOKINETIC STUDY; PLASMA MATRIX; PLASMA SAMPLES; RAT PLASMA; REVERSED PHASE; SEPARATION EFFICIENCY; SIMULTANEOUS DETERMINATIONS; TRACE CONSTITUENTS; TRADITIONAL CHINESE MEDICINE;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; TRACE ANALYSIS;

MEDICINE;

CHINESE DRUG; ISOVERTICINE; PLANT EXTRACT; UNCLASSIFIED DRUG; VERTICINE; VERTICINONE;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD SAMPLING; CHINESE MEDICINE; CHROMATOGRAPHY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; FRITILLARIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; TURBULENT FLOW;

ADMINISTRATION, ORAL; ANIMALS; CALIBRATION; CEVANES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; LIMIT OF DETECTION; MASS SPECTROMETRY; ONLINE SYSTEMS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; TRITERPENES;

FRITILLARIA THUNBERGII; RATTUS;

EID: 74049111548     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.12.027     Document Type: Article

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