Determination of the γ-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS)

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 25, 2010, Pages 2348-2352

  Bai, Feng ^a   Tagen, Michael ^a   Colotta, Courtney ^a   Miller, Laura ^a   Fouladi, Maryam ^b   Stewart, Clinton F ^a,c  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Electrospray tandem mass spectrometry (ESI MS MS); High turbulence liquid chromatography (HTLC); MK 0752; Online sample preparation

Indexed keywords

ANALYTES; ANALYTICAL COLUMNS; AQUEOUS SOLUTIONS; BRAIN TUMORS; ELECTROSPRAY TANDEM MASS SPECTROMETRY; ESI-MS/MS; HIGH TURBULENCE LIQUID CHROMATOGRAPHY (HTLC); HUMAN PLASMAS; INTERNAL STANDARDS; ION TRANSITION; LC-MS/MS; MK-0752; MOBILE PHASE; NEGATIVE MULTIPLE REACTION MONITORING MODES; ON-LINE EXTRACTION COLUMNS; ON-LINE SAMPLE PREPARATION; ONLINE EXTRACTION; PEDIATRIC PATIENTS; PHASE I; PLASMA SAMPLES; SAMPLE MATRIX; SECRETASES;

MASS SPECTROMETRY; PLASMA (HUMAN); PLASMAS; SOLUTIONS; TURBULENCE;

LIQUID CHROMATOGRAPHY;

MK 0752;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG STABILITY; ELECTROSPRAY; HUMAN; LIQUID CHROMATOGRAPHY; ONLINE ANALYTICAL PROCESSING; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

AMYLOID PRECURSOR PROTEIN SECRETASES; BRAIN NEOPLASMS; CHILD; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; LINEAR MODELS; PROPIONIC ACIDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONES; TANDEM MASS SPECTROMETRY;

EID: 77955842543     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.07.019     Document Type: Article

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