A review of clinical diagnostic applications of liquid chromatography- tandem mass spectrometry

Mass Spectrometry Reviews

Volumn 29, Issue 6, 2010, Pages 930-944

  Shushan, Bori ^a  

^a Clinical Mass Spec Consultants   (Canada)

Author keywords

atmospheric pressure ionization; clinical diagnosis; multidimensional chromatography; multiplexed multiparametric assays; tandem mass spectrometry

Indexed keywords

ATMOSPHERIC PRESSURE IONIZATION; CLINICAL DIAGNOSIS; MULTIDIMENSIONAL CHROMATOGRAPHY; MULTIPLEXED MULTIPARAMETRIC ASSAYS; TANDEM MASS SPECTROMETRY;

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; CHROMATOGRAPHIC ANALYSIS; DIAGNOSIS; IONIZATION; LIQUIDS; MASS SPECTROMETRY; MULTIPLEXING; PARTICLE DETECTORS;

LIQUID CHROMATOGRAPHY;

BIOLOGICAL MARKER; PEPTIDE; PROTEIN;

ARTICLE; CHEMISTRY; DIAGNOSIS, MEASUREMENT AND ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INSTRUMENTATION; METABOLOMICS; METHODOLOGY; TANDEM MASS SPECTROMETRY;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES; METABOLOMICS; PEPTIDES; PROTEINS; TANDEM MASS SPECTROMETRY;

EID: 78149447309     PISSN: 02777037     EISSN: 10982787     Source Type: Journal    
DOI: 10.1002/mas.20295     Document Type: Article

References (100)

1. Altmaier E, Ramsay SL, Graber A, Mewes H-W, Weinberger KM, Suhre K,. 2008. Bioinformatics analysis of targeted metabolomics-Uncovering old and new tales of diabetic mice under medication. Endocrinology 149: 3478 - 3489.
2. Anderson L, Hunter CL,. 2006. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol Cell Proteomics 5: 573 - 588.
3. Anderson NL, Anderson NG, Haines LR, Hardie DB, Olafson RW, Pearson TW,. 2004. Mass spectrometric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibodies (SISCAPA). J Proteome Res 3: 235 - 244.
4. Anderson NL, Jackson A, Smith D, Hardie D, Borchers C, Pearson TW,. 2009. SISCAPA peptide enrichment on magnetic beads using an in-line bead trap device. Mol Cell Proteomics 8: 995 - 1005.
5. Annesley T,. 2009. Mass spectrometry in the clinical laboratory: How have we done, and where do we need to be ? Clin Chem 55: 1236 - 1239.
6. Awalt E, Barnard D, Dooley K,. 2001. Tandem mass spectrometry-A screening tool for hemoglobinopathies. Clin Chem 47 (6 Suppl): A165, abstract 540.
7. 15N-isotopically labeled albumin internal standard. Clin Chem 53 (3): 540 - 542.
8. Back DJ, Khoo SH, Gibbons SE, Merry C,. 2001. The role of therapeutic drug monitoring in treatment of HIV infection. Br J Clin Pharmacol 51: 301 - 308. (Pubitemid 32391484)
9. Barr JR, Maggio VL, Patterson DG, Jr., Cooper GR, Henderson LO, Turner WE, Smith SJ, Hannon WH, Needham LL, Sampson EJ,. 1996. Isotope dilution-mass spectrometric quantification of specific proteins: Model application with apolipoprotein A-I. Clin Chem 42: 1676 - 1682.
10. Bateman RH, Green BN, Morris B,. 2008. Electrospray ionization mass spectrometric analysis of the globin chains in hemoglobin heterozygotes can detect the variants HbC, D, and E. Clin Chem 54: 1256 - 1257.
11. Bateman KP, Kellmann M, Muenster H, Papp R, Taylor L,. 2009. Quantitative-qualitative data acquisition using a bench-top Orbitrap mass spectrometer. J Am Soc Mass Spectrom 20: 1441 - 1450.
12. Boemer F, Ketelslegers O, Minon J-M, Bours V, Schoos R,. 2008. Newborn screening for sickle cell disease using tandem mass spectrometry. Clin Chem 54: 2036 - 2041.
13. Bondar OP, Barnidge DR, Klee EW, Davis BJ, Klee GG,. 2007. LC-MS/MS quantification of Zn-2 glycoprotein: A potential serum biomarker for prostate cancer. Clin Chem 53: 673 - 678.
14. Bruni S, Loschi L, Incerti C, Gabrielli O, Coppa GV,. 2007. Update on treatment of lysosomal storage diseases. Acta Myol 26: 87 - 92.
15. Carr SA, Anderson L,. 2008. Protein quantitation through targeted mass spectrometry: The way out of biomarker purgatory ? Clin Chem 54: 1749 - 1752.
16. Ceglarek U, Casetta B, Lembcke J, Baumann S, Fiedler GM, Thiery J,. 2006. Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants. Clin Chim Acta 373: 168 - 171.
17. Ceglarek U, Kortz L, Leichtle A, Fiedler GM, Kratzsch J, Thiery J,. 2009. Rapid quantification of steroid patterns in human serum by on-line solid phase extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry. Clin Chim Acta 401: 114 - 118.
18. Chace DH,. 2009. Mass spectrometry in newborn and metabolic screening: Historical perspective and future directions. J Mass Spectrom 44: 163 - 170.
19. Chace DH, Millington DS, Tekada N, Kahler SG, Roe CR, Hofman LF,. 1993. Rapid diagnosis of phenylketonuria by quantitative analysis for phenylalanine and tyrosine in neonatal blood spots by tandem mass spectrometry. Clin Chem 39: 66 - 71.
20. Chace DH, Kalas TA, Naylor EW,. 2003. Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns. Clin Chem 49: 1797 - 1817.
21. Chamoles NA, Blanco M, Gaggioli D,. 2001a. Diagnosis of -L-iduronidase deficiency in dried blood spots on filter paper: The possibility of newborn diagnosis. Clin Chem 47: 780 - 781.
22. Chamoles NA, Blanco M, Gaggioli D,. 2001b. Fabry disease: Enzymatic diagnosis in dried blood spots on filter paper. Clin Chim Acta 308: 195 - 196. (Pubitemid 32537628)
23. Chamoles NA, Blanco M, Gaggioli D, Casentini C,. 2002a. Gaucher and Niemann-Pick diseases-Enzymatic diagnosis in dried blood spots on filter paper: Retrospective diagnoses in newborn-screening cards. Clin Chim Acta 317: 191 - 197. (Pubitemid 34114035)
24. Chamoles NA, Blanco M, Gaggioli D, Casentini C,. 2002b. Tay-Sachs and Sandhoff diseases: Enzymatic diagnosis in dried blood spots on filter paper: Retrospective diagnoses in newborn-screening cards. Clin Chim Acta 318: 133 - 137. (Pubitemid 34195597)
25. Constanzer M, Chavez C, Matuszewski B,. 1995. Development and comparison of high-performance liquid chromatographic methods with tandem mass spectrometric and ultraviolet absorbance detection for the determination of cyclobenzaprine in human plasma and urine. J Chromatogr B 666: 117 - 126.
26. Crouch D,. 2008. The analysis of fentanyl and norfentanyl using turboflow column analyte isolation and multiplex-HPLC/MS/MS, Ameritox, Midland, TX. Presented at the 60th Annual Meeting of the American Association of Forensic Scientists, Washington, DC, February 19, 2008.
27. Dajnoki A, Mühl A, Fekete G, Keutzer J, Orsini J, De Jesus V, Zhang XK, Bodamer OA,. 2008. Newborn screening for Pompe disease by measuring acid -glucosidase activity using tandem mass spectrometry. Clin Chem 54: 1624 - 1629.
28. Daniel YA, Turner C, Haynes RM, Hunt BJ, Dalton RN,. 2005. Rapid and specific detection of clinically significant haemoglobinopathies using electrospray mass spectrometry-mass spectrometry. Br J Haematol 130: 635 - 643.
29. Daniel YA, Turner C, Haynes RM, Hunt BJ, Dalton RN,. 2007. Quantification of hemoglobin A2 by tandem mass spectrometry. Clin Chem 53: 1448 - 1454.
30. Daniel Y, Turner C, Farrar L, Dalton RN,. 2008. A comparison of IEF and MSMS for clinical hemoglobinopathy screening in 40,000 newborns. 50th Annual Meeting of the American Hematology Society, San Francisco, CA, December 2008, Poster II-481.
31. De Jesus VR, Zhang XK, Keutzer J, Bodamer OA, Mühl A, Orsini JJ, Caggana M, Vogt RF, Hannon WH,. 2009a. Development and evalution of quality control dried blood spot materials in newborn screening for lysosomal storage disorders. Clin Chem 55: 158 - 164.
32. De Jesus VR, Zhou H, Vogt RF, Hannon WH,. 2009b. Changes in solvent composition in tandem mass spectrometry multiplex assay for lysosomal storage disorders do not affect assay results. Clin Chem 55: 596 - 597.
33. deWilde A, Sadilkova K, Sadilek M, Vasta V, Hahn SH,. 2008. Tryptic peptide analysis of ceruloplasmin in dried blood spots using liquid chromatography-tandem mass spectrometry: Application to newborn screening. Clin Chem 54: 1961 - 1968.
34. Diamandis EP,. 2009. Protein quantification by mass spectrometry: Is it ready for prime time ? Clin Chem 55: 1427 - 1430.
35. Dooley KC,. 2003. Tandem mass spectrometry in the clinical chemistry laboratory. Clin Biochem 36: 471 - 481.
36. Ellis DI, Dunn WB, Griffin JL, Allwood JW, Goodacre R,. 2007. Metabolic fingerprinting as a diagnostic tool. Pharmacogenomics 8: 1243 - 1266.
37. Fowler KT, Hugh-Jones P,. 1957. Mass spectrometry applied to clinical practice and research. Br Med J 1: 1205 - 1211.
38. Gerber SA, Scott CR, Turecek F, Gelb MH,. 2001. Direct profiling of multiple enzyme activities in human cell lysates by affinity chromatography/electrospray ionization mass spectrometry: Application to clinical enzymology. Anal Chem 73: 1651 - 1657.
39. Gerber SA, Rush J, Stenman O, Kirschner MW, Gygi SP,. 2003. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci USA 100: 6940 - 6945.
40. Gieger CH, Geistlinger L, Altmaier E, de Angelis H, Kronenberg F, Meitinger T, Mewes H-W, Wichmann H-E, Weinberger KM, Adamski J, Illig T, Suhre K,. 2008. Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum. PLoS Genet 4: e1000282.
41. Goshal AK, Haddon WF, Reitz RE, Clarke N,. 2007. Detection and quantification of dehydroepiandrosterone in human serum by liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry. Presented at the Annual Meeting of the Endocrine Society, ENDO07, Toronto.
42. Grant RP, Cameron C, Mackenzie-McMurter S,. 2002. Generic serial and parallel on-line direct-injection using turbulent flow liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 16: 1785 - 1792.
43. Grant R, Wagner AD, Morr MK, Patel M,. 2007. Development and application of 2D-LC/MS/MS in clinical diagnostics. Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Poster WPK-167.
44. Gu J, Soldin SJ,. 2007. Modification of tandem mass spectrometric method to permit simultaneous quantification of 17 anti-HIV drugs which include atazanavir and tipranavir. Clin Chim Acta 378: 222 - 224.
45. Gu J, Soldin OP, Soldin SJ,. 2007. Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry. Clin Biochem 40: 1386 - 1391.
46. Guo T, Chan M, Soldin SJ,. 2004. Steroid profiles using liquid chromatography-tandem mass spectrometry with atmospheric pressure photoionization source. Arch Pathol Lab Med 128: 469 - 475.
47. Haschke M, Zhang YL, Kahle C, Klawitter J, Korecka M, Shaw LM, Christians U,. 2007. HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma. Clin Chem 53: 489 - 497.
48. Henion JD,. 2009. The origins of ion spray liquid chromatography-tandem mass spectrometry. Clin Chem 55: 1234 - 1235.
49. Holst JP, Soldin OP, Guo T, Soldin SJ,. 2004. Steroid hormones: Relevance and measurement in the clinical laboratory. Clin Lab Med 24: 105 - 118.
50. Holst JP, Soldin SJ, Tractenberg RE, Guo T, Kundra P, Verbalis JG, Jonklaas J,. 2007. Use of steroid profiles in determining the cause of adrenal insufficiency. Steroids 72: 71 - 84.
51. Hoofnagle AN, Becker JO, Wener MH, Heinecke JW,. 2008. Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clin Chem 54: 1796 - 1804.
52. Janzen N, Peter M, Sander S, Steuerwald U, Terhardt M, Holtkamp U, Sander J,. 2007. Newborn screening for congenital adrenal hyperplasia: Additional steroid profile using liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 92: 2581 - 2589.
53. Kasper DC, Herman J, De Jesus V, Mechtler TP, Metz T, Shushan B,. (in press). The application of multiplexed, multi-dimensional UHPLC-MS/MS to the high throughput screening of lysosomal storage disorders in newborn bloodspots. Rapid Commun Mass Spectrom.
54. Kleinert P, Schmid M, Zurbriggen K, Speer O, Schmugge M, Roschitzki B, Durka SS, Leopold U, Kuster T, Heizmann CW, Frischknecht H, Troxler H,. 2008. Mass spectrometry: A tool for enhanced detection of hemoglobin variants. Clin Chem 54: 69 - 76.
55. Koster RA, Dijkers ECF, Uges DRA,. 2009. Robust, high-throughput LC-MS/MS method for therapeutic drug monitoring of cyclosporine, tacrolimus, everolimus, and sirolimus in whole blood. Ther Drug Monit 31: 116 - 125.
56. Koulman A, Woffendin G, Narayana VK, Welchman H, Crone C, Volmer DA,. 2009. High-resolution extracted ion chromatography, a new tool for metabolomics and lipidomics using a second-generation orbitrap mass spectrometer. Rapid Commun Mass Spectrom 23: 1411 - 1418.
57. Kuhn E, Addona T, Keshishian H, Burgess M, Mani DR, Lee RT, Sabatine MS, Gerszten RE, Carr SA,. 2009. Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry. Clin Chem 55: 1108 - 1117.
58. la Marca G, Casetta C, Malvagia S, Guerrini R, Zammarchi E,. 2009. New strategy for the screening of lysosomal storage disorders: The use of the online trapping-and-cleanup liquid chromatography/mass spectrometry. Anal Chem 81: 6113 - 6121.
59. Lacey JM, Minutti CZ, Magera MJ, Tauscher AL, Casetta B, McCann M, Lymp J, Hahn SH, Rinaldo P, Matern D,. 2004. Improved specificity of newborn screening for congenital adrenal hyperplasia by second-tier steroid profiling using tandem mass spectrometry. Clin Chem 50: 621 - 625. (Pubitemid 38297314)
60. Lacey JM, Magera MJ, Di Bussolo JM, Tortorelli S, Hahn SH, Rinaldo P, Matern D,. 2006. Rapid determination of steroids for newborn screening for congenital adrenal hyperplasia (CAH) by turbulent flow liquid chromatography-tandem mass spectrometry (LC/MS/MS). Proceedings of the 54th ASMS Conference, Seattle, WA, Poster MP04-094.
61. Lacey JM, Magera MJ, Di Bussolo JM, Lorey F, Tortorelli S, Gavrilov D, Rinaldo P, Matern D,. 2007. Development of a method for the determination of congenital adrenal hyperplasia (CAH) by turbulent flow chromatography and LC/MS/MS. Presented at the American Association of Clinical Chemistry Annual Meeting, San Diego, CA, July 18, 2007, Poster D-135.
62. Lennard L,. 2001. Therapeutic drug monitoring of cytotoxic drugs. Br J Clin Pharmacol 52: 75S - 87S.
63. Li Y, Scott CR, Chamoles NA, Ghavami A, Pinto BM, Turecek F, Gelb MH,. 2004a. Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening. Clin Chem 50: 1785 - 1786.
64. Li Y, Brockman K, Turecek F, Scott CR, Gelb MH,. 2004b. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: Application to newborn screening for Krabbe disease. Clin Chem 50: 638 - 640.
65. Makarov A,. 2000. Electrostatic axially harmonic orbital trapping: A high-performance technique of mass analysis. Anal Chem 72: 1156 - 1162.
66. Marsden D, Larson CA,. 2004. Emerging role for tandem mass spectrometry in detecting congenital adrenal hyperplasia. Clin Chem 50: 467 - 468.
67. Mauerer HH,. 2007. Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Anal Bioanal Chem 388: 1315 - 1325.
68. Millington DS,. 2005. Newborn screening for lysosomal storage disorders. Clin Chem 51: 808 - 809.
69. Millington DS,. 2008. Rapid and effective screening for lysosomal storage disease: How close are we ? Clin Chem 54: 1592 - 1594.
70. Nedelkov D, Kiernan UA, Niederkofler EE, Tubbs KA, Nelson RW,. 2005. Investigating diversity in human plasma proteins. Proc Natl Acad Sci USA 102: 10852 - 10857.
71. Nelson RE, Grebe SK, Singh RJ,. 2005. A high-throughput on-line extraction LC/MS/MS assay for testosterone in human serum (abstract E-108). Clin Chem 51 (6 Suppl): A242.
72. Niederkofle EE, Kiernan UA, O'Rear J, Menon S, Saghir S, Protter AA, Nelson RW, Schellenberger U,. 2008. Detection of endogenous B-type natriuretic peptide at very low concentrations in patients with heart failure. Circ Heart Fail 1: 258 - 264.
73. Nieminen MS, Böhm M, Cowie MR, Drexler H, Filippatos GS, Jondeau G, Hasin Y, Lopez-Sendon J, Mebazaa A, Metra M, Rhodes A, Swedberg K,. 2005. Executive summary of the guidelines on the diagnosis and treatment of acute heart failure. Eur Heart J 26: 384 - 416.
74. Patel M, Wagner AD, Morr M, Grant RP,. 2007. Advanced applications of LC/MS/MS in clinical diagnosis in endocrinology. Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Poster WPS-309.
75. Paulovich AG, Whiteaker JR, Hoofnagle AN, Wang P,. 2008. The interface between biomarker discovery and clinical validation: The tar pit of the protein biomarker pipeline. Proteomics Clin Appl 2: 1386 - 1402.
76. Rai DK, Landin B, Alvelius G, Griffiths WJ,. 2002. Electrospray tandem mass spectrometry of intact b-chain hemoglobin variants. Anal Chem 74: 2097 - 2102.
77. Rashed MS, Bucknall MP, Little D, Awad A, Jacob M, Alamoudi M, Alwattar M, Ozand PT,. 1997. Screening blood spots for inborn errors of metabolism by electrospray tandem mass spectrometry with a microplate batch process and a computer algorithm for automated flagging of abnormal profiles. Clin Chem 43: 1129 - 1141.
78. Redor-Goldman MM, Salameh WA, Reitz RE, Clarke N,. 2007a. Detection and quantification of estrone in human serum by high turbulent flow liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry. Presented at the Annual Meeting of the Endocrine Society, ENDO07, Toronto, Poster P1-344.
79. Redor-Goldman MM, Salameh WA, Reitz RE, Clarke N,. 2007b. Detection and quantification of estradiol in human serum by high turbulent flow liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry. Presented at the Annual Meeting of the Endocrine Society, ENDO07, Toronto, Poster P1-345.
80. Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H,. 2007. Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement. J Clin Endocrinol Metab 92: 405 - 413.
81. Sauvage FL, Gaulier JM, Lachatre G, Marquet P,. 2006a. A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum. Ther Drug Monit 28: 123 - 130.
82. Sauvage F-L, Saint-Marcoux F, Duretz B, Deporte D, Lachatre G, Marquet P,. 2006b. Screening of drugs and toxic compounds with liquid chromatography-linear ion trap tandem mass spectrometry. Clin Chem 52: 1735 - 1742.
83. Schwarz E, Liu A, Randall H, Haslip C, Keune F, Murray M, Longo N, Pasquali M,. 2009. Use of steroid profiling by UPLC-MS/MS as a second tier test in newborn screening for congenital adrenal hyperplasia: The Utah experience. Pediatr Res 66: 230 - 235.
84. Schwudke D, Hannich JT, Surendranath V, Grimard V, Moehring T, Burton L, Kurzchalia T, Shevchenko A,. 2007. Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra. Anal Chem 79: 4083 - 4093.
85. Soldin SJ, Soldin OP,. 2009. Steroid hormone analysis by tandem mass spectrometry. Clin Chem 55: 1061 - 1066.
86. Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A, Hoes A, Jaarsma T, Korewicki J, Lévy S, Linde C, Lopez-Sendon JL, Nieminen MS, Piérard L, Remme WJ,. 2005. Guidelines for the diagnosis and treatment of chronic heart failure: Executive summary (update 2005). Eur Heart J 26: 1115 - 1140. (Pubitemid 40839912)
87. Taylor PJ, Jones A, Balderson GA, Lynch SV, Norris RLG, Pond SM,. 1996. Sensitive, specific quantitative analysis of tacrolimus (FK506) in blood by liquid chromatography-electrospray tandem mass spectrometry. Clin Chem 42: 279 - 285.
88. Taylor RL, Grebe SK, Singh RJ,. 2005. High throughput analysis of 25-hydroxyvitamins D2 & D3 by LC/MS/MS using automated on-line extraction. Presented at the American Association of Clinical Chemistry Annual Meeting (Abstract D-117). Clin Chem 51 (6 Suppl): A103.
89. ThermoFisher Exactive Product Specification Brochure PS30157-E 07/08C, 2008.
90. Thienpont L,. 2008. A major step forward in the routine measurement of serum free thyroid hormones. Clin Chem 54: 625 - 626.
91. Thomson BA,. 1998. Atmospheric pressure ionization and liquid chromatography/mass spectrometry together at last. J Am Soc Mass Spectrom 9: 187 - 193.
92. Vogeser M, Parhofer KG,. 2007. Liquid chromatography tandem-mass spectrometry (LC-MS/MS)-Technique and applications in endocrinology. Exp Clin Endocrinol Diabetes 115: 559 - 570.
93. Vogeser M, Seger C,. 2008. Review: A decade of HPLC-MS/MS in the routine clinical laboratory-Goals for further developments. Clin Biochem 41: 649 - 662.
94. Wehr T, Oberhauser C, Niggebrugge A, Lachance D, Takarewski J, Pegram M, Quinn H,. 2000. Turbulent-flow LC for LC-MS and LC-MS-MS bioanalysis. LC-GC 18: 716 - 724.
95. Wichmann HE, Gieger C, Illig T, for the KORA Study Group. 2005. KORA-gen. Resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitwesen 67 (Suppl 1): 26 - 30.
96. Winchester B, Vellodi A, Young E,. 2000. The molecular basis of lysosomal storage diseases and their treatment. Biochem Soc Trans 28: 150 - 154.
97. Yang Z, Peng Y, Wang S,. 2005. Immunosuppressants: Pharmacokinetics, methods of monitoring and role of high performance liquid chromatography/mass spectrometry. Clin Appl Immunol Rev 5: 405 - 430.
98. Yue B, Rockwood AL, Sandrock T, La'ulu SL, Kushnir MM, Meikle AW,. 2008. Free thyroid hormones in serum by direct equilibrium dialysis and online solid phase extraction-liquid chromatography/tandem mass spectrometry. Clin Chem 54: 642 - 651.
99. Zhang K, Elbin CS, Chuang W-L, Cooper SK, Marashio CA, Beauregard C, Keutzer JM,. 2008. Multiplex enzyme assay screening of dried blood spots for lysosomal storage disorders by using tandem mass spectrometry. Clin Chem 54: 1725 - 1728.
100. Zhang NR, Yu S, Tiller P, Yeh S, Mahan E, Emary WB,. 2009. Quantitation of small molecules using high-resolution accurate mass spectrometers-A different approach for analysis of biological samples. Rapid Commun Mass Spectrom 23: 1085 - 1094.