Investigation of an on-line two-dimensional chromatographic approach for peptide analysis in plasma by LC-MS-MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 20-21, 2009, Pages 1873-1881

  Liu, Ang ^a   Tweed, Joseph ^b   Wujcik, Chad E ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c MONSANTO COMPANY   (United States)

Author keywords

Bioanalytical; HILIC; LC MS MS; On line extraction; Peptide; Two dimensional

Indexed keywords

BIOANALYTICAL; BIOLOGICAL SAMPLES; CHROMATOGRAPHIC RETENTION; HILIC; HYDROPHILIC INTERACTION CHROMATOGRAPHY; INTERNAL STANDARDS; ION-PAIRING; LC-MS/MS; MATRIX; MINIMAL SAMPLE; ON-LINE EXTRACTION; OPTIMIZED CONDITIONS; ORGANIC COMPOSITIONS; PEPTIDE ANALYSIS; PEPTIDE TRANSFER; POST-COLUMN; QUANTITATIVE ANALYSIS; REVERSED PHASE; SIGNAL SUPPRESSION; TRIFLUOROACETIC ACIDS;

CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; PEPTIDES; PLASMAS; TWO DIMENSIONAL;

AMINES;

ACETIC ACID; CARBON; EDETIC ACID; TRIFLUOROACETIC ACID;

AMINO ACID SEQUENCE; ARTICLE; ELECTROSPRAY; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PLASMA; PRIORITY JOURNAL; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; STANDARD;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ONLINE SYSTEMS; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE FRAGMENTS; RATS; TANDEM MASS SPECTROMETRY; TRIFLUOROACETIC ACID;

RATTUS;

EID: 67249086250     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.05.012     Document Type: Article

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