Development of a fully automated toxicological LC-MSn screening system in urine using online extraction with turbulent flow chromatography

Analytical and Bioanalytical Chemistry

Volumn 400, Issue 1, 2011, Pages 89-100

  Mueller, Daniel M ^a   Duretz, Bénédicte ^b   Espourteille, Francois A ^b   Rentsch, Katharina M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Thermo Fisher Scientific   (United States)

Author keywords

Clinical toxicology; LC MS; Online extraction; Toxicological screening; Turbulent flow chromatography

Indexed keywords

CHROMATOGRAPHIC SEPARATIONS; CLINICAL TOXICOLOGY; INTERNAL STANDARDS; LC-MS; LC-MS METHODS; LC-MS N; LINEAR ION TRAP; MATRIX EFFECTS; OFFLINE; ONLINE EXTRACTION; REPRODUCIBILITIES; SCREENING METHODS; SCREENING SYSTEM; SENSITIVE ANALYSIS; SPECTRAL LIBRARIES; TOXICOLOGICAL SCREENING; URINE SAMPLE; XENOBIOTIC SUBSTANCES;

BODY FLUIDS; CENTRIFUGATION; ENZYMATIC HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; TURBULENT FLOW; TURNAROUND TIME;

SOLVENT EXTRACTION;

DRUG;

ALGORITHM; ARTICLE; AUTOMATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY; URINE;

ALGORITHMS; AUTOMATION; CHROMATOGRAPHY, LIQUID; HUMANS; LIMIT OF DETECTION; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 79954438988     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4560-4     Document Type: Article

References (32)

1. HH Maurer 2004 Position of chromatographic techniques in screening for detection of drugs or poisons in clinical and forensic toxicology and/or doping control Clin Chem Lab Med 42 1310 1324 10.1515/CCLM.2004.250 1:CAS:528:DC%2BD2cXhtVGqtbnK (Pubitemid 39600332)
2. LR Baden G Horowitz H Jacoby GM Eliopoulos 2001 Quinolones and false-positive urine screening for opiates by immunoassay technology JAMA 286 3115 3119 10.1001/jama.286.24.3115 1:CAS:528:DC%2BD38XhsFejsg%3D%3D (Pubitemid 34016526)
3. B Aebi W Bernhard 2002 Advances in the use of mass spectral libraries for forensic toxicology J Anal Toxicol 26 149 156 1:CAS:528:DC%2BD38XivV2hu7Y%3D (Pubitemid 34309725)
4. F Pragst M Herzler B Erxleben 2004 Systematic toxicological analysis by high-performance liquid chromatography with diode array detection (HPLC-DAD) Clin Chem Lab Med 42 1325 1340 10.1515/CCLM.2004.251 1:CAS:528: DC%2BD2cXhtVGqtbbI (Pubitemid 39600333)
5. L Schönberg T Grobosch D Lampe C Kloft 2006 New screening method for basic compounds in urine by on-line extraction-high-performance liquid chromatography with photodiode-array detection J Chromatogr A 1134 177 185 10.1016/j.chroma.2006.09.009 (Pubitemid 44633944)
6. S Binder M Regalia M Biaggi McEachern M Mazhar 1989 Automated liquid chromatographic analysis of drugs in urine by on-line sample cleanup and isocratic muticolumn separation J Chromatogr 473 325 341 10.1016/S0021-9673(00) 91317-7 1:STN:280:DyaL1MzlvFKrsw%3D%3D (Pubitemid 19178886)
7. C Kratzsch O Tenberken FT Peters AA Weber T Kraemer HH Maurer 2004 Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization J Mass Spectrom 39 856 872 10.1002/jms.599 1:CAS:528: DC%2BD2cXntVCjuro%3D (Pubitemid 39173092)
8. AG Lips W Lameijer RH Fokkens NM Nibbering 2001 Methodology for the development of a drug library based upon collision-induced fragmentation for the identification of toxicologically relevant drugs in plasma samples J Chromatogr B Biomed Sci Appl 759 191 207 10.1016/S0378-4347(01)00249-3 1:CAS:528:DC%2BD3MXkvVensbc%3D (Pubitemid 32575280)
9. H-C Liu RH Liu D-L Lin H-O Ho 2010 Rapid screening and confirmation of drugs and toxic compounds in biological specimens using liquid chromatography/ion trap tandem mass spectrometry and automated library search Rapid Commun Mass Spectrum 24 75 84 10.1002/rcm.4365
10. S Dulaurent C Moesch P Marquet JM Gaulier G Lachatre 2010 Screening of pesticides in blood with liquid chromatography-linear ion trap mass spectrometry Anal Bioanal Chem 396 2235 2249 10.1007/s00216-009-3443-z 1:CAS:528: DC%2BC3cXhs1ykuro%3D
11. S Sturm F Hammann J Drewe HH Maurer A Scholer 2010 An automated screening method for drugs and toxic compounds in human serum and urine using liquid chromatography-tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci 878 2726 2732 10.1016/j.jchromb.2010.08.013 1:CAS:528: DC%2BC3cXht1Cgsb3E
12. P Marquet F Saint-Marcoux T Gamble J Leblanc 2003 Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupole-linear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique J Chromatogr B 789 9 18 10.1016/S1570-0232(03)00071-0 1:CAS:528:DC%2BD3sXjt1Grt74%3D (Pubitemid 36513782)
13. CA Mueller W Weinmann S Dresen A Schreiber M Gergov 2005 Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching Rapid Commun Mass Spectrom 19 1332 1338 10.1002/rcm.1934 1:CAS:528: DC%2BD2MXkvVyqsLs%3D (Pubitemid 40728148)
14. S Dresen N Ferreiros H Gnann R Zimmermann W Weinmann 2010 Detection and identification of 700 drugs by multi-target screening with a 3200 Q TRAP LC-MS/MS system and library searching Anal Bioanal Chem 396 2425 2434 10.1007/s00216-010-3485-2 1:CAS:528:DC%2BC3cXhsVWhtrc%3D
15. KL Lynch AR Breaud H Vandenberghe AH Wu W Clarke 2010 Performance evaluation of three liquid chromatography mass spectrometry methods for broad spectrum drug screening Clin Chim Acta 411 1474 1481 10.1016/j.cca.2010.05.046 1:CAS:528:DC%2BC3cXptlGjtrk%3D
16. S Dresen M Gergov L Politi C Halter W Weinmann 2009 ESI-MS/MS library of 1, 253 compounds for application in forensic and clinical toxicology Anal Bioanal Chem 395 2521 2526 10.1007/s00216-009-3084-2 1:CAS:528: DC%2BD1MXhtFCnsrnF
17. R Jansen G Lachatre P Marquet 2005 LC-MS/MS systematic toxicological analysis: comparison of MS/MS spectra obtained with different instruments and settings Clin Biochem 38 362 372 10.1016/j.clinbiochem.2004.11.003 1:CAS:528:DC%2BD2MXit1Ciuro%3D (Pubitemid 40342866)
18. C Hopley T Bristow A Lubben A Simpson E Bull K Klagkou J Herniman J Langley 2008 Towards a universal product ion mass spectral library - reproducibility of product ion spectra across eleven different mass spectrometers Rapid Commun Mass Spectrom 22 1779 1786 10.1002/rcm.3545 1:CAS:528:DC%2BD1cXotVygsrY%3D (Pubitemid 351947742)
19. H Oberacher M Pavlic K Libiseller B Schubert M Sulyok R Schuhmacher E Csaszar HC Kofeler 2009 On the inter-instrument and inter-laboratory transferability of a tandem mass spectral reference library: 1. Results of an Austrian multicenter study J Mass Spectrom 44 485 493 10.1002/jms.1545 1:CAS:528:DC%2BD1MXls1Squ7w%3D
20. H Oberacher M Pavlic K Libiseller B Schubert M Sulyok R Schuhmacher E Csaszar HC Kofeler 2009 On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library: 2. Optimization and characterization of the search algorithm J Mass Spectrom 44 494 502 10.1002/jms.1525 1:CAS:528:DC%2BD1MXls1Squ70%3D
21. JC Eichhorst ML Etter N Rousseaux DC Lehotay 2009 Drugs of abuse testing by tandem mass spectrometry: a rapid, simple method to replace immunoassays Clin Biochem 42 1531 1542 10.1016/j.clinbiochem.2009.07.019 1:CAS:528: DC%2BD1MXhtFKntr7O
22. HK Lee CS Ho YPH Iu PSJ Lai CC Shek Y-C Lo HB Klinke M Wood 2009 Development of a broad toxicological screening technique for urine using ultra-performance liquid chromatography and time-of-flight mass spectrometry Anal Chim Acta 649 80 90 10.1016/j.aca.2009.06.068 1:CAS:528: DC%2BD1MXps1CqsLs%3D
23. S Ojanperä A Pelander M Pelzing I Krebs E Vuori I Ojanperä 2006 Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometry Rapid Commun Mass Spectrom 20 1161 1167 10.1002/rcm.2429
24. T Decaestecker S Vande Casteele P Wallemacq C Van Peteghem D Defore J Van Bocxlaer 2004 Information-dependent acquisition-mediated LC-MS/MS screening procedure with semiquantitative potential Anal Chem 76 6365 6373 10.1021/ac0492315 1:CAS:528:DC%2BD2cXnvVelu74%3D (Pubitemid 39458470)
25. U Ceglarek J Lembcke G Martin Fiedler M Werner H Witzigmann J Peter Hauss J Thiery 2004 Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry Clin Chim Acta 346 181 190 10.1016/j.cccn.2004.03.017 1:CAS:528:DC%2BD2cXlslyhtLk%3D (Pubitemid 38901049)
26. AR Breaud R Harlan JM Di Bussolo GA McMillin W Clarke 2010 A rapid and fully-automated method for the quantitation of tricyclic antidepressants in serum using turbulent-flow liquid chromatography-tandem mass spectrometry Clin Chim Acta 411 825 832 10.1016/j.cca.2010.02.067 1:CAS:528:DC%2BC3cXmsF2nsb8%3D
27. R Dams MA Huestis WE Lambert CM Murphy 2003 Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid J Am Soc Mass Spectrom 14 1290 1294 10.1016/S1044-0305(03)00574-9 1:CAS:528:DC%2BD3sXosVWqsbs%3D (Pubitemid 37330133)
28. S Zgraggen R Bonatim U Gutteck-Amsler KM Rentsch 2007 Toxicological screening after the REMEDI™-comparison of a GC-MS screening with the REMEDI™ Ther Drug Monit 29 492 492
29. Mueller DM, Rentsch KM (2009) Development and validation of a library-assisted toxicological screening method in urine by LC-MS2. In: Proceedings XVI GTFCh-Symposium. pp. 166-169
30. R Bonfiglio R King T Olah K Merkle 1999 The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds Rapid Commun Mass Spectrom 13 1175 1185 10.1002/(SICI)1097- 0231(19990630)13:12<1175::AID-RCM639>3.0.CO;2-0 1:CAS:528: DyaK1MXkt1ejtb8%3D (Pubitemid 29285118)
31. BK Matuszewski ML Constanzer CM Chavez-Eng 2003 Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS Anal Chem 75 3019 3030 10.1021/ac020361s 1:CAS:528: DC%2BD3sXltV2jsL8%3D (Pubitemid 36830428)
32. F-L Sauvage 2006 Screening of drugs and toxic compounds with liquid chromatography-linear ion trap tandem mass spectrometry Clin Chem 52 1735 1742 10.1373/clinchem.2006.067116 1:CAS:528:DC%2BD28Xpt1WitrY%3D (Pubitemid 44330708)