Profiling of endogenous peptides by multidimensional liquid chromatography: On-line automated sample cleanup for biomarker discovery in human urine

Journal of Separation Science

Volumn 32, Issue 13, 2009, Pages 2223-2232

  Machtejevras, Egidijus ^a   Marko Varga, Gyorgy ^b   Lindberg, Claes ^b   Lubda, Dieter ^c   Hendriks, Robertus ^c   Unger, Klaus K ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

^c MERCK KGAA   (Germany)

Author keywords

Peptidomics; Restricted access material; Sample clean up; Urine peptide analysis

Indexed keywords

ADJUSTABLE PARAMETERS; ADSORPTION SITE; BIO-MARKER DISCOVERY; BIOLOGICAL SAMPLES; CHARGED COMPOUNDS; COLUMN SWITCHING; CONCENTRATION-DEPENDENT; FLEXIBLE SYSTEM; HUMAN URINE; INTERNAL PORES; LOADING PROCESS; MAIN PARAMETERS; MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY; PEPTIDOMICS; PH ADJUSTMENT; POSITIVELY CHARGED PEPTIDES; PROOF OF PRINCIPLES; REPRODUCIBILITIES; RESTRICTED ACCESS MATERIAL; RESTRICTED ACCESS MATERIALS; SAMPLE CLEAN UP; URINE PEPTIDE ANALYSIS; URINE SAMPLE;

ADSORPTION; BIOCOMPATIBILITY; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; LIQUID CHROMATOGRAPHY; PEPTIDES; PORE STRUCTURE; RANDOM ACCESS STORAGE; TRACE ANALYSIS;

AMINES;

ADSORPTION CHROMATOGRAPHY; ARTICLE; AUTOANALYSIS; BIOCOMPATIBILITY; CATION EXCHANGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DILUTION; DISEASE MARKER; FLOW RATE; HUMAN; ION EXCHANGE CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR SIZE; MOLECULAR WEIGHT; ONLINE ANALYSIS; PEPTIDE ANALYSIS; PEPTIDE MAPPING; PRIORITY JOURNAL; PROCESS DESIGN; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SURFACE CHARGE; URINALYSIS; URINE PH; CHEMISTRY; EVALUATION; INSTRUMENTATION; LABORATORY DIAGNOSIS; METHODOLOGY; PH; URINE;

BIOLOGICAL MARKER; PEPTIDE;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR WEIGHT; PEPTIDES; REPRODUCIBILITY OF RESULTS; SPECIMEN HANDLING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 70149087179     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900058     Document Type: Article

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