-
2
-
-
33750029285
-
Aging and immortality: Quasiprogrammed senescence and its pharmacologic inhibition
-
Blagosklonny MV. Aging and immortality: quasiprogrammed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102.
-
(2006)
Cell Cycle
, vol.5
, pp. 2087-2102
-
-
Blagosklonny, M.V.1
-
3
-
-
33644755871
-
Unlocking the secrets of longevity genes
-
Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Sci Am 2006; 294:48-51.
-
(2006)
Sci Am
, vol.294
, pp. 48-51
-
-
Sinclair, D.A.1
Guarente, L.2
-
4
-
-
67649347537
-
Growth and aging: A common molecular mechanism
-
Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging 2009; 1:357-62.
-
(2009)
Aging
, vol.1
, pp. 357-362
-
-
Blagosklonny, M.V.1
Hall, M.N.2
-
5
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
6
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogenous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460:392-6.
-
(2009)
Nature
, vol.460
, pp. 392-396
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
7
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury A, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.6
-
8
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61.
-
(2008)
Cell Cycle
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
9
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle 2009; 8:1888-95.
-
(2009)
Cell Cycle
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
10
-
-
67649369064
-
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
-
Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009; 8:1896-900.
-
(2009)
Cell Cycle
, vol.8
, pp. 1896-1900
-
-
Demidenko, Z.N.1
Shtutman, M.2
Blagosklonny, M.V.3
-
11
-
-
69249206717
-
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
-
Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009; 5:279-89.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 279-289
-
-
Castilho, R.M.1
Squarize, C.H.2
Chodosh, L.A.3
Williams, B.O.4
Gutkind, J.S.5
-
12
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7:3344-54.
-
(2008)
Cell Cycle
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
13
-
-
59049086591
-
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
-
Pérez VI, Van Remmen H, Bokov A, Epstein CJ, Vijg J, Richardson A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 2009; 8:73-5.
-
(2009)
Aging Cell
, vol.8
, pp. 73-75
-
-
Pérez, V.I.1
Van Remmen, H.2
Bokov, A.3
Epstein, C.J.4
Vijg, J.5
Richardson, A.6
-
14
-
-
61449184625
-
-
Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009; 5:1000361.
-
Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009; 5:1000361.
-
-
-
-
15
-
-
66749126389
-
Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?
-
Gems D, Doonan R. Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? Cell Cycle 2009; 8:1681-7.
-
(2009)
Cell Cycle
, vol.8
, pp. 1681-1687
-
-
Gems, D.1
Doonan, R.2
-
16
-
-
66149165913
-
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster
-
Edman U, Garcia AM, Busuttil RA, Sorensen D, Lundell M, Kapahi P, et al. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell 2009; 8:331-8.
-
(2009)
Aging Cell
, vol.8
, pp. 331-338
-
-
Edman, U.1
Garcia, A.M.2
Busuttil, R.A.3
Sorensen, D.4
Lundell, M.5
Kapahi, P.6
-
17
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
18
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131:3897-906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
19
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001; 292:107-10.
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
20
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90.
-
(2004)
Curr Biol
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
21
-
-
33644507693
-
Long-lived Klotho mice: New insights into the roles of IGF-1 and insulin in aging
-
Bartke A. Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab 2006; 17:33-5.
-
(2006)
Trends Endocrinol Metab
, vol.17
, pp. 33-35
-
-
Bartke, A.1
-
22
-
-
0001047561
-
The effect of retardation of growth upon the breeding period and duration of life of rats
-
Osborne TB, Mendel LB, Ferry EL. The effect of retardation of growth upon the breeding period and duration of life of rats. Science 1917; 45:294-5.
-
(1917)
Science
, vol.45
, pp. 294-295
-
-
Osborne, T.B.1
Mendel, L.B.2
Ferry, E.L.3
-
23
-
-
67650439330
-
Caloric restriction delays disease onset and mortality in rhesus monkeys
-
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009; 325:201-4.
-
(2009)
Science
, vol.325
, pp. 201-204
-
-
Colman, R.J.1
Anderson, R.M.2
Johnson, S.C.3
Kastman, E.K.4
Kosmatka, K.J.5
Beasley, T.M.6
-
24
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
25
-
-
33751246173
-
A stress response pathway involving sirtuins, forkhead and 14-3-3 proteins
-
Berdichevsky A, Guarente L. A stress response pathway involving sirtuins, forkhead and 14-3-3 proteins. Cell Cycle 2006; 5:2588-91.
-
(2006)
Cell Cycle
, vol.5
, pp. 2588-2591
-
-
Berdichevsky, A.1
Guarente, L.2
-
26
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5:493-506.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
27
-
-
67649369072
-
At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
-
Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle 2009; 8:1901-4.
-
(2009)
Cell Cycle
, vol.8
, pp. 1901-1904
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
28
-
-
74849124984
-
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
-
Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging 2009; 1:515-28.
-
(2009)
Aging
, vol.1
, pp. 515-528
-
-
Armour, S.M.1
Baur, J.A.2
Hsieh, S.N.3
Land-Bracha, A.4
Thomas, S.M.5
Sinclair, D.A.6
-
29
-
-
74849106934
-
Inhibition of S6K by resveratrol: In search of the purpose
-
Blagosklonny MV. Inhibition of S6K by resveratrol: In search of the purpose. Aging 2009; 1:511-4.
-
(2009)
Aging
, vol.1
, pp. 511-514
-
-
Blagosklonny, M.V.1
-
30
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425:191-6.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
-
31
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004; 430:686-9.
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
-
32
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444:337-42.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
-
33
-
-
34548293807
-
Protein synthesis and aging: EIF4E and the soma vs. germline distinction
-
Tavernarakis N. Protein synthesis and aging: eIF4E and the soma vs. germline distinction. Cell Cycle 2007; 6:1168-71.
-
(2007)
Cell Cycle
, vol.6
, pp. 1168-1171
-
-
Tavernarakis, N.1
-
34
-
-
33847199335
-
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
-
Syntichaki P, Troulinaki K, Tavernarakis N. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 2007; 445:922-6.
-
(2007)
Nature
, vol.445
, pp. 922-926
-
-
Syntichaki, P.1
Troulinaki, K.2
Tavernarakis, N.3
-
35
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, et al. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 2007; 6:111-9.
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
-
36
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 2007; 6:95-110.
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
37
-
-
67649316034
-
Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacological deceleration
-
Blagosklonny MV. Aging-suppressants: cellular senescence (hyperactivation) and its pharmacological deceleration. Cell Cycle 2009; 8:1883-7.
-
(2009)
Cell Cycle
, vol.8
, pp. 1883-1887
-
-
Blagosklonny, M.V.1
-
38
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
this issue
-
Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle 2009; 8 (this issue).
-
(2009)
Cell Cycle
, pp. 8
-
-
Pospelova, T.V.1
Demidenko, Z.N.2
Bukreeva, E.I.3
Pospelov, V.A.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
39
-
-
33847226657
-
An anti-aging drug today: From senescence-promoting genes to anti-aging pill
-
Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today 2007; 12:218-24.
-
(2007)
Drug Disc Today
, vol.12
, pp. 218-224
-
-
Blagosklonny, M.V.1
-
40
-
-
38149107357
-
Paradoxes of aging
-
Blagosklonny MV. Paradoxes of aging. Cell Cycle 2007; 6:2997-3003.
-
(2007)
Cell Cycle
, vol.6
, pp. 2997-3003
-
-
Blagosklonny, M.V.1
-
41
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19-24.
-
(2005)
Nat Genet
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.L.3
-
42
-
-
12344262762
-
mTOR, translational control and human disease
-
Tee AR, Blenis J. mTOR, translational control and human disease. Semin Cell Dev Biol 2005; 16:29-37.
-
(2005)
Semin Cell Dev Biol
, vol.16
, pp. 29-37
-
-
Tee, A.R.1
Blenis, J.2
-
43
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today 2007; 12:112-24.
-
(2007)
Drug Disc Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.S.4
-
44
-
-
33646056392
-
Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis the prospective, randomized oral rapamycin in Argentina (ORAR II) study
-
Rodriguez AE, Granada JF, Rodriguez-Alemparte M, Vigo CF, Delgado J, Fernandez-Pereira C, et al. Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis the prospective, randomized oral rapamycin in Argentina (ORAR II) study. J Am Coll Cardiol 2006; 47:1522-9.
-
(2006)
J Am Coll Cardiol
, vol.47
, pp. 1522-1529
-
-
Rodriguez, A.E.1
Granada, J.F.2
Rodriguez-Alemparte, M.3
Vigo, C.F.4
Delgado, J.5
Fernandez-Pereira, C.6
-
45
-
-
4043142865
-
Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Results from five multicenter studies
-
Mathew T, Kreis H, Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant 2004; 18:446-9.
-
(2004)
Clin Transplant
, vol.18
, pp. 446-449
-
-
Mathew, T.1
Kreis, H.2
Friend, P.3
-
46
-
-
27644436740
-
Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
-
Kauffman HM, Cherikh WS, Cheng Y, Hanto DW, Kahan BD. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 2005; 80:883-9.
-
(2005)
Transplantation
, vol.80
, pp. 883-889
-
-
Kauffman, H.M.1
Cherikh, W.S.2
Cheng, Y.3
Hanto, D.W.4
Kahan, B.D.5
-
47
-
-
33645458234
-
Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation
-
Campistol JM, Eris J, Oberbauer R, Friend P, Hutchison B, Morales JM, et al. Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation. J Am Soc Nephrol 2006; 17:581-9.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 581-589
-
-
Campistol, J.M.1
Eris, J.2
Oberbauer, R.3
Friend, P.4
Hutchison, B.5
Morales, J.M.6
-
48
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A, Miller EA, Morimoto RI. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 2009; 106:14914-9.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
49
-
-
70149085849
-
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
-
Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, Gilpin C, et al. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci USA 2009; 106:14564-9.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14564-14569
-
-
Jia, K.1
Thomas, C.2
Akbar, M.3
Sun, Q.4
Adams-Huet, B.5
Gilpin, C.6
|