메뉴 건너뛰기




Volumn 8, Issue 24, 2009, Pages 4055-4059

TOR-driven aging: Speeding car without brakes

Author keywords

Aging; mTOR; Rapamycin; Senescence; TOR

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN;

EID: 74849115774     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.24.10310     Document Type: Short Survey
Times cited : (74)

References (49)
  • 2
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: Quasiprogrammed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasiprogrammed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 3
    • 33644755871 scopus 로고    scopus 로고
    • Unlocking the secrets of longevity genes
    • Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Sci Am 2006; 294:48-51.
    • (2006) Sci Am , vol.294 , pp. 48-51
    • Sinclair, D.A.1    Guarente, L.2
  • 4
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: A common molecular mechanism
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging 2009; 1:357-62.
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 5
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 6
  • 8
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 10
    • 67649369064 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
    • Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009; 8:1896-900.
    • (2009) Cell Cycle , vol.8 , pp. 1896-1900
    • Demidenko, Z.N.1    Shtutman, M.2    Blagosklonny, M.V.3
  • 12
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7:3344-54.
    • (2008) Cell Cycle , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 14
    • 61449184625 scopus 로고    scopus 로고
    • Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009; 5:1000361.
    • Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009; 5:1000361.
  • 15
    • 66749126389 scopus 로고    scopus 로고
    • Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?
    • Gems D, Doonan R. Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? Cell Cycle 2009; 8:1681-7.
    • (2009) Cell Cycle , vol.8 , pp. 1681-1687
    • Gems, D.1    Doonan, R.2
  • 16
    • 66149165913 scopus 로고    scopus 로고
    • Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster
    • Edman U, Garcia AM, Busuttil RA, Sorensen D, Lundell M, Kapahi P, et al. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell 2009; 8:331-8.
    • (2009) Aging Cell , vol.8 , pp. 331-338
    • Edman, U.1    Garcia, A.M.2    Busuttil, R.A.3    Sorensen, D.4    Lundell, M.5    Kapahi, P.6
  • 18
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131:3897-906.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 19
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001; 292:107-10.
    • (2001) Science , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 20
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 21
    • 33644507693 scopus 로고    scopus 로고
    • Long-lived Klotho mice: New insights into the roles of IGF-1 and insulin in aging
    • Bartke A. Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab 2006; 17:33-5.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 33-35
    • Bartke, A.1
  • 22
    • 0001047561 scopus 로고
    • The effect of retardation of growth upon the breeding period and duration of life of rats
    • Osborne TB, Mendel LB, Ferry EL. The effect of retardation of growth upon the breeding period and duration of life of rats. Science 1917; 45:294-5.
    • (1917) Science , vol.45 , pp. 294-295
    • Osborne, T.B.1    Mendel, L.B.2    Ferry, E.L.3
  • 24
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 25
    • 33751246173 scopus 로고    scopus 로고
    • A stress response pathway involving sirtuins, forkhead and 14-3-3 proteins
    • Berdichevsky A, Guarente L. A stress response pathway involving sirtuins, forkhead and 14-3-3 proteins. Cell Cycle 2006; 5:2588-91.
    • (2006) Cell Cycle , vol.5 , pp. 2588-2591
    • Berdichevsky, A.1    Guarente, L.2
  • 26
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5:493-506.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 27
    • 67649369072 scopus 로고    scopus 로고
    • At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
    • Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle 2009; 8:1901-4.
    • (2009) Cell Cycle , vol.8 , pp. 1901-1904
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 29
    • 74849106934 scopus 로고    scopus 로고
    • Inhibition of S6K by resveratrol: In search of the purpose
    • Blagosklonny MV. Inhibition of S6K by resveratrol: In search of the purpose. Aging 2009; 1:511-4.
    • (2009) Aging , vol.1 , pp. 511-514
    • Blagosklonny, M.V.1
  • 30
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425:191-6.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 31
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004; 430:686-9.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6
  • 32
  • 33
    • 34548293807 scopus 로고    scopus 로고
    • Protein synthesis and aging: EIF4E and the soma vs. germline distinction
    • Tavernarakis N. Protein synthesis and aging: eIF4E and the soma vs. germline distinction. Cell Cycle 2007; 6:1168-71.
    • (2007) Cell Cycle , vol.6 , pp. 1168-1171
    • Tavernarakis, N.1
  • 34
    • 33847199335 scopus 로고    scopus 로고
    • eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
    • Syntichaki P, Troulinaki K, Tavernarakis N. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 2007; 445:922-6.
    • (2007) Nature , vol.445 , pp. 922-926
    • Syntichaki, P.1    Troulinaki, K.2    Tavernarakis, N.3
  • 36
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 2007; 6:95-110.
    • (2007) Aging Cell , vol.6 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.J.5    Kenyon, C.6
  • 37
    • 67649316034 scopus 로고    scopus 로고
    • Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacological deceleration
    • Blagosklonny MV. Aging-suppressants: cellular senescence (hyperactivation) and its pharmacological deceleration. Cell Cycle 2009; 8:1883-7.
    • (2009) Cell Cycle , vol.8 , pp. 1883-1887
    • Blagosklonny, M.V.1
  • 39
    • 33847226657 scopus 로고    scopus 로고
    • An anti-aging drug today: From senescence-promoting genes to anti-aging pill
    • Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today 2007; 12:218-24.
    • (2007) Drug Disc Today , vol.12 , pp. 218-224
    • Blagosklonny, M.V.1
  • 40
    • 38149107357 scopus 로고    scopus 로고
    • Paradoxes of aging
    • Blagosklonny MV. Paradoxes of aging. Cell Cycle 2007; 6:2997-3003.
    • (2007) Cell Cycle , vol.6 , pp. 2997-3003
    • Blagosklonny, M.V.1
  • 41
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19-24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 42
    • 12344262762 scopus 로고    scopus 로고
    • mTOR, translational control and human disease
    • Tee AR, Blenis J. mTOR, translational control and human disease. Semin Cell Dev Biol 2005; 16:29-37.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 43
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today 2007; 12:112-24.
    • (2007) Drug Disc Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 44
    • 33646056392 scopus 로고    scopus 로고
    • Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis the prospective, randomized oral rapamycin in Argentina (ORAR II) study
    • Rodriguez AE, Granada JF, Rodriguez-Alemparte M, Vigo CF, Delgado J, Fernandez-Pereira C, et al. Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis the prospective, randomized oral rapamycin in Argentina (ORAR II) study. J Am Coll Cardiol 2006; 47:1522-9.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1522-1529
    • Rodriguez, A.E.1    Granada, J.F.2    Rodriguez-Alemparte, M.3    Vigo, C.F.4    Delgado, J.5    Fernandez-Pereira, C.6
  • 45
    • 4043142865 scopus 로고    scopus 로고
    • Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Results from five multicenter studies
    • Mathew T, Kreis H, Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant 2004; 18:446-9.
    • (2004) Clin Transplant , vol.18 , pp. 446-449
    • Mathew, T.1    Kreis, H.2    Friend, P.3
  • 46
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffman HM, Cherikh WS, Cheng Y, Hanto DW, Kahan BD. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 2005; 80:883-9.
    • (2005) Transplantation , vol.80 , pp. 883-889
    • Kauffman, H.M.1    Cherikh, W.S.2    Cheng, Y.3    Hanto, D.W.4    Kahan, B.D.5
  • 47
    • 33645458234 scopus 로고    scopus 로고
    • Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation
    • Campistol JM, Eris J, Oberbauer R, Friend P, Hutchison B, Morales JM, et al. Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation. J Am Soc Nephrol 2006; 17:581-9.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 581-589
    • Campistol, J.M.1    Eris, J.2    Oberbauer, R.3    Friend, P.4    Hutchison, B.5    Morales, J.M.6
  • 48
    • 70349266064 scopus 로고    scopus 로고
    • Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    • Ben-Zvi A, Miller EA, Morimoto RI. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 2009; 106:14914-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14914-14919
    • Ben-Zvi, A.1    Miller, E.A.2    Morimoto, R.I.3
  • 49
    • 70149085849 scopus 로고    scopus 로고
    • Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
    • Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, Gilpin C, et al. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci USA 2009; 106:14564-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14564-14569
    • Jia, K.1    Thomas, C.2    Akbar, M.3    Sun, Q.4    Adams-Huet, B.5    Gilpin, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.