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Volumn 1, Issue 1, 2010, Pages

Cytotoxicity of apigenin on leukemia cell lines: Implications for prevention and therapy

Author keywords

apigenin; apoptosis; cell cycle arrest; kinase; leukemia; STAT

Indexed keywords

APIGENIN; CASPASE 3; CASPASE 7; CASPASE 8; VINCRISTINE; ANTINEOPLASTIC AGENT; JANUS KINASE; STAT PROTEIN;

EID: 79953038110     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2009.18     Document Type: Article
Times cited : (169)

References (35)
  • 2
    • 0033933197 scopus 로고    scopus 로고
    • Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines
    • DOI 10.1002/1098-2744(200006)28:2<102::AID-MC6>3.0.CO;2-2
    • Wang W, Heideman L, Chung C, Pelling J, Koehler K, Birt D. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol Carcinog 2000; 28: 102-110. (Pubitemid 30432478)
    • (2000) Molecular Carcinogenesis , vol.28 , Issue.2 , pp. 102-110
    • Wang, W.1    Heideman, L.2    Chung, C.S.3    Pelling, J.C.4    Koehler, K.J.5    Birt, D.F.6
  • 3
    • 0032856994 scopus 로고    scopus 로고
    • Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
    • DOI 10.1016/S0959-8049(99)00168-9, PII S0959804999001689
    • Wang I, Lin-Shiau S, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999; 35: 1517-1525. (Pubitemid 29454650)
    • (1999) European Journal of Cancer , vol.35 , Issue.10 , pp. 1517-1525
    • Wang, I.-K.1    Lin-Shiau, S.-Y.2    Lin, J.-K.3
  • 4
    • 18044383342 scopus 로고    scopus 로고
    • Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells
    • DOI 10.1016/j.bcp.2005.02.022
    • Chen D, Daniel K, Chen M, Kuhn D, Landis-Piwowar K, Dou Q. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol 2005; 69: 1421-1432. (Pubitemid 40602442)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.10 , pp. 1421-1432
    • Chen, D.1    Daniel, K.G.2    Chen, M.S.3    Kuhn, D.J.4    Landis-Piwowar, K.R.5    Dou, Q.P.6
  • 5
    • 33847361829 scopus 로고    scopus 로고
    • Protein kinase CK2α as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia
    • DOI 10.1158/1078-0432.CCR-06-1602
    • Kim J, Eom J, Cheong J, Choi A, Lee J, Yang W et al. Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia. Clin Cancer Res 2007; 13: 1019-1028. (Pubitemid 46340381)
    • (2007) Clinical Cancer Research , vol.13 , Issue.3 , pp. 1019-1028
    • Jin, S.K.1    Ju, I.E.2    Cheong, J.-W.3    Ae, J.C.4    Jin, K.L.5    Woo, I.Y.6    Yoo, H.M.7
  • 6
    • 9744225155 scopus 로고    scopus 로고
    • Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways
    • Monasterio A, Urdaci M, Pinchuk I, López-Moratalla N, Martínez-Irujo J. Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpaindependent pathways. Nutr Cancer 2004; 50: 90-100. (Pubitemid 39587610)
    • (2004) Nutrition and Cancer , vol.50 , Issue.1 , pp. 90-100
    • Monasterio, A.1    Urdaci, M.C.2    Pinchuk, I.V.3    Lopez-Moratalla, N.4    Martinez-Irujo, J.J.5
  • 7
    • 33747188963 scopus 로고    scopus 로고
    • Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells
    • DOI 10.1016/j.bcp.2006.06.010, PII S0006295206003315
    • Vargo M, Voss O, Poustka F, Cardounel A, Grotewold E, Doseff AI. Apigenin-inducedapoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol 2006; 72: 681-692. (Pubitemid 44233544)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.6 , pp. 681-692
    • Vargo, M.A.1    Voss, O.H.2    Poustka, F.3    Cardounel, A.J.4    Grotewold, E.5    Doseff, A.I.6
  • 8
    • 1042289764 scopus 로고    scopus 로고
    • Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway
    • DOI 10.1074/jbc.M305529200
    • Way T-D, Kao M-C, Lin J-K. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 2004; 279: 4479-4489. (Pubitemid 38199038)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 4479-4489
    • Way, T.-D.1    Kao, M.-C.2    Lin, J.-K.3
  • 9
    • 38949194993 scopus 로고    scopus 로고
    • Modulation of STAT5 interaction with LMW-PTP during early megakaryocyte differentiation
    • DOI 10.1021/bi701131e
    • Rigacci S, Guidotti V, Parri M, Berti A. Modulation of STAT5 interaction with LMW-PTP during early megakaryocyte differentiation. Biochemistry 2008; 47: 1482-1489. (Pubitemid 351231199)
    • (2008) Biochemistry , vol.47 , Issue.6 , pp. 1482-1489
    • Rigacci, S.1    Guidotti, V.2    Parri, M.3    Berti, A.4
  • 10
    • 44449164361 scopus 로고    scopus 로고
    • Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells
    • Bispo de Jesus M, Zambuzzi WF, Ruela de Sousa R, Areche C, Souza A, Aoyama H et al. Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells. Biochimie 2008; 90: 843-854.
    • (2008) Biochimie , vol.90 , pp. 843-854
    • Bispo De Jesus, M.1    Zambuzzi, W.F.2    Ruela De Sousa, R.3    Areche, C.4    Souza, A.5    Aoyama, H.6
  • 13
    • 4444302229 scopus 로고    scopus 로고
    • Molecular mechanism of violacein-mediated human leukemia cell death
    • DOI 10.1182/blood-2004-02-0594
    • Ferreira C, Bos C, Versteeg H, Justo G, Duran N, Peppelenbosch M. Molecular mechanism of violacein-mediated human leukemia cell death. Blood 2004; 104: 1459-1464. (Pubitemid 39166525)
    • (2004) Blood , vol.104 , Issue.5 , pp. 1459-1464
    • Ferreira, C.V.1    Bos, C.L.2    Versteeg, H.H.3    Justo, G.Z.4    Duran, N.5    Peppelenbosch, M.P.6
  • 15
    • 33646907207 scopus 로고    scopus 로고
    • Control of the G2/M transition
    • Stark G, Taylor W. Control of the G2/M transition. Mol Biotechnol 2006; 32: 227-248.
    • (2006) Mol Biotechnol , vol.32 , pp. 227-248
    • Stark, G.1    Taylor, W.2
  • 16
    • 0029910364 scopus 로고    scopus 로고
    • 1 checkpoint
    • Lukas J, Bartkova J, Bartek J. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol 1996; 16: 6917-6925. (Pubitemid 26389751)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.12 , pp. 6917-6925
    • Lukas, J.1    Bartkova, J.2    Bartek, J.3
  • 17
    • 61749103821 scopus 로고    scopus 로고
    • Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells
    • Choi EJ, Kim G-H. Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells. J Nutr Biochem 2009; 20: 285-290.
    • (2009) J Nutr Biochem , vol.20 , pp. 285-290
    • Choi, E.J.1    Kim, G.-H.2
  • 18
    • 0030796989 scopus 로고    scopus 로고
    • 1 cell-cycle arrest by the chemopreventive agent apigenin
    • DOI 10.1002/(SICI)1098-2744(199707)19:2<74::AID-MC2>3.0.CO;2-L
    • Lepley D, Pelling J. Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin. Mol Carcinog 1997; 19: 74-82. (Pubitemid 27296738)
    • (1997) Molecular Carcinogenesis , vol.19 , Issue.2 , pp. 74-82
    • Lepley, D.M.1    Pelling, J.C.2
  • 19
    • 33846653627 scopus 로고    scopus 로고
    • Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
    • Ujiki M, Ding X-Z, Salabat M, Bentrem D, Golkar L, Milam B et al. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol Cancer 2006; 5: 76.
    • (2006) Mol Cancer , vol.5 , pp. 76
    • Ujiki, M.1    Ding, X.-Z.2    Salabat, M.3    Bentrem, D.4    Golkar, L.5    Milam, B.6
  • 20
    • 42649110670 scopus 로고    scopus 로고
    • Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
    • Shukla S, Gupta S. Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radic Biol Med 2008; 44: 1833-1845.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1833-1845
    • Shukla, S.1    Gupta, S.2
  • 21
    • 70350026142 scopus 로고    scopus 로고
    • The synthesized 2-(2- fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells
    • Chou L-C, Yang J-S, Huang L-J, Wu H-C, Lu C-C, Chiang J-H et al. The synthesized 2-(2- fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells. J Gastroenterol 2009; 44: 1055-1063.
    • (2009) J Gastroenterol , vol.44 , pp. 1055-1063
    • Chou, L.-C.1    Yang, J.-S.2    Huang, L.-J.3    Wu, H.-C.4    Lu, C.-C.5    Chiang, J.-H.6
  • 22
    • 70349335623 scopus 로고    scopus 로고
    • Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis
    • Hsu Y-L, Uen Y-H, Chen Y, Liang H-L, Kuo P-L. Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. J Agric Food Chem 2009; 57: 8688-8695.
    • (2009) J Agric Food Chem , vol.57 , pp. 8688-8695
    • Hsu, Y.-L.1    Uen, Y.-H.2    Chen, Y.3    Liang, H.-L.4    Kuo, P.-L.5
  • 24
    • 70350097409 scopus 로고    scopus 로고
    • Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
    • Kang KB, Zhu C, Yong SK, Gao Q, Wong MC. Enhanced sensitivity of celecoxib in human glioblastoma cells: induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. Mol Cancer 2009; 8: 66.
    • (2009) Mol Cancer , vol.8 , pp. 66
    • Kang, K.B.1    Zhu, C.2    Yong, S.K.3    Gao, Q.4    Wong, M.C.5
  • 25
    • 68849090700 scopus 로고    scopus 로고
    • Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells
    • Fuhler G, Tyl M, Olthof S, Lyndsay Drayer A, Blom N, Vellenga E. Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells. Eur J Haematol 2009; 83: 235-245.
    • (2009) Eur J Haematol , vol.83 , pp. 235-245
    • Fuhler, G.1    Tyl, M.2    Olthof, S.3    Lyndsay Drayer, A.4    Blom, N.5    Vellenga, E.6
  • 26
    • 33646057653 scopus 로고    scopus 로고
    • Pten, tumorigenesis, and stem cell self-renewal
    • Rossi DJ, Weissman IL. Pten, tumorigenesis, and stem cell self-renewal. Cell 2006; 125: 229-231.
    • (2006) Cell , vol.125 , pp. 229-231
    • Rossi, D.J.1    Weissman, I.L.2
  • 27
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • DOI 10.1038/nature04703, PII NATURE04703
    • Yilmaz O, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006; 441: 475-482. (Pubitemid 44050144)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 28
    • 67349114222 scopus 로고    scopus 로고
    • Programmed cell death pathways and current antitumor targets
    • Tan M, Ooi J, Ismail N, Moad A, Muhammad T. Programmed cell death pathways and current antitumor targets. Pharm Res 2009; 26: 1547-1560.
    • (2009) Pharm Res , vol.26 , pp. 1547-1560
    • Tan, M.1    Ooi, J.2    Ismail, N.3    Moad, A.4    Muhammad, T.5
  • 29
    • 0032544087 scopus 로고    scopus 로고
    • Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
    • Conseil G, Baubichon-Cortay H, Dayan G, Jault J-M, Barron D, Di Pietro A. Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein. Proc Natl Acad Sci USA 1998; 95: 9831-9836.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9831-9836
    • Conseil, G.1    Baubichon-Cortay, H.2    Dayan, G.3    Jault, J.-M.4    Barron, D.5    Di Pietro, A.6
  • 30
    • 0029912466 scopus 로고    scopus 로고
    • Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin
    • Huang Y, Kuo M, Liu J, Huang S, Lin J. Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin. Eur J Cancer 1996; 32: 146-151.
    • (1996) Eur J Cancer , vol.32 , pp. 146-151
    • Huang, Y.1    Kuo, M.2    Liu, J.3    Huang, S.4    Lin, J.5
  • 31
    • 41549160315 scopus 로고    scopus 로고
    • Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
    • DOI 10.1096/fj.06-7859rev
    • Junttila MR, Li S-P, Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 2008; 22: 954-965. (Pubitemid 351519953)
    • (2008) FASEB Journal , vol.22 , Issue.4 , pp. 954-965
    • Junttila, M.R.1    Li, S.-P.2    Westermarck, J.3
  • 32
    • 0034658499 scopus 로고    scopus 로고
    • STAT signaling in head and neck cancer
    • Song J, Grandis J. STAT signaling in head and neck cancer. Oncogene 2000; 19: 2489-2495. (Pubitemid 30339204)
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2489-2495
    • Song, J.I.1    Grandis, J.R.2
  • 33
    • 32144453842 scopus 로고    scopus 로고
    • JAK/STAT signal transduction: Regulators and implication in hematological malignancies
    • DOI 10.1016/j.bcp.2005.12.017, PII S0006295205008464
    • Valentino L, Pierre J. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 2006; 71: 713-721. (Pubitemid 43208827)
    • (2006) Biochemical Pharmacology , vol.71 , Issue.6 , pp. 713-721
    • Valentino, L.1    Pierre, J.2
  • 34
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63. (Pubitemid 14203433)
    • (1983) Journal of Immunological Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 35
    • 0026535128 scopus 로고
    • Ageing adipokinetic cells in Locusta migratoria: An ultrastructural morphometric study
    • Diederen J, Peppelenbosch M, Vullings H. Ageing adipokinetic cells in Locusta migratoria: an ultrastructural morphometric study. Cell Tissue Res 1992; 268: 117-121.
    • (1992) Cell Tissue Res , vol.268 , pp. 117-121
    • Diederen, J.1    Peppelenbosch, M.2    Vullings, H.3


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