HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

Nature Cell Biology

Volumn 3, Issue 11, 2001, Pages 973-982

  Zhou, Binhua P ^a   Liao, Yong ^a   Xia, Weiya ^a   Zou, Yiyu ^a   Spohn, Bill ^a   Hung, Mien Chie ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ETOPOSIDE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P19; PROTEIN P300; PROTEIN P53; SERINE; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION; WILD TYPE;

3T3 CELLS; ANIMALS; CELL LINE, TRANSFORMED; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; E1A-ASSOCIATED P300 PROTEIN; ETOPOSIDE; HUMANS; MICE; NUCLEAR PROTEINS; NUCLEIC ACID SYNTHESIS INHIBITORS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTOR, ERBB-2; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

ANIMALIA;

EID: 0035736487     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1101-973     Document Type: Article

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