Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway

Cell Death and Disease

Volumn 2, Issue 12, 2011, Pages

  Lee, S H ^a   Jung, Y S ^a   Chung, J Y ^a   Oh, A Y ^a   Lee, S J ^a   Choi, D H ^b   Jang, S M ^c   Jang, K S ^c   Paik, S S ^c   Ha, N C ^a   Park, B J ^a  

^a Pusan National University   (South Korea)

^b Soonchunhyang University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Colon cancer; DPC4 Smad4; PAK1; PUMA

Indexed keywords

P21 ACTIVATED KINASE 1; PUMA PROTEIN; SMAD4 PROTEIN; VON HIPPEL LINDAU PROTEIN; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CADHERIN; NUCLEAR PROTEIN; ONCOPROTEIN; P21 ACTIVATED KINASE; PROTEIN P53; SEVEN IN ABSENTIA PROTEINS; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER TISSUE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; CULTURE MEDIUM; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

GASTROPODA;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CADHERINS; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; HUMANS; NUCLEAR PROTEINS; P21-ACTIVATED KINASES; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 84862974915     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.116     Document Type: Article

References (34)

1. Weinberg RA. How cancer arises. Sci Am 1996; 275: 62-70.
2. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10: 789-799. (Pubitemid 39070849)
3. Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nature Rev Cancer 2002; 2: 897-909. (Pubitemid 37328891)
4. Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ et al. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 2000; 102: 387-397.
5. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271: 350-353.
6. Gallione CJ, Repetto GM, Legius E, Rustgi AK, Schelley SL, Tejpar S et al. A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet 2004; 363: 852-859. (Pubitemid 38368834)
7. Lee SH, Lee SJ, Jung YS, Xu Y, Kang HS, Ha NC et al. Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia 2009; 11: 22-31.
8. Lee SH, Shen GN, Jung YS, Lee SJ, Chung JY, Kim HS et al. Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells. Oncogene 2010; 29: 4576-4587.
9. Massague J, Blain SW, Lo RS. TGF-b signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
10. Chen ZY. Cell cycle, differentiation and regeneration: where to begin? Cell Cycle 2006; 5: 2609-2612.
11. Zavadil J, Böttinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764-5774.
12. Wu WS. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 2006; 25: 695-705.
13. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7: 683-694. (Pubitemid 32706359)
14. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7: 673-682. (Pubitemid 32706358)
15. Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL et al. Targeted deletion of Smad4 shows it is required for transforming growth factor b and activin signaling in colorectal cancer cells. Proc Natl Acad Sci USA 1998; 95: 2412-2416. (Pubitemid 28145955)
16. Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W et al. E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci USA 1994; 91: 1858-1862. (Pubitemid 24080305)
17. Melki JR, Vincent PC, Brown RD, Clark SJ. Hypermethylation of E-cadherin in leukemia. Blood 2000; 95: 3208-3213. (Pubitemid 30321175)
18. Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-1936. (Pubitemid 36254551)
19. Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP. Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci 2010; 30: 16938-16948.
20. Dummler B, Ohshiro K, Kumar R, Field J. Pak protein kinases and their role in cancer. Cancer Metastasis Rev 2009; 28: 51-63.
21. Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 2005; 307: 1621-1625. (Pubitemid 40354744)
22. Weisz Hubsman M, Volinsky N, Manser E, Yablonski D, Aronheim A. Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. Biochem J 2007; 404: 487-497. (Pubitemid 46953923)
23. Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 1997; 7: 202-210. (Pubitemid 27164726)
24. Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998; 1: 611-617. (Pubitemid 128374697)
25. Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005; 307: 1603-1609. (Pubitemid 40354739)
26. Xu J, Lamouille S, Derynck R. TGF-b-induced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-172.
27. Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 2011; 470: 269-273.
28. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3: 401-410. (Pubitemid 37328844)
29. Carter JH, Douglass LE, Deddens JA, Colligan BM, Bhatt TR, Pemberton JO et al. Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Clin Cancer Res 2004; 10: 3448-3456. (Pubitemid 38685452)
30. Qiu W, Carson-Walter EB, Kuan SF, Zhang L, Yu J. PUMA suppresses intestinal tumorigenesis in mice. Cancer Res 2009; 69: 4999-5006.
31. Ma X, Yang K, Lindblad P, Egevad L, Hemminki K. VHL gene alterations in renal cell carcinoma patients: novel hotspot or founder mutations and linkage disequilibrium. Oncogene 2001; 20: 5393-5400. (Pubitemid 32844071)
32. Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M et al. SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). Proc Natl Acad Sci USA 1999; 96: 8070-8073. (Pubitemid 29328409)
33. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008; 68: 3645-3654.
34. Langeveld D, van Hattem WA, de Leng WW, Morsink FH, Ten Kate FJ, Giardiello FM et al. SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome. Clin Cancer Res 2010; 16: 4126-4134.