βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis

Cell Death and Disease

Volumn 2, Issue 10, 2011, Pages

  Ma, B ^a,b   Sen, T ^a   Asnaghi, L ^a   Valapala, M ^a   Yang, F ^a   Hose, S ^a   McLeod, D S ^a   Lu, Y ^b   Eberhart, C ^a   Zigler Jr , J S ^a   Sinha, D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b EYE AND ENT HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

A3 A1 crystallin; Anoikis; Astrocytes; Lens denucleation; PI3K AKT mTOR and ERK pathways

Indexed keywords

BCL 2 INHIBITOR OF TRANSCRIPTION 1; BETA A1 CRYSTALLIN; BETA A3 CRYSTALLIN; BETA CRYSTALLIN; CELL PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE D; SOMATOMEDIN B; UNCLASSIFIED DRUG; BETAA3 CRYSTALLIN, RAT; BETAA3-CRYSTALLIN, RAT; CARBOXYLESTERASE; CRYSTALLIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANOIKIS; ARTICLE; ASTROCYTE; CELL DEATH; CONTROLLED STUDY; ENUCLEATION; GOLGI COMPLEX; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LENS; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RETINA CELL; SURVIVAL RATE; ANIMAL; APOPTOSIS; CYTOLOGY; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANOIKIS; APOPTOSIS; ASTROCYTES; CARBOXYLIC ESTER HYDROLASES; CRYSTALLINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 80055015834     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.100     Document Type: Article

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