Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

Cell Death and Disease

Volumn 1, Issue 12, 2010, Pages

  McCoy, F ^a   Hurwitz, J ^a   McTavish, N ^a   Paul, I ^b   Barnes, C ^b   O'Hagan, B ^a   Odrzywol, K ^a   Murray, J ^a   Longley, D ^a   McKerr, G ^b   Fennell, D A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Apoptosis; Atg7; Autophagy; BAX BAK; Obatoclax

Indexed keywords

AUTOPHAGY PROTEIN 7; BECLIN 1; CELL PROTEIN; OBATOCLAX; PROTEIN BAK; PROTEIN BAX; S6 KINASE; SIRNA 027; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; ATG7 PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BCL 2; PYRROLE DERIVATIVE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL VACUOLE; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG TARGETING; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE INACTIVATION; GENE SILENCING; LIGHT CHAIN; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TARGETING; ANIMAL; CELL MEMBRANE; DRUG EFFECT; DRUG RESISTANCE; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL MEMBRANE; DRUG RESISTANCE, NEOPLASM; HUMANS; MEMBRANE PROTEINS; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; UBIQUITIN-ACTIVATING ENZYMES;

EID: 79959774131     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.86     Document Type: Article

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