Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Cell Death and Disease

Volumn 1, Issue 10, 2010, Pages

  Marino, M L ^a   Fais, S ^a   Djavaheri Mergny, M ^b,c   Villa, A ^d   Meschini, S ^a   Lozupone, F ^a   Venturi, G ^a   Della Mina, P ^d,e   Pattingre, S ^f   Rivoltini, L ^e   Codogno, P ^b   De Milito, A ^a,g  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c INSTITUT BERGONIÉ   (France)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e NATIONAL CANCER INSTITUTE   (Italy)

^f INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^g KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Autophagy; ESOM; Proton pumps; Tumour pH; V ATPase

Indexed keywords

ACETYLCYSTEINE; AUTOPHAGY PROTEIN 5; BECLIN 1; ESOMEPRAZOLE; MAMMALIAN TARGET OF RAPAMYCIN; PEPSTATIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; S6 KINASE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; ATG5 PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; EIF4EBP1 PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; OMEPRAZOLE; PHOSPHOPROTEIN; PROTON PUMP INHIBITOR; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ACIDIFICATION; ARTICLE; AUTOPHAGY; CELL DEATH; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION KINETICS; ENZYME DEGRADATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MELANOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; GENETICS; MELANOMA; METABOLISM; PH; PHOSPHORYLATION; TUMOR CELL LINE;

MAMMALIA;

ACETYLCYSTEINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; HUMANS; HYDROGEN-ION CONCENTRATION; MELANOMA; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NADPH OXIDASE; OMEPRAZOLE; OXIDATIVE STRESS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTON PUMP INHIBITORS; REACTIVE OXYGEN SPECIES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 79958759965     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.67     Document Type: Article

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