IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter

Cell Death and Disease

Volumn 1, Issue 6, 2010, Pages

  Mitchell, G C ^a   Fillinger, J L ^b   Sittadjody, S ^b   Avila, J L ^c   Burd, R ^b   Limesand, K H ^a,b,c  

^a Cancer Biology Graduate Interdisciplinary Program   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c Physiological Sciences Graduate Interdisciplinary Program   (United States)

Author keywords

Cell cycle arrest; IGF1; P53; P63; Radiation; Xerostomia

Indexed keywords

DELTA NP63 PROTEIN; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; PROTEIN P63; SOMATOMEDIN C; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PHOSPHOPROTEIN; TRANSACTIVATOR PROTEIN; TRP63 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMATIN IMMUNOPRECIPITATION; DNA REPAIR; FEMALE; GEL ELECTROPHORESIS; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RADIOTHERAPY; REAL TIME POLYMERASE CHAIN REACTION; SALIVARY GLAND FUNCTION; SALIVATION; WESTERN BLOTTING; ANIMAL; CELL DIVISION; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; PAROTID GLAND; PHOSPHORYLATION; PROMOTER REGION; RADIATION EXPOSURE;

MUS;

ANIMALS; APOPTOSIS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; G2 PHASE; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, KNOCKOUT; PAROTID GLAND; PHOSPHOPROTEINS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77956176703     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.28     Document Type: Article

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