The role of reactive oxygen species and autophagy in safingol-induced cell death

Cell Death and Disease

Volumn 2, Issue 3, 2011, Pages

  Ling, L U ^a   Tan, K B ^a   Lin, H ^a   Chiu, G N C ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Autophagy; Glucose uptake inhibition; Necrosis; ROS; Safingol

Indexed keywords

3 METHYLADENINE; 7 AMINODACTINOMYCIN; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; BAFILOMYCIN A1; GLUCOSE; PROTEIN BAX; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SAFINGOL; DRUG DERIVATIVE; SPHINGOSINE;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL LINE; CELL REGENERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; CELL; CELL STRAIN HT29; CYTOLOGY; DRUG EFFECT; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; TUMOR CELL LINE;

AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELLS; HT29 CELLS; HUMANS; NEOPLASMS; REACTIVE OXYGEN SPECIES; SPHINGOSINE;

EID: 79960013681     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.12     Document Type: Article

References (40)

1. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
2. Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 2009; 11: 777-790.
3. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16: 3-11.
4. Festjens N, Vanden Berghe T, Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 2006; 1757: 1371-1387. (Pubitemid 44472550)
5. Scherz-Shouval R, Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 2007; 17: 422-427. (Pubitemid 47499043)
6. Buehrer B, Bell R. Sphingosine kinase: properties and cellular functions. Adv Lipid Res 1993; 26: 59-67.
7. Schwartz G, Farsi K, Maslak P, Kelsen D, Spriggs D. Potentiation of apoptosis by flavopiridol in mitomycin-C-treated gastric and breast cancer cells. Clin Cancer Res 1997; 3: 1467-1472. (Pubitemid 27431552)
8. Kedderis L, Bozigian H, Kleeman J, Hall R, Palmer T, Harrison SJ et al. Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents. Fundam Appl Toxicol 1995; 25: 201-217.
9. Carvajal RD. A phase I clinical trial of safingol followed by cisplatin: promising activity in refractory adrenocortical cancer with novel pharmacology. Proc Am Soc Clin Oncol 2006; 24: 13044.
10. Hoffmann T, Leenen K, Hafner D, Balz V, Gerharz C, Grund A et al. Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. Anticancer Drugs 2002; 13: 93-100. (Pubitemid 34169532)
11. Jarvis W, Fornari FJ, Tombes R, Erukulla R, Bittman R, Schwartz G et al. Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-β-D- arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. Mol Pharmacol 1998; 54: 844-856. (Pubitemid 28523176)
12. Maurer B, Melton L, Billups C, Cabot M, Reynolds C. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst 2000; 92: 1897-1909. (Pubitemid 32036920)
13. Sachs C, Safa A, Harrison S, Fine R. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J Biol Chem 1995; 270: 26639-26648.
14. Schwartz G, Haimovitz-Friedman A, Dhupar S, Ehleiter D, Maslak P, Lai L et al. Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. J Natl Cancer Inst 1995; 87: 1394-1399.
15. Ling LU, Lin H, Tan KB, Chiu GN. The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. Int J Oncol 2009; 35: 1463-1471.
16. Hannun Y, Loomis C, Merrill AJ, Bell R. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 1986; 261: 12604-12609. (Pubitemid 17213985)
17. Coward J, Ambrosini G, Musi E, Truman JP, Haimovitz-Friedman A, Allegood JC et al. Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. Autophagy 2009; 5: 184-193.
18. Morales P, Dillehay D, Moody S, Pallas D, Pruett S, Allgood J et al. Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation. Drug Chem Toxicol 2007; 30: 197-216. (Pubitemid 47026913)
19. Noda T, Iwai S, Hamada M, Fujita Y, Yura Y. Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. Apoptosis 2009; 14: 287-297.
20. Hamada M, Sumi T, Iwai S, Nakazawa M, Yura Y. Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. Apoptosis 2006; 11: 47-56. (Pubitemid 43151643)
21. Cheng J, Park TS, Chio LC, Fischl AS, Ye XS. Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. Mol Cell Biol 2003; 23: 163-177. (Pubitemid 36008510)
22. Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J et al. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Res 2007; 17: 1030-1040. (Pubitemid 350261800)
23. Villena J, Henriquez M, Torres V, Moraga F, Diaz-Elizondo J, Arredondo C et al. Ceramideinduced formation of ROS and ATP depletion trigger necrosis in lymphoid cells. Free Radic Biol Med 2008; 44: 1146-1160.
24. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptoti proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-939. (Pubitemid 41345209)
25. Yee KS, Wilkinson S, James J, Ryan KM, Vousden KH. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ 2009; 16: 1135-1145.
26. Amin H, Ergin M, Denning M, Quevedo M, Alkan S. Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia. Br J Haematol 2000; 110: 552-562.
27. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008; 4: 313-321. (Pubitemid 351550892)
28. Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63: 2103-2108. (Pubitemid 36538613)
29. Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 1982; 79: 1889-1892. (Pubitemid 12088533)
30. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 1998; 23: 33-42. (Pubitemid 28223394)
31. Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 1998; 72: 8586-8596. (Pubitemid 28471796)
32. Murray D, Hill M, Nelson D. Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: studies with hydrogen peroxide and phorbol ester. Life Sci 1990; 46: 1843-1849. (Pubitemid 20191703)
33. Nelson D, Murray D. Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose. Biochem Biophys Res Commun 1986; 138: 463-467. (Pubitemid 16053472)
34. Isaev NK, Stelmashook EV, Dirnagl U, Plotnikov EY, Kuvshinova EA, Zorov DB. Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons. Biochemistry (Mosc) 2008; 73: 149-155. (Pubitemid 351374342)
35. Meijer AJ, Codogno P. AMP-activated protein kinase and autophagy. Autophagy 2007; 3: 238-240. (Pubitemid 46752685)
36. Cheng TJ, Wang YJ, Kao WW, Chen RJ, Ho YS. Protection against arsenic trioxideinduced autophagic cell death in U118 human glioma cells by use of lipoic acid. Food Chem Toxicol 2007; 45: 1027-1038.
37. Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R et al. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 2006; 281: 8518-8527. (Pubitemid 43847954)
38. Tang Y, Chen Y, Jiang H, Nie D. The role of short-chain fatty acids in orchestrating two types of programmed cell death in colon cancer. Autophagy 2011; 7: 235-237.
39. Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007; 8: 774-785. (Pubitemid 47462132)
40. Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WGT, Schlattner U et al. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 2004; 279: 43940-43951. (Pubitemid 39390702)