-
2
-
-
43849103812
-
Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions
-
Alonso-Ron, C., de la Peña, P., Miranda, P., Dominguez, P., and Barros, F. (2008). Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions. Biophys. J. 94, 3893-3911.
-
(2008)
Biophys. J.
, vol.94
, pp. 3893-3911
-
-
Alonso-Ron, C.1
de la Peña, P.2
Miranda, P.3
Dominguez, P.4
Barros, F.5
-
3
-
-
67349135030
-
Role of intracellular domains in the function of the herg potassium channel
-
Al-Owais, M., Bracey, K., and Wray, D. (2009). Role of intracellular domains in the function of the herg potassium channel. Eur. Biophys. J. 38, 569-576.
-
(2009)
Eur. Biophys. J.
, vol.38
, pp. 569-576
-
-
Al-Owais, M.1
Bracey, K.2
Wray, D.3
-
4
-
-
0016354136
-
Charge movement associated with the opening and closing of the activation gates of the Na channels
-
Armstrong, C. M., and Bezanilla, F. (1974). Charge movement associated with the opening and closing of the activation gates of the Na channels. J. Gen. Physiol. 63, 533-552.
-
(1974)
J. Gen. Physiol.
, vol.63
, pp. 533-552
-
-
Armstrong, C.M.1
Bezanilla, F.2
-
7
-
-
84866053486
-
Cytoplasmic domains and voltagedependent potassium channel gating
-
doi:10.3389/fphar.2012.00049
-
Barros, F., Domínguez, P., and de la Peña, P. (2012). Cytoplasmic domains and voltagedependent potassium channel gating. Front. Pharmacol. 3:49. doi:10.3389/fphar.2012.00049
-
(2012)
Front. Pharmacol.
, vol.3
, pp. 49
-
-
Barros, F.1
Domínguez, P.2
de la Peña, P.3
-
9
-
-
80052494606
-
Models of HERG gating
-
Bett, G. C., Zhou, Q., and Rasmusson, R. L. (2011). Models of HERG gating. Biophys. J. 101, 631-642.
-
(2011)
Biophys. J.
, vol.101
, pp. 631-642
-
-
Bett, G.C.1
Zhou, Q.2
Rasmusson, R.L.3
-
10
-
-
0034017867
-
The voltage sensor in voltage-dependent ion channels
-
Bezanilla, F. (2000). The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80, 555-592.
-
(2000)
Physiol. Rev.
, vol.80
, pp. 555-592
-
-
Bezanilla, F.1
-
11
-
-
0028213205
-
+ channels: II The components of gating currents and a model of channel activation
-
+ channels: II. The components of gating currents and a model of channel activation. Biophys. J. 66,1011-1021.
-
(1994)
Biophys. J.
, vol.66
, pp. 1011-1021
-
-
Bezanilla, F.1
Perozo, E.2
Stefani, E.3
-
12
-
-
58149343437
-
Structure, function, and modification of the voltage sensor in voltagegated ion channels
-
Börjesson, S. I., and Elinder, F. (2008). Structure, function, and modification of the voltage sensor in voltagegated ion channels. Cell Biochem. Biophys. 52, 149-174.
-
(2008)
Cell Biochem. Biophys.
, vol.52
, pp. 149-174
-
-
Börjesson, S.I.1
Elinder, F.2
-
13
-
-
34249946312
-
Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of shaker K channel
-
Campos, F. V., Chanda, B., Roux, B., and Bezanilla,F. (2007). Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of shaker K channel. Proc. Natl. Acad. Sci. U.S.A. 104, 7904-7909.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 7904-7909
-
-
Campos, F.V.1
Chanda, B.2
Roux, B.3
Bezanilla, F.4
-
14
-
-
77956996917
-
Ion channel voltage sensors: structure, function, and pathophysiology
-
Catterall, W. A. (2010). Ion channel voltage sensors: structure, function, and pathophysiology. Neuron 67, 915-928.
-
(2010)
Neuron
, vol.67
, pp. 915-928
-
-
Catterall, W.A.1
-
15
-
-
0030840167
-
+ channel with fluorescence
-
+ channel with fluorescence. Neuron 19, 1127-1140.
-
(1997)
Neuron
, vol.19
, pp. 1127-1140
-
-
Cha, A.1
Bezanilla, F.2
-
16
-
-
38749112951
-
A common pathway for charge transport through voltage-sensing domains
-
Chanda, B., and Bezanilla, F. (2008). A common pathway for charge transport through voltage-sensing domains. Neuron 57, 345-351.
-
(2008)
Neuron
, vol.57
, pp. 345-351
-
-
Chanda, B.1
Bezanilla, F.2
-
17
-
-
0035949603
-
The S4-S5 linker couples voltage sensing and activation of pacemaker channels
-
Chen, J., Mitcheson, J. S., Tristani-Firouzi,M.,Lin,M.,and Sanguinetti, M. C. (2001). The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc. Natl. Acad. Sci. U.S.A. 98, 11277-11282.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 11277-11282
-
-
Chen, J.1
Mitcheson, J.S.2
Tristani-Firouzi, M.3
Lin, M.4
Sanguinetti, M.C.5
-
18
-
-
77954895219
-
Structure of the full-length shaker potassium channel Kv1 2 by normal-mode-based X-ray crystallographic refinement
-
Chen, X., Wang, Q., Ni, F., and Ma, J. (2010). Structure of the full-length shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc. Natl. Acad. Sci. U.S.A. 107, 11352-11357.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11352-11357
-
-
Chen, X.1
Wang, Q.2
Ni, F.3
Ma, J.4
-
19
-
-
84866012654
-
Molecular determinants of voltage-dependent gating in hERG potassium channels
-
Cheng, Y. M., Hull, C. M., Niven, C. M., Allard, C. R., and Claydon, T. W. (2012). Molecular determinants of voltage-dependent gating in hERG potassium channels. Biophys. J. 102, 329a.
-
(2012)
Biophys. J.
, vol.102
-
-
Cheng, Y.M.1
Hull, C.M.2
Niven, C.M.3
Allard, C.R.4
Claydon, T.W.5
-
20
-
-
0035028582
-
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death
-
Clancy, C. E., and Rudy, Y. (2001). Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc. Res. 50, 301-313.
-
(2001)
Cardiovasc. Res.
, vol.50
, pp. 301-313
-
-
Clancy, C.E.1
Rudy, Y.2
-
21
-
-
79956326492
-
Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel
-
de la Peña, P., Alonso-Ron, C., Machin, A., Fernández-Trillo, J., Carretero, L., Dominguez, P., and Barros, F. (2011). Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel. J. Biol. Chem. 286, 19065-19075.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 19065-19075
-
-
de la Peña, P.1
Alonso-Ron, C.2
Machin, A.3
Fernández-Trillo, J.4
Carretero, L.5
Dominguez, P.6
Barros, F.7
-
24
-
-
0036020149
-
Tail end of the S6 segment: role in permeation in shaker potassium channels
-
Ding, S., and Horn, R. (2002). Tail end of the S6 segment: role in permeation in shaker potassium channels. J. Gen. Physiol. 120, 87-97.
-
(2002)
J. Gen. Physiol.
, vol.120
, pp. 87-97
-
-
Ding, S.1
Horn, R.2
-
25
-
-
0037214636
-
Effect of S6 tail mutations on charge movement in shaker potassium channels
-
Ding, S., and Horn, R. (2003). Effect of S6 tail mutations on charge movement in shaker potassium channels. Biophys. J. 84, 295-305.
-
(2003)
Biophys. J.
, vol.84
, pp. 295-305
-
-
Ding, S.1
Horn, R.2
-
26
-
-
0032478818
-
+ conduction and selectivity
-
+ conduction and selectivity. Science 280, 69-77.
-
(1998)
Science
, vol.280
, pp. 69-77
-
-
Doyle, D.A.1
Morais-Cabral, J.H.2
Pfuetzner, R.A.3
Kuo, A.4
Gulbis, J.M.5
Cohen, S.L.6
Chait, B.T.7
Mackinnon, R.8
-
27
-
-
0031877384
-
+ channels in open, closed, and inactivated conformations
-
+ channels in open, closed, and inactivated conformations. J. Struct. Biol. 121, 263-284.
-
(1998)
J. Struct. Biol.
, vol.121
, pp. 263-284
-
-
Durell, S.R.1
Hao, Y.2
Guy, H.R.3
-
28
-
-
70350780324
-
Movement of the S4 segment in the hERG potassium channel during membrane depolarization
-
Elliott, D. J., Dondas, N. Y., Munsey, T. S., and Sivaprasadarao, A. (2009). Movement of the S4 segment in the hERG potassium channel during membrane depolarization. Mol. Membr. Biol. 26, 435-447.
-
(2009)
Mol. Membr. Biol.
, vol.26
, pp. 435-447
-
-
Elliott, D.J.1
Dondas, N.Y.2
Munsey, T.S.3
Sivaprasadarao, A.4
-
29
-
-
77956274149
-
Fluorescencetracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening
-
doi:10.1371/journal.pone.0010876
-
Es-Salah-Lamoureux, Z., Fougere, R., Xiong, P. Y., Robertson, G. A., and Fedida, D. (2010). Fluorescencetracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. PLoS ONE 5, e10876. doi:10.1371/journal.pone.0010876
-
(2010)
PLoS ONE
, vol.5
-
-
Es-Salah-Lamoureux, Z.1
Fougere, R.2
Xiong, P.Y.3
Robertson, G.A.4
Fedida, D.5
-
30
-
-
84866025087
-
Movement of the S4-S5 linker of KvAP during gating
-
Faure, E., McGuire, H., Marsolais, M., and Blunck, R. (2012). Movement of the S4-S5 linker of KvAP during gating. Biophys. J. 102, 13a.
-
(2012)
Biophys. J.
, vol.102
-
-
Faure, E.1
McGuire, H.2
Marsolais, M.3
Blunck, R.4
-
31
-
-
0034982579
-
Gating of voltage-dependent potassium channels
-
Fedida, D., and Hesketh, J. C. (2001). Gating of voltage-dependent potassium channels. Prog. Biophys. Mol. Biol. 75, 165-199.
-
(2001)
Prog. Biophys. Mol. Biol.
, vol.75
, pp. 165-199
-
-
Fedida, D.1
Hesketh, J.C.2
-
32
-
-
1642370447
-
Physicochemical features of the hERG channel drug binding site
-
Fernandez, D., Ghanta, A., Kauffman, G. W., and Sanguinetti, M. C. (2004). Physicochemical features of the hERG channel drug binding site. J. Biol. Chem. 279, 10120-10127.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10120-10127
-
-
Fernandez, D.1
Ghanta, A.2
Kauffman, G.W.3
Sanguinetti, M.C.4
-
35
-
-
84863047730
-
The solution structure of the S4S5 linker of the hERG potassium channel
-
Gayen, S., Li, Q., and Kang, C. (2012). The solution structure of the S4S5 linker of the hERG potassium channel. J. Pept. Sci. 18, 140-145.
-
(2012)
J. Pept. Sci.
, vol.18
, pp. 140-145
-
-
Gayen, S.1
Li, Q.2
Kang, C.3
-
36
-
-
0018860036
-
Gating current and potassium channels in the giant axon of the squid
-
Gilly, W. F., and Armstrong, C. M. (1980). Gating current and potassium channels in the giant axon of the squid. Biophys. J. 29, 485-492.
-
(1980)
Biophys. J.
, vol.29
, pp. 485-492
-
-
Gilly, W.F.1
Armstrong, C.M.2
-
38
-
-
69149108876
-
A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels
-
Gustina, A. S., and Trudeau, M. C. (2009). A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proc. Natl.Acad. Sci. U.S.A. 106, 13082-13087.
-
(2009)
Proc. Natl.Acad. Sci. U.S.A.
, vol.106
, pp. 13082-13087
-
-
Gustina, A.S.1
Trudeau, M.C.2
-
39
-
-
79952120982
-
hERG potassium channel gating is mediated by Nand Cterminal region interactions
-
Gustina, A. S., and Trudeau, M. C. (2011). hERG potassium channel gating is mediated by Nand Cterminal region interactions. J. Gen. Physiol. 137, 315-325.
-
(2011)
J. Gen. Physiol.
, vol.137
, pp. 315-325
-
-
Gustina, A.S.1
Trudeau, M.C.2
-
41
-
-
35649001607
-
A quantitative description of membrane current and its application to conduction and excitation in nerve
-
Hodgkin,A. L., and Huxley,A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500-544.
-
(1952)
J. Physiol. (Lond.)
, vol.117
, pp. 500-544
-
-
Hodgkin, A.L.1
Huxley, A.F.2
-
44
-
-
0037198625
-
The open pore conformation of potassium channels
-
Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002a). The open pore conformation of potassium channels. Nature 417, 523-526.
-
(2002)
Nature
, vol.417
, pp. 523-526
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
Cadene, M.4
Chait, B.T.5
MacKinnon, R.6
-
45
-
-
0037198626
-
Crystal structure and mechanism of a calciumgated potassium channel
-
Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002b). Crystal structure and mechanism of a calciumgated potassium channel. Nature 417, 515-522.
-
(2002)
Nature
, vol.417
, pp. 515-522
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
Cadene, M.4
Chait, B.T.5
MacKinnon, R.6
-
46
-
-
0038076054
-
+ channel
-
+ channel. Nature 423, 33-41.
-
(2003)
Nature
, vol.423
, pp. 33-41
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
Ruta, V.4
Cadene, M.5
Chait, B.T.6
MacKinnon, R.7
-
47
-
-
0032770402
-
Determinants of voltage-dependent gating and open-state stability in the S5 segment of shaker potassium channels
-
Kanevsky,M., and Aldrich,R.W. (1999). Determinants of voltage-dependent gating and open-state stability in the S5 segment of shaker potassium channels. J. Gen. Physiol. 114, 215-242.
-
(1999)
J. Gen. Physiol.
, vol.114
, pp. 215-242
-
-
Kanevsky, M.1
Aldrich, R.W.2
-
48
-
-
3142682246
-
The screw-helical voltage gating of ion channels
-
Keynes, R. D., and Elinder, F. (1999). The screw-helical voltage gating of ion channels. Proc. Biol. Sci. 266, 843-852.
-
(1999)
Proc. Biol. Sci.
, vol.266
, pp. 843-852
-
-
Keynes, R.D.1
Elinder, F.2
-
49
-
-
77952700991
-
Calculation of the gating charge for the Kv1 2 voltage-activated potassium channel
-
Khalili-Araghi, F., Jogini, V., Yarov-Yarovoy, V., Tajkhorshid, E., Roux, B., and Schulten, K. (2010). Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J 98, 2189-2198.
-
(2010)
Biophys J
, vol.98
, pp. 2189-2198
-
-
Khalili-Araghi, F.1
Jogini, V.2
Yarov-Yarovoy, V.3
Tajkhorshid, E.4
Roux, B.5
Schulten, K.6
-
50
-
-
5144223114
-
Stabilizing the closed S6 gate in the shaker Kv channel through modification of a hydrophobic seal
-
Kitaguchi, T., Sukhareva, M., and Swartz, K. J. (2004). Stabilizing the closed S6 gate in the shaker Kv channel through modification of a hydrophobic seal. J. Gen. Physiol. 124, 319-332.
-
(2004)
J. Gen. Physiol.
, vol.124
, pp. 319-332
-
-
Kitaguchi, T.1
Sukhareva, M.2
Swartz, K.J.3
-
51
-
-
33745216690
-
A structural interpretation of voltagegated potassium channel inactivation
-
Kurata, H. T., and Fedida, D. (2006). A structural interpretation of voltagegated potassium channel inactivation. Prog. Biophys. Mol. Biol. 92, 185-208.
-
(2006)
Prog. Biophys. Mol. Biol.
, vol.92
, pp. 185-208
-
-
Kurata, H.T.1
Fedida, D.2
-
52
-
-
59649096789
-
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
-
Labro, A. J., Raes, A. L., Grottesi, A., Van, H. D., Sansom, M. S., and Snyders, D. J. (2008). Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. J. Gen. Physiol. 132, 667-680.
-
(2008)
J. Gen. Physiol.
, vol.132
, pp. 667-680
-
-
Labro, A.J.1
Raes, A.L.2
Grottesi, A.3
Van, H.D.4
Sansom, M.S.5
Snyders, D.J.6
-
55
-
-
0032894433
-
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation
-
Ledwell, J. L., and Aldrich, R. W. (1999). Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113, 389-414.
-
(1999)
J. Gen. Physiol.
, vol.113
, pp. 389-414
-
-
Ledwell, J.L.1
Aldrich, R.W.2
-
56
-
-
78649713129
-
NMR solution structure of the Nterminal domain of hERG and its interaction with the S4-S5 linker
-
Li, Q., Gayen, S., Chen, A. S., Huang, Q., Raida, M., and Kang, C. (2010). NMR solution structure of the Nterminal domain of hERG and its interaction with the S4-S5 linker. Biochem. Biophys. Res. Commun. 403, 126-132.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.403
, pp. 126-132
-
-
Li, Q.1
Gayen, S.2
Chen, A.S.3
Huang, Q.4
Raida, M.5
Kang, C.6
-
58
-
-
79961124704
-
R1 in the shaker S4 occupies the gating charge transfer center in the resting state
-
Lin, M. C., Hsieh, J. Y., Mock, A. F., and Papazian, D. M. (2011). R1 in the shaker S4 occupies the gating charge transfer center in the resting state. J. Gen. Physiol. 138, 155-163.
-
(2011)
J. Gen. Physiol.
, vol.138
, pp. 155-163
-
-
Lin, M.C.1
Hsieh, J.Y.2
Mock, A.F.3
Papazian, D.M.4
-
59
-
-
44349170359
-
Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating
-
Lin, M. C., and Papazian, D. M. (2007). Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating. Channels (Austin) 1, 429-437.
-
(2007)
Channels (Austin)
, vol.1
, pp. 429-437
-
-
Lin, M.C.1
Papazian, D.M.2
-
60
-
-
0038580641
-
Negative charges in the transmembrane domains of the HERG K channel are involved in the activationand deactivationgating processes
-
Liu, J., Zhang, M., Jiang, M., and Tseng, G. N. (2003). Negative charges in the transmembrane domains of the HERG K channel are involved in the activationand deactivationgating processes. J. Gen. Physiol. 121, 599-614.
-
(2003)
J. Gen. Physiol.
, vol.121
, pp. 599-614
-
-
Liu, J.1
Zhang, M.2
Jiang, M.3
Tseng, G.N.4
-
61
-
-
0030049457
-
Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes
-
Liu, S., Rasmusson, R. L., Campbell, D. L., Wang, S., and Strauss, H. C. (1996). Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes. Biophys. J. 70, 2704-2715.
-
(1996)
Biophys. J.
, vol.70
, pp. 2704-2715
-
-
Liu, S.1
Rasmusson, R.L.2
Campbell, D.L.3
Wang, S.4
Strauss, H.C.5
-
64
-
-
23244441222
-
Voltage sensor of Kv1 2: structural basis of electromechanical coupling
-
Long, S. B., Campbell, E. B., and MacKinnon, R. (2005b). Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309, 903-908.
-
(2005)
Science
, vol.309
, pp. 903-908
-
-
Long, S.B.1
Campbell, E.B.2
MacKinnon, R.3
-
68
-
-
0030048243
-
Direct physical measure of conformational rearrangement underlying potassium channel gating
-
Mannuzzu, L. M., Moronne, M. M., and Isacoff, E. Y. (1996). Direct physical measure of conformational rearrangement underlying potassium channel gating. Science 271, 213-216.
-
(1996)
Science
, vol.271
, pp. 213-216
-
-
Mannuzzu, L.M.1
Moronne, M.M.2
Isacoff, E.Y.3
-
69
-
-
0035816728
-
Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis
-
Mazhari, R., Greenstein, J. L., Winslow, R. L., Marban, E., and Nuss, H. B. (2001). Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circ. Res. 89, 33-38.
-
(2001)
Circ. Res.
, vol.89
, pp. 33-38
-
-
Mazhari, R.1
Greenstein, J.L.2
Winslow, R.L.3
Marban, E.4
Nuss, H.B.5
-
71
-
-
0025818388
-
+ channels
-
+ channels. Proc. Natl.Acad. Sci. U.S.A. 88, 2931-2935.
-
(1991)
Proc. Natl.Acad. Sci. U.S.A.
, vol.88
, pp. 2931-2935
-
-
McCormack, K.1
Tanouye, M.A.2
Iverson, L.E.3
Lin, J.W.4
Ramaswami, M.5
McCormack, T.6
Campanelli, J.T.7
Mathew, M.K.8
Rudy, B.9
-
72
-
-
0032567106
-
Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
-
Morais Cabral, J. H., Lee, A., Cohen, S. L., Chait, B. T., Li, M., and Mackinnon, R. (1998). Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell 95, 649-655.
-
(1998)
Cell
, vol.95
, pp. 649-655
-
-
Morais Cabral, J.H.1
Lee, A.2
Cohen, S.L.3
Chait, B.T.4
Li, M.5
Mackinnon, R.6
-
74
-
-
79251559440
-
The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation
-
doi:10.1371/journal.pone.0016191
-
Ng, C. A., Hunter, M. J., Perry, M. D., Mobli, M., Ke, Y., Kuchel, P. W., King, G. F., Stock, D., and Vandenberg, J. I. (2011). The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation. PLoS ONE 6, e16191. doi:10.1371/journal.pone.0016191
-
(2011)
PLoS ONE
, vol.6
-
-
Ng, C.A.1
Hunter, M.J.2
Perry, M.D.3
Mobli, M.4
Ke, Y.5
Kuchel, P.W.6
King, G.F.7
Stock, D.8
Vandenberg, J.I.9
-
75
-
-
84857127272
-
The s4-s5 linker acts as a signal integrator for HERG k channel activation and deactivation gating
-
doi:10.1371/journal.pone.0031640
-
Ng, C. A., Perry, M. D., Tan, P. S., Hill, A. P., Kuchel, P. W., and Vandenberg, J. I. (2012). The s4-s5 linker acts as a signal integrator for HERG k channel activation and deactivation gating. PLoS ONE 7, e31640. doi:10.1371/journal.pone.0031640
-
(2012)
PLoS ONE
, vol.7
-
-
Ng, C.A.1
Perry, M.D.2
Tan, P.S.3
Hill, A.P.4
Kuchel, P.W.5
Vandenberg, J.I.6
-
76
-
-
50349088433
-
Molecular dynamics simulation of Kv channel voltage sensor helix in a lipid membrane with applied electric field
-
Nishizawa, M., and Nishizawa, K. (2008). Molecular dynamics simulation of Kv channel voltage sensor helix in a lipid membrane with applied electric field. Biophys. J. 95, 1729-1744.
-
(2008)
Biophys. J.
, vol.95
, pp. 1729-1744
-
-
Nishizawa, M.1
Nishizawa, K.2
-
77
-
-
68949118408
-
Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels
-
Nishizawa, M., and Nishizawa, K. (2009). Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels. Biophys. J. 97, 90-100.
-
(2009)
Biophys. J.
, vol.97
, pp. 90-100
-
-
Nishizawa, M.1
Nishizawa, K.2
-
78
-
-
0029741699
-
+ channels
-
+ channels. J. Gen. Physiol. 108, 143-155.
-
(1996)
J. Gen. Physiol.
, vol.108
, pp. 143-155
-
-
Noceti, F.1
Baldelli, P.2
Wei, X.3
Qin, N.4
Toro, L.5
Birnbaumer, L.6
Stefani, E.7
-
79
-
-
0021123234
-
Primary structure of electrophorus electricus sodium channel deduced from cDNA sequence
-
Noda, M., Shimizu, S., Tanabe, T., Takai, T., Kayano, T., Ikeda, T., Takahashi, H., Nakayama, H., Kanaoka, Y., Minamino, N., Kangawa, K., Matsuo, H., Raftery, M., Hirose, T., Inayama, S., Hayashida, H., Miyata, T., and Numa, S. (1984). Primary structure of electrophorus electricus sodium channel deduced from cDNA sequence. Nature 312, 121-127.
-
(1984)
Nature
, vol.312
, pp. 121-127
-
-
Noda, M.1
Shimizu, S.2
Tanabe, T.3
Takai, T.4
Kayano, T.5
Ikeda, T.6
Takahashi, H.7
Nakayama, H.8
Kanaoka, Y.9
Minamino, N.10
Kangawa, K.11
Matsuo, H.12
Raftery, M.13
Hirose, T.14
Inayama, S.15
Hayashida, H.16
Miyata, T.17
Numa, S.18
-
80
-
-
0036853035
-
Mathematical model of the rapidly activating delayed rectifier potassium current I(Kr) in rabbit sinoatrial node
-
Oehmen, C. S., Giles, W. R., and Demir, S. S. (2002). Mathematical model of the rapidly activating delayed rectifier potassium current I(Kr) in rabbit sinoatrial node. J. Cardiovasc. Electrophysiol. 13, 1131-1140.
-
(2002)
J. Cardiovasc. Electrophysiol.
, vol.13
, pp. 1131-1140
-
-
Oehmen, C.S.1
Giles, W.R.2
Demir, S.S.3
-
81
-
-
0036112239
-
Three-dimensional structure of the S4-S5 segment of the shaker potassium channel
-
Ohlenschlager, O., Hojo, H., Ramachandran, R., Gorlach, M., and Haris, P. I. (2002). Three-dimensional structure of the S4-S5 segment of the shaker potassium channel. Biophys. J. 82, 2995-3002.
-
(2002)
Biophys. J.
, vol.82
, pp. 2995-3002
-
-
Ohlenschlager, O.1
Hojo, H.2
Ramachandran, R.3
Gorlach, M.4
Haris, P.I.5
-
82
-
-
21944444329
-
How does an ion channel sense voltage?
-
Papazian, D. M., and Bezanilla, F. (1997). How does an ion channel sense voltage? News Physiol. Sci. 12, 203-210.
-
(1997)
News Physiol. Sci.
, vol.12
, pp. 203-210
-
-
Papazian, D.M.1
Bezanilla, F.2
-
83
-
-
0023225798
-
Cloning of genomic and complementary DNA from shaker, a putative potassium channel gene from Drosophila
-
Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N., and Jan, L. Y. (1987). Cloning of genomic and complementary DNA from shaker, a putative potassium channel gene from Drosophila. Science 237, 749-753.
-
(1987)
Science
, vol.237
, pp. 749-753
-
-
Papazian, D.M.1
Schwarz, T.L.2
Tempel, B.L.3
Jan, Y.N.4
Jan, L.Y.5
-
85
-
-
0026032209
-
Alteration of voltage-dependence of shaker potassium channel by mutations in the S4 sequence
-
Papazian, D. M., Timpe, L. C., Jan,Y. N., and Jan, L. Y. (1991). Alteration of voltage-dependence of shaker potassium channel by mutations in the S4 sequence. Nature 349, 305-310.
-
(1991)
Nature
, vol.349
, pp. 305-310
-
-
Papazian, D.M.1
Timpe, L.C.2
Jan, Y.N.3
Jan, L.Y.4
-
86
-
-
34748848687
-
+ channel
-
+ channel. Neuron 56, 124-140.
-
(2007)
Neuron
, vol.56
, pp. 124-140
-
-
Pathak, M.M.1
Yarov-Yarovoy, V.2
Agarwal, G.3
Roux, B.4
Barth, P.5
Kohout, S.6
Tombola, F.7
Isacoff, E.Y.8
-
87
-
-
14844318017
-
Regional specificity of human ether-a'-go-gorelated gene channel activation and inactivation gating
-
Piper, D. R., Hinz, W. A., Tallurri, C. K., Sanguinetti, M. C., and Tristani-Firouzi, M. (2005). Regional specificity of human ether-a'-go-gorelated gene channel activation and inactivation gating. J. Biol. Chem. 280, 7206-7217.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7206-7217
-
-
Piper, D.R.1
Hinz, W.A.2
Tallurri, C.K.3
Sanguinetti, M.C.4
Tristani-Firouzi, M.5
-
88
-
-
38349135764
-
Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels
-
Piper, D. R., Rupp, J., Sachse, F. B., Sanguinetti, M. C., and Tristani-Firouzi, M. (2008). Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels. Cell. Physiol. Biochem. 21, 37-46.
-
(2008)
Cell. Physiol. Biochem.
, vol.21
, pp. 37-46
-
-
Piper, D.R.1
Rupp, J.2
Sachse, F.B.3
Sanguinetti, M.C.4
Tristani-Firouzi, M.5
-
89
-
-
0041836223
-
Gating currents associated with intramembrane charge displacement in HERG potassium channels
-
Piper, D. R., Varghese, A., Sanguinetti, M. C., and Tristani-Firouzi, M. (2003). Gating currents associated with intramembrane charge displacement in HERG potassium channels. Proc. Natl.Acad. Sci. U.S.A. 100, 10534-10539.
-
(2003)
Proc. Natl.Acad. Sci. U.S.A.
, vol.100
, pp. 10534-10539
-
-
Piper, D.R.1
Varghese, A.2
Sanguinetti, M.C.3
Tristani-Firouzi, M.4
-
90
-
-
84860390173
-
Contributions of counter-charge in a potassium channel voltagesensor domain
-
Pless, S. A., Galpin, J. D., Niciforovic, A. P., and Ahern, C. A. (2011). Contributions of counter-charge in a potassium channel voltagesensor domain. Nat. Chem. Biol. 7, 617-623.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 617-623
-
-
Pless, S.A.1
Galpin, J.D.2
Niciforovic, A.P.3
Ahern, C.A.4
-
91
-
-
33845383109
-
Modulation of HERG gating by a charge cluster in the N-terminal proximal domain
-
Saenen, J. B., Labro, A. J., Raes, A., and Snyders, D. J. (2006). Modulation of HERG gating by a charge cluster in the N-terminal proximal domain. Biophys. J. 91, 4381-4391.
-
(2006)
Biophys. J.
, vol.91
, pp. 4381-4391
-
-
Saenen, J.B.1
Labro, A.J.2
Raes, A.3
Snyders, D.J.4
-
92
-
-
33645317063
-
hERG potassium channels and cardiac arrhythmia
-
Sanguinetti, M. C., and Tristani-Firouzi, M. (2006). hERG potassium channels and cardiac arrhythmia. Nature 440, 463-469.
-
(2006)
Nature
, vol.440
, pp. 463-469
-
-
Sanguinetti, M.C.1
Tristani-Firouzi, M.2
-
93
-
-
0033082093
-
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
-
Sanguinetti, M. C., and Xu, Q. P. (1999). Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J. Physiol. (Lond.) 514, 667-675.
-
(1999)
J. Physiol. (Lond.)
, vol.514
, pp. 667-675
-
-
Sanguinetti, M.C.1
Xu, Q.P.2
-
94
-
-
0030054878
-
Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
-
Schonherr, R., and Heinemann, S. H. (1996). Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J. Physiol. (Lond.) 493, 635-642.
-
(1996)
J. Physiol. (Lond.)
, vol.493
, pp. 635-642
-
-
Schonherr, R.1
Heinemann, S.H.2
-
95
-
-
0026594721
-
The size of gating charge in wild-type and mutant shaker potassium channels
-
Schoppa, N. E., McCormack, K., Tanouye, M. A., and Sigworth, F. J. (1992). The size of gating charge in wild-type and mutant shaker potassium channels. Science 255, 1712-1715.
-
(1992)
Science
, vol.255
, pp. 1712-1715
-
-
Schoppa, N.E.1
McCormack, K.2
Tanouye, M.A.3
Sigworth, F.J.4
-
96
-
-
0031952461
-
Activation of shaker potassium channels III. An activation gating model for wild-type and V2 mutant channels
-
Schoppa, N. E., and Sigworth, F. J. (1998a). Activation of shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111, 313-342.
-
(1998)
J. Gen. Physiol.
, vol.111
, pp. 313-342
-
-
Schoppa, N.E.1
Sigworth, F.J.2
-
97
-
-
0031952460
-
Activation of shaker potassium channels II. Kinetics of the V2 mutant channel
-
Schoppa, N. E., and Sigworth, F. J. (1998b). Activation of shaker potassium channels. II. Kinetics of the V2 mutant channel. J. Gen. Physiol. 111, 295-311.
-
(1998)
J. Gen. Physiol.
, vol.111
, pp. 295-311
-
-
Schoppa, N.E.1
Sigworth, F.J.2
-
98
-
-
77953578254
-
Down-state model of the voltagesensing domain of a potassium channel
-
Schow, E. V., Freites, J. A., Gogna, K., White, S. H., and Tobias, D. J. (2010). Down-state model of the voltagesensing domain of a potassium channel. Biophys. J. 98, 2857-2866.
-
(2010)
Biophys. J.
, vol.98
, pp. 2857-2866
-
-
Schow, E.V.1
Freites, J.A.2
Gogna, K.3
White, S.H.4
Tobias, D.J.5
-
101
-
-
0036097030
-
Fast and slow voltage sensor movements in HERG potassium channels
-
Smith, P. L., and Yellen, G. (2002). Fast and slow voltage sensor movements in HERG potassium channels. J. Gen. Physiol. 119, 275-293.
-
(2002)
J. Gen. Physiol.
, vol.119
, pp. 275-293
-
-
Smith, P.L.1
Yellen, G.2
-
102
-
-
0029926887
-
Fast inactivation causes rectification of the IKr channel
-
Spector, P. S., Curran, M. E., Zou, A., Keating, M. T., and Sanguinetti, M. C. (1996). Fast inactivation causes rectification of the IKr channel. J. Gen. Physiol. 107, 611-619.
-
(1996)
J. Gen. Physiol.
, vol.107
, pp. 611-619
-
-
Spector, P.S.1
Curran, M.E.2
Zou, A.3
Keating, M.T.4
Sanguinetti, M.C.5
-
104
-
-
1142274549
-
A proton pore in a potassium channel voltage sensor reveals a focused electric field
-
Starace, D. M., and Bezanilla, F. (2004). A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427, 548-553.
-
(2004)
Nature
, vol.427
, pp. 548-553
-
-
Starace, D.M.1
Bezanilla, F.2
-
106
-
-
4344686915
-
Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel
-
Subbiah, R. N., Clarke, C. E., Smith, D. J., Zhao, J., Campbell, T. J., and Vandenberg, J. I. (2004). Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel. J. Physiol. (Lond.) 558, 417-431.
-
(2004)
J. Physiol. (Lond.)
, vol.558
, pp. 417-431
-
-
Subbiah, R.N.1
Clarke, C.E.2
Smith, D.J.3
Zhao, J.4
Campbell, T.J.5
Vandenberg, J.I.6
-
108
-
-
77957963878
-
Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations
-
Subbotina, J., Yarov-Yarovoy, V., Lees-Miller, J., Durdagi, S., Guo, J., Duff, H. J., and Noskov, S.Y. (2010). Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations. Proteins 78, 2922-2934.
-
(2010)
Proteins
, vol.78
, pp. 2922-2934
-
-
Subbotina, J.1
Yarov-Yarovoy, V.2
Lees-Miller, J.3
Durdagi, S.4
Guo, J.5
Duff, H.J.6
Noskov, S.Y.7
-
109
-
-
77950488909
-
A gating charge transfer center in voltage sensors
-
Tao, X., Lee, A., Limapichat, W., Dougherty, D. A., and Mackinnon, R. (2010). A gating charge transfer center in voltage sensors. Science 328, 67-73.
-
(2010)
Science
, vol.328
, pp. 67-73
-
-
Tao, X.1
Lee, A.2
Limapichat, W.3
Dougherty, D.A.4
Mackinnon, R.5
-
112
-
-
13244272072
-
Voltagesensing arginines in a potassium channel permeate and occlude cation-selective pores
-
Tombola, F., Pathak, M. M., and Isacoff, E. Y. (2005). Voltagesensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron 45, 379-388.
-
(2005)
Neuron
, vol.45
, pp. 379-388
-
-
Tombola, F.1
Pathak, M.M.2
Isacoff, E.Y.3
-
114
-
-
0029007356
-
HERG, a human inward rectifier in the voltage-gated potassium channel family
-
Trudeau, M. C., Warmke, J. W., Ganetzky, B., and Robertson, G. A. (1995). HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269, 92-95.
-
(1995)
Science
, vol.269
, pp. 92-95
-
-
Trudeau, M.C.1
Warmke, J.W.2
Ganetzky, B.3
Robertson, G.A.4
-
116
-
-
83355177269
-
In search of a consensus model of the resting state of a voltage-sensing domain
-
Vargas, E., Bezanilla, F., and Roux, B. (2011). In search of a consensus model of the resting state of a voltage-sensing domain. Neuron 72, 713-720.
-
(2011)
Neuron
, vol.72
, pp. 713-720
-
-
Vargas, E.1
Bezanilla, F.2
Roux, B.3
-
119
-
-
0031742141
-
Regulation of deactivation by an amino terminal domain in human ether-a-go-go-related gene potassium channels
-
Wang, J., Trudeau, M. C., Zappia, A. M., and Robertson, G. A. (1998). Regulation of deactivation by an amino terminal domain in human ether-a-go-go-related gene potassium channels. J. Gen. Physiol. 112, 637-647.
-
(1998)
J. Gen. Physiol.
, vol.112
, pp. 637-647
-
-
Wang, J.1
Trudeau, M.C.2
Zappia, A.M.3
Robertson, G.A.4
-
120
-
-
0033433966
-
Effect of cysteine substitutions on the topology of the S4 segment of the shaker potassium channel: implications for molecular models of gating
-
Wang, M. H., Yusaf, S. P., Elliott, D. J., Wray, D., and Sivaprasadarao, A. (1999). Effect of cysteine substitutions on the topology of the S4 segment of the shaker potassium channel: implications for molecular models of gating. J. Physiol. (Lond.) 521(Pt 2), 315-326.
-
(1999)
J. Physiol. (Lond.)
, vol.521
, Issue.PART 2
, pp. 315-326
-
-
Wang, M.H.1
Yusaf, S.P.2
Elliott, D.J.3
Wray, D.4
Sivaprasadarao, A.5
-
121
-
-
0030819954
-
A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes
-
Wang, S., Liu, S., Morales, M. J., Strauss, H. C., and Rasmusson, R. L. (1997). A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J. Physiol. (Lond.) 502(Pt 1), 45-60.
-
(1997)
J. Physiol. (Lond.)
, vol.502
, Issue.PART 1
, pp. 45-60
-
-
Wang, S.1
Liu, S.2
Morales, M.J.3
Strauss, H.C.4
Rasmusson, R.L.5
-
122
-
-
59449096598
-
hERG gating microdomains defined by S6 mutagenesis and molecular modeling
-
Wynia-Smith, S. L., Gillian-Daniel, A. L., Satyshur, K. A., and Robertson, G. A. (2008). hERG gating microdomains defined by S6 mutagenesis and molecular modeling. J. Gen. Physiol. 132, 507-520.
-
(2008)
J. Gen. Physiol.
, vol.132
, pp. 507-520
-
-
Wynia-Smith, S.L.1
Gillian-Daniel, A.L.2
Satyshur, K.A.3
Robertson, G.A.4
-
124
-
-
0029845542
-
Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel
-
Yusaf, S. P., Wray, D., and Sivaprasadarao, A. (1996). Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflugers Arch. 433, 91-97.
-
(1996)
Pflugers Arch
, vol.433
, pp. 91-97
-
-
Yusaf, S.P.1
Wray, D.2
Sivaprasadarao, A.3
-
125
-
-
0028140472
-
Shaker potassium channel gating III: evaluation of kinetic models for activation
-
Zagotta,W. N.,Hoshi,T.,and Aldrich,R. W. (1994a). Shaker potassium channel gating. III: evaluation of kinetic models for activation. J. Gen. Physiol. 103, 321-362.
-
(1994)
J. Gen. Physiol.
, vol.103
, pp. 321-362
-
-
Zagotta, W.N.1
Hoshi, T.2
Aldrich, R.W.3
-
126
-
-
0028085276
-
Shaker potassium channel gating II: transitions in the activation pathway
-
Zagotta, W. N., Hoshi, T., Dittman, J., and Aldrich, R. W. (1994b). Shaker potassium channel gating. II: transitions in the activation pathway. J. Gen. Physiol. 103, 279-319.
-
(1994)
J. Gen. Physiol.
, vol.103
, pp. 279-319
-
-
Zagotta, W.N.1
Hoshi, T.2
Dittman, J.3
Aldrich, R.W.4
-
127
-
-
33645122652
-
Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel
-
Zhang, M., Liu, J., Jiang, M., Wu, D. M., Sonawane, K., Guy, H. R., and Tseng, G. N. (2005). Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel. J. Membr. Biol. 207, 169-181.
-
(2005)
J. Membr. Biol.
, vol.207
, pp. 169-181
-
-
Zhang, M.1
Liu, J.2
Jiang, M.3
Wu, D.M.4
Sonawane, K.5
Guy, H.R.6
Tseng, G.N.7
-
128
-
-
10344246598
-
Gating charges in the activation and inactivation processes of the HERG channel
-
Zhang, M., Liu, J., and Tseng, G. N. (2004). Gating charges in the activation and inactivation processes of the HERG channel. J. Gen. Physiol. 124, 703-718.
-
(2004)
J. Gen. Physiol.
, vol.124
, pp. 703-718
-
-
Zhang, M.1
Liu, J.2
Tseng, G.N.3
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