Functional characterization of the C-terminus of the human ether-à-go-go-related gene K+ channel (HERG)

Journal of Physiology

Volumn 534, Issue 1, 2001, Pages 1-14

  Aydar, Ebru ^a   Palmer, Christopher ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; POTASSIUM CHANNEL; POTASSIUM ION; POTASSIUM; POTASSIUM CHANNEL HERG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; DELETION MUTANT; FEMALE; FUNCTIONAL ASSESSMENT; GENE CONSTRUCT; GENE DELETION; HUMAN; KINETICS; MEMBRANE POTENTIAL; MUTANT; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; REGULATORY MECHANISM; XENOPUS; ANALYTICAL PARAMETERS; EXTRACELLULAR POTASSIUM; HUMAN ETHER A GO GO RELATED GENE; XENOPUS LAEVIS;

ANIMALS; CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ELECTRIC CONDUCTIVITY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GENE DELETION; HUMANS; KINETICS; MUTATION; OOCYTES; OSMOLAR CONCENTRATION; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TRANS-ACTIVATORS; XENOPUS LAEVIS;

EID: 0035396969     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.t01-3-00001.x     Document Type: Article

References (47)

1. Kr potassium channels with HERG and is associated with cardiac arrhythmia
2. Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae
3. Time course of TEA induced anomalous rectification in the squid giant axons
4. + channel
5. Determinants of potassium channel assembly localised within the cytoplasmic C-terminal domain of Kv2.1
6. C-terminal HERG mutations: The role of hypokalemia and a KCNQ1-associated mutation in cardiac event occurrence
7. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
8. + channel by dual pathways
9. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
10. Tetramerization of the AKT1 plant potassium channel involves its C-terminal cytoplasmic domain
11. + channel behaves like an open-channel blocker
12. + channels
13. + channels
14. + channels: Effects of alterations in the carboxy-terminal region
15. Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome
16. Voltage-gated and inwardly rectifying potassium channels
17. + channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains
18. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
19. HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways
20. + channels by interaction with a family of membrane-associated guanylate kinases
21. + channel
22. + channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current
23. + channel determined by construction of multimeric cDNAs
24. Subunit stoichiometry of cyclic nucleotide-gated channels and effects of subunit order on channel function
25. Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-à-go-go potassium channel
26. New insights into the structure and function of potassium channels
27. 2+-activated K-channel
28. + channel KAT1 depend on the N and C termini
29. + channel by three amino acid substitutions
30. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel
31. +-glucose cotransport
32. + channels. Implications for activation and inactivation models
33. + channel selectivity filter by mutant cycle-based structure analysis
34. Kr potassium channel
35. + current
36. Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome
37. Cloning and expression in yeast of a plant potassium ion transport system
38. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
39. Kr channel
40. Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase
41. Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment
42. HERG, a human inward rectifier in the voltage-gated potassium channel family
43. + channel function by deletions at the N- and C-termini
44. Regulation of deactivation by an amino terminal domain in human ether-a-go-go-related gene potassium channels
45. A family of potassium channel genes related to eag in Drosophila and mammals
46. + (BK) channels
47. HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects