Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels

Biophysical Journal

Volumn 99, Issue 9, 2010, Pages 2841-2852

  Van Slyke, Aaron C ^a   Rezazadeh, Saman ^a   Snopkowski, Mischa ^a   Shi, Patrick ^a   Allard, Charlene R ^a   Claydon, Tom W ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78349240756     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.08.030     Document Type: Article

References (43)

1. Sanguinetti, M. C., C. Jiang., M. T. Keating. 1995. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81:299-307.
2. Trudeau, M. C., J. W. Warmke., G. A. Robertson. 1995. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science. 269:92-95.
3. Warmke, J. W., and B. Ganetzky. 1994. A family of potassium channel genes related to eag in Drosophila and mammals. Proc. Natl. Acad. Sci. USA. 91:3438-3442.
4. Sanguinetti, M. C., and M. Tristani-Firouzi. 2006. hERG potassium channels and cardiac arrhythmia. Nature. 440:463-469.
5. Piper, D. R., W. A. Hinz., M. Tristani-Firouzi. 2005. Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating. J. Biol. Chem. 280:7206-7217.
6. Elliott, D. J., N. Y. Dondas., A. Sivaprasadarao. 2009. Movement of the S4 segment in the hERG potassium channel during membrane depolarization. Mol. Membr. Biol. 26:435-447.
7. Smith, P. L., and G. Yellen. 2002. Fast and slow voltage sensor movements in HERG potassium channels. J. Gen. Physiol. 119:275-293.
8. Piper, D. R., A. Varghese., M. Tristani-Firouzi. 2003. Gating currents associated with intramembrane charge displacement in HERG potassium channels. Proc. Natl. Acad. Sci. USA. 100:10534-10539.
9. Wang, S., S. Liu., R. L. Rasmusson. 1997. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J. Physiol. 502:45-60.
10. Subbiah, R. N., C. E. Clarke., J. I. Vandenberg. 2004. Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel. J. Physiol. 558:417-431.
11. + channel: the S4 domain is loosely packed and likely to be lipid exposed. J. Physiol. 569:367-379.
12. Liu, J., M. Zhang., G. N. Tseng. 2003. Negative charges in the transmembrane domains of the HERG K channel are involved in the activation-and deactivation-gating processes. J. Gen. Physiol. 121:599-614.
13. Zhang, M., J. Liu, and G. N. Tseng. 2004. Gating charges in the activation and inactivation processes of the HERG channel. J. Gen. Physiol. 124:703-718.
14. Zhang, M., J. Liu., G. N. Tseng. 2005. Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel. J. Membr. Biol. 207:169-181.
15. Spector, P. S., M. E. Curran., M. C. Sanguinetti. 1996. Fast inactivation causes rectification of the IKr channel. J. Gen. Physiol. 107:611-619.
16. Schönherr, R., and S. H. Heinemann. 1996. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J. Physiol. 493:635-642.
17. Wang, J., M. C. Trudeau., G. A. Robertson. 1998. Regulation of deactivation by an amino terminal domain in human ether-à-go-gorelated gene potassium channels. J. Gen. Physiol. 112:637-647.
18. Morais Cabral, J. H., A. Lee., R. Mackinnon. 1998. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell. 95:649-655.
19. Wang, J., C. D. Myers, and G. A. Robertson. 2000. Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K (+) channels. J. Gen. Physiol. 115:749-758.
20. Gustina, A. S., and M. C. Trudeau. 2009. A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proc. Natl. Acad. Sci. USA. 106:13082-13087.
21. Alonso-Ron, C., P. de la Peña., F. Barros. 2008. Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions. Biophys. J. 94:3893-3911.
22. + channels. J. Membr. Biol. 187:117-133.
23. Sanguinetti, M. C., and Q. P. Xu. 1999. Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J. Physiol. 514:667-675.
24. + channels. J. Biol. Chem. 277:18994-19000.
25. Long, S. B., E. B. Campbell, and R. Mackinnon. 2005. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 309:903-908.
26. + channel. J. Biol. Chem. 281:12858-12864.
27. + channels. J. Gen. Physiol. 109:767-778.
28. + channel. Science. 309:897-903.
29. + channel. J. Gen. Physiol. 119:521-532.
30. Wynia-Smith, S. L., A. L. Gillian-Daniel., G. A. Robertson. 2008. hERG gating microdomains defined by S6 mutagenesis and molecular modeling. J. Gen. Physiol. 132:507-520.
31. + channels. Proc. Natl. Acad. Sci. USA. 88:2931-2935.
32. + channels. Neuron. 12:301-315.
33. Schoppa, N. E., K. McCormack., F. J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715.
34. Schoppa, N. E., and F. J. Sigworth. 1998. Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel. J. Gen. Physiol. 111:295-311.
35. Schoppa, N. E., and F. J. Sigworth. 1998. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
36. Mannuzzu, L. M., M. M. Moronne, and E. Y. Isacoff. 1996. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science. 271:213-216.
37. + channel with fluorescence. Neuron. 19:1127-1140.
38. + channels at low pH. J. Gen. Physiol. 129:437-455.
39. Lacroix, E., A. R. Viguera, and L. Serrano. 1998. Elucidating the folding problem of alpha-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters. J. Mol. Biol. 284:173-191.
40. + channel in a lipid membrane-like environment. Nature. 450:376-382.
41. Jiang, M., W. Dun, and G. N. Tseng. 1999. Mechanism for the effects of extracellular acidification on HERG-channel function. Am. J. Physiol. 277: H1283-H1292.
42. Bett, G. C., and R. L. Rasmusson. 2003. Functionally-distinct protonbinding in HERG suggests the presence of two binding sites. Cell Biochem. Biophys. 39:183-193.
43. Es-Salah-Lamoureux, Z., R. Fougere., D. Fedida. 2010. Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. PLoS ONE. 5: e10876.