Physicochemical Features of the hERG Channel Drug Binding Site

Journal of Biological Chemistry

Volumn 279, Issue 11, 2004, Pages 10120-10127

  Fernandez, David ^a   Ghanta, Azad ^a   Kauffman, Gregory W ^b   Sanguinetti, Michael C ^a  

^a UNIVERSITY OF UTAH   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; DRUG PRODUCTS; HYDROPHOBICITY; PHYSIOLOGY; VAN DER WAALS FORCES;

MEDICATIONS;

BIOCHEMISTRY;

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; CISAPRIDE; ION CHANNEL; POTASSIUM CHANNEL HERG; PROLYLVALYLPROLINE; TERFENADINE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL DEATH; CHANNEL GATING; DRUG BINDING SITE; HYDROPHOBICITY; LONG QT SYNDROME; MOLECULAR INTERACTION; NONHUMAN; PHYSICAL CHEMISTRY; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTIVE FIELD; RECEPTOR AFFINITY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BENZOPYRANS; BINDING SITES; BIOPHYSICS; CATION TRANSPORT PROTEINS; CISAPRIDE; ETHER-A-GO-GO POTASSIUM CHANNELS; HISTAMINE H1 ANTAGONISTS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PHENYLALANINE; PIPERIDINES; POINT MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, COMPLEMENTARY; SEQUENCE HOMOLOGY, AMINO ACID; SEROTONIN AGONISTS; TEMPERATURE; TERFENADINE; TYROSINE; XENOPUS;

ANIMALIA;

EID: 1642370447     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310683200     Document Type: Article

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