메뉴 건너뛰기




Volumn 137, Issue 3, 2011, Pages 315-325

hERG potassium channel gating is mediated by N-and C-terminal region interactions

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC NUCLEOTIDE; ERG1 POTASSIUM CHANNEL; HYBRID PROTEIN; POTASSIUM; POTASSIUM CHANNEL HERG;

EID: 79952120982     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.201010582     Document Type: Article
Times cited : (93)

References (33)
  • 1
    • 67349135030 scopus 로고    scopus 로고
    • Role of intracellular domains in the function of the herg potassium channel
    • doi:10.1007/s00249-009-0408-2
    • Al-Owais, M., K. Bracey, and D. Wray. 2009. Role of intracellular domains in the function of the herg potassium channel. Eur. Biophys. J. 38:569-576. doi:10.1007/s00249-009-0408-2
    • (2009) Eur. Biophys. J , vol.38 , pp. 569-576
    • Al-Owais, M.1    Bracey, K.2    Wray, D.3
  • 2
    • 0035396969 scopus 로고    scopus 로고
    • + channel (HERG)
    • DOI 10.1111/j.1469-7793.2001.t01-3-00001.x
    • Aydar, E., and C. Palmer. 2001. Functional characterization of the C-terminus of the human ether-à-go-go-related gene K (+) channel (HERG). J. Physiol. 534:1-14. doi:10.1111/j.1469-7793.2001.t01-3-00001.x (Pubitemid 32631751)
    • (2001) Journal of Physiology , vol.534 , Issue.1 , pp. 1-14
    • Aydar, E.1    Palmer, C.2
  • 3
    • 70350514521 scopus 로고    scopus 로고
    • Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods
    • doi:10.1074/jbc. M109.016337
    • Brelidze, T. I., A. E. Carlson, and W. N. Zagotta. 2009. Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods. J. Biol. Chem. 284:27989-27997. doi:10.1074/jbc. M109.016337
    • (2009) J. Biol. Chem. , vol.284 , pp. 27989-27997
    • Brelidze, T.I.1    Carlson, A.E.2    Zagotta, W.N.3
  • 4
    • 0033537885 scopus 로고    scopus 로고
    • Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
    • DOI 10.1074/jbc.274.15.10113
    • Chen, J., A. Zou, I. Splawski, M. T. Keating, and M. C. Sanguinetti. 1999. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J. Biol. Chem. 274:10113-10118. doi:10.1074/jbc.274.15.10113 (Pubitemid 29180880)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.15 , pp. 10113-10118
    • Chen, J.1    Zou, A.2    Splawski, I.3    Keating, M.T.4    Sanguinetti, M.C.5
  • 5
    • 0030989240 scopus 로고    scopus 로고
    • + channels: Spike-frequency adaptation
    • DOI 10.1111/j.1469-7793.1997.313bn.x
    • Chiesa, N., B. Rosati, A. Arcangeli, M. Olivotto, and E. Wanke. 1997. A novel role for HERG K+ channels: spike-frequency adaptation. J. Physiol. 501:313-318. (Pubitemid 27280806)
    • (1997) Journal of Physiology , vol.501 , Issue.2 , pp. 313-318
    • Chiesa, N.1    Rosati, B.2    Arcangeli, A.3    Olivotto, M.4    Wanke, E.5
  • 6
    • 79952144445 scopus 로고    scopus 로고
    • published erratum appears in, doi:10.1111/j.1469-7793.1997.313bn. x
    • (published erratum appears in J. Physiol. (Lond). 1997 502:715). doi:10.1111/j.1469-7793.1997.313bn. x
    • (1997) J. Physiol. (Lond) , vol.502 , pp. 715
  • 7
    • 0028914969 scopus 로고
    • A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
    • doi:10.1016/0092-8674 95 90358-5
    • Curran, M. E., I. Splawski, K. W. Timothy, G. M. Vincent, E. D. Green, and M. T. Keating. 1995. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 80:795-803. doi:10.1016/0092-8674 (95) 90358-5
    • (1995) Cell. , vol.80 , pp. 795-803
    • Curran, M.E.1    Splawski, I.2    Timothy, K.W.3    Vincent, G.M.4    Green, E.D.5    Keating, M.T.6
  • 8
    • 24344487347 scopus 로고    scopus 로고
    • Expression Pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: Evidence for coassembly of different subunits
    • DOI 10.1002/cne.20721
    • Guasti, L., E. Cilia, O. Crociani, G. Hofmann, S. Polvani, A. Becchetti, E. Wanke, F. Tempia, and A. Arcangeli. 2005. Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J. Comp. Neurol. 491:157-174. doi:10.1002/cne.20721 (Pubitemid 41262866)
    • (2005) Journal of Comparative Neurology , vol.491 , Issue.2 , pp. 157-174
    • Guasti, L.1    Cilia, E.2    Crociani, O.3    Hofmann, G.4    Polvani, S.5    Becchetti, A.6    Wanke, E.7    Tempia, F.8    Arcangeli, A.9
  • 9
    • 69149108876 scopus 로고    scopus 로고
    • A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels
    • doi:10.1073/pnas.0900180106
    • Gustina, A. S., and M. C. Trudeau. 2009. A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proc. Natl. Acad. Sci. USA. 106:13082-13087. doi:10.1073/pnas.0900180106
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 13082-13087
    • Gustina, A.S.1    Trudeau, M.C.2
  • 10
    • 0032529096 scopus 로고    scopus 로고
    • Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels
    • DOI 10.1111/j.1469-7793.1998.003bi.x
    • Herzberg, I. M., M. C. Trudeau, and G. A. Robertson. 1998. Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J. Physiol. 511:3-14. doi:10.1111/j.1469-7793.1998. 003bi.x (Pubitemid 28421307)
    • (1998) Journal of Physiology , vol.511 , Issue.1 , pp. 3-14
    • Herzberg, I.M.1    Trudeau, M.C.2    Robertson, G.A.3
  • 11
    • 66749174141 scopus 로고    scopus 로고
    • A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    • doi:10.1038/nm.1962
    • Huffaker, S. J., J. Chen, K. K. Nicodemus, F. Sambataro, F. Yang, V. Mattay, B. K. Lipska, T. M. Hyde, J. Song, D. Rujescu, et al. 2009. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat. Med. 15:509-518. doi:10.1038/nm.1962
    • (2009) Nat. Med. , vol.15 , pp. 509-518
    • Huffaker, S.J.1    Chen, J.2    Nicodemus, K.K.3    Sambataro, F.4    Yang, F.5    Mattay, V.6    Lipska, B.K.7    Hyde, T.M.8    Song, J.9    Rujescu, D.10
  • 12
    • 0026065274 scopus 로고
    • The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium
    • doi:10.1016/0166-2236 91 90087-B
    • Kaupp, U. B. 1991. The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium. Trends Neurosci. 14:150-157. doi:10.1016/0166-2236 (91) 90087-B
    • (1991) Trends Neurosci. , vol.14 , pp. 150-157
    • Kaupp, U.B.1
  • 13
    • 0024805680 scopus 로고
    • Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
    • DOI 10.1038/342762a0
    • Kaupp, U. B., T. Niidome, T. Tanabe, S. Terada, W. Bönigk, W. Stühmer, N. J. Cook, K. Kangawa, H. Matsuo, T. Hirose, et al. 1989. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature. 342:762-766. doi:10.1038/342762a0 (Pubitemid 20023808)
    • (1989) Nature , vol.342 , Issue.6251 , pp. 762-766
    • Kaupp, U.B.1    Niidome, T.2    Tanabe, T.3    Terada, S.4    Bonigk, W.5    Stuhmer, W.6    Cook, N.J.7    Kangawa, K.8    Matsuo, H.9    Hirose, T.10    Numa, S.11
  • 14
    • 78649713129 scopus 로고    scopus 로고
    • NMR solution structure of the N-terminal domain of hERG and its interaction with the S4-S5 linker
    • doi:10.1016/j.bbrc.2010.10.132
    • Li, Q., S. Gayen, A. S. Chen, Q. Huang, M. Raida, and C. Kang. 2010. NMR solution structure of the N-terminal domain of hERG and its interaction with the S4-S5 linker. Biochem. Biophys. Res. Commun. 403:126-132. doi:10.1016/j.bbrc. 2010.10.132
    • (2010) Biochem. Biophys. Res. Commun. , vol.403 , pp. 126-132
    • Li, Q.1    Gayen, S.2    Chen, A.S.3    Huang, Q.4    Raida, M.5    Kang, C.6
  • 15
    • 51049115964 scopus 로고    scopus 로고
    • FRET with multiply labeled HERG K (+) channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains
    • doi:10.1016/j.bbamcr.2008.06.009
    • Miranda, P., D. G. Manso, F. Barros, L. Carretero, T. E. Hughes, C. Alonso-Ron, P. Domínguez, and P. de la Peña. 2008. FRET with multiply labeled HERG K (+) channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains. Biochim. Biophys. Acta. 1783:1681-1699. doi:10.1016/j.bbamcr.2008.06.009
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 1681-1699
    • Miranda, P.1    Manso, D.G.2    Barros, F.3    Carretero, L.4    Hughes, T.E.5    Alonso-Ron, C.6    Domínguez, P.7    De La Peña, P.8
  • 16
    • 0032567106 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain
    • Morais Cabral, J. H., A. Lee, S. L. Cohen, B. T. Chait, M. Li, and R. Mackinnon. 1998. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell. 95:649-655. doi:10.1016/S0092-8674 (00) 81635-9 (Pubitemid 28544126)
    • (1998) Cell , vol.95 , Issue.5 , pp. 649-655
    • Morals Cabral, J.H.1    Lee, A.2    Cohen, S.L.3    Chait, B.T.4    Li, M.5    Mackinnon, R.6
  • 17
    • 54049090005 scopus 로고    scopus 로고
    • ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones
    • doi:10.1113/jphysiol.2008.155762
    • Pessia, M., I. Servettini, R. Panichi, L. Guasti, S. Grassi, A. Arcangeli, E. Wanke, and V. E. Pettorossi. 2008. ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones. J. Physiol. 586:4877-4890. doi:10.1113/jphysiol.2008.155762
    • (2008) J. Physiol. , vol.586 , pp. 4877-4890
    • Pessia, M.1    Servettini, I.2    Panichi, R.3    Guasti, L.4    Grassi, S.5    Arcangeli, A.6    Wanke, E.7    Pettorossi, V.E.8
  • 18
    • 0141856608 scopus 로고    scopus 로고
    • Functional roles of an ERG current isolated in cerebellar Purkinje neurons
    • DOI 10.1152/jn.00104.2003
    • Sacco, T., A. Bruno, E. Wanke, and F. Tempia. 2003. Functional roles of an ERG current isolated in cerebellar Purkinje neurons. J. Neurophysiol. 90:1817-1828. doi:10.1152/jn. 00104.2003 (Pubitemid 37129388)
    • (2003) Journal of Neurophysiology , vol.90 , Issue.3 , pp. 1817-1828
    • Sacco, T.1    Bruno, A.2    Wanke, E.3    Tempia, F.4
  • 19
    • 0035399872 scopus 로고    scopus 로고
    • + channels in brain
    • Saganich, M. J., E. Machado, and B. Rudy. 2001. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. J. Neurosci. 21:4609-4624. (Pubitemid 32565620)
    • (2001) Journal of Neuroscience , vol.21 , Issue.13 , pp. 4609-4624
    • Saganich, M.J.1    Machado, E.2    Rudy, B.3
  • 20
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    • doi:10.1016/0092-8674 95 90340-2
    • Sanguinetti, M. C., C. Jiang, M. E. Curran, and M. T. Keating. 1995. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81:299-307. doi:10.1016/0092-8674 (95) 90340-2
    • (1995) Cell. , vol.81 , pp. 299-307
    • Sanguinetti, M.C.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 21
    • 0030054878 scopus 로고    scopus 로고
    • Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
    • Schönherr, R., and S. H. Heinemann. 1996. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J. Physiol. 493:635-642. (Pubitemid 26232101)
    • (1996) Journal of Physiology , vol.493 , Issue.3 , pp. 635-642
    • Schonherr, R.1    Heinemann, S.H.2
  • 22
    • 0029926887 scopus 로고    scopus 로고
    • Fast inactivation causes rectification of the IKr channel
    • doi:10.1085/jgp. 107.5.611
    • Spector, P. S., M. E. Curran, A. Zou, M. T. Keating, and M. C. Sanguinetti. 1996. Fast inactivation causes rectification of the IKr channel. J. Gen. Physiol. 107:611-619. doi:10.1085/jgp. 107.5.611
    • (1996) J. Gen. Physiol. , vol.107 , pp. 611-619
    • Spector, P.S.1    Curran, M.E.2    Zou, A.3    Keating, M.T.4    Sanguinetti, M.C.5
  • 23
    • 0037061704 scopus 로고    scopus 로고
    • An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindness
    • DOI 10.1016/S0896-6273(02)00647-5
    • Trudeau, M. C., and W. N. Zagotta. 2002. An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindness. Neuron. 34:197-207. doi:10.1016/S0896-6273 (02) 00647-5 (Pubitemid 34442563)
    • (2002) Neuron , vol.34 , Issue.2 , pp. 197-207
    • Trudeau, M.C.1    Zagotta, W.N.2
  • 24
    • 0029007356 scopus 로고
    • HERG, a human inward rectifier in the voltage-gated potassium channel family
    • doi:10.1126/science.7604285
    • Trudeau, M. C., J. W. Warmke, B. Ganetzky, and G. A. Robertson. 1995. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science. 269:92-95. doi:10.1126/science.7604285
    • (1995) Science , vol.269 , pp. 92-95
    • Trudeau, M.C.1    Warmke, J.W.2    Ganetzky, B.3    Robertson, G.A.4
  • 26
    • 0030863675 scopus 로고    scopus 로고
    • Interdomain interactions underlying activation of cyclic nucleotide- gated channels
    • DOI 10.1126/science.278.5335.110
    • Varnum, M. D., and W. N. Zagotta. 1997. Interdomain interactions underlying activation of cyclic nucleotide-gated channels. Science. 278:110-113. doi:10.1126/science.278.5335.110 (Pubitemid 27446287)
    • (1997) Science , vol.278 , Issue.5335 , pp. 110-113
    • Varnum, M.D.1    Zagotta, W.N.2
  • 27
    • 0033917883 scopus 로고    scopus 로고
    • + channel gating
    • Viloria, C. G., F. Barros, T. Giráldez, D. Gómez-Varela, and P. de la Peña. 2000. Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K (+) channel gating. Biophys. J. 79:231-246. doi:10.1016/S0006-3495 (00) 76286-2 (Pubitemid 30436740)
    • (2000) Biophysical Journal , vol.79 , Issue.1 , pp. 231-246
    • Viloria, C.G.1    Barros, F.2    Giraldez, T.3    Gomez-Varela, D.4    De La Pena, P.5
  • 28
    • 0031742141 scopus 로고    scopus 로고
    • Regulation of deactivation by an amino terminal domain in human ether- a-go-go-related gene potassium channels
    • DOI 10.1085/jgp.112.5.637
    • Wang, J., M. C. Trudeau, A. M. Zappia, and G. A. Robertson. 1998. Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels. J. Gen. Physiol. 112:637-647. published erratum appears in (Pubitemid 28518961)
    • (1998) Journal of General Physiology , vol.112 , Issue.5 , pp. 637-647
    • Wang, J.1    Trudeau, M.C.2    Zappia, A.M.3    Robertson, G.A.4
  • 29
    • 0032895617 scopus 로고    scopus 로고
    • doi:10.1085/jgp. 112.5.637
    • J. Gen. Physiol. 1999. 113:359). doi:10.1085/jgp. 112.5.637
    • (1999) J. Gen. Physiol. , vol.113 , pp. 359
  • 33
    • 0141831003 scopus 로고    scopus 로고
    • Structural basis for modulation and agonist specificity of HCN pacemaker channels
    • DOI 10.1038/nature01922
    • Zagotta, W. N., N. B. Olivier, K. D. Black, E. C. Young, R. Olson, and E. Gouaux. 2003. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature. 425:200-205. doi:10.1038/nature01922 (Pubitemid 37150901)
    • (2003) Nature , vol.425 , Issue.6954 , pp. 200-205
    • Zagotta, W.N.1    Olivier, N.B.2    Black, K.D.3    Young, E.C.4    Olson, R.5    Gouaux, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.