R1 in the Shaker S4 occupies the gating charge transfer center in the resting state

Journal of General Physiology

Volumn 138, Issue 2, 2011, Pages 155-163

  Lin, Meng chin A ^a   Hsieh, Jui Yi ^a   Mock, Allan F ^a   Papazian, Diane M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE; MEMBRANE PROTEIN; SHAKER POTASSIUM CHANNEL; ZINC;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; XENOPUS;

ANIMALS; HISTIDINE; ION CHANNEL GATING; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTATION; OOCYTES; PROTEIN STRUCTURE, TERTIARY; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; XENOPUS; ZINC;

EID: 79961124704     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.201110642     Document Type: Article

References (24)

1. + channel. Neuron. 16:1169-1177.
2. + channel voltage sensor. Proc. Natl. Acad. Sci. USA. 102:18718-18723.
3. Campos, F.V., B. Chanda, B. Roux, and F. Bezanilla. 2007. Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc. Natl. Acad. Sci. USA. 104:7904-7909.
4. Chen, X., Q. Wang, F. Ni, and J. Ma. 2010. Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc. Natl. Acad. Sci. USA. 107:11352-11357.
5. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
6. Islas, L.D., and F.J. Sigworth. 1999. Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. J. Gen. Physiol. 114:723-742.
7. Khalili-Araghi, F., V. Jogini, V. Yarov-Yarovoy, E. Tajkhorshid, B. Roux, and K. Schulten. 2010. Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys. J. 98:2189-2198.
8. Lainé, M., M.C. Lin, J.P.A. Bannister, W.R. Silverman, A.F. Mock, B. Roux, and D.M. Papazian. 2003. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron. 39:467-481.
9. 2+ binds to resting state to modulate channel opening. J. Gen. Physiol. 135:415-431.
10. + channel in a lipid membrane-like environment. Nature. 450:376-382.
11. Papazian, D.M., L.C. Timpe, Y.N. Jan, and L.Y. Jan. 1991. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature. 349:305-310.
12. + channel. Neuron. 56:124-140.
13. Perozo, E., L. Santacruz-Toloza, E. Stefani, F. Bezanilla, and D.M. Papazian. 1994. S4 mutations alter gating currents of Shaker K channels. Biophys. J. 66:345-354.
14. Schoppa, N.E., K. McCormack, M.A. Tanouye, and F.J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715.
15. + channel. Neuron. 16:1159-1167.
16. 2+ modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between trans- membrane segments S2 and S3. J. Gen. Physiol. 116:663-678.
17. Silverman, W.R., J.P.A. Bannister, and D.M. Papazian. 2004. Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel. Biophys. J. 87:3110-3121.
18. Starace, D.M., and F. Bezanilla. 2004. A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature. 427:548-553.
19. 2+ modulates slow gating transitions and the opening of Drosophila ether-à-go-go potassium channels. J. Gen. Physiol. 115:319-338.
20. Tao, X., A. Lee, W. Limapichat, D.A. Dougherty, and R. MacKinnon. 2010. A gating charge transfer center in voltage sensors. Science. 328:67-73.
21. Tempel, B.L., D.M. Papazian, T.L. Schwarz, Y.N. Jan, and L.Y. Jan. 1987. Sequence of a probable potassium channel compo- nent encoded at Shaker locus of Drosophila. Science. 237:770-775.
22. Timpe, L.C., T.L. Schwarz, B.L. Tempel, D.M. Papazian, Y.N. Jan, and L.Y. Jan. 1988. Expression of functional potassium chan- nels from Shaker cDNA in Xenopus oocytes. Nature. 331:143-145.
23. Tombola, F., M.M. Pathak, and E.Y. Isacoff. 2005. Voltage-sensing argi- nines in a potassium channel permeate and occlude cation-selective pores. Neuron. 45:379-388.
24. + channels. Proc. Natl. Acad. Sci. USA. 103:7292-7297.